RICH, Judge.
This appeal is from the majority decision of the divided Board of Appeals (board) of the United States Patent and Trademark Office (PTO) affirming the rejection of claim 5 of application serial No. 477,766, filed June 10, 1974. We reverse.
The Invention
The subject of the application, which, when filed, had the noncommittal title “Process,” is made clear from the Abstract of the Disclosure, which reads:
Microbiological process for preparing the antibiotic lincomycin at temperatures ranging from 18° C. to 45° C. using the newly discovered microorganism Strepto-myces vellosus. The subject process advantageously results in the preparation of lincomycin without the concomitant production of lincomycin B (4'-depropyl-4'-ethyllincomycin). The absence of linco-mycin B production results in increased lincomycin recovery efficiency.
On demand of the examiner, the title was later changed to “Process for Preparing Lincomycin.” The application was filed with four claims to such a process which the examiner allowed. By a preliminary amendment, filed before any action on the application but not reached by the examiner until his- second action, claim 5 was added together with the attorney’s statement that “Basis for claim 5 can be found throughout the disclosure.” That claim reads:
5. A biologically pure culture of the microorganism Streptomyces vellosus, having the identifying characteristics of NRRL 8037, said culture being capable of producing the antibiotic lincomycin in a recoverable quantity upon fermentation in an aqueous nutrient medium containing assimilable sources of carbon, nitrogen and inorganic substances.
The designation “NRRL 8037” in claim 5 is elucidated by the following statement in the specification:
The Microorganism
The novel actinomycete used according to this invention for the production of lincomycin is Streptomyces vellosus. One of its strain characteristics is the production of lincomycin without the concomitant production of lincomycin B. Another of its strain characteristics is the production of comparable titers of lincomy-cin at a temperature of 28° C. and 45° C. A subculture of this living organism can be obtained upon request from the permanent collection of the Northern Regional Research Laboratories, Agricultural Research Services, U. S. Department of Agriculture, Peoria, Illinois, U.S.A. Its accession number in this repository is NRRL 8037.
The specification continues:
The microorganism of this invention was studied and characterized by Alma Dietz of the Upjohn Research Laboratory.
What follows that statement is an elaborate, highly technical, detailed description of the microorganism, including its type designation as “Streptomyces vellosus Dietz, sp.n.,” occupying over ten pages of the printed specification, followed by exemplary descriptions of the production of lin-comycin therefrom by fermentation processes and the recovery of the lincomy-cin produced by the fermentation.
The Rejection
No references have been cited against claim 5 because the novelty and unobviousness of the biologically pure culture claimed are not questioned. Neither has utility been questioned.
The examiner’s sole ground of rejection of claim 5, as stated in his final rejection, was:
Claim 5 is rejected under 35 USC 101 as non-statutory subject matter. Claim 5 claims a product of nature (Streptomyces [1033]*1033vellosus NRRL 8037). See In re Mancy et a1. [499 F.2d 1289] 182 USPQ 303 at page 306, second sentence before [4].
Appellants responded with a request to reconsider this rejection supported by affidavits of three Upjohn microbiologists, Dr. Joseph E. Grady, Dr. Thomas L. Miller, and “the well-known microbial taxonomist Alma Dietz,” pointing out that the microorganism did not exist as a biologically pure culture in nature and asserting that such a culture is a “manufacture” under § 101, which reads:
Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent therefor, subject to the conditions and requirements of this title.
In so arguing, appellants made the point that the pure culture is “a product of a microbiologist.” The examiner adhered to his position and appeal was taken to the board.
Since the only ground given by the examiner in support of his nonstatutory-subject-matter rejection was that the culture was a product of nature, that was the only point argued by appellants in their brief before the board, in which they cited a number of precedents for holding that a pure product could be patentable over a known impure product of similar kind.
The Examiner’s Answer — only two pages of the printed record — merely summarized his product-of-nature position and cited two cases in addition to In re Mancy, supra, previously cited by him, namely, Guaranty Trust Co. of New York v. Union Solvents Corp., 54 F.2d 400, 12 USPQ 47 (D.Del. 1931), aff’d, 61 F.2d 1041,15 USPQ 237 (CA 3 1932), and Funk Bros. Seed Co. v. Kalo Inoculant Co., 333 U.S. 127, 68 S.Ct. 440, 92 L.Ed. 588, 76 USPQ 280 (1948). With reference to the cases cited by appellants as precedents for patenting pure materials, the examiner noted that they were all pure chemical compounds “as contrasted with the instant microorganism.” He noted that the cases cited by him all “involve isolated or biologically pure microorganisms.” Appellants replied briefly, taking exception to the last-quoted statement of the examiner
* * * since (1) none of the decisions cited, nor any known decision, has held that a “biologically pure culture” is un-patentable, and (2) there is no evidence that a “biologically pure culture” was in issue in any of the cited decisions.
On the issue thus framed, the case went to the board.
The Board Opinions
The opinion of the majority of the board is quite out of the ordinary. While it affirms the “decision” of the examiner, that is to say his rejection of claim 5, it wholly disregards his reason for rejecting it to the point of expressly declining to consider it. Instead, the board majority decided that claim 5 is not directed to statutory subject matter within the meaning of § 101 because it is for “a living organism,” an issue entirely new to the application at bar, so far as the record shows. The dissenting board member’s opinion confirms in its first paragraph that that is, strictly, the basis of the majority’s decision. Without stating a new ground of rejection was being made (cf. 37 CFR 1.196(b)), the majority opinion commences its explanation of its reasoning as follows:
We have extensively researched prior court decisions for guidance to the question of whether or not a microorganism, being a living thing, is or is not within the realm of statutory patentable subject matter, but, other than possibly non-controlling dicta, have not found any case directly in point.
It is our view that 35 U.S.C. 101 must be strictly construed and, when so interpreted, precludes the patenting of a living organism. We reach this conclusion on the basis that only those categories of subject matter specifically enumerated in the statute are patentable and a living organism does not fall within the scope of any of those categories listed. An analogous result has been reached by the courts with respect to non-patentability [1034]*1034of mental processes, printed matter or methods of doing business none of which are also expressly excluded by the indicated section of the statute, but neither can they be said or have been held to be included thereby.
The board majority opinion then makes two points in support of its conclusion that § 101 precludes patenting anything living. The first is based on this court’s decision in In re Arzberger, 112 F.2d 834, 27 CCPA 1315, 46 USPQ 32 (1940), that bacteria are not included in the plant patent provision of former Title 35 (then part of § 4886 of the Revised Statutes, since 1952 separately treated in 35 U.S.C. §§ 161-164), notwithstanding that they may be scientifically classified as plants, because Congress plainly did not intend them to be when, in 1930, it enacted the Plant Patent Act (46 Stat. 376). The case was concerned only with the plant patent statute and this court did not have before it any other issue, such as inclusion of bacteria in any other statutory category, appellant having applied for a “plant patent” on a bacterium. The second aspect of the board majority’s supporting reasoning is fully stated in the following paragraph:
If we were to adopt a liberal interpretation of 35 U.S.C. 101 new types of insects, such as honeybees, or new varieties of animals produced by selective breeding and cross-breeding would be patentable. Moreover, those plants which are excluded from the scope of 35 U.S.C. 161, such as tuber propagated plants or plants which can be reproduced only sexually, would be patentable under 35 U.S.C. 101. We do not believe that Congress intended 35 U.S.C. 101 to encompass any living organism, whether they be plants or microorganisms.
The dissenting board member, stating that he had reviewed all of the precedents cited by either side and others as well, many of which he discussed in detail, expressed these views:
* * * I do not believe that the fact that plants and bacteria have some properties in common is sufficient basis for holding that bacteria are to be excluded from patent coverage. * * *
* * * I do not find it improper to claim living organisms * * *.
In view of the discussed eases, and since 35 U.S.C. 101 does not expressly exclude patents to living organisms, it is my opinion that living organisms, as claimed, may be patented if such claims also fulfill the other requirements of the statute.
He also expressed disagreement with the examiner’s view that claim 5 defined a “product of nature,” or that being a product of nature was sufficient reason, alone, for holding an invention nonstatutory. He made these observations:
Rather, I view a “product of nature” as being something that “exists” in nature and therefore evidence that it may not be “new” as this expression finds meaning in the Patent Statute. Accordingly, I would treat “products of nature” like any other material and determine whether they are new or obvious in view of the state of the art.
Certainly vitamin B-12, as it exists in liver, and adrenalin, as it appears in adrenal glands, are products of nature, yet the courts have held (Merck & Co., B-12 and Parke Davis and Co., adrenalin)1 that when such materials are extracted and concentrated in a purified form they are patentable. Accordingly, it is not sufficient to determine whether the pure culture claimed is a product of nature.
OPINION
Under the peculiar circumstances of this case, in which the board switched the supporting reasoning for the rejection of claim 5 as for nonstatutory subject matter without expressly making a new rejection, we deem it prudent to clarify the issue we have to decide. The brief of the PTO Solic[1035]*1035itor sees but a single issue: “whether living organisms are the kind of ‘manufacture’ or ‘composition of matter’ intended by Congress to be included within 35 U.S.C. 101.” (Emphasis ours.) Appellants argue that issue, making no objection to the board having raised it sua sponte, and also — perhaps out of an abundance of caution — argue the product-of-nature question sidetracked by the board. Appellants forcefully presented the latter issue before the board and submitted affidavits of three experts in the field to the effect that the “biologically pure culture” of claim 5 is not found in nature. The evidence appears to us to be incontrovertible. The dissenting member of the board accepted it. The board did not refute it, and the solicitor has not challenged it. The circumstances persuade us that the board went in search of another reason to support the rejection because it realized the examiner’s position was untenable. We consider the product-of-nature issue to have been abandoned and no longer in the case. However, since the solicitor indicated at oral argument that he was not sure the board had removed it entirely, we state that we find it wholly lacking in merit. The biologically pure culture of claim 5 clearly does not exist in, is not found in, and is not a product of, “nature.” It is man-made and can be produced only under carefully controlled laboratory conditions.
We take note of the fact that, since their appearance before the board, appellants have added another statutory category string to their bow. Before the board, they argued that the claim 5 pure culture is a “manufacture” under § 101. Before us they also argue that it is a “composition of matter,” which is another § 101 category. This is not a matter of great moment since there is considerable overlap between these two broad categories, notwithstanding what some textwriters have said. The arguments have not made a distinction between the two. If it is either, it is statutory subject matter, and it is not intellectually profitable to attempt a distinction in this regard.
We therefore proceed to a decision solely on the basis of the issue as the solicitor has stated it, deeming it to involve the single question of whether the uncontroverted fact that the biologically pure culture, as claimed, is alive removes it from the categories of inventions enumerated in § 101. Our conclusion is that it does not.
As to what the issue is, however, we make one further clarifying observation. We do so in part because of the solicitor’s statement that a similar issue was present but not decided in In re Merat, 519 F.2d 1390, 186 USPQ 471 (Cust.Ct. & Pat.App. 1975), a case involving chicken breeding, and in part because of the board’s reasoning herein. The solicitor’s statement about Merat is correct, but we emphasize that we are not here deciding the issue left open in Merat or anything other than the issue before us in this case, whether the subject matter of claim 5 is within either of the terms “manufacture” or “composition of matter” in § 101. In other words, we are not deciding whether living things in general, or, at most, whether any living things other than microorganisms, are within § 101. These questions must be decided on a case-by-case basis and anything said herein is >to be taken as said in the context of a discussion of the subject matter of claim 5 and § 101.
As presented to us, the question is clearly one of first impression. There is a substantial volume of literature bearing on it, both directly and indirectly, which the solicitor has helpfully collected in his brief, containing some private views on the question on which, it seems to be agreed, no court has passed.
One of the peripheral court comments, the first to be cited, is from our opinion in In re Mancy, 49.9 F.2d 1289, 182 USPQ 303 (Cust.Ct. & Pat.App.1974). All that the case has been cited for is a bit of dictum bearing on a hypothetical situation which was not before us. The ease involved claims to a process of producing a particular known antibiotic by aerobically cultivating a particular strain of Streptomyces bifurcus. The claims were rejected for obviousness under 35 U.S.C. § 103 on references show[1036]*1036ing various strains of other Streptomyces species used for the same purpose. We reversed, holding that In re Kuehl, 475 F.2d 658, 177 USPQ 250 (Cust.Ct. & Pat.App.1973), was controlling and that the new Streptomyces bifurcus strain discovered by Mancy himself as part of the invention being claimed could not be used as prior art in determining the obviousness under § 103 of his claims to a process of using it to produce the old antibiotic. In comparing the facts of the case before us in Mancy with the facts of Kuehl, we said (499 F.2d at 1294, 182 USPQ at 306):
We recognize the differences between this case and the situation in Kuehl, where the novel zeolite used as a catalyst in the claimed hydrocarbon cracking processes was itself the subject of allowed claims in the application. Here appellants not only have no allowed claim to the novel strain of Streptomyces used •in their process but would, we presume (without deciding), be unable to obtain such a claim because the strain, while new in the sense that it is not shown by any art of record, is, as we understand it, a “product of nature.” However, it is not required for unobviousness of the method-of-use claims that the new starting material be patentable * * *.
If it is not clear from the context that we were not discussing what is or is not statutory subject matter within § 101 but only a difference between two cases which we found not to be a reason for distinguishing them, and that we were not expressing any view, even by way of dictum, on the patent-ability of living organisms as such, we now make it explicit that the thought underlying our presumption that Mancy could not have obtained a claim to the strain of microorganism he had described was simply that it lacked novelty. We were thinking of something preexisting and merely plucked from the earth and claimed as such, a far cry from a biologically pure culture produced by great labor in a laboratory and so claimed. The dissenting board member was entirely correct in so interpreting our Mancy dictum. The examiner relied on it only to support his product-of-nature reasoning, and the board majority did not mention it, having abandoned that reasoning. Furthermore, it now appears to us, in light of what we have learned in this case about the separation and identification of new strains of Streptomyces, that our dictum was ill-considered. Had we known what we now know, we would likely have abjured the stated presumption.
Guaranty Trust Co. v. Union Solvents Corp., supra, was cited by the examiner as “especially pertinent” and again by the solicitor as a “judicial precedent” solely for the following passage appearing at the very end of the long trial court opinion (54 F.2d at 410, 12 USPQ at 57, emphasis ours):
Lastly, the defendant contends that the invention of the Weizmann patent is unpatentable since it is for the life process of a living organism. Were the patent for bacteria per se, a different situation would be presented. As before stated, the patent is not for bacteria per se. It is for a fermentation process employing bacteria discovered by Weizmann under conditions set forth in the specification and claims. Undoubtedly there is patentable subject-matter in the invention. Cochrane v. Deener, 94 U.S. 780, 24 L.Ed. 139; Risdon Iron & Locomotive Works v. Medart, 158 U.S. 68, 15 S.Ct. 745, 39 L.Ed. 899; Cameron Septic Tank Co. v. Village of Saratoga Springs, 159 F. 453 (C.C.A. 2); Dick v. Lederle Antitoxin Laboratories (D.C.) 43 F.2d 628. [6 USPQ 40 (S.D.N.Y.1930)].
The statement the examiner relied on, “Were the patent for bacteria per se, a different situation would be presented,” is a trite observation of minimal magnitude as precedent, dealing with a non-issue on which no opinion was expressed. What we find of interest and, indeed, “pertinent” is the fact that the defendant urged the unpa-tentability of claims because they involved a life process of a living organism and the court rejected the argument. At the outset, the opinion states that one of the defenses was “non-patentable subject matter." The real plaintiff in the case was Commercial Solvents Corporation, exclusive [1037]*1037ensee under the Weizmann patent in suit, hich corporation was making butyl alcohol id acetone by the Weizmann bacteriologi,1 fermentation process, and, with its edecessors, had been doing so since 1918. 1929 the production was 107,500,000 mnds. The trial court noted that “The cord shows that an important and extenue new industry has now been developed id established upon the Weizmann proeis.” It was very clear to the court that it as dealing with a life process for, in deiribing the invention, it said, “ ‘Fermentaon’ is the chemical change, or the decomosition into new chemical compounds, of a ibstratum, by living organisms, such, for sample, as yeast or bacteria.” On the isue whether a process dependent upon ving organisms and their life processes ms patentable subject matter, the court ad no doubts. In the last case cited in the bove quotation, Dick v. Lederle, two years arlier the court had found a scarlet fever oxin and antitoxin and process of making he same to be patentable subject matter iotwithstanding the employment of life rocesses in their preparation. On appeal n the Guaranty Trust case, the Third Cir-uit Court of Appeals affirmed per curiam m the opinion of the trial judge, commentng, inter alia, that it had been persuaded 'that the invention disclosed in the patent created a new and important commercial enterprise * * *
These decisions illustrate what we lelieve to have been the state of the law iver since, namely, that processes, one of ;he categories of patentable subject matter specified in § 101, are uniformly and consistently considered to be statutory subject natter notwithstanding the employment therein of living organisms and their life processes. Witness the action of the PTO n the present case in allowing the process ilaims. Other examples of such patentable process claims involving living bacteria are to be seen in the bacterial sewage treatment cases of which one is City of Milwaukee v. Activated Sludge, Inc., 69 F.2d 577, 21 USPQ 69 (CA 7 1934). (See quoted claims 8 and 10 of reissue patent No. 15, 140 in fn. 4.) A still earlier one is the Cameron Septic Tank Co. ease cited in Guaranty Trust and decided by the Second Circuit Court of Appeals in 1908, wherein the trial court was reversed and bacterial-action process claims were held valid and infringed. (The original “septic tank.”) It seems illogical to us to insist that the existence of life in a manufacture or composition of matter in the form of a biologically pure culture of a microorganism removes it from the category of subject matter which can be patented while the functioning of a living organism and the utilization of its life functions in processes does not affect their status under § 101. Of course it is clear, as the dissenting board member noted, that there is nothing in the words of § 101 which excludes patents for living organisms.
We cannot agree with the board majority’s view that § 101 “must be strictly construed.” But even a “strict construction,” whatever that may entail, fails to lead inexorably to the exclusion of a manufacture or composition of matter because it is alive. The statute makes no distinction between manufactures and compositions on the one hand and processes on the other. If the board is right in excluding products because there is life in them, then logic dictates that it should take the same position with regard to processes. But it does not do so. Indeed, in light of what the courts have done over the past seventy years in holding such process claims valid, it could not properly do so. We have never heard of a case holding that the categories of patentable subject matter, as enumerated in § 101 or any of its predecessor statutes, should be strictly construed and the board has cited none.
In 1932, when the Board of Appeals was faced with an examiner’s contention that a biological process for producing butyl and isopropyl alcohols by bacterial action was unpatentable because the bacteria were doing only what by nature they are capable of doing, its response was that if such a.view were accepted, it would hardly be possible to grant a patent on any chemical process, indicating an early appreciation of the essential similarity of what we normally think of as “chemical reactions” and the complex [1038]*1038chemical procedures wrought by the life processes of microorganisms. Ex parte Prescott, 19 USPQ 178 (1932). As a result of that decision, according to the report of the case, patent No. 1,933,683 was issued Nov. 7, 1933, for “Production of Butyl and Isopropyl Alcohols” with process claims. The board said (19 USPQ at 180):
We are unable to agree with the Examiner that processes involving bacterial action do not involve patentable subject matter * * *.
What we have before us is an industrial product used in an industrial process — a useful or technological art if there ever was one. See In re Waldbaum, 457 F.2d 997, 59 CCPA 940, 173 USPQ 430 (1972). The nature and commercial uses of biologically pure cultures of microorganisms like the one defined in claim 5 are much more akin to inanimate chemical compositions such as reactants, reagents, and catalysts than they are to horses and honeybees or raspberries and roses. According to an article cited but not relied on by the solicitor entitled “Microbiological Applications and Patents” by Harvey W. Edelblute in The Encyclopedia of Patent Practice and Invention Management at 567, edited by R. Calvert (1964), microbiological processes have long been used “to make beer, wine, cheese, bread, pickles and sauerkraut, rett flax, age tobacco, bate leather, produce silage and digest sewage.” But more to the point here, in recent years, according to Edelblute, they have come to be used to “produce a vast variety of chemicals and drugs such as alcohols, ketones, fatty acids, amino acids, vitamins, antibiotics, steroids, and enzymes.” Edelblute provides a “far from complete list” of chemical reactions carried out by microorganisms, which he names, which include oxidation, reduction, condensation, esterification, amination, deamination, phosphorylation, hydrolysis, decarboxylation, methylation, dismutation, acylation, and dehydration.2 In short, microorganisms have come to be important tools in the chemical industry, especially the pharmaceutical branch thereof, and when a new and useful tangible industrial tool is invented which is unobvious, so that it complies with the prerequisites to patentability other than the enumerated statutory categories, we do not see any reason to deprive it or its creator or owner of the protection and advantages of the patent system by excluding it from the § 101 categories of patentable invention on the sole ground that it is alive. It is because it is alive that it is useful. The law unhesitatingly grants patent protection to new, useful, and unob-vious chemical compounds and compositions, in which category are to be found the products of microbiological processes, for example, vitamin B-12 and adrenalin, referred to in note 1 above, and countless other pharmaceuticals. We see no sound reason to refuse patent protection to the microorganisms themselves — a kind of tool used by chemists and chemical manufacturers in much the same way as they use chemical elements, compounds, and compositions which are not considered to be alive, notwithstanding their capacities to react and to promote reaction to produce new compounds and compositions by chemical processes in much the same way as do microorganisms. We think it is in the public interest to include microorganisms within the terms “manufacture” and “composition of matter” in § 101. In short, we think the fact that microorganisms, as distinguished from chemical compounds, are alive is a distinction without legal significance and that disposes of the board’s ground of rejection and the sole reason for refusal of a patent argued by the solicitor.
As for the board’s fears that our holding will of necessity, or “logically,” make all new, useful, and unobvious species of plants, animals, and insects created by man patentable, we think the fear is far-fetched. In any case, that question is not before us, as we have indicated above. Nor are we influenced by the legislative history of the Plant Patent Act of 1930 in the course of [1039]*1039which nobody had anything to say about patent protection for microorganisms, so far as we know. The collective mind of Congress was not turned in that direction. We are not here concerned with interpretation of the Plant Patent Act as this court was in In re Arzberger, supra, which simply held that that act did not encompass bacteria.
The decision of the board affirming the rejection of claim 5 is reversed.
REVERSED.