Fluidigm Corporation, a Delaware Corporation v. Ionpath, Inc., a Delaware Corporation

CourtDistrict Court, N.D. California
DecidedJanuary 28, 2021
Docket3:19-cv-05639
StatusUnknown

This text of Fluidigm Corporation, a Delaware Corporation v. Ionpath, Inc., a Delaware Corporation (Fluidigm Corporation, a Delaware Corporation v. Ionpath, Inc., a Delaware Corporation) is published on Counsel Stack Legal Research, covering District Court, N.D. California primary law. Counsel Stack provides free access to over 12 million legal documents including statutes, case law, regulations, and constitutions.

Bluebook
Fluidigm Corporation, a Delaware Corporation v. Ionpath, Inc., a Delaware Corporation, (N.D. Cal. 2021).

Opinion

1 2 3 4 5 6 UNITED STATES DISTRICT COURT 7 NORTHERN DISTRICT OF CALIFORNIA 8

10 FLUIDIGM CORPORATION, et al., 11 Plaintiffs, No. C 19-05639 WHA

12 v.

13 IONPATH, INC., ORDER ON SUMMARY JUDGMENT 14 Defendant.

15 16 INTRODUCTION 17 Cross motions for summary judgment dispute the validity of asserted patents and their 18 infringement by certain accused products. The technology at issue, mass cytometry, involves 19 analysis of biological tissue samples via mass spectrometry. The properly construed claims 20 preclude literal infringement and patent owner has abdicated its burden under the doctrine of 21 equivalents. Defendant’s motion is GRANTED IN PART. 22 STATEMENT 23 Prior orders detail the facts here (Dkt. Nos. 46, 58, 143). In brief, plaintiff Fluidigm 24 Corporation has developed mass cytometry methods and systems for cell structure and 25 biomarker analysis, disclosed in U.S. Patent Nos. 10,180,386 and 10,436,698. These methods 26 involve labelling a sample, a cell or clump of cells, with metal tags attached to antibodies in a 27 process called “staining.” Different antibodies bind to different analytes (organic material of 1 staining and washing, to remove unbound antibodies, only antibody-metal tags bound to 2 present analytes remain. 3 Sample analysis begins with vaporization, atomization, and ionization of the samples and 4 metal tags. A mass spectrometer then measures the mass-to-charge ratio of the ions and, using 5 the different weights of different metals, identifies the various metal tags released from the 6 sample. And, because the various metal tags bound to antibodies which in-turn bound to 7 specific analytes, identifying the metal tags identifies the analytes present in the sample. Apart 8 from the patents covering this process, patent owner also sells its own line of embodying 9 products, but those are irrelevant here (Dkt. No. 161-4). 10 Defendant IONpath, Inc. competes in the same market. The complaint charges defendant 11 with intentional interference with patent owner’s contractual relations with customers, but that 12 charge does not come into play here. Our present dispute, instead, centers on patent owner’s 5 13 claims of patent infringement by defendant’s accused product, the MIBIscope. 14 The parties do not dispute how the MIBIscope functions. Similar to patent owner’s

15 methods, the MIBIscope analyzes antibody-metal-tag stained biological samples with mass 16 spectrometry. And again, as with patent owner’s methods, each antibody-metal tag attaches to 3 17 a unique analyte. So identification of a metal tag will in turn identify an analyte in the sample.

Z 18 Unlike the claimed invention, though, which operates on cells, the MIBIscope operates on 19 thinly sliced tissue samples (around four micrometers thick, much thinner than any intact cell 20 might be) mounted onto a slide. 21 For the accused analysis, a narrow beam of high-energy ions bombards the sample. The 22 beam “rasters across the sample,” that is, the beam traces row by row across the sample, just as 23 a cathode-ray tube television projects onto a screen. OCOOOOSOD > ° OOOCOO00COD 28

1 The ion beam can be trained to hit quarter-micrometer elements as it traces along the sample. 2 As the beam hits each element, it ionizes or “ablates” the metal tags within that element (and 3 not the surrounding ones) for introduction into and identification by the mass spectrometer. 4 The description of this sequence as “pixel-by-pixel” is somewhat of a misnomer, as the 5 elements on the sample are not themselves pixels on a screen. But the MIBIscope preserves 6 the location as it scans each element of a sample for mapping to a corresponding pixel in post- 7 processing, making the phrase “pixel-by-pixel,” if not entirely accurate, descriptively effective. 8 As shown in the figure below, the MIBIscope uses this data to produce a map which displays 9 the presence (or not) of desired analytes across a sample. Further software processing also 10 allows the MIBIscope to estimate the locations of cell borders within the sample (Dkt. Nos. 11 158-6 at 5—6; 161-4 at 4-5, 17-18). 2 = ; Rcd eh “"3 oes 13 “3. Se < Fae <2 : i 6 14 Primary ions ss “cena 2 15 aie \ J ok CSL LIE IE 16 xg Mee Ee Lg gig Me 2 17 aaa “ee ee a tg 5 [ | eal 2 ar [ ar Z 18 Ion Beam Raster Scan Sample Analysis Map 19 Following several iterations of the complaint and a few rounds of infringement and 20 invalidity contention amendment, we now reach our first taste of the merits in our patent 21 “showdown.” Each side has chosen the single claim it finds most promising for its cause. 22 Patent owner has chosen Claim 9 of the ’386 Patent; defendant, Claim 6 of the ’698 Patent. 23 The claims are substantially similar, and the patents share a single specification, so patent 24 owner moves for summary judgment of validity and the MIBIscope’s infringement of both, 25 and defendant moves for summary judgment of noninfringement and invalidity of both. It also 26 moves to strike patent owner’s expert report and portions of the motion which it asserts to be 27 directed toward newly, and untimely, accused versions of the MIBIscope. This order follows 28 full briefing and oral argument held telephonically due to public health and security crises.

1 ANALYSIS 2 Summary judgment is appropriate if there is no genuine dispute of material fact, those 3 facts “that might affect the outcome of the suit.” “[T]he substantive law’s identification of 4 which facts are critical and which facts are irrelevant . . . governs.” A genuine dispute contains 5 “sufficient evidence” such that a “reasonable jury could return a verdict for the nonmoving 6 party.” Anderson v. Liberty Lobby, 477 U.S. 242, 248–49 (1986). “In judging evidence at the 7 summary judgment stage, the court does not make credibility determinations or weigh 8 conflicting evidence. Rather, it draws all inferences in the light most favorable to the 9 nonmoving party.” Soremekun v. Thrifty Payless, Inc., 509 F.3d 978, 984 (9th Cir. 2007). If 10 “a proper jury question” remains, summary judgment is inappropriate. See Anderson, 477 U.S. 11 at 249. 12 Patent infringement requires that an accused product practices every limitation of a 13 properly construed claim. See Tessera, Inc. v. Int’l Trade Comm’n, 646 F.3d 1357, 1364 (Fed. 14 Cir. 2011). Our dispute focuses on the independent claims underlying the asserted dependent 15 claims. 16 ’386 Patent, Claim 9 ’698 Patent, Claim 6

17 1. A method of sequentially analyzing 1. A system for sequentially analyzing single cells by mass spectrometry, single cells in a sample by mass 18 comprising: spectrometry,

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Fluidigm Corporation, a Delaware Corporation v. Ionpath, Inc., a Delaware Corporation, Counsel Stack Legal Research, https://law.counselstack.com/opinion/fluidigm-corporation-a-delaware-corporation-v-ionpath-inc-a-delaware-cand-2021.