United States v. Wang

981 F.3d 39
CourtCourt of Appeals for the First Circuit
DecidedNovember 20, 2020
Docket18-2232P
StatusPublished
Cited by6 cases

This text of 981 F.3d 39 (United States v. Wang) is published on Counsel Stack Legal Research, covering Court of Appeals for the First Circuit primary law. Counsel Stack provides free access to over 12 million legal documents including statutes, case law, regulations, and constitutions.

Bluebook
United States v. Wang, 981 F.3d 39 (1st Cir. 2020).

Opinion

United States Court of Appeals For the First Circuit

Nos.18-2232,18-2233,19-1910,19-1911

United States,

Appellee,

v.

SCHULTZ CHAN, a/k/a JASON CHAN; SONGJIANG WANG,

Defendants, Appellants.

APPEALS FROM THE UNITED STATES DISTRICT COURT FOR THE DISTRICT OF MASSACHUSETTS

[Hon. Indira Talwani, U.S. District Judge]

Before

Thompson, Barron, Circuit Judges.*

Peter Charles Horstmann, with whom Elliot Weinstein was on brief, for appellants. Carol Head, Assistant United States Attorney, with whom Andrew E. Lelling, United States Attorney, Jordi DeLlano, Assistant United States Attorney, and Kriss Basil, Assistant United States Attorney, were on brief, for appellee.

* Judge Torruella heard oral argument in this matter and participated in the semble, but he did not participate in the issuance of the panel's opinion in this case. The remaining two panelists therefore issued the opinion pursuant to 28 U.S.C. § 46(d). November 20, 2020

- 2 - THOMPSON, Circuit Judge. Two biostatisticians employed

by two publicly traded biopharmaceutical companies were convicted

of securities fraud and conspiracy to commit securities fraud after

they bought and sold shares in each other's employing companies.

When processing their stock transactions, both were in possession

of confidential raw data from clinical trials of drug treatments

from the other's company. On appeal, they make several claims of

trial and sentencing error, including challenges to: (1) the

denial of their motions for judgments of acquittal on each count

of conviction, (2) the denial of a motion to compel production of

a letter, (3) the calculation method for the adjusted base offense

level for one of the defendants, and (4) the restitution order.

For the reasons discussed below, we affirm across the board.

BACKGROUND

When, as here, defendants challenge the sufficiency of

the evidence to support their convictions, we provide our summary

of the facts in the light most favorable to the jury's verdict.

United States v. Charriez-Rolón, 923 F.3d 45, 47 (1st Cir. 2019).

We use this section to paint the big picture of what happened in

this case; we'll save some of the nitty-gritty detail for the

discussion section below, as needed, to complete the picture as we

tackle each issue on appeal.

- 3 - Akebia & Defendant Chan

Akebia Therapeutics, Inc. (Akebia) is a publicly traded

biopharmaceutical company focused on the development of treatments

for kidney disease. Schultz Chan, one of the defendants, is a

biostatistician who has spent his career working on clinical trials

in biotech companies. In the summer of 2015, Akebia hired Chan to

be its first in-house statistician; his role as Akebia's Director

of Biostatistics started on August 17, 2015. This was an important

time for the company; it was in the midst of closing out an

important clinical trial of a treatment for dialysis patients with

chronic kidney disease (known as the "11 study"). The results of

the "11 study" would not only affect the target patient population

but also those who had invested in Akebia by holding shares of its

publicly traded stock.1

Three days before Chan started working at Akebia, one of

its in-house attorneys sent an email to all Akebia's employees

imposing a blackout period on them, effective immediately. A

1 According to Akebia's Chief Medical Officer, there are three phases of clinical trials involving humans when a new treatment is developed. A phase 1 trial typically involves healthy volunteers to determine the general safety of the treatment. A phase 2 trial involves one- to two-hundred patients who are sick with the illness the new medicine is designed to treat. When a phase 2 trial achieves good results, then phase 3 is designed with oversight from the Food and Drug Administration to test the treatment with hundreds or thousands of patients with the target illness. The "11 study" was a phase 2 trial of a treatment which came to be known as Vadadustat.

- 4 - "blackout period" is when a company prohibits its employees -- or

a group of its employees -- from buying or selling its stock

because those employees may be, or are, in possession of important

information that has not yet been released to the public. This

information is referred to as "material, non-public information"

(MNPI) to those in the industry. Blackout periods are often

imposed around the quarterly release of financial information or

the release of clinical trial data because it prevents insiders

from using company information which could impact stock pricing.

Chan was part of the team responsible for analyzing the

data from the clinical trial and delivering some key results to

Akebia's executives, such as whether the treatment has been working

and whether there are any red flags about the safety of the

treatment. Data from the completed "11 study" was ready for

analysis in the first days of Chan's employment. Akebia's

executives needed the analyzed results from the "11 study" as soon

as possible so they could decide how and when to release the

results to the public and, most importantly, to Akebia's existing

and potential investors.

On August 19, 2015, Chan and others on his team received

good news; the preliminary data from the "11 study" showed almost

zero "sudden adverse effects" from the treatment tested such as

- 5 - deaths, strokes, deep vein thrombosis, or heart attacks.2 This

was important news because a report released the month before had

highlighted the results from a study of the same treatment tested

on non-dialysis patients with chronic kidney disease (the phase 2

"7 study") in which three patients who had received the treatment

died. That report had posited that these "safety issues" had the

effect of "weigh[ing] down" Akebia's stock price. Akebia announced

the full results from the "11 study" to the general public on

September 8, 2015.

Merrimack & Defendant Wang

Merrimack Pharmaceuticals, Inc. (Merrimack) is a

publicly traded biopharmaceutical company dedicated to the

development of diagnostics and treatments for cancer. In 2013 and

2014, Merrimack tested a treatment it had developed to prolong the

survival of those with metastatic pancreatic cancer who were also

undergoing chemotherapy. The development of this treatment (known

as MM-398) had progressed to a phase 3 trial (see supra note 1),

referred to as the NAPOLI-1 study. The NAPOLI-1 study's design

included specific benchmarks; for instance, they needed

approximately 405 patients to enroll in the trial and the study's

data would close out upon the 305th patient death. Merrimack used

press releases to communicate information about these benchmarks.

2 One patient had suffered a heart attack.

- 6 - For example, a press release issued on August 28, 2013, announced

Merrimack had reached its patient enrollment goal of 405 patients

in the NAPOLI-1 study. Merrimack also announced the results from

the completed NAPOLI-1 study through a press release issued on May

1, 2014, after the 305th patient had passed away in February and

the team had analyzed the results.

Merrimack initially thought the 305th patient death

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981 F.3d 39, Counsel Stack Legal Research, https://law.counselstack.com/opinion/united-states-v-wang-ca1-2020.