Seagen Inc v. Daiichi Sankyo Co Ltd

CourtDistrict Court, W.D. Washington
DecidedApril 1, 2024
Docket2:22-cv-01613
StatusUnknown

This text of Seagen Inc v. Daiichi Sankyo Co Ltd (Seagen Inc v. Daiichi Sankyo Co Ltd) is published on Counsel Stack Legal Research, covering District Court, W.D. Washington primary law. Counsel Stack provides free access to over 12 million legal documents including statutes, case law, regulations, and constitutions.

Bluebook
Seagen Inc v. Daiichi Sankyo Co Ltd, (W.D. Wash. 2024).

Opinion

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3 4 5 6 7 UNITED STATES DISTRICT COURT WESTERN DISTRICT OF WASHINGTON 8 AT SEATTLE 9 10 SEAGEN INC., CASE NO. C22-1613JLR 11 Petitioner, ORDER v. 12 DAIICHI SANKYO CO., LTD., 13 Respondent. 14 15 I. INTRODUCTION 16 Before the court are (1) Petitioner Seagen Inc.’s (“Seagen”) petition to vacate an 17 August 11, 2022 interim arbitration award and a November 17, 2023 final arbitration 18 award (together, the “Award”) (Petition (Dkt. # 78); Pet. Mem. (Dkt. ## 81 (sealed), 115 19 (redacted)); Pet. Reply (Dkt. ## 116 (sealed), 118 (redacted)); see 12/1/23 Chivvis Decl. 20 (Dkt. # 82) ¶ 2, Ex. 77 (“Award”); 12/13/23 Chivvis Decl. (Dkt. # 89) ¶ 5, Ex. 4 21 // 22 // 1 (“Interim Award”))1; and (2) Respondent Daiichi Sankyo Co., Ltd.’s (“DSC”) 2 cross-motion to confirm the Award (Resp. Mem. (Dkt. # 112); Resp. Reply (Dkt. # 120)).

3 The court has considered the parties’ submissions, the relevant portions of the record, and 4 the governing law. Being fully advised,2 the court DENIES Seagen’s petition to vacate 5 the Award and GRANTS DSC’s cross-motion to confirm the Award. 6 II. BACKGROUND 7 This case arises out of a failed partnership between Seagen, a Bothell-based 8 biotech company, and DSC, a Japanese pharmaceutical company. (See generally

9 12/13/23 Chivvis Decl. ¶ 2, Ex. 1 (Dkt. ## 89-1 (cover page), 90 (sealed)) 10 (“Collaboration Agreement”).) Seagen describes itself as a “pioneer” in antibody-drug 11 conjugates (“ADCs”) and holds several patents relating to the technology. (Pet. Mem. at 12 3; see Collaboration Agreement at 39-403 (listing Seagen patents).) According to 13 Seagen, DSC was interested in its ADC technology and initiated negotiations that

14 eventually led to the execution of a collaboration agreement on July 2, 2008. (See Pet. 15 Mem. at 4. See generally Collaboration Agreement.) That agreement granted DSC a 16 license to develop, manufacture, and sell Seagen’s proprietary ADC technology. (See 17 generally Collaboration Agreement.) The collaboration agreement, however, didn’t work 18 1 Because the final arbitration award “fully adopts and integrates by reference” the 19 interim award (except where otherwise specified), all references and citations to the “Award” in this order refer to the final arbitration award. (Award at 20.) 20 2 Neither party requests oral argument (see Petition at 1; Pet. Mem. at 1; Resp. at 1), and the court concludes that oral argument would not be helpful to its disposition of Seagen’s 21 petition or DSC’s cross-motion, see Local Rules W.D. Wash. LCR 7(b)(4).

3 Citations to the collaboration agreement reference page numbers in the CM/ECF 22 header. 1 |} out, and DSC terminated the agreement in 2015. (Award at 9.) Years later, on 2 || November 12, 2019, Seagen filed a demand for arbitration for breach of contract and 3 || quiet title claims against DSC, arguing that DSC improperly filed patent applications on 4 || Seagen’s technology and incorporated that technology into its own drug pipeline. 5 (12/13/23 Chiwvis Decl. ¥ 3, Ex. 2 (arbitration demand) at 1-2.) The case proceeded to 6 || arbitration, and on November 14, 2023, the Arbitrator issued a 67-page final arbitration 7 award in DSC’s favor. (See generally Award.) Below, the court summarizes the relevant 8 || technology, the parties’ collaboration agreement, and the Arbitrator’s conclusions and 9 || reasoning. 10 1. ADC Technology 11 ADCs are a family of therapeutic agents that can be used to treat various cancers. 12 || (See 12/13/23 Chivvis Decl. 4 7, Ex. 6 (Dkt. ## 89-6 (cover page), 91-1 (sealed)) (3/5/21 13 || Bertozzi Rpt.’’) 9§ 25-27.) They comprise a Y-shaped monoclonal antibody, a cytotoxic 14 || drug called the “payload,” and a “linker” component connecting the payload to the 15 antibody. (Ud. 23, 25-26.) The following image is a representation of an ADC: 16 17 \Z ADC 19 20 "pike Linker 21 . » Payload 22

1 (Id. ¶ 26.) The antibodies used in ADCs “preferentially target cancer cells over normal 2 cells due to the presence of antigens on the surface of the cancer cells.” (Id. ¶ 27.) This

3 provides a significant advantage over traditional chemotherapy, in which “drugs are 4 administered in an untargeted fashion,” harming both cancer cells and normal, healthy 5 cells. (Id.) The toxic payload in an ADC “gets delivered where it is needed,” meaning 6 ADCs function like “smart bombs that target cancer cells.” (Id.) 7 Various antibodies, payloads, and linkers can be used in ADCs. (See id. 8 ¶¶ 28-29.) Different antibodies seek out different cancer cells, meaning the antibody

9 used in a treatment for one type of cancer may not be effective against another. (See id. 10 Annex B at 4.) There are also several families of payload drugs, which kill cancer cells 11 in different ways. Two such examples are camptothecin and auristatin derivatives, which 12 inhibit different enzymes and proteins necessary for cells to live and reproduce. (See id. 13 Annex B at 4-5; Award at 42.) Linking the chosen antibody to the desired payload

14 presents “one of the most complex problems that researchers have faced in developing 15 ADCs” because the bond must be strong enough to remain stable in the blood stream and 16 yet permit release of the payload drug once the ADC arrives at a cancer cell. (3/5/21 17 Bertozzi Rpt. ¶ 28.) Some linkers are so strong that the entire antibody must dissolve in a 18 cancer cell before the payload is released, but other linkers quickly degrade when

19 exposed to certain environments or enzymes inside a cancer cell, providing for a more 20 efficient release. (See id. ¶¶ 29-37 (describing acid-cleavable and protease-cleavable 21 linkers).) 22 // 1 Altogether, the right antibody, payload, and linker combine to form an inspiring 2 cancer treatment.

3 2. The Collaboration Agreement 4 The parties’ July 2, 2008 collaboration agreement contemplates ownership rights 5 of “Improvements” related to the “Drug Conjugation Technology” at issue. (E.g., 6 Collaboration Agreement at 12.) Section 3.3.1 describes the parties’ rights to any such 7 improvements: 8 3.3.1 Improvements. In the event that, during the Term, [DSC] conceives, develops or reduces to practice an Improvement that relates to the Drug 9 Conjugation Technology, [DSC] shall promptly notify [Seagen] of the discovery of such Improvement. [Seagen] shall own all such Improvements 10 that relate to the Drug Conjugation Technology and, to the extent that such Improvements shall have been conceived, developed or reduced to practice 11 by [DSC], [DSC] hereby assigns all of its right, title and interest therein to [Seagen]. [Seagen’s] interest in any such Improvements that it Controls shall 12 be included in the [Seagen] Technology and made available to [DSC] via the Exclusive License provided in Article 3. [DSC] may use such Improvement 13 assigned to [Seagen] by [DSC] for any purpose within the scope of the Exclusive License granted herein solely during the Term of this Agreement. 14 (Id. at 12.) The collaboration agreement defines the terms “Improvements” and “Drug 15 Conjugation Technology” at sections 1.1.32 and 1.1.17, respectively: 16 1.1.32 “Improvements” means all patentable or non-patentable inventions, 17 discoveries or other know-how developed and Controlled by either Party after the Effective Date that utilize, incorporate, derive directly from, directly 18 relate to, are made using or are based directly on the [Seagen] Technology . . . .

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