State Teachers Retirement System of Ohio v. Charles River Laboratories International, Inc.

CourtCourt of Appeals for the First Circuit
DecidedAugust 15, 2025
Docket24-1705
StatusPublished

This text of State Teachers Retirement System of Ohio v. Charles River Laboratories International, Inc. (State Teachers Retirement System of Ohio v. Charles River Laboratories International, Inc.) is published on Counsel Stack Legal Research, covering Court of Appeals for the First Circuit primary law. Counsel Stack provides free access to over 12 million legal documents including statutes, case law, regulations, and constitutions.

Bluebook
State Teachers Retirement System of Ohio v. Charles River Laboratories International, Inc., (1st Cir. 2025).

Opinion

United States Court of Appeals For the First Circuit

No. 24-1705

STATE TEACHERS RETIREMENT SYSTEM OF OHIO, individually and on behalf of all others similarly situated,

Plaintiff, Appellant,

SHARAN COLEMAN, individually and on behalf of all others similarly situated,

Plaintiff,

v.

CHARLES RIVER LABORATORIES INTERNATIONAL, INC.; JAMES C. FOSTER; DAVID R. SMITH,

Defendants, Appellees,

FLAVIA PEASE,

Defendant.

APPEAL FROM THE UNITED STATES DISTRICT COURT FOR THE DISTRICT OF MASSACHUSETTS

[Hon. Denise J. Casper, U.S. District Judge]

Before

Montecalvo, Lynch, and Kayatta, Circuit Judges.

Matthew W.H. Wessler, with whom Thomas Scott-Railton, Gabriel E. Chess, Alisa C. Philo, Gupta Wessler LLP, Frederic S. Fox, Donald R. Hall, Jeffrey P. Campisi, Pamela A. Mayer, Brandon Fox, Carihanna Morrison, Kaplan Fox & Kilsheimer LLP, Edward F. Haber, Patrick J. Vallely, and Shapiro Haber & Urmy LLP were on brief, for appellant. Charles S. Duggan, with whom David B. Toscano, Luca Marzorati, Oliver Kaufman, Davis Polk & Wardwell LLP, Mara Theophila, and McDermott Will & Emery LLP were on brief, for appellees.

August 15, 2025 KAYATTA, Circuit Judge. Lead plaintiff State Teachers

Retirement System of Ohio ("State Teachers") and other investors

of defendant Charles River Laboratories International, Inc.

("Charles River") brought this securities-fraud class action

alleging that Charles River and two of its officers misled

investors as to the integrity of the overseas supply chain

undergirding its supply of long-tailed macaques -- a central part

of the company's business. Charles River moved to dismiss the

complaint for failure to state a claim. The district court agreed

that State Teachers had failed to allege false or misleading

statements as well as scienter; thus, without reaching any further

issues, the district court dismissed the action. State Teachers

timely appealed.

For the following reasons, we agree with State Teachers

that it plausibly alleged that Charles River knowingly or

recklessly misled investors as to problems lurking in its supply

chain. We therefore reverse the district court's dismissal of the

complaint as to one set of misleading statements. And we remand

for the district court to consider in the first instance whether

State Teachers plausibly alleged that any of its losses were caused

by Charles River's misdirection.

- 3 - I.

A.

"As this case comes to us on a motion to dismiss, we

accept the factual allegations set forth in the amended complaint,"

Constr. Indus. & Laborers Joint Pension Tr. v. Carbonite, Inc., 22

F.4th 1, 4 (1st Cir. 2021), and "disregard any conclusory

allegations," Ponsa-Rabell v. Santander Sec. LLC, 35 F.4th 26, 30

n.2 (1st Cir. 2022). We also consider "documents incorporated

into the complaint by reference." Tellabs, Inc. v. Makor Issues

& Rts., Ltd., 551 U.S. 308, 322 (2007).

Charles River is a global drug-development company that

is "the largest provider of outsourced drug discovery, non-

clinical development, and regulated safety testing services

worldwide." The company derives over 80% of its revenue from two

business segments: providing animals for drug-development research

and safety testing, and conducting that research itself. Per U.S.

Food and Drug Administration (FDA) regulations, biologic drug

development typically requires safety testing on live monkeys

("non-human primates," as they are known in the industry). Charles

River is "the largest commercial user of [non-human primates] in

the [United States]."

One of the most commonly used monkeys for these purposes

is the long-tailed macaque, the international trade of which was

valued at nearly $1.26 billion between 2010 and 2019. Before

- 4 - spring 2020, Charles River relied on Chinese exports for over 60%

of its long-tailed macaque supply. But when the COVID-19 pandemic

hit, China halted exports of many species of wildlife, and its

"exports of long-tailed macaques to the U.S. declined to zero."

At the same time, also as a result of the pandemic, demand for

Charles River's safety-testing services increased. To maintain

its profitability, therefore, Charles River needed to overhaul its

supply chain.

Toward that end, Charles River rapidly increased exports

from Cambodia. Charles River obtained at least 2,262 long-tailed

macaques from Envigo Global Services, Inc. ("Envigo") and Orient

BioResource Center, Inc. ("Orient BioResource"), which were

acquired by Inotiv, Inc. ("Inotiv"), a publicly traded U.S.

company, on November 5, 2021, and January 27, 2022, respectively.

Envigo and Orient BioResource "obtained approximately 60% of

[their] Cambodia[n] long-tailed macaques from the Vanny Group," a

Hong Kong-based network led by CEO James Lau which bred macaques

in Cambodia and Vietnam for export. Inotiv's "principal supplier"

of long-tailed macaques was the Vanny Group.

Charles River also directly obtained at least 512

macaques from a Vietnam-based company that was also part of the

Vanny Group, Nafovanny, a joint venture between another Vanny Group

- 5 - subsidiary and the government of Vietnam;1 over 1,000 live macaques

or macaque-based extracts from another Vanny Group subsidiary, KHI

Bioservices Ltd. ("KHI"); at least 956 long-tailed macaques in

2022 from Florida-based broker WorldWide Primates, Inc. ("WW

Primates"); and over 10,000 macaques between 2020 and 2022 from

K.F. (Cambodia) Ltd. ("KF Cambodia"), a Cambodian company that

managed a macaque breeding farm.

Between May 7, 2020 and November 2, 2022, Charles River

repeatedly disclosed in filings with the U.S. Securities and

Exchange Commission (SEC) that "limited global supply or regional

restrictions on transportation for certain products may require us

to source products from non-preferred vendors." Nevertheless,

Charles River's safety-testing business "boomed," with stock

prices increasing from $156.56 per share in May 2020 to a high of

$460.21 per share in September 2021.

Meanwhile, Cambodia's macaque export boom -- up to an

86% increase in exports to the United States from 2019 to

2020 -- was beginning to ring alarm bells at the U.S. Department

of Justice (DOJ) and the U.S. Fish and Wildlife Service (the

"Service"). This is because, put simply, breeding long-tailed

macaques in captivity takes time, thus raising doubts that any

short-term increase in supply was entirely of captive-bred

1 Lau, the Vanny Group CEO, founded Nafovanny.

- 6 - macaques. Their gestation period is a full six months; successful

pregnancies typically produce only one baby. And infant macaques

must stay with their mothers until they are at least two years old

before they are deemed sufficiently mature by medical researchers.

Supplementing the captive-bred population with wild-

caught macaques, however, is ill-advised: Wild populations

frequently have pathogens that make them unsuitable for medical

research. And, most importantly for federal investigators,

Cambodia outlaws the capture and export of wild macaques due to

Free access — add to your briefcase to read the full text and ask questions with AI

Related

Tellabs, Inc. v. Makor Issues & Rights, Ltd.
551 U.S. 308 (Supreme Court, 2007)
Bell Atlantic Corp. v. Twombly
550 U.S. 544 (Supreme Court, 2007)
Hill v. Gozani
638 F.3d 40 (First Circuit, 2011)
Downing v. Globe Direct LLC
682 F.3d 18 (First Circuit, 2012)
Vaughn Leroy Meyer v. JinkoSolar Holding Co.
761 F.3d 245 (Second Circuit, 2014)
In Re: Ocular Therapeutix Inc v.
955 F.3d 194 (First Circuit, 2020)
Securities & Exchange Comm'n v. Johnston
986 F.3d 63 (First Circuit, 2021)
Karth v. Keryx Biopharmaceuticals, Inc.
6 F.4th 123 (First Circuit, 2021)
Ponsa-Rabell v. Santander Securities, LLC
35 F.4th 26 (First Circuit, 2022)
Zhou v. Desktop Metal, Inc.
120 F. 4th 278 (First Circuit, 2024)

Cite This Page — Counsel Stack

Bluebook (online)
State Teachers Retirement System of Ohio v. Charles River Laboratories International, Inc., Counsel Stack Legal Research, https://law.counselstack.com/opinion/state-teachers-retirement-system-of-ohio-v-charles-river-laboratories-ca1-2025.