Spiegel, J.
There were complaints against the defendants for unlawfully having in their possession a certain narcotic drug, marihuana,2 and for conspiracy to violate the Narcotic Drugs Law.3 They were found guilty in the District Court and appeals were filed in the Superior Court. In addition the defendants were indicted for illegal possession of marihuana with intent to sell it unlawfully.4 In the Superior Court the defendants filed motions to dismiss the complaints and the indictments, asserting that the statutory provisions regulating the possession, use and sale of marihuana in this Commonwealth are unconstitutional. After a lengthy hearing at which eighteen expert witnesses testified,5 the trial judge denied the defendants’ motions and reported the cases on the following question: "Are the provisions of G. L. chapter 94, sections 205, 213A and 217B constitutional as applied to the defendants, or either [191]*191of them under the provisions of the Fourth, Fifth, Eighth, Ninth and Fourteenth Amendments to the United States Constitution and Article I, part 1; Article IV, part 2; Article VII, part 1; Article XIV, part 1; and Article XXVI, part 1, of the Constitution of the Commonwealth of Massachusetts?” The transcript of the hearing is before us.
The parties have stipulated to the following facts. “The defendants were arrested at Logan International Airport . . . on March 11, 1967 by . . . members of the Boston Vice Squad when one of the defendants presented a claims check for a trunk at an airline baggage terminal. The trunk contained fifty pounds of sand and five pounds of marihuana. . . . [N]either of the defendants has been convicted previously for any violation of the narcotic drug laws of the Commonwealth.”
1. The defendants allege that the Narcotic Drugs Law of the Commonwealth is “arbitrary and irrational and not suited to achieve any valid legislative end in that . . . it imposes harsh penalties upon mere possession of marihuana, or possession with intent to sell, or being present where marihuana is kept, without a showing that use of this substance poses a threat to the public health, safety, welfare or morals.” They conclude that it therefore violates Part II, c. 1, § 1, art. 4, of the Constitution of the Commonwealth6 and the Due Process Clause of the Fourteenth Amendment of the Constitution of the United States.7 The defendants contend that the law, “as applied to marihuana, goes beyond the police power of the Commonwealth in that it is not and cannot be aimed at achieving any valid legislative end, namely protection of the health, safety, welfare and morals.” They assert that it therefore violates, in addition to Part II, c. 1, § 1, art. 4, of the Constitution [192]*192of the Commonwealth and the Due Process Clause of the Fourteenth Amendment of the Constitution of the United States, art. 78 and art. 19 of the Declaration of Rights of the Constitution of the Commonwealth.
The defendants first argue that the law is “irrational and unreasonable” because the Legislature did not thoroughly investigate the available scientific and medical evidence concerning marihuana when enacting and revising the law.
We know of nothing that compels the Legislature to thoroughly investigate the available scientific and medical evidence when enacting a law. The test of whether an act of the Legislature is rational and reasonable is not whether the records of the Legislature contain a sufficient basis of fact to sustain that act. The Legislature is presumed to have acted rationally and reasonably. See Commonwealth v. Finnigan, 326 Mass. 378, 379; Coffee-Rich, Inc. v. Commissioner of Pub. Health, 348 Mass. 414, 422. “Unless the act of the Legislature cannot be supported upon any rational basis of fact that reasonably can be conceived to sustain it, the court has no power to strike it down as violative of the Constitution.” Sperry & Hutchinson Co. v. Director of the Div. on the Necessaries of Life, 307 Mass. 408, 418. See United States v. Carolene Prod. Co. 304 U. S. 144, 154.
The defendants then argue that the law is irrational and unreasonable and that it serves no legitimate State interest because there is no evidence that marihuana endangers the health, safety, welfare or morals of the community. They assert, inter alia, that there is no evidence to support the “allegations” that the smoking of marihuana causes psychotic reactions or “psychotic breaks” and that the use of marihuana leads to the use of more dangerous drugs. [193]*193They summarily dispose of “[ifjhe charge that marihuana causes disorientation, psychomotor discoordination, excitement and confusion” as merely a statement that marihuana causes a state of intoxication if used to excess, and of the “charge” that marihuana causes automobile accidents as pure “speculation.”
The testimony of the experts fully justifies the conclusion that marihuana is a - “mind-altering” drug. There was evidence that the effect of such a drug is “a complex interaction between the physical or pharmacological properties of that drug . . . and most importantly the personality or character structure of the person consuming that drug, and . . . the social setting or context in which the drug is taken, including expectations, attitudes, et cetera.” The smoking of marihuana may cause a state of euphoria and hallucinations or mental confusion and acute panic. It tends to exacerbate an underlying mental condition and to accentuate the smoker’s basic personality makeup. When used by persons who have personality disorders or who are predisposed to “psychotic breaks,” it may contribute to the onset of a “psychotic break.” 10 The problem is magnified by the fact that persons having personality disorders and predispositions to “psychotic breaks” are more likely to experiment with marihuana and to become psychologically dependent upon it. Although the smoking of marihuana triggers only “acute [short-term] psychotic breaks” and does not apparently cause permanent psychotic injury or mental deterioration, an acute psychotic break, while it lasts, is as serious as a chronic mental disorder.
[194]*194Essentially the experts do not point to any evidence of a direct, causal relationship between the smoking of marihuana and the use of more dangerous drugs. The studies that do exist discount the once prevalent belief that the smoking of marihuana inevitably leads to the use of more dangerous drugs.11 However, it is not necessary to show such a direct, causal relationship. There is considerable evidence that marihuana does lead some people to the use of more dangerous drugs. The progression from marihuana to heroin or LSD is a frequent sequence.
In an attempt to disprove the claim that the use of marihuana may cause automobile accidents, the defendants say that "no evidence [was] produced Unking marihuana use with . . . [such] accidents.” The evidence, however, showed there is no accurate, rehable scientific means of determining whether the operator of a motor vehicle has recently smoked marihuana. A person "high” on marihuana is unhkely to stagger or weave when he walks. While the smoking of marihuana may cause dilatation of the conjunctival blood vessels, there is recent evidence that it does not cause pupillary dilatation.12
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Spiegel, J.
There were complaints against the defendants for unlawfully having in their possession a certain narcotic drug, marihuana,2 and for conspiracy to violate the Narcotic Drugs Law.3 They were found guilty in the District Court and appeals were filed in the Superior Court. In addition the defendants were indicted for illegal possession of marihuana with intent to sell it unlawfully.4 In the Superior Court the defendants filed motions to dismiss the complaints and the indictments, asserting that the statutory provisions regulating the possession, use and sale of marihuana in this Commonwealth are unconstitutional. After a lengthy hearing at which eighteen expert witnesses testified,5 the trial judge denied the defendants’ motions and reported the cases on the following question: "Are the provisions of G. L. chapter 94, sections 205, 213A and 217B constitutional as applied to the defendants, or either [191]*191of them under the provisions of the Fourth, Fifth, Eighth, Ninth and Fourteenth Amendments to the United States Constitution and Article I, part 1; Article IV, part 2; Article VII, part 1; Article XIV, part 1; and Article XXVI, part 1, of the Constitution of the Commonwealth of Massachusetts?” The transcript of the hearing is before us.
The parties have stipulated to the following facts. “The defendants were arrested at Logan International Airport . . . on March 11, 1967 by . . . members of the Boston Vice Squad when one of the defendants presented a claims check for a trunk at an airline baggage terminal. The trunk contained fifty pounds of sand and five pounds of marihuana. . . . [N]either of the defendants has been convicted previously for any violation of the narcotic drug laws of the Commonwealth.”
1. The defendants allege that the Narcotic Drugs Law of the Commonwealth is “arbitrary and irrational and not suited to achieve any valid legislative end in that . . . it imposes harsh penalties upon mere possession of marihuana, or possession with intent to sell, or being present where marihuana is kept, without a showing that use of this substance poses a threat to the public health, safety, welfare or morals.” They conclude that it therefore violates Part II, c. 1, § 1, art. 4, of the Constitution of the Commonwealth6 and the Due Process Clause of the Fourteenth Amendment of the Constitution of the United States.7 The defendants contend that the law, “as applied to marihuana, goes beyond the police power of the Commonwealth in that it is not and cannot be aimed at achieving any valid legislative end, namely protection of the health, safety, welfare and morals.” They assert that it therefore violates, in addition to Part II, c. 1, § 1, art. 4, of the Constitution [192]*192of the Commonwealth and the Due Process Clause of the Fourteenth Amendment of the Constitution of the United States, art. 78 and art. 19 of the Declaration of Rights of the Constitution of the Commonwealth.
The defendants first argue that the law is “irrational and unreasonable” because the Legislature did not thoroughly investigate the available scientific and medical evidence concerning marihuana when enacting and revising the law.
We know of nothing that compels the Legislature to thoroughly investigate the available scientific and medical evidence when enacting a law. The test of whether an act of the Legislature is rational and reasonable is not whether the records of the Legislature contain a sufficient basis of fact to sustain that act. The Legislature is presumed to have acted rationally and reasonably. See Commonwealth v. Finnigan, 326 Mass. 378, 379; Coffee-Rich, Inc. v. Commissioner of Pub. Health, 348 Mass. 414, 422. “Unless the act of the Legislature cannot be supported upon any rational basis of fact that reasonably can be conceived to sustain it, the court has no power to strike it down as violative of the Constitution.” Sperry & Hutchinson Co. v. Director of the Div. on the Necessaries of Life, 307 Mass. 408, 418. See United States v. Carolene Prod. Co. 304 U. S. 144, 154.
The defendants then argue that the law is irrational and unreasonable and that it serves no legitimate State interest because there is no evidence that marihuana endangers the health, safety, welfare or morals of the community. They assert, inter alia, that there is no evidence to support the “allegations” that the smoking of marihuana causes psychotic reactions or “psychotic breaks” and that the use of marihuana leads to the use of more dangerous drugs. [193]*193They summarily dispose of “[ifjhe charge that marihuana causes disorientation, psychomotor discoordination, excitement and confusion” as merely a statement that marihuana causes a state of intoxication if used to excess, and of the “charge” that marihuana causes automobile accidents as pure “speculation.”
The testimony of the experts fully justifies the conclusion that marihuana is a - “mind-altering” drug. There was evidence that the effect of such a drug is “a complex interaction between the physical or pharmacological properties of that drug . . . and most importantly the personality or character structure of the person consuming that drug, and . . . the social setting or context in which the drug is taken, including expectations, attitudes, et cetera.” The smoking of marihuana may cause a state of euphoria and hallucinations or mental confusion and acute panic. It tends to exacerbate an underlying mental condition and to accentuate the smoker’s basic personality makeup. When used by persons who have personality disorders or who are predisposed to “psychotic breaks,” it may contribute to the onset of a “psychotic break.” 10 The problem is magnified by the fact that persons having personality disorders and predispositions to “psychotic breaks” are more likely to experiment with marihuana and to become psychologically dependent upon it. Although the smoking of marihuana triggers only “acute [short-term] psychotic breaks” and does not apparently cause permanent psychotic injury or mental deterioration, an acute psychotic break, while it lasts, is as serious as a chronic mental disorder.
[194]*194Essentially the experts do not point to any evidence of a direct, causal relationship between the smoking of marihuana and the use of more dangerous drugs. The studies that do exist discount the once prevalent belief that the smoking of marihuana inevitably leads to the use of more dangerous drugs.11 However, it is not necessary to show such a direct, causal relationship. There is considerable evidence that marihuana does lead some people to the use of more dangerous drugs. The progression from marihuana to heroin or LSD is a frequent sequence.
In an attempt to disprove the claim that the use of marihuana may cause automobile accidents, the defendants say that "no evidence [was] produced Unking marihuana use with . . . [such] accidents.” The evidence, however, showed there is no accurate, rehable scientific means of determining whether the operator of a motor vehicle has recently smoked marihuana. A person "high” on marihuana is unhkely to stagger or weave when he walks. While the smoking of marihuana may cause dilatation of the conjunctival blood vessels, there is recent evidence that it does not cause pupillary dilatation.12 The burning of marihuana does produce a recognizable odor, but that odor could be easily disguised. These properties of the drug undoubtedly account for the unavailability of statistical data. However, there is agreement among the experts [195]*195that marihuana causes an alteration of sensory perception, a degree of psychomotor discoordination and an inability to concentrate. All of these effects of marihuana would interfere with the operation of a motor vehicle.
We do not think that the present unavailability of or inability to collect absolute, statistical and scientific proof that the smoking of marihuana (1) triggers “psychotic breaks,” (2) leads to the use of more dangerous drugs and (3) causes automobile accidents prevents the Legislature from acting to prohibit its use. Surely the defendants would not contend, for example, that unless experiments absolutely establish that thalidomide causes birth defects the Legislature could not prevent the distribution of that drug. To prevent “psychotic breaks,” to guard against the use of more dangerous drugs and to eliminate a cause of automobile accidents are valid State interests.
The defendants insist that the right to smoke marihuana is guaranteed by the Constitutions of the Commonwealth and of the United States and must be balanced against the interests of the State in prohibiting its use. No such right exists. It is not specifically preserved by either Constitution. The right to smoke marihuana is not “fundamental to the American scheme of justice . . . necessary to an Anglo-American regime of ordered liberty.” Duncan v. Louisiana, 391 U. S. 145, 149-150, note 14. It is not within a “zone of privacy” formed by “penumbras” of the First, Third, Fourth and Fifth Amendments and the Ninth Amendment of the Constitution of the United States. See Griswold v. Connecticut, 381 U. S. 479, 484. The defendants have no right, fundamental or otherwise, to become intoxicated by means of the smoking of marihuana. See Robinson v. California, 370 U. S. 660, 664. Cf. Crane v. Campbell, 245 U. S. 304, 307-308.
We do not agree with the defendants that the Legislature is bound to adopt the “least restrictive alternative” that would fulfill its purpose of protecting the health, safety and welfare of the community. The least restrictive alternative doctrine does not apply to the instant case. It has been [196]*196limited to regulations affecting interstate commerce (see e.g. Dean Milk Co. v. City of Madison, 340 U. S. 349, 354), constitutionally sheltered activity (see e.g. Aptheker v. Secretary of State, 378 U. S. 500, 512), and economic regulations (see e.g. Weaver v. Palmer Bros. Co. 270 U. S. 402, 414-415). The Narcotic Drugs Law is not an economic regulation. It affects neither interstate commerce nor constitutionally sheltered activity.
In any event, there is ample justification for the Legislature to conclude that the total prohibition of marihuana is the “least restrictive alternative.” The evidence indicates that the effects of smoking marihuana are unpredictable. No one can predict how a given person will react, or how such a person will react to the drug at any given time. There is no known means of determining whether a person has smoked marihuana, how much he has smoked or even how much causes intoxication. The difficulty of estabhshing the intoxication of the driver who is under the influence of marihuana renders G. L. c. 90, § 24 (1) (a),13 as amended through St. 1963, c. 369, § 2, an insufficient safeguard with regard to the danger of automobile accidents.
2. The defendants maintain that the Narcotic Drugs Law “has singled out for prohibition and punishment possessors of and possessors of with intent to sell, marihuana, while the laws permit the regulated use, sale and possession of substances far more harmful than marihuana . . . punish less harshly possession and sale of substances far more harmful than marihuana . . . and punish equally harshly substances far more harmful than marihuana.” Therefore, they say that it violates art. 1 of the Declaration of Rights of the Constitution of the Commonwealth and the Equal Protection Clause of the Fourteenth Amendment of the Constitution of the United States.14
[197]*197The defendants argue that the inclusion of marihuana in the class of drugs defined by G. L. c. 94, § 197, to be “narcotic drugs” is arbitrary. This argument ignores “the rules by which this contention must be tested ... 1. The equal protection clause of the Fourteenth Amendment does not take from the State the power to classify in the adoption of police laws, but admits of the exercise of a wide scope of discretion in that regard, and avoids what is done only when it is without any reasonable basis and therefore is purely arbitrary. 2. A classification having some reasonable basis does not offend against that clause merely because it is not made with mathematical nicety or because in practice it results in some inequality. 3. When the classification in such a law is called in question, if any state of facts reasonably can be conceived that would sustain it, the existence of that state of facts at the time the law was enacted must be assumed. 4. One who assails the classification in such a law must carry the burden of showing that it does not rest upon any reasonable basis, but is essentially arbitrary. ’ ’ Lindsley v. Natural Carbonic Gas Co. 220 U. S. 61, 78-79.
“Narcotic drug” as defined in G. L. c. 94, § 197, as amended through St. 1966, c. 71, §§ 1 and 2, includes “coca leaves, cocaine, alpha or beta eucaine . . . opium, morphine, heroin, codeine, apomorphine, isonipecaine, amidone, isoam-idone, keto-bemidone, peyote, LSD, psyilocybin, D.M.T. . . . and cannabis (sometimes called marihuana . . .).” All of these substances are “mind-altering” drugs. The fact that some are more potent or more dangerous than others does not render the classification arbitrary. To some degree they are all capable of producing psychotic disorders, states of intoxication and psychological dependency, and consequently present some danger to the health and safety of the community. We do not think that the classification of marihuana with the others is arbitrary or irrational.
The defendants also contend that the noninclusion of other “mind-altering” drugs in G. L. c. 94, § 197, as amended - through St. 1966, c. 71, §§ 1 and 2, which are “acknowledged to be . . . more harmful” than marihuana, causes the law [198]*198to “run afoul of the requirements of equal protection.” They concede that the Legislature may select the kinds of behavior that it wishes to proscribe. They claim, however, that this “does not mean that a Legislature may actually proscribe behavior of one class of people (e.g., those who choose to obtain a mild state of intoxication with marihuana) and allow another class of people to freely indulge in behavior of an exactly similar nature (e.g., those who choose to obtain a mild state of intoxication with alcohol).”
We do not think that a statute which proscribes generally certain conduct can be said to be discriminatory simply because a certain group of persons tend to engage more often in that conduct than others. Such “de facto” discrimination does not violate the Equal Protection Clause. There are at least two distinctions between alcohol and the “mind-altering” intoxicants that are defined by the law to be narcotic drugs. First, alcohol is susceptible to a less restrictive alternative means of control. There are recognized, accurate means of determining its use and its abuse. Second, the effects of alcohol upon the user are known. We think that the Legislature is warranted in treating this known intoxicant differently from marihuana, LSD or heroin, the effects of which are largely still unknown and subject to extensive dispute. The Legislature is free to recognize degrees of harm and may confine its restrictions to instances where it determines the need for them is clearest. See Hall v. Geiger-Jones Co. 242 U. S. 539, 556-557; Skinner v. Oklahoma, 316 U. S. 535, 539-540; Mulligan v. Hilton, 305 Mass. 5, 13.
3. Finally, the defendants contend that the “penalties provided for offenses under the Narcotic Drugs Law, as applied to marihuana, constitute cruel and excessive punishment.” They contend that it therefore violates art. 26 of the Declaration of Rights of the Constitution of the Commonwealth15 and the Eighth Amendment of the Constitution of the United States.16
[199]*199The defendants were convicted and sentenced on the complaints in the District Court. They have appealed to the Superior Court and are awaiting trials de nova on the complaints in that court. They have not yet been tried on the indictments. As they have not as yet been convicted of the offences with which they are charged, it is doubtful that they have standing to even challenge the minimum penalties provided by G. L. c. 94. See Weems v. United States, 217 U. S. 349; Lehon v. Atlanta, 242 U. S. 53, 56. In any event, no mandatory minimum penalty is provided in the law for any of the violations charged. G. L. c. 94, §§ 205, 213A, and 217B. The defendants could be found guilty of all three violations and not be required to serve any sentence or to pay any fine.
The defendants also argue that “any sentence” would be excessive or that the incidental consequences of being convicted constitute cruel and unusual punishment. The defendants are not charged with having a “status” over which they have no control. See Robinson v. California, 370 U. S. 660. “The basic concept underlying the Eighth Amendment is nothing less than the dignity of man. . . . Fines, imprisonment and even execution may be imposed depending upon the enormity of the crime.” Trop v. Dulles, 356 U. S. 86, 100. Unless the punishment exceeds a constitutional limit, the task of assigning penalties is for the Legislature. Neither constitution requires the Legislature “to fix or impose any particular penalty for any crime . . . or to impose the same or ‘proportionate’ sentences for separate and independent crimes.” Williams v. Oklahoma, 358 U. S. 576, 586. See Harding v. Commonwealth, 283 Mass. 369, 374. Here the Legislature has seen fit to give the trial judge considerable leeway in sentencing. We have no reason to believe that a judge will not continue to exercise this discretion wisely and fail to distinguish between the youth who was experimenting with marihuana or even a constant user of the drug and the “pusher” or person trafficking in marihuana for financial gain.
4. Because of the extensive testimony introduced at the [200]*200hearing we have commented on a number of the factual contentions. It is clear that the Legislature acted well within constitutional limitations.
5. The question is answered in the affirmative.
So ordered.