MAYNARD, Justice.
Jonella Yates and her husband, Donald Yates, the appellants and plaintiffs below in a medical malpractice case, appeal the final order of the Circuit Court of Cabell County entered December 3, 1999. The appellants raise several issues on appeal to this Court. After careful consideration of these issues, we reverse the judgment of the circuit court.
I.
FACTS
On May 4, 1994, appellant, Jonella Yates (“Mrs.Yates”) was hospitalized at St. Mary’s Hospital in Huntington, West Virginia, with complaints of chest pain.1 Mrs. Yates’ attending physician at St. Mary’s Hospital was Dr. Gretehen Oley, an internal medicine specialist and employee of the Marshall University School of Medicine which was governed at this time by the appellee, University of West Virginia Board of Trustees.2
On May 6, 1994, a cardiac catheterization was performed on Mrs. Yates by Dr. Robert Touchon and she was diagnosed with a 60% stenosis of the left circumflex coronary artery. In order to assess the significance of Mrs. Yates’ condition, she underwent a stress test3 on May 9 which was stopped because she experienced a rapid heart beat and chest pain.
On May 10, Dr. Mark Studeny performed an atherectomy on Mrs. Yates, which is the insertion of a catheter with a small blade on the end and the cutting away of deposits from the lining of the artery. Incidental to this procedure, Dr. Studeny discovered that Mrs. Yates’ right iliac artery was blocked. The iliac .artery is the artery which branches off from the abdominal artery and delivers blood to the legs. There is evidence that this blockage was a rare complication resulting from injury to the internal wall of the artery occurring during the catheterization procedure of May 6.4 Dr. Studeny consulted with Dr. Dennis Burton, a radiologist, who attempted, the next day, to dissolve the blockage in the right iliac artery through the performance of an angioplasty, stent placement, and the administration of urokinase, an enzyme used intravenously to dissolve blood clots.
Subsequent angiograms5 on May 12 revealed persistent blockage in the iliac artery [491]*491and an additional blockage in the trifurcation of the popliteal artery. This artery is located at the back part of the knee joint and branches into the anterior and posterior tibial and peroneal arteries.6 That evening, Dr. Timothy Robarts, a surgical resident, noted that “if foot not better in a.m. (pulseless now), [Mrs. Yates] will need re-agram and likely emboleetomy and fem fem crossover.”7 Generally, from the time of the discovery of the blockage in the right iliac artery, until May 16, when surgery was ultimately performed, the condition of Mrs. Yates’ right foot waxed and waned. Sometimes foot pulses were palpable, or apparent to the touch, and sometimes not. At times the pulses were dopplerable, or audible through a hand-held device, and at times they were not. The foot alternated between being cool to the touch and pale or blue to being pink and warm.
The evidence indicates that on the morning of May 13, Dr. Venkata Raman, a vascular surgeon, became involved in Mrs. Yates’ treatment for the first time. Dr. Raman was an employee of the Marshall University School of Medicine. Evidence was presented that Mrs. Yates’ right foot had improved by the morning of May 13. Late that night, an angiogram showed that the iliac artery, the trifurcation, and its adjoining vessels were now open. Nevertheless, Mrs. Yates’ right foot continued to show signs of ischemia, or lack of oxygen. It was thought that, although all of the major arteries of the right leg were now open, that Mrs. Yates was suffering from blood clots in the small vessels of the foot which carry blood from the major arteries to the muscles. For this reason, the infusion of urokinase was continued to dissolve these clots.
In the early morning hours of May 14, Mrs. Yates suffered a retroperitoneal hema-toma which is a mass of blood in the membrane lining the abdominal cavity apparently caused by a break in a blood vessel. Evidence was presented that this break in the vessel may have occurred during the angioplasty and initial infusion of urokinase on May 12. The hematoma resulted in significant blood loss which was treated with several blood transfusions. Also, infusions of urokinase and administration of heparin, an anticoagulant use to prevent clotting, were discontinued at this time in order to aid in stopping the blood loss. The blood transfusions were successful in treating the hemato-ma.
However, after the infusion of urokinase and administration of heparin were stopped, Mrs. Yates’ right leg artery reelotted. Also, the condition of her right foot continued to worsen. As a result, on May 16 Dr. Raman performed an emboleetomy on Mrs. Yates to remove the blood clot and a fasciotomy to release the pressure in her swollen and tender right calf. It was subsequently discovered that Mrs. Yates had suffered significant muscle death in her right foot and lower leg, and a below the knee amputation was performed on May 29.
On May 6, 1996, Mrs. Yates and her husband brought a medical malpractice action against all of the doctors involved in her treatment, Radiology, Inc., of which Dr. Burton was an employee, and St. Mary’s Hospital. By the time of the trial, in June, 1999, all of the defendants had been dismissed from the case except the University of West Virginia Board of Trustees who was substituted in lieu of defendants Drs. Oley and Raman.
At trial, the appellants’ theory was that Dr. Oley, Mrs. Yates’ attending physician, and Dr. Raman, her vascular surgeon, were tardy in their treatment of her right iliac artery, and this tardiness resulted in the amputation. Specifically, they alleged that when the blockage was first discovered on May 10, Dr. Oley should have immediately consulted with a vascular surgeon instead of a radiologist. Also, they alleged that Dr. Raman, upon becoming involved in Mrs. [492]*492Yates’ treatment on May 13, should have immediately performed surgery rather than assenting to the continued infusion of uroki-nase. In support of this theory, the appellants presented the testimony of Dr. Alex Zachariah, a cardiovascular and thoracic surgeon, who opined that Dr. Oley deviated from the applicable standard of care by not consulting a vascular surgeon on May 10, and that Dr. Raman was negligent in not operating to remove the blood clots on May 13.
In response, the appellee presented the testimony of Dr. John Bergan, a vascular surgeon, who opined that interventional radiology is an acceptable method of treating the blockage of an artery so that Dr. Oley was not negligent in consulting a radiologist rather than a vascular surgeon. Likewise, he testified that Dr. Raman was not negligent in assenting to the radiology treatment already initiated when he became involved in the ease on May 13.
After a five-day trial, the jury returned a verdict for the appellee. The trial court subsequently denied the appellants’ motion to set aside the verdict and for a new trial. As a result, the appellants now appeal to this Court.
II.
DISCUSSION
The appellants complain, first, that the trial court abused its discretion in admitting the expert opinion testimony of Dr. John Bergan because there was no evidence that Dr.
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MAYNARD, Justice.
Jonella Yates and her husband, Donald Yates, the appellants and plaintiffs below in a medical malpractice case, appeal the final order of the Circuit Court of Cabell County entered December 3, 1999. The appellants raise several issues on appeal to this Court. After careful consideration of these issues, we reverse the judgment of the circuit court.
I.
FACTS
On May 4, 1994, appellant, Jonella Yates (“Mrs.Yates”) was hospitalized at St. Mary’s Hospital in Huntington, West Virginia, with complaints of chest pain.1 Mrs. Yates’ attending physician at St. Mary’s Hospital was Dr. Gretehen Oley, an internal medicine specialist and employee of the Marshall University School of Medicine which was governed at this time by the appellee, University of West Virginia Board of Trustees.2
On May 6, 1994, a cardiac catheterization was performed on Mrs. Yates by Dr. Robert Touchon and she was diagnosed with a 60% stenosis of the left circumflex coronary artery. In order to assess the significance of Mrs. Yates’ condition, she underwent a stress test3 on May 9 which was stopped because she experienced a rapid heart beat and chest pain.
On May 10, Dr. Mark Studeny performed an atherectomy on Mrs. Yates, which is the insertion of a catheter with a small blade on the end and the cutting away of deposits from the lining of the artery. Incidental to this procedure, Dr. Studeny discovered that Mrs. Yates’ right iliac artery was blocked. The iliac .artery is the artery which branches off from the abdominal artery and delivers blood to the legs. There is evidence that this blockage was a rare complication resulting from injury to the internal wall of the artery occurring during the catheterization procedure of May 6.4 Dr. Studeny consulted with Dr. Dennis Burton, a radiologist, who attempted, the next day, to dissolve the blockage in the right iliac artery through the performance of an angioplasty, stent placement, and the administration of urokinase, an enzyme used intravenously to dissolve blood clots.
Subsequent angiograms5 on May 12 revealed persistent blockage in the iliac artery [491]*491and an additional blockage in the trifurcation of the popliteal artery. This artery is located at the back part of the knee joint and branches into the anterior and posterior tibial and peroneal arteries.6 That evening, Dr. Timothy Robarts, a surgical resident, noted that “if foot not better in a.m. (pulseless now), [Mrs. Yates] will need re-agram and likely emboleetomy and fem fem crossover.”7 Generally, from the time of the discovery of the blockage in the right iliac artery, until May 16, when surgery was ultimately performed, the condition of Mrs. Yates’ right foot waxed and waned. Sometimes foot pulses were palpable, or apparent to the touch, and sometimes not. At times the pulses were dopplerable, or audible through a hand-held device, and at times they were not. The foot alternated between being cool to the touch and pale or blue to being pink and warm.
The evidence indicates that on the morning of May 13, Dr. Venkata Raman, a vascular surgeon, became involved in Mrs. Yates’ treatment for the first time. Dr. Raman was an employee of the Marshall University School of Medicine. Evidence was presented that Mrs. Yates’ right foot had improved by the morning of May 13. Late that night, an angiogram showed that the iliac artery, the trifurcation, and its adjoining vessels were now open. Nevertheless, Mrs. Yates’ right foot continued to show signs of ischemia, or lack of oxygen. It was thought that, although all of the major arteries of the right leg were now open, that Mrs. Yates was suffering from blood clots in the small vessels of the foot which carry blood from the major arteries to the muscles. For this reason, the infusion of urokinase was continued to dissolve these clots.
In the early morning hours of May 14, Mrs. Yates suffered a retroperitoneal hema-toma which is a mass of blood in the membrane lining the abdominal cavity apparently caused by a break in a blood vessel. Evidence was presented that this break in the vessel may have occurred during the angioplasty and initial infusion of urokinase on May 12. The hematoma resulted in significant blood loss which was treated with several blood transfusions. Also, infusions of urokinase and administration of heparin, an anticoagulant use to prevent clotting, were discontinued at this time in order to aid in stopping the blood loss. The blood transfusions were successful in treating the hemato-ma.
However, after the infusion of urokinase and administration of heparin were stopped, Mrs. Yates’ right leg artery reelotted. Also, the condition of her right foot continued to worsen. As a result, on May 16 Dr. Raman performed an emboleetomy on Mrs. Yates to remove the blood clot and a fasciotomy to release the pressure in her swollen and tender right calf. It was subsequently discovered that Mrs. Yates had suffered significant muscle death in her right foot and lower leg, and a below the knee amputation was performed on May 29.
On May 6, 1996, Mrs. Yates and her husband brought a medical malpractice action against all of the doctors involved in her treatment, Radiology, Inc., of which Dr. Burton was an employee, and St. Mary’s Hospital. By the time of the trial, in June, 1999, all of the defendants had been dismissed from the case except the University of West Virginia Board of Trustees who was substituted in lieu of defendants Drs. Oley and Raman.
At trial, the appellants’ theory was that Dr. Oley, Mrs. Yates’ attending physician, and Dr. Raman, her vascular surgeon, were tardy in their treatment of her right iliac artery, and this tardiness resulted in the amputation. Specifically, they alleged that when the blockage was first discovered on May 10, Dr. Oley should have immediately consulted with a vascular surgeon instead of a radiologist. Also, they alleged that Dr. Raman, upon becoming involved in Mrs. [492]*492Yates’ treatment on May 13, should have immediately performed surgery rather than assenting to the continued infusion of uroki-nase. In support of this theory, the appellants presented the testimony of Dr. Alex Zachariah, a cardiovascular and thoracic surgeon, who opined that Dr. Oley deviated from the applicable standard of care by not consulting a vascular surgeon on May 10, and that Dr. Raman was negligent in not operating to remove the blood clots on May 13.
In response, the appellee presented the testimony of Dr. John Bergan, a vascular surgeon, who opined that interventional radiology is an acceptable method of treating the blockage of an artery so that Dr. Oley was not negligent in consulting a radiologist rather than a vascular surgeon. Likewise, he testified that Dr. Raman was not negligent in assenting to the radiology treatment already initiated when he became involved in the ease on May 13.
After a five-day trial, the jury returned a verdict for the appellee. The trial court subsequently denied the appellants’ motion to set aside the verdict and for a new trial. As a result, the appellants now appeal to this Court.
II.
DISCUSSION
The appellants complain, first, that the trial court abused its discretion in admitting the expert opinion testimony of Dr. John Bergan because there was no evidence that Dr. Bergan was licensed to practice medicine in one of the states of the United States as required by W.Va.Code § 55-7B-7 (1986).8 The appellee responds that the appellants waived this assignment of error by failing to make a timely objection at trial. We agree.
The record shows that prior to Dr. Ber-gan’s testimony, appellants’ counsel objected to Dr. Bergan as a witness on the grounds that Dr. Bergan and Dr. Raman were friends; Dr. Bergan testified previously on behalf of Dr. Raman in a medical malpractice case; on the evening prior to Dr. Bergan’s scheduled testimony, Dr. Bergan helped Dr. Raman to prepare for his impending testimony; and Dr. Bergan has not performed vascular surgery on the arterial system in the last ten years. These objections were rejected by the trial court, and Dr. Bergan proceeded to testify on Friday, June 18. On cross-examination, appellants’ counsel questioned Dr. Bergan on the matters raised in them objections. On Tuesday, June 22, following the testimony of Dr. Raman, the defense rested.9 At that point, appellants’ counsel moved to strike the testimony of Dr. Bergan because it was not disclosed whether Dr. Bergan was licensed to practice medicine in a state of the United States.10
Our rules clearly indicate that a party who assigns error on appeal based on a trial court’s admission of evidence must timely object to that evidence. Rule 103 of the West Virginia Rules of Evidence states:
(a) Effect of erroneous ruling.Error may not be predicated upon a ruling which admits or excludes evidence unless a substantial right of the party is affected, and
(b) Objection.In ease the ruling is one admitting evidence, a timely objection or motion to strike appears of record, stating the specific ground of the objection, if the specific ground was not apparent from the context[.]
In addition, this Court has held that “[a] proper objection to the competency of a wit[493]*493ness must be made and the point saved when the witness or his testimony is offered at trial[.]” Syllabus Point 3, in part, First Nat. Bank Of Ronceverte v. Bell, 158 W.Va. 827, 215 S.E.2d 642 (1975).
The appellants did not timely object to Dr. Bergan’s testimony when it was offered at trial, despite the fact that they had the opportunity to conduct voir dire of Dr. Bergan or to cross-examine him concerning his licen-sure to practice medicine. In their reply brief to this Court, the appellants argue that Rule 103 permits either a timely objection or a motion to strike so that they adequately preserved the alleged error. However, the point of Rule of Evidence 103 is that a motion to strike, as well as an objection, must be timely. This is because a timely objection or motion to strike “gives both the court and the party’s opponent fair warning and a timely opportunity to acknowledge and correct the errors so that eases can be decided squarely on the merits.” Franklin D. Cleck-ley, Handbook On Evidence For West Virginia Lawyers, Vol. 1, § l-7(B)(7)(a), at 1-62 (4th ed.2000). A timely objection by the appellants would have given the appellee an opportunity to clarify Dr. Bergan’s licensing status, and the trial court could have ruled accordingly. Instead, appellants’ counsel waited four days until Dr. Bergan was no longer available before making their motion to strike. Accordingly, we decline to consider the appellants’ first assignment of error.
The appellants next aver that the trial court erred in denying their motions for a judgment as a matter of law11 at the close of the evidence and subsequent motion to set aside the jury verdict.12 According to the appellants, Dr. Oley’s and Dr. Raman’s failure to timely order and/or perform surgery to remove the clot in Mrs. Yates’ iliac artery is an “open and shut case of liability.” The appellants conclude that Drs. Oley and Raman did nothing to treat Mrs. Yates’ clotted vessels and that this is not an acceptable standard of care.
“We review de novo ... the denial of the [judgment as a matter of law]” made pursuant to Rule 50(a) of the West Virginia Rules of Civil Procedure. Adkins v. Chevron, USA, Inc., 199 W.Va. 518, 522, 485 S.E.2d 687, 691 (1997). This Court has said that a judgment as a matter of law should be granted at the close of the evidence when, after considering the evidence in the light most favorable to the nonmovant, only one reasonable verdict is possible. Barefoot v. Sundale Nursing Home, 193 W.Va. 475, 481 n. 6, 457 S.E.2d 152, 158 n. 6 (1995). In addition, “[u]pon a motion for a [judgment as a matter of law], all reasonable doubts and inferences should be resolved in favor of the party against whom the verdict is asked to be directed.” Syllabus Point 5, Wager v. Sine, 157 W.Va. 391, 201 S.E.2d 260 (1973).
The appellee’s evidence indicates that upon discovery of the clot in Mrs. Yates’ iliac artery on May 10,1994, Dr. Oley, her attending physician, consulted with Dr. Studeny, a cardiologist, and it was decided that the clot would be treated by means of interventional radiology instead of surgery. On May 12, Dr. Burton, a radiologist, attempted to dissolve the clot with angioplasty, stent placement, and administration of urokinase, an enzyme used intravenously to dissolve clots. Dr. Raman became involved in Mrs. Yates’ treatment on the morning of May 13, and by late that night the major vessels of Mrs. Yates’ right leg were open. There was also testimony that it was only after the administration of urokinase was stopped, in order to treat Mrs. Yates’ hematoma, that blockages formed in the microscopic vessels of the right foot which ultimately lead to the amputation. Concerning the choice of interventional radiology rather than surgery to treat the [494]*494blockage in Mrs. Yates’ iliac artery, the ap-pellee’s expert, Dr. John Bergan, opined that Drs. Oley and Raman did not deviate from the standard of care because both interven-tional radiology and surgery are valid methods of treatment.
In light of this evidence and resolving all doubts and inferences in favor of the appel-lee, we do not believe that only one reasonable verdict was possible. Accordingly, we conclude that the trial court was correct to deny the appellants’ motion for a judgment as a matter of law at the end of the evidence.
For the same reason, we believe that the trial court did not err in denying the appellants’ motion to set aside the jury verdict. “An appellate court will not set aside the verdict of a jury, founded on conflicting testimony and approved by the trial court, unless the verdict is against the plain preponderance of the evidence.” Syllabus Point 2, Stephens v. Bartlett, 118 W.Va. 421, 191 S.E. 550 (1937). Additionally,
[i]n determining whether the verdict of a jury is supported by the evidence, every reasonable and legitimate inference, fairly arising from the evidence in favor of the party for whom the verdict was returned, must be considered, and those facts, which the jury might properly find under the evidence, must be assumed as true.
Syllabus Point 3, Walker v. Monongahela Power Co., 147 W.Va. 825, 131 S.E.2d 736 (1963).
Again, we believe that the evidence, set forth above, is sufficient to support the jury’s verdict. There was conflicting evidence whether Mrs. Yates’ treatment, performed by Drs. Oley and Raman, breached the applicable standard of care. The jury obviously found the evidence presented by the appellee to be more credible, and concluded that Drs. Oley and Raman were not negligent. Accordingly, we find no error in the trial court’s denial of the appellants’ motion to set aside the verdict based on insufficiency of the ap-pellee’s evidence.
The third assignment of error raised by the appellants is that the trial court erred in giving a jury instruction concerning multiple methods of treatment. This instruction stated:
A doctor is not negligent if he selects one of several or more approved methods of treatment within the standard of care. In other words, if there is more than one generally recognized method of diagnosis or treatment and no one method is used exclusively or uniformly by all physicians, a physician is not negligent if, in the exercise of his medical judgment, he selects one of the approved methods within the standard of care — even if you believe in retrospect that the alternative chosen may not have been the best method of treatment — as long as he utilizes that method of treatment in a non-negligent manner as otherwise instructed by the Court.
The appellants argue that this instruction is faulty because it allows for the possibility that the only doctors in the world who would choose the alternate treatment are the defendant doctor and his testifying expert. The appellants suggest that this instruction should be abandoned or modified to require that a “considerable number” of doctors adhere to a method of treatment before it is recognized as a valid alternative treatment method.
We decline to abandon the multiple methods of treatment instruction. Rather, this Court believes that the multiple method of treatment instruction is a necessary recognition that the practice of medicine is an inexact science often characterized by a myriad of therapeutic approaches to a medical problem, all of which may command respect within the medical profession. This instruction properly informs jurors that a physician’s professional judgment in choosing the most effective treatment in a given situation is a fundamental and indispensable element of practicing medicine. Also, the instruction relieves jurors of the task of deciding which treatment, among several alternatives, should have been performed by a defendant physician. In addition, the instruction guards against the propensity to assess a physician’s judgment with the advantage of hindsight. Finally, our research discovered [495]*495that a significant number of other jurisdictions continue to utilize the instruction.13
We do, however, share the appellants’ concern that the only doctors in the world who would choose the alternative treatment are the defendant physician and his testifying expert. For this reason, we clarify that it is insufficient to show that there exists only a small minority of physicians who agree with the defendant’s challenged treatment. On the other hand, it is not necessary for the defendant to show that the challenged treatment is utilized by the majority of physicians. Rather, the defendant must show that the challenged treatment enjoys such substantial support within the medical community that it truly is generally recognized. In order to make this showing, the defendant’s expert must opine that the challenged method of diagnosis or treatment has substantial support and is generally recognized within the medical community. This testimony should usually be supported by sufficient extrinsic evidence such as medical textbooks, treatises, journal articles, or other similar evidence. Upon a proper showing by the defendant, a multiple methods of treatment instruction may properly be given. Once the trial court makes this determination, it is ultimately a question for the jury to determine whether it believes that the challenged method of diagnosis or treatment is generally recognized, and the burden of per[496]*496suasion on that issue remains with the plaintiff.
Therefore, we hold that in medical malpractice cases, the “multiple methods of treatment” jury instruction (which states that a health care provider is not negligent if he or she selects and utilizes in a non-negligent manner one of two or more generally recognized methods of diagnosis or treatment within the standard of care) is appropriate where the evidence shows that the challenged method of diagnosis or treatment enjoys such substantial support within the medical community that it is, in fact, widely and generally recognized. The necessity of presenting evidence sufficient to support a multiple methods of treatment instruction rests with the defendant.14
Applying this standard to the present set of facts, our review of the record shows that the defendant’s evidence on this issue was insufficient to support a multiple methods of treatment instruction, in that Dr. Bergan opined that Drs. Oley and Raman did not deviate from the applicable standards of care in their treatment of Ms. Yates but presented no extrinsic evidence in support of this testimony. Therefore, the defendant did not meet its burden of proof. In determining the effect of the multiple methods of treatment instruction, we are mindful that “[a]n erroneous instruction is presumed to be prejudicial and warrants a new trial unless it appears that the complaining party was not prejudiced by such instruction.” Syllabus Point 2, Hollen v. Linger, 151 W.Va. 255, 151 S.E.2d 330 (1966). A party is prejudiced when his or her substantial rights are affected or when “there is a reasonable probability that the jury’s verdict was affected or influenced” by the improper instruction. Tennant v. Marion Health Care Found., Inc., 194 W.Va. 97, 111, 459 S.E.2d 374, 388 (1995). Because the primary issue in this case concerned the propriety of Drs. Oley’s and Ra-man’s decision to use interventional radiology rather than immediate surgery as the preferred method of treating Ms. Yates’s blockage, we find that there is a reasonable probability that the jury’s verdict was influenced by the improper instruction and, thus, constitutes reversible error. Upon remand, the burden rests with the appellee to present additional evidence to support a multiple methods of treatment instruction.15
Next, the appellants argue that it was prejudicial error for the trial court to give a jury instruction concerning mistakes in judgment.. The appellee responds that any error in giving the instruction was harmless.
The complained of instruction stated:
A health care provider who exercises ordinary skill and care while keeping within recognized and approved methods within the standard of care is not negligent because [of] a reasonable and honest mistake of judgment. On the other hand, it is no defense for a health care provider to say that he exercised his best judgment, if that judgment breached the standard of care.
In the recent ease of Pleasants v. Alliance Corporation, 209 W.Va. 39, 543 S.E.2d 320 (2000), we disapproved of the “error in judgment” instruction and held in Syllabus Point 5:
The “mistake of judgment” jury instruction, which this Court first approved in Dye v. Corbin, 59 W.Va. 266, 53 S.E. 147 (1906), wrongly injects subjectivity into an objective standard of care, is argumenta[497]*497tive and misleading, and should no longer be used to instruct the jury concerning the relevant standard of care in a medical malpractice action. Accordingly, we hereby overrule Dye v. Corbin, 59 W.Va. 266, 53 S.E. 147 (1906), and its progeny, insofar as those eases approve the giving of a “mistake of judgment” instruction.
However, we found in Pleasants that the giving of the instruction was harmless error.16
Again, the primary issue in this case concerned the judgment of Drs. Oley and Raman in choosing to treat Mrs. Yates’ blocked artery with interventional radiology rather than immediate surgery to remove the blockage.17 Accordingly, an instruction which indicates that a mistake in judgment is not negligent as long as it is “reasonable and honest” more likely than not influenced the jury’s decision. Said another way, there is a reasonable probability that the jury’s verdict was influenced by the erroneous instruction. Also, any effect that the giving of the instruction had on the jury was compounded by the closing argument of appellee’s counsel in which he made several references to it.18 Finally, many of the courts which have disapproved of the mistake of judgment instruction consequently have reversed the judgment below.19 Therefore, we conclude that the circuit court’s giving of the mistake of [498]*498judgment jury instruction constitutes reversible error.20
III.
CONCLUSION
In sum, because we find that the circuit court’s giving of the multiple methods of treatment and mistake of judgment jury instructions prejudiced the appellants, we reverse and remand for proceedings consistent with this opinion.
Reversed and remanded.