Trach v. Fellin

817 A.2d 1102, 2003 Pa. Super. 53, 2003 Pa. Super. LEXIS 180

• Court: Superior Court of Pennsylvania
• Decided: February 11, 2003
• Status: Published

Opinions

Opinion by

FORD ELLIOTT, J.

¶ 1 We granted en banc review in this case in order to reevaluate the circumstances under which a party seeking to exclude expert scientific evidence may test the admissibility of that evidence pursuant to Frye v. United States, 293 F. 1013 (D.C.Cir.1923). In the process, we are required to revisit several recent panel decisions of this court to determine whether we have extended Frye beyond the parameters our supreme court has established, keeping in mind that Frye is an exclusionary rule of evidence. As such, it must be construed narrowly so as not to impede admissibility of evidence that will aid the trier of fact in the search for truth. See Pa.R.E. 702, 42 Pa.C.S.A. (“If scientific, technical or other specialized knowledge beyond that possessed by a layperson will assist the trier of fact to understand the evidence or to determine a fact in issue, a witness qualified as an expert by knowledge, skill, experience, training or education may testify thereto in the form of an opinion or otherwise! ]”). See also id. at Comment — -1998 (noting that Rule 702 does not alter Pennsylvania’s adoption of the Frye standard; also noting that the Rule does not change the rule for qualifying a witness as an expert enunciated in Miller v. Brass Rail Tavern, Inc., 541 Pa. 474, 480-481, 664 A.2d 525, 528 (1995) (holding, “The test to be applied ... is whether the witness has any reasonable pretension to specialized knowledge on the subject under investigation. If he does, he may testify and the weight to be given to such testimony is for the trier of fact to determine.”)).

¶ 2 In this case, the trial court vacated the jury’s verdict of $5 million and granted Thrift Drug, Inc. a new trial as to damages, having determined that it erred when it allowed Allen Trach’s scientific expert to testify. Thrift Drug challenged the expert’s methodologies and conclusions, claiming neither had been generally accepted in the scientific community. After a thorough analysis of the circumstances under which a party may invoke Frye to exclude expert testimony, however, we are constrained to conclude that the trial court erred when it vacated the jury’s verdict because Trach allegedly failed to establish a causal connection between Trach’s long-term medical problems and Thrift Drug’s negligence.

¶ 3 The facts of this case are not in dispute. Mien Trach (“Trach”), a healthy, 47-year-old man, went to his dentist on July 11, 1995, complaining of pain in his jaw. The dentist, suspecting an infection, gave Trach a prescription for forty 250-mg. capsules of Amoxil, an antibiotic, which Trach then took to a Thrift Drug Store pharmacy to fill. A pharmacy assistant mistakenly gave Trach 29 capsules of the antidepressant Doxepin, and told him to return for the remaining 11 capsules in a few days, as the pharmacy did not have 40 capsules in stock.

¶ 4 Doxepin has the potential to cause serious adverse reactions in individuals who take it in the recommended dosage. Trach, however, took the Doxepin according to the dosage his dentist prescribed for Amoxil, for which the dosage was appropriate.¹ According to Trach’s expert’s report, Trach took 1,800 milligrams (“mg.”) of Doxepin on the first day. (Expert report of John J. Shane, M.D. (“Shane’s expert report”), citing Physician’s Desk Reference (“PDR”) for Doxepin, R. at 31 Exhibit A.) The recommended optimal dose range for Doxepin is between 75 mg. and 150 per day, while the maximum recommended dose is 300 mg. per day. Physicians’ Desk Reference (“PDR”) at 2408 (53rd ed.1999).²

¶ 5 When Trach immediately experienced side effects, including visual symptoms, he consulted his physician, who diagnosed the problem as trigeminal neuralgia, but did not believe it was a side effect of the antibiotic. (Plaintiffs complaint at 3 ¶ 12, R. at 7.) Trach subsequently developed a sore throat, and, believing the sinus infection caused it, took an additional ten capsules of Doxepin over the next 24 hours. (Id.) Despite suffering hallucinations, heartburn, confusion, and extreme difficulty concentrating, Trach continued to take the medication until, according to Dr. Shane, he had consumed 4,800 mg. of Doxepin over a five-day period. (Shane’s expert report at 1.)

¶ 6 On July 18, Trach returned to Thrift Drug to pick up the remainder of the prescription, and his wife noticed that the 11 new pills were different from the original 29. She called the pharmacy, and upon investigation, the pharmacist stated that Trach had been given the wrong medication initially, an antidepressant called Doxepin. Trach then went to the hospital for testing. (Trial court opinion, 5/18/00 at 5.) While most of Trach’s reactions to the Doxepin subsided within a month, he continues to experience cognitive difficulties, cluster headaches, and vision problems.

¶ 7 In March of 1996, eight months after the Doxepin overdose and following repeated efforts to determine the nature of Trach’s problems with his vision, Trach was diagnosed with glaucoma. (Notes of testimony, 6/17/99 at 138.) Mark E. Moran, D.O., the ophthalmologist who treated Trach’s glaucoma, described it as “chronic open-angle glaucoma or even more specifically pigmentary glaucoma.” (Id. at 116.) Additionally, Trach has a crescent-shaped blind spot, known as an arcuate scotoma, in his right eye as a result of optic nerve damage from the glaucoma. The damage to his eyesight is permanent and affects his ability to read and to engage in the hobbies of photography and hunting that he previously enjoyed. He is also concerned that he may not be able to retain his job because of his vision and cognitive problems.

¶8 According to the PDR, adverse reactions to Doxepin when taken in the recommended dosage may include blurred vision, confusion, disorientation, and hallucinations. The PDR also indicates that death or coma may result from an overdose of Doxepin, as well as confusion, disturbed concentration, transient visual hallucination, dilated pupils, and other serious consequences. Additionally, one of Thrift Drug’s medical experts, Michael Naidoff, M.D., an ophthalmologist, acknowledged that Doxepin can cause narrow or closed-angle glaucoma in susceptible individuals. (Deposition of Michael A. Naidoff, M.D. (“Naidoff deposition”), 6/8/99 at 25, Defendant’s Exhibit 4.) For obvious reasons, however, no one has conducted studies to determine the effects of a massive overdose of Doxepin such as the dose Trach took; therefore, no studies exist indicating that a massive overdose can cause open angle or pig-mentary glaucoma, the form of glaucoma from which Trach continues to suffer. Similarly, no studies exist indicating that the usually transient side-effects of Doxe-pin, such as unsteadiness, confusion, poor memory, cluster headaches, and inability to concentrate, of which Trach still complains, can become permanent when an individual takes a massive overdose of Doxepin.

¶ 9 To support his claim that the Doxe-pin overdose caused the cognitive and vision problems he continues to experience, Trach proffered expert testimony from a board-certified pathologist and toxicologist, Dr. John Shane. Prior to trial, Thrift Drug filed a motion in limine to preclude Dr. Shane’s testimony, claiming it did not meet the requirements for scientific expert evidence set forth in Frye, supra, and its progeny in Pennsylvania (the Frye test). See, e.g., Commonwealth v. Blasioli, 552 Pa. 149, 713 A.2d 1117 (1998); Commonwealth v. Crews, 536 Pa. 508, 640 A.2d 395 (1994); and Commonwealth v. Topa, 471 Pa. 223, 369 A.2d 1277 (1977), the case in which our supreme court adopted the Frye test. See also Blum v. Merrell Dow Pharmaceuticals, Inc., 705 A.2d 1314 (Pa.Super.1997), affirmed, 564 Pa. 3, 764 A.2d 1 (2000). The trial court denied Thrift Drug’s motion.

¶ 10 Dr. Shane was Trach’s only expert witness on the issue of causation. The trial court in its opinion summarized Dr. Shane’s expert testimony as follows:

Doxepin is a tricyclic antidepressant... Doxepin works by blocking the amine pump that transmits nerve impulses across synapses, the junction points at which nerve cells hook up with each other. The transmission of nerve impulses across synapses depends on an intact chemical environment. Doxepin interferes with this environment by blocking the transmission of the chemical acetylcholine. This blocking action is ■ known as an anticholinergic effect. There may be adverse reactions or side effects from even a therapeutic dose of Doxepin. There are also contraindications for Doxepin, i.e., symptoms or conditions that may be exacerbated by the drug. The known side effects and contraindications have been determined through clinical trials prior to approval of the drug by the Federal Food and Drug Administration (the ‘FDA’) and also from clinical experience since the drug has been on the market. The side effects and contraindications for a therapeutic dose of Doxepin are identified in the manufacturer’s insert and in the Physician’s Desk Reference (the ‘PDR’). The manufacturer’s insert is included with each package of a drug that has been approved for marketing by the FDA. The PDR is a compilation of drugs that are available for the treatment of patients. It is considered authoritative and is relied on regularly by physicians in prescribing drugs to patients... The symptoms experienced by Trach after ingesting Doxepin are consistent with the adverse reactions identified in the manufacturer’s package insert and in the PDR. These adverse reactions or side effects included ataxia (unsteadiness on his feet), dizziness, blurred vision and disorientation... Glaucoma is a condition of increased ocular pressure in the eye that causes pathologic change to the eye. It may result in damage to the optic nerve that is irreversible, and in some cases, loss of vision. Both the manufacturer’s insert and the PDR state that Doxepin is contraindicated for glaucoma. This is for two reasons. First, the anticholinergic effect of Doxepin causes the pupils of the eye to dilate unequally, a condition known as mydriasis. Second, the anti-cholinergic effect also causes the ciliary muscle of the eye to become inactive, a condition referred to as cycloplegia... The combination of mydriasis and cyclo-plegia leads to blurred vision. It also leads to changes in the eye, specifically a blockage of the Canal of Schlemm, a circulatory channel between the front chamber and back chamber of the eye. The result is increased pressure in the eye. In addition, the dilation of the iris, the colored part of the eye, causes pig-mentary loss. The pigment is deposited in the filter system at the Canal of Schlemm, further clogging up the filter and also causing increased pressure in the eye. The combination of mydriasis and cycloplegia is a mechanism that leads to narrow-angle glaucoma, sometimes referred to as closed-angle glaucoma. However, the distinctions between narrow or closed-angle glaucoma and open-angle glaucoma are often confused in the medical profession. Consequently, some authorities have recommended that the nomenclature be changed to eliminate the distinction...

Trial court opinion, 5/18/00 at 7-9, citing notes of testimony, 6/16/99 at 168-251.

¶ 11 Further, Dr. Shane testified to a reasonable degree of toxicological certainty that all the symptoms Trach suffered immediately after ingesting the Doxepin, and his continuing symptoms, including the glaucoma and scotoma and various cognitive problems, are the direct result of the overdose of Doxepin. (Notes of testimony, 6/16/99 at 208-215.) At the close of all the evidence, Thrift Drug moved to strike Dr. Shane’s testimony in its entirety; however, the trial court denied the motion.³ As noted supra, Trach also called Dr. Moran, the ophthalmologist who has been treating Trach for his eye problems and who referred Trach to various specialists, one of whom finally diagnosed glaucoma. Dr. Moran did not testify as to causation, however. (Notes of testimony, 6/17/99 at 114-148.)

¶ 12 In response to Trach’s expert testimony, Thrift Drug offered the testimony of two experts; Dr. Naidoff, the ophthalmologist mentioned earlier, who regularly treats glaucoma patients and who had examined Trach’s medical records but had never examined Trach; and Richard I. Katz, M.D., a board-certified neurologist who, like Dr. Naidoff, had only examined-Trach’s medical records. Dr. Naidoff, through his videotaped deposition, testified that while Doxepin can cause closed-angle glaucoma, there is nothing in the medical literature indicating it can cause the type of glaucoma from which Trach suffers, of which the cause is unknown. (Naidoff deposition, 6/8/99 at 14-24.) Dr. Katz testified that Trach’s neurological symptoms would have subsided within a month, and that Trach’s medical records indicated no objective signs of neurological damage, instead indicating that he was neurologically normal. (Notes of testimony, 6/16/99 at 252-315.)

¶ 13 As noted supra, at the close of the evidence, Thrift Drug moved for a compulsory nonsuit, a directed verdict, or a motion to strike Dr. Shane’s testimony. Instead, the trial court directed a verdict in Trach’s favor as to negligence and sent to the jury the issue of damages. The jury returned a verdict in favor of Trach in the amount of $5 million. Thrift Drug then filed a post-trial motion requesting judgment n.o.v. or, in the alternative, a new trial, arguing that the trial court should not have admitted Dr. Shane’s testimony. The trial court denied Thrift Drug’s motion for j.mo.v. but granted a new trial as to damages only, agreeing that Dr. Shane’s causation testimony as to the long-term effects of Doxepin did not meet the standard required by Frye. (Trial court opinion, 5/18/00 at 33.) Both parties filed appeals, Trach claiming trial court error in ordering a new trial as to damages on the basis that Dr. Shane’s testimony as to the long-term effects of Doxepin did not pass the Frye test; and Thrift Drug claiming trial court error in not granting a j.n.o.v. as to Trach’s long-term injuries, and/or a new trial as to both causation and damages because Dr. Shane’s allegedly inadmissible testimony prejudiced Thrift Drug. (Trach’s brief at 4; Thrift Drug’s brief at 1.)

¶ 14 We first note our standard of review in this appeal from the grant of a new trial. Where, as here, the trial court set forth the specific basis for its grant of a new trial, we consider whether the court abused its discretion or committed an error of law in its decision on that stated basis only. Coker v. S.M. Flickinger Co., 533 Pa. 441, 449-450, 625 A.2d 1181, 1185-1186 (1993). Therefore, we consider only whether the trial judge erred in ordering a new trial as to damages on the basis that a portion of Trach’s causation evidence did not meet the Frye test and was improperly admitted at trial.⁴

¶ 15 We first consider the circumstances under which our supreme court has analyzed the admissibility of evidence pursuant to Frye. We begin with the observation that Frye, by definition, only applies where expert testimony is required. Frye, 293 F. at 1014 (“ “When the question involved does not lie within the range of common experience or common knowledge, but requires special experience or special knowledge, then the opinions of witnesses skilled in that particular science ... are admissible in evidence” ’), quoting brief for the United States.

¶ 16 A review of our supreme court’s application of Frye over the past twenty-five years also supports the proposition that Frye only applies when a party seeks to introduce novel scientific evidence. See Blasioli, supra at 153, 713 A.2d at 1119 (“In determining whether novel scientific evidence is admissible ..., Pennsylvania courts apply the test set forth in Frye (emphasis added). See also Topa, supra, a case involving novel scientific methodology. Thus, Frye does not apply every time science enters the courtroom.

¶ 17 The supreme court reaffirmed the proper application of Frye when it adopted Pa.R.Civ.P. 207.1, “Motion to Exclude Expert Testimony Which Relies upon Novel Scientific Evidence.” Pa.R.Civ.P. 207.1, 42 Pa.C.S.A., adopted 2001, January 22, 2001, effective July 1, 2001. As the explanatory comment to that Rule states, “The purpose of new Rule 207.1 is to provide the procedure for pre-trial motions concerning the admissibility of expert testimony which relies upon novel scientific evidence.” Id., Explanatory Comment — 2001.⁵

¶ 18 We are therefore concerned with this court’s pronouncement in Blum, supra, in which a panel of this court opined that Frye applies “whenever science enters the courtroom, because 'there is the danger that the trial judge or jury will ascribe a degree of certainty to the testimony of the expert ... which may not be deserved.” ’ Blum, 705 A.2d at 1317 (emphasis added), quoting Topa, supra at 230, 369 A.2d at 1281. See also Commonwealth v. Rodgers, 413 Pa.Super. 498, 605 A.2d 1228, 1234 (1992) (stating, “Before scientifically adduced evidence may be considered admissible, it must first be shown that it meets the standard established in Frye .. .”).⁶

¶ 19 In both Topa, supra, and Rodgers, supra, however, the cases upon which a panel of our court relied in Blum, supra, the statements regarding the necessity for applying the Frye standard every time science enters the courtroom involved novel scientific methodology; in Topa, the methodology was spectrography, or voice print analysis; in Frye, the novel methodology was a systolic blood pressure deception test, which was alleged to determine whether an individual was telling the truth. Likewise, Rodgers involved DNA/RFLP⁷ analyses performed on bloodstains found on the victim’s and Rodgers’ clothing. Thus, in the context of those cases, the court stated that Frye applied because the scientific methodology was novel. Clearly, however, our supreme court did not intend that trial courts be required to apply the Frye standard every time scientific experts are called to render an opinion at trial, a result that is nothing short of Kafkaesque to contemplate.

¶ 20 We, like the dissent, are aware that ebb and flow are at the heart of the scientific method: the theory of relativity is only valid until someone disproves it. As the Frye court so elegantly stated, however, “While courts will go a long way in admitting expert testimony deduced from a well-recognized scientific principle or discovery, the thing from which the deduction is made must be sufficiently established to have gained general acceptance in the particular field in which it belongs.” Frye, 293 F. at 1013. In this single, simple sentence, the Frye court recognized that the essence of admissibility is general acceptance: that a principle or discovery can fall by the wayside as science advances is just another way of saying it is not generally accepted. We therefore conclude that we are merely stating the law in Pennsylvania when we state that Frye applies only to novel science.

¶ 21 Having delineated two prerequisites for applying Frye, that expert scientific evidence is being offered and that the scientific evidence is, in some sense, novel, we must next ask what it is that must be novel about the science. We note recent cases from this court and from our sister court holding that the Frye standard applies when either the methodology the scientist uses or the conclusion the scientist reaches is novel. See Blum, 705 A.2d at 1322 (opining, “A close reading of the relevant cases yields two ways to analyze the question of whether the causation testimony proffered in this case meets the Frye/Topa standard. One focuses on whether the causal relationship is generally accepted by the scientific community, and the other on whether the methodology is generally accepted by the scientific community[ ]”).

¶ 22 The panel of this court deciding Blum, supra, relied on McKenzie v. Westinghouse Elec. Corp., 674 A.2d 1167 (Pa.Commw.1996), appeal denied, 547 Pa. 733, 689 A.2d 237 (1997), to reach the conclusion that both the causal relationship and the methodology must be generally accepted in the relevant scientific community. According to Blum, supra, the McKenzie court interpreted Frye and Topa to hold that “ ‘there must be a showing, not that the studies establishing the causal relationship follow generally accepted methodologies, but that the existence of the causal relationship is generally accepted by the relevant medical community.’ ” Blum, 705 A.2d at 1322, quoting McKenzie, 674 A.2d at 1172 (emphasis in Blum).

¶ 23 While our supreme court affirmed this court’s decision in Blum, supra, it based its affirmance on the fact that “the primary evidence at trial supporting the conclusion that Bend[e]ctin [the drug at issue in that case] caused appellant’s birth defect ... was so flawed as to render [the expert’s] conclusions unreliable and therefore inadmissible under either Frye or Daubert.” Blum, supra at 8, 764 A.2d at 4. The majority did not state that the scientific community must have generally accepted the causal relationship about which the expert is to testify. Rather, in a footnote quoting an opinion from the Ninth Circuit Court of Appeals, the majority stated, “ When a scientist claims to rely on a method practiced by most scientists, yet presents conclusions that are shared by no other scientist, the [trial] court should be wary that the method has not been faithfully applied.’ ” Id. at 7 n. 5, 764 A.2d at 4 n. 5, quoting Lust v. Merrell Dow Pharmaceuticals, Inc., 89 F.3d 594, 598 (9th Cir.1996) (emphasis added).⁸

¶ 24 Additionally, we note that two justices in Blum wrote strong dissents, both specifically rejecting McKenzie, supra, and its “two bases” analysis. Justice, now Chief Justice, Cappy, for example, observing that the majority had not addressed this court’s reasoning in its affirmance of Blum, stated, “I believe that in this matter it is important to discuss the Superior Court’s recitation of the Frye test as it has the potential to mislead the lower courts and the practicing bar.” Blum, supra at 9, 764 A.2d at 5 (Cappy, C.J., dissenting). As Chief Justice Cappy continued:

Specifically, I refer to the Superior Court’s statement that there are ‘two ways to analyze the question of whether the causation testimony proffered ... meets the Frye ... standard. One focuses on whether the causal relationship is generally accepted by the scientific community, and the other on whether the methodology is generally accepted by the scientific community.’

Id. Noting that the supreme court has “not stated that the conclusion reached by the scientist regarding causation must also be generally accepted,” id., Chief Justice Cap-py opined:

The Frye standard is limited to an inquiry into whether the methodoloyies by which the scientist has reached her conclusions have been generally accepted in the scientific community.... It restricts the scientific evidence which may be admitted as it ensures that the proffered evidence results from scientific research which has been conducted in a fashion that is generally recognized as being sound, and is not the fanciful creations [sic] of a renegade researcher. Yet, such a standard is not senselessly restrictive for it allows a scientist to testify as to new conclusions which have emerged during the course of properly-conducted research.

Id. at 9-10, 764 A.2d at 5 (Cappy, C.J., dissenting) (emphasis in original). Hence, Chief Justice Cappy concluded that he would “squarely reject that portion of the Superior Court’s holding which would require that a scientist’s conclusions, as well as the methodologies utilized in reaching those conclusions, are generally accepted in the medical community.” Id. at 10, 764 A.2d at 5 (Cappy, C.J., dissenting).

¶ 25 Similarly, Justice Castille, in a lengthy and provocative dissent, rejected . Commonwealth court’s “rather novel opinion” that “the expert’s opinion as to the causal relationship at issue, and not just the expert’s methodology, must find general acceptance in the relevant scientific community before it may even be heard.” Id. at 13, 764 A.2d at 7 (Castille, J., dissenting).⁹

¶ 26 Finally, we note that the Supreme Court in Daubert, supra, discussing F.R.E. 702, explicitly stated that “the focus ... must be solely on principles and methodology, not on the conclusions that they generate.” Daubert, 509 U.S. at 595, 113 S.Ct. 2786. Thus, having reviewed the case law and history behind the “two bases” analysis, we conclude that our supreme court has never adopted it, and therefore hold that Frye only applies to determine if the relevant scientific community has generally accepted the principles and methodology the scientist employs, not the conclusions the scientist reaches, before the court may allow the expert to testify. See Blasioli, supra at 153, 713 A.2d at 1119. To the extent the decisions of this court in Blum, supra; Thomas v. West Bend Co., Inc., 760 A.2d 1174 (Pa.Super.2000), appeal denied, 566 Pa. 647, 781 A.2d 147 (2001); and Wack v. Farmland Industries, Inc., 744 A.2d 265 (Pa.Super.1999), appeal denied, 565 Pa. 649, 771 A.2d 1287 (2001), relying on McKenzie, supra, have followed or referenced the two-bases analysis, we can find no support for doing so in our supreme court’s Frye analysis. Rather, it appears as if the two-bases analysis arose from confusing “principles” with “conclusions.” See McKenzie, 674 A.2d at 1172, quoting Rodgers, 605 A.2d at 1234 (opining that the Frye/Topa standard “ ‘assures that those most qualified to assess the general validity of a scientific method will have the determinative voice by requiring that the principle or discovery forming the basis for evidence presented at trial must have gained general acceptance in the particular field to which it belongs[ ]’ ”) (emphasis in McKenzie).

¶ 27 In this case, the trial court relied on the two-bases analysis; however, it intertwined methodology and conclusion in such a way that we must discuss both.¹⁰ We begin by observing that there is no question that the scientific community has generally accepted the basic principle Dr. Shane employed, The “Dose-Response” principle. This principle is not as old as the pyramids cited by an en banc panel of this court in Grady v. Frito-Lay, Inc., 789 A.2d 735, 742-743 (Pa.Super.2001) (en banc), allocatur granted, 569 Pa. 46, 800 A.2d 294 (2002), when referring to crush and compression strength calculations. Nevertheless, the dose-response principle originated in the sixteenth century when Paracelsus, a Swiss physician and alchemist born in 1493 and considered by some to be the “Father of Toxicology,” revolutionized the disciplines of chemistry and medicine with his statement, “ ‘Alie Ding sind Gift und nichts ohn Gift; alein die Dosis macht das ein Ding kein Gift ist” [all things are poison and not without poison; only the dose makes a thing not a poison’].” William C. Krieger, Foreword on Paracelsus — Dose Response, in Academic Press: Handbook of Pesticide Toxicology, at xxvii-xxxiv (2d ed.2002).¹¹ According to Krieger, “With the exception of E = me2, perhaps no' other single statement has wielded such force in establishing the popular notoriety and the professional stature of an individual in the history of science ....” Id. atxxvii.¹²

¶ 28 Next, we address the meaning of “methodology” for purposes of the Frye test. As The Supreme Court observed in Daubert, supra, “‘Scientific methodology today is based on generating hypotheses and testing them to see if they can be falsified; indeed, this methodology is what distinguishes science from other fields of human inquiry.’ ” Daubert, 509 U.S. at 593, 113 S.Ct. 2786, quoting Green, Expert Witnesses and Sufficiency of Evidence in Toxic Substances Litigation: The Legacy of Agent Orange and Bendectin Litigation, 86 Nw. U.L.Rev. 643, 645 (1992). Stated differently, the scientific method is “a method of research in which a problem is identified, relevant data are gathered, a hypothesis is formulated from these data, and the hypothesis is empirically tested.” Webster’s Encyclopedic Unabridged Dictionary of the English Language (“Webster’s”) 1279 (1989). Within the meaning of the definition of the scientific method, “empirical” means “provable or verifiable by experience or experiment.” Id. 468. Key aspects of the scientific method include the ability to test or verify a scientific experiment by a parallel experiment or other standard of comparison (control) and to replicate the experiment to expose or reduce error. Id. 318-319, 1217.

¶ 29 In this case, the trial court accepted Dr. Shane’s “methodology” as it related to Trach’s immediate adverse reactions to the Doxepin overdose based on the PDR and the epidemiological and other studies underlying its findings. (Trial court opinion, 5/18/00 at 21.) The trial court rejected Dr. Shane’s “methodology” as to the long-term effects of Doxepin, however, because Dr. Shane did not refer to studies, texts, and other sources indicating general acceptance of his opinion as to those effects. (Id. at 30.) As the trial court opined, “Dr. Shane’s opinions on these issues were based on his own reasoning from general toxicological principles. There is no evidence that any other members of the medical community share his conclusions or concur in his reasoning process.” (Id.)

¶ 30 The trial court relied in particular on this court’s analysis in Checchio v. Frankford Hospital-Torresdale Division, 717 A.2d 1058 (Pa.Super.1998), appeal denied, 566 Pa. 633, 781 A.2d 137 (2001), to support its conclusion that an expert’s testimony must be based on more than his or her own observations and experience in the field, without reference to outside sources. (Trial court opinion, 5/18/00 29-30, citing Checchio, 717 A.2d at 1062.) We find error in the trial court’s analysis for two reasons.

¶ 31 As noted supra, expert testimony is only required where the knowledge is “beyond that possessed by a layperson” and may only be offered by a witness with “reasonable pretension to specialized knowledge on the subject under investigation.” Pa.R.E. 702 and Comment — 1998. As our supreme court recently observed in the context of the “two schools of thought” doctrine:

Limiting evidence to medical literature would have the effect of preventing expert witnesses from testifying to the existence of a school of thought based on their experience as practitioners and on information they obtained during their medical training and while attending lectures and other educational programs sponsored by institutions and professional societies. Furthermore, in cases where medical literature is silent with regard to certain techniques or treatments," the lack1 of written materials would necessarily be fatal to the [proponent’s] claim.

Gala v. Hamilton, 552 Pa. 466, 472, 715 A.2d 1108, 1111 (1998).¹³

¶ 32 As with the two schools of thought doctrine, Frye’s general acceptance standard requires only that the scientific community generally accept the principles from which the scientist is proceeding and the methodology the scientist is employing to reach his or her conclusions. Assuming the expert is properly qualified to testify, as Dr. Shane was in this case, his or her expertise, appropriately brought to bear on the issue through use of generally accepted scientific principles and methodology, should also pass muster under Frye.

¶ 33 Furthermore, it is clear from the definition of the scientific method, set forth supra, that extrapolation, one of the methodologies Dr. Shane used to conclude that a massive overdose of Doxepin could result in permanent and/or exacerbated adverse effects documented at the recommended dose, is not science: in fact, it is a logical method used “to estimate the value of a variable outside its tabulated or observed range” or “to infer (that which is not known) from that which is known.” Webster’s 505. The question then becomes whether extrapolation, although not science, is a methodology generally accepted and used by scientists within the relevant scientific community.¹⁴

¶ 34 While we have found no Pennsylvania cases discussing the admissibility of scientific testimony based on extrapolation, we have found several cases decided by other jurisdictions which have addressed the admissibility of extrapolation evidence under the Frye test. We recognize that we are not bound by these cases; however, we may use them for guidance to the degree we find them useful and not incompatible with Pennsylvania law. See, e.g., Gutteridge v. A.P. Green Services, Inc., 804 A.2d 643, 651 (Pa.Super.2002) (opining that “Federal court decisions do not control the determinations of the Superior Court[]”) (citations omitted); Commonwealth v. Santarelli, 334 Pa.Super. 589, 483 A.2d 895, 900 (1984) (observing, “We receive [out-of-state] decisions as persuasive authority but not binding precedent ]”) (citation omitted), cert. denied sub nom. Steingraber v. Pennsylvania, 476 U.S. 1116, 106 S.Ct. 1973, 90 L.Ed.2d 656 (1986). With the foregoing in mind, we consider these extra-jurisdictional cases.

¶ 35 In Donaldson v. Central Illinois Public Service Co., 199 Ill.2d 63, 262 Ill.Dec. 854, 767 N.E.2d 314 (2002), for example, the plaintiffs, who were parents of four children exposed to coal tar during the clean-up of a former coal gasification plant site, brought suit against Central Illinois Public Service Co. (“CIPS”) and three of its contractors. According to the parents, their children developed neuroblastoma, a rare form of cancer that attacks the peripheral nervous system, as a result of various acts or omissions committed by CIPS and/or its contractors during the clean-up. Id. at 65-66, 262 Ill.Dec. 854, 767 N.E.2d at 317-318.

¶ 36 Neuroblastoma is a very rare form of cancer, usually occurring in young children and infants at a rate of nine out of one million. Id. The community in which the four children lived recorded 520 live births in 1988. Statistically, such a small community would record a case of neurob-lastoma once every 29 years; however, between March 1989 and August 1991, the community recorded cases of neuroblasto-ma in three infants and one teenager. Id. While published scientific research warned that coal tar was “ ‘among the most powerful carcinogens known to exist[,]’ ” id. at 68, 262 Ill.Dec. 854, 767 N.E.2d at 319, quoting the Handbook on Manufactured Gas, the scientific community had been limited by the small number of neuroblas-toma cases in its ability specifically to link exposure to coal tar with development of neuroblastoma. Id. at 85, 262 Ill.Dec. 854, 767 N.E.2d at 328.

¶ 37 Furthermore, as one of the plaintiffs’ experts explained, ethical considerations prevented exposing humans to coal tar for research purposes. Id. at 87, 262 Ill.Dec. 854, 767 N.E.2d at 330. Additionally, environmental exposure is often not detected until the onset of illness, thereby preventing controlled settings to study the effects of exposure. Id. As a result, the experts who testified on behalf of the children extrapolated from similar, but not identical, studies and theories to conclude that coal tar exposure caused the children’s neuroblastomas. Id. at 88, 262 Ill.Dec. 854, 767 N.E.2d at 330. These experts included an epidemiologist specializing in childhood cancers, a toxicologist specializing in molecular biology, and a physician specializing in occupational and environmental medicine. Id. at 74, 262 Ill.Dec. 854, 767 N.E.2d at 322.

¶ 38 The jury returned a verdict in favor of the plaintiffs and against CIPS alone in the amount of $3.2 million, and the intermediate appellate court affirmed. On appeal to the supreme court, CIPS claimed, inter alia, that the trial court erred when it admitted the-extrapolation testimony because it did not pass muster under the Frye test. Id. at 76, 262 Ill.Dec. 854, 767 N.E.2d at 323.

¶ 39 In its analysis, the Donaldson court set out the parameters of Frye, much as we have done supra. The court then addressed the admissibility of extrapolation evidence, reviewing prior Illinois cases as well as a federal appellate court case, Ferebee v. Chevron Chemical Co., 736 F.2d 1529 (D.C.Cir.1984), cert. denied, 469 U.S. 1062, 105 S.Ct. 545, 83 L.Ed.2d 432 (1984), which upheld the admissibility of extrapolation testimony under facts similar to the facts of this case.¹⁵ Donaldson, 199 Ill.2d at 86, 262 Ill.Dec. 854, 767 N.E.2d at 328-329. As the Donaldson court observed, “extrapolation is commonly used by scientists in certain limited instances ... for example, when the medical inquiry is new or the opportunities to examine a specific cause and effect relationship are limited; when the number of cases limits study of the disease; or, as noted supra, when ethical considerations prevent exposing individuals to a toxic substance for research purposes. Id. at 85, 87, 262 Ill.Dec. 854, 767 N.E.2d at 328, 330. According to the Donaldson court, when an expert relies upon scientific literature discussing similar, but not identical, cause and effect relationships, the fact that the expert must extrapolate affects the weight of the testimony rather than its admissibility. Id. at 85, 262 Ill.Dec. 854, 767 N.E.2d at 328 (citation omitted).

¶ 40 As this court and our supreme court have recognized, the rationale behind the Frye test is to attempt to measure the quality of scientific evidence prior to its admission because “ ‘there is the danger that the trial judge or jury will' ascribe a degree of certainty to the testimony of the expert ... which may not be deserved.’ ” Blum, 705 A.2d at 1317, quoting Topa, supra at 230, 369 A.2d at 1281. The Donaldson court, acknowledging this concern, observed, however, that “the method of extrapolation does not concern a technique new to science that may instill a sense of ‘false confidence’ or carry a misleading sense of scientific ‘infallibility.’ ” Id. at 86, 262 Ill.Dec. 854, 767 N.E.2d at 329 (citation omitted). As the Donaldson court continued, “[Ejxtrapolation by nature admits its fallibility — the lack of specific support to establish the existence of a known cause and effect relationship.” Id. at 87, 262 Ill.Dec. 854, 767 N.E.2d at 329 (citation omitted). As a result, the Donaldson court concluded that the trial court did not err in admitting the testimony of the plaintiffs’ experts. Id. at 88, 262 Ill.Dec. 854, 767 N.E.2d at 330.

¶ 41 Ferebee, supra, involved an employee’s long-term exposure to a chemical herbicide, paraquat, which its manufacturer, Chevron Chemical Co. (“Chevron”), acknowledged was “acutely toxic — that is, that any injuries resulting from exposure to paraquat occur within a very short time of exposure ... and that when exposure ceases, so too does the injury.” Ferebee, 736 F.2d at 1585. Ferebee, and later his estate, claimed, however, that Ferebee ultimately died from pulmonary fibrosis caused by long-term exposure to paraquat poisoning. Id. at 1533.

¶ 42 In support of its theory, Ferebee’s estate presented the testimony of Fere-bee’s treating physicians, who were both specialists in pulmonary medicine, as expert witnesses. They relied on their personal observation of Ferebee and tests they performed on him, as well as “upon medical studies which, they asserted, suggested that dermal absorption of paraquat can lead to chronic lung abnormalities of the sort characterized as pulmonary fibrosis.” Id. Finding the experts’ opinions as to causation admissible, the Ferebee court opined:

Thus, a cause-effect relationship need not be clearly established by animal or epidemiological studies before a doctor can testify that, in his opinion, such a relationship exists. As long as the basic methodology employed to reach such a conclusion is sound, such as use of tissue samples, standard tests, and patient examination, products liability law does not preclude recovery until a ‘statistically significant’ number of people have been injured or until science has had the time and resources to complete sophisticated laboratory studies of the chemical. In a courtroom, the test for allowing a plaintiff to recover in a tort suit of this type is not scientific certainty but legal sufficiency; if reasonable jurors could conclude from the expert testimony that paraquat more likely than not caused Ferebee’s injury, the fact that another jury might reach the opposite conclusion or that science would require more evidence before conclusively considering the causation question resolved is irrelevant. That Ferebee’s case may have been the first of its exact type, or that his doctors may have been the first alert enough to recognize such a case, does not mean that the testimony of those doctors, who are concededly well qualified in their fields, should not have been admitted.

Id. at 1535-1536 (emphasis in original).

¶ 43 In Ferebee, substantial scientific evidence existed as to the acute adverse effects of intense, short-term exposure to paraquat, but little if any evidence existed linking low-level exposure over a prolonged period to long-term side effects: in our case, substantial scientific evidence exists as to the acute adverse effects of Doxepin taken in its recommended dosage, but little if any evidence exists linking an extremely high-level dosage to long-term side effects. Addressing this issue, the Ferebee court observed:

Judges, both trial and appellate, have no special competence to resolve the complex and refractory causal issues raised by the attempt to link low-level exposure to toxic chemicals with human disease. On questions such as these, which stand at the frontier of current medical and epidemiological inquiry, if experts are willing to testify that such a link exists, it is for the jury to decide whether to credit such testimony.

Id. at 1534.

¶ 44 We find the facts of this case even more compelling than the facts of Ferebee, supra, or Donaldson, supra, based on the even stronger logical inference that a substance known to cause adverse side effects in its recommended dose is likely to cause a heightened level of the same or similar adverse effects when taken in a massive overdose.

¶ 45 We have set forth the trial court’s summary of Dr. Shane’s testimony, in which Dr. Shane explained in minute detail how Doxepin works on the brain’s chemistry; the adverse effects and contraindications for Doxepin in therapeutic doses as determined through clinical trials and clinical experience; the PDR’s description of those side effects and contraindications; the manner in which Doxepin works on vision, especially its “known anticholinergic effect” which, even in its recommended dosage, can cause excessive dilation of the pupil of the eye. Prolonged dilation, in turn, causes pigmentary loss, thereby causing the pigment to be deposited in the filter system at the Canal of Schlemm, further clogging up the filter and also causing increased pressure in the eye. (Trial court opinion, 5/18/00 at 7-10, citing notes of testimony, 6/16/99 at 198.) The result of the pigmentary loss and clogging is pigmentary glaucoma, the type of glaucoma from which Trach suffers and which both Drs. Moran and Naidoff acknowledged is a form of open-angle glaucoma. (Notes of testimony, 6/17/99 at 116; Nai-doff deposition, 6/8/99 at 17.)

¶46 With regard to Trach’s cognitive difficulties, Dr. Shane testified that the negative results of the neurological tests administered to Trach after the Doxepin cleared his system further supported the conclusion that ingestion of a massive overdose of Doxepin caused his problems. According to Dr. Shane, an MRI or EEG will reflect tumors and some nervous system diseases, but will not reflect chemical changes, such as those induced by a drug overdose. (Notes of testimony, 6/16/99 at 208-215.)

¶ 47 As our supreme court observed, “‘[W]hile courts will go a long way in admitting expert testimony deduced from a well-recognized scientific principle or discovery, the thing from which the deduction is made must be sufficiently established to have gained general acceptance in the particular field in which it belongs.’ ” Commonwealth v. Nazarovitch, 496 Pa. 97, 101, 436 A.2d 170, 172 (1981), quoting Frye, 293 F. at 1013 (emphasis in Nazarovitch).

¶ 48 In this case, we agree with the trial court that the thing from which Dr. Shane deduced that a massive overdose of Doxe-pin caused Trach’s acute symptoms has been sufficiently established to have gained general acceptance in the particular field to which it belongs. In the case of the immediate adverse reactions, “the thing” consists of the clinical trials and clinical experience with Doxepin at therapeutic dosages, documented in the PDR and manufacturer’s inserts.

¶ 49 Unlike the trial court, however, we conclude that the dose-response principle Dr. Shane used is generally accepted in the scientific community. We also conclude that extrapolation, the methodology Dr. Shane used to deduce that Trach’s chronic symptoms, including glaucoma, were the result of a massive Doxepin overdose, is neither novel nor “scientific” in its strict sense. Extrapolation has, however, gained general acceptance in the scientific community under certain limited circumstances, delineated supra. As the Donaldson and Ferebee courts opined, as long as the basic methodology employed to reach such a conclusion is sound, such as use of tissue samples, standard tests, and patient examinations, the scientist may extrapolate from this sound scientific basis when it is either impossible or unethical to perform the sorts of clinical trials that would yield definitive results. Donaldson, 262 Ill.Dec. 854, 767 N.E.2d at 329, citing Ferebee, 736 F.2d at 1535-1536. As the Ferebee court continued, “In a courtroom, the test for allowing a plaintiff to recover in a tort suit of this type is not scientific certainty but legal sufficiency!/]” Ferebee, 736 F.2d at 1536. It was for the jury, aware of the fallibility of extrapolation, to decide whether Dr. Shane’s testimony was credible. It was for Thrift Drug, through vigorous cross-examination, to prove that it was not.

¶ 50 The dissent, while agreeing that extrapolation is an acceptable methodology, finds, however, that remand is necessary because Trach purportedly did not have an opportunity adequately to establish the underlying scientific foundation from which Dr. Shane extrapolated, and Thrift Drug did not have an opportunity to challenge that foundation. (Klein, J., dissenting at 17.) We cannot agree. In fact, we find the record complete as to this issue.

¶ 51 As we have already stated, Dr. Shane extrapolated from the known adverse effects of Doxepin in recommended doses, documented in the PDR and the manufacturer’s inserts. Trach introduced into evidence a three-column chart showing Trach’s symptoms after taking Doxe-pin, the manufacturer’s insert reflecting possible adverse reactions and contraindications for Doxepin, and the PDR’s enumeration of the same adverse reactions and contraindications. (Notes of testimony, 9/16/99 at 192-194, and Plaintiffs Exhibit 10.) Based upon this information, as well as Trach’s medical records following the Doxepin overdose, Dr. Shane extrapolated to reach his ultimate conclusion.

¶ 52 Additionally, our review of the record indicates that defense counsel cross-examined Dr. Shane as to the underlying basis for his extrapolation testimony, to which Dr. Shane responded:

Every opinion I have given today is supported very definitely in the medical literature. It’s supported in things that are available on every physician’s desk like the Physician’s Desk Reference. It’s supported in the medical literature by the various textbooks. It is supported in the medical literature by the textbook on toxicology written by Randall Bassault. It’s supported by other textbooks. Ellenhorn will support what I have said. I said nothing today to this jury that isn’t supported by medical literature.

What’s not in the medical literature is how does it block that distal end of the synapse? We don’t know....

Id at 220-221. Defense counsel did not object to Dr. Shane’s references to the texts or challenge the accuracy of Dr. Shane’s representations of that literature. Defense counsel’s only challenge came during direct examination, with reference to the specific content of a text to which Dr. Shane referred. (Id at 206-207.) In response, the trial court stated, “[T]he witness can give his opinion in which he’s taken into consideration the authoritative text but he’s not to state the specifics of that text. That would be considered a violation of the hearsay rule under Pennsylvania Rules of Evidence.” (Id at 207.)

¶ 53 The dissent also expresses concern that our review has been significantly hampered by the trial court’s reversing itself without taking any evidence on the Frye issue. (Klein, J., dissenting at 15 n. 6.) We disagree. We recognize that “[t]he Superior Court, as an error-correcting court, may not purport to reverse a trial court’s order where the only basis for a finding of error is a claim that the responsible party never gave the trial court an opportunity to consider.” Harber Philadelphia Center City Office Ltd. v. LPCI, 764 A.2d 1100, 1105, (Pa.Super.2000), appeal denied 566 Pa. 664, 782 A.2d 546 (2001).

¶ 54 In this case, the trial court opined, “Dr. Shane’s opinions [as to the effects of a massive overdose of Doxepin] were based on his own reasoning from general toxicological principles.” (Trial court opinion, 5/18/00 at 30.) As the trial court continued, “There is no evidence that any other members of the medical community share his conclusions or concur in his reasoning process.” (Id.) We therefore find that the trial court had the first opportunity to address whether the scientific community has generally accepted extrapolation based on the dose-response principle and erred in its conclusion.

¶ 55 Order granting a new trial as to damages is vacated and the jury’s verdict of $5 million is reinstated. Order denying j.n.o.v. or a new trial as to liability and damages is affirmed. Case is remanded for the trial court to address Thrift Drug’s post-trial motions regarding the excessiveness of the verdict and, in turn, Trach’s motion for delay damages. Jurisdiction is relinquished.

¶ 56 DEL SOLE, P. J., files a Concurring Statement in which MUSMANNO, J. joins.

¶ 57 KLEIN, J. files a Dissenting Opinion in which LALLY-GREEN, J. joins.

1 . The prescription called for Trach to take two 250 mg. capsules of the antibiotic four times per day, or 2,000 mg. per day. Testimony presented at trial indicated that the Doxepin capsules the pharmacy assistant gave Trach were 150 mg. capsules. (Notes of testimony, 6/16/99 at 184.)

2 . While slight discrepancies existed between Dr. Shane's report and his testimony at trial as to the exact amount of Doxepin Trach took, no one disputed that it was a massive overdose.

3 . Trach argues that Thrift Drug waived its Frye challenge when it failed to object to Shane's testimony during trial, instead waiting until the close of all the evidence to move for a nonsuit, a directed verdict, or to .strike Dr. Shane’s testimony in its entirety. We note, however, that Pa.R.E. 103(a)(1) provides that when a litigant challenges the admission of evidence, the issue is preserved if there is "a timely objection, motion to strike or motion in limine stating the specific ground of objection.” The Comment to the Rule further states: "A ruling on a motion in limine on the record is sufficient to preserve the issue for appeal, without renewal of the objection or offer at trial.” Nevertheless, we agree with Trach that it is questionable whether Thrift Drug’s Frye challenge in this case comports with established procedure because Thrift Drug’s limited challenge to Dr. Shane’s expert report in its motion in limine did not support a motion to strike Dr. Shane's testimony in its entirety, especially at the close of all the evidence. We therefore do not condone the manner in which Thrift Drug raised and preserved its Frye challenge, and caution counsel against using such a procedure in the future. We will, however, address the issue in this case.

4 . We recognize that Thrift Drug challenged both Dr. Shane's conclusions and his methodology, and the trial court addressed both in its May 18, 2000 opinion. Nevertheless, the trial court granted a new trial solely on the basis of Dr. Shane's causation testimony. (See trial court opinion, 5/18/00 at 33; trial court opinion, 8/18/00 at 1-2.) Because we find that Dr. Shane's conclusions and his methodology are inextricably intertwined, however, we will address both.

5 . Rule 207.1 did not take effect until after the trial in this case; however, it clearly indicates the state of the law in Pennsylvania.

6 . We note additionally that the Supreme Court in Daubert v. Merrell Dow Pharmaceuticals, Inc., 509 U.S. 579, 113 S.Ct. 2786, 125 L.Ed.2d 469 (1993), although abandoning the Frye test as having been superseded by the Federal Rules of Evidence, nevertheless observed:

Although the Fiye decision itself focused exclusively on ‘novel scientific techniques, we do not read the requirements of Rule 702 to apply specially or exclusively to unconventional evidence. Of course, well-established propositions are less likely to be challenged than those that are novel, and they are more handily defended. Indeed, theories that are so firmly established as to have attained the status of scientific law, such as the laws of thermodynamics, properly are subject to judicial notice under Federal Rules of Evidence 201 [ ]”).

Id. at 592 n. 11, 113 S.Ct. 2786 (emphasis added). Thus, even though the Daubert court abandoned Frye, it recognized that Frye was limited to novel scientific evidence.

Our supreme court, which so far has not abandoned the Frye test in favor of the Daubert analysis, granted allocatur in Grady v. Frito-Lay, Inc., 789 A.2d 735 (Pa.Super.2001) (en banc), to address the issue whether the en banc panel of this court correctly applied the law when it reversed the decision of the trial court to preclude [plaintiff’s] expert testimony. Grady v. Frito-Lay, Inc., 569 Pa. 46, 800 A.2d 294 (2002) (per curiam). The supreme court also directed the parties to address the effect of both Frye, supra, and Daubert, supra, on the analysis of this issue. Id. We suspect that our decision here today will ultimately travel the same route.

7 . DNA/RFLP signifies “deoxyribonucleic acid restriction fragment length polymorphism.” Rodgers, 605 A.2d at 1234-1235.

8 . In Blum, Dr. Done, one of the Blums' experts, recalculated the data that appeared in a published study, one of the studies Justice Castille so vigorously criticized in his dissent, discussed infra, because Merrell Dow's lead expert witness was the editor of the journal in which it appeared, and because the attorneys representing Merrell Dow allegedly edited the studies. Blum, supra at 14-15 and 15 n. 3, 764 A.2d at 8 and 8 n. 3 (Castille, J. dissenting), citing trial court slip op. at 67-68, 70-71.

Nevertheless, Dr. Done based his re-calculation on a methodology that was not generally accepted. Blum, 705 A.2d at 1320. As Judge Beck explained in Blum, "Epidemiology deals with population samples and seeks to generalize those results; it goes from the specific, i.e., a sample, to the general, i.e., a population.” Id. at 1323-1324. According to Judge Beck, "While epidemiologists choose their data and engage in statistical analysis in order to ensure that their experimental populations are not biased, Dr. Done did not.” Id. at 1324. Instead, Dr. Done eliminated all the standardization and used simple arithmetic. Id. As Judge Beck observed, “Epidemiological analyses that are not standardized are not generally accepted.” Id.

9 . In his dissent, Justice Castille vigorously objected to the manner in which Merrell Dow allegedly obtained "general acceptance” for its methodology and conclusions in the relevant scientific community. As Justice Castille observed:

The trial court disagreed [with Merrell Dow’s assertion that the scientific community did not support the Blums’ experts' conclusions] for two reasons: first, because it did not believe that conclusions on causation are a separate methodology needing general acceptance ...; and second, because ... [a]s the trial court succinctly put it: 'The testimony in this case demonstrates how "scientific consensus” can be created through purchased research and the manipulation of a "scientific” literature, funded as part of litigation defense, and choreographed by counsel.'

Blum, supra at 13-14, 764 A.2d at 7-8 (Castille, J., dissenting), quoting trial court slip op. at 46.

10 . It appears as if the dissent, although purporting to agree with us as to Frye's limitations, in fact, like the trial court, applies Frye to conclusions as well as methodology. See discussion infra.

11 . In Blum, one of the Blums’ experts, Dr. Gross, applied the dose-response principle to determine the effect of Bendectin on humans based solely on animal studies, a relationship which scientists widely acknowledge is not reliable without corroborating human data. Blum, 705 A.2d at 1320.

12 . At least one court has recognized the venerability of this principle. In United States v. 2,116 Boxes of Boned Beef Weighing Approximately 154,121 Pounds, et al., 516 F.Supp. 321 (U.S.D.C. Kansas 1981), the court quoted Paracelsus for the proposition that " 'the dose determines the poison.’ ” Id. at 327.

13 . In fact, one might reasonably wonder why expert testimony would be needed at all if the parties could merely refer to medical texts and treatises to support their positions.

14 . Pennsylvania appellate courts have apparently not addressed the admissibility of scientific testimony based on extrapolation. Our supreme court, however, recently decided a case in which the defendant attacked the validity of applying a principle of statistical probability to DNA forensic analysis and then admitting the results into evidence. Blasioli, supra at 153, 713 A.2d at 1119. The Blasioli court therefore addressed the admissibility of both the results of DNA testing and certain probabilities derived from that testing using two statistical methods, the product rule and the ceiling principle. Id. at 152, 713 A.2d at 1118. As the Blasioli court observed, “This court has generally required that both the theory and technique underlying novel scientific evidence must be generally accepted.” Id. at 153, 713 A.2d at 1119, citing Crews, supra at 522, 640 A.2d at 402. As the Blasio-li, court recognized, however, general acceptance of a methodology does not require unanimity. Id. at 168, 713 A.2d at 1127 (citations omitted).

15 . We will discuss Ferebee infra. We are aware that numerous courts have recognized that Cipollone v. Liggett Group, Inc., 505 U.S. 504, 112 S.Ct. 2608, 120 L.Ed.2d 407 (1992), abrogated Ferebee's preemption analysis. See, e.g., Etcheverry v. Tri-Ag Service, Inc., 22 Cal.4th 316, 327, 93 Cal.Rptr.2d 36, 993 P.2d 366, 371-372 (2000) (collecting cases finding that Ferebee’s preemption analysis is no longer good law). Preemption is not, however, relevant to our disposition of this case.