Fate Therapeutics, Inc. v. Shoreline Biosciences, Inc.

District Court, S.D. California·Decided October 16, 2023·No. 3:22-cv-00676·Unknown

Opinion

1 2 3 4 5 6 7 10 11 FATE THERAPEUTICS, INC.; and Case No.: 22-cv-00676-H-MSB WHITEHEAD INSTITUTE FOR 12 BIOMEDICAL RESEARCH, ORDER DENYING DEFENDANT’S 13 MOTION FOR ATTORNEY’S FEES Plaintiffs,

14 v. [Doc. No. 396.] 15 SHORELINE BIOSCIENCES, INC., 16 Defendant. 17 18 On September 14, 2023, Defendant Shoreline Biosciences, Inc. (“Shoreline”) filed 19 a motion for attorney’s fees. (Doc. No. 396.) On October 2, 2023, the Court took the 20 matter under submission. (Doc. No. 409.) On October 2, 2023, Plaintiffs Fate 21 Therapeutics, Inc. (“Fate”) and Whitehead Institute for Biomedical Research 22 (“Whitehead”) filed a response in opposition to Shoreline’s motion. (Doc. No. 413.) On 23 October 6, 2023, Shoreline filed a reply. (Doc. No. 423.) For the reasons below, the Court 24 denies Shoreline’s motion for attorney’s fees. 25 Background 26 In this action, Plaintiffs asserted claims for patent infringement under 35 U.S.C. §§ 27 271(a), (b), and (g) against Defendant Shoreline, alleging claims for infringement of U.S. 28 Patent Nos. 8,071,369 (“the ’369 Patent”), 8,932,856 (“the ’856 Patent”), 8,951,797 (“the 1 ’797 Patent”), 8,940,536 (“the ’536 Patent”), 9,169,490 (“the ’490 Patent”), 10,457,917 2 (“the ’917 Patent”), and 10,017,744 (“the ’744 Patent”) (collectively, “the asserted 3 patents”). (Doc. No. 162, Supp. FAC ¶¶ 157-414.) Specifically, Plaintiffs alleged that 4 Shoreline makes, uses, sells, offers for sale, and/or imports induced pluripotent stem cells 5 (“iPSCs”) that infringe one or more claims of the asserted patents.1, 2 (Id. ¶ 140; see, e.g., 6 id. ¶¶ 162 (“Defendants’ use of their ‘iPSC-derived cell therapy manufacturing platform’ 7 infringed at least claim 1 of the ’369 Patent.”), 212 (“iPSCs used by Defendants to make 8 at least the iPSC-derived natural kill (NK) cell platforms are made by a process that 9 comprises at least each step of claim 1 of the ’856 Patent.”).) 10 Plaintiff Whitehead is the owner via assignment of the patents-in-suit. See U.S. 11 Patent No. 8,071,369, at [73] (issued Dec. 6, 2011); U.S. Patent No. 8,932,856, at [73] 12 (issued Jan. 13, 2015); U.S. Patent No. 8,951,797, at [73] (issued Feb. 10, 2015); U.S. 13 Patent No. 8,940,536, at [73] (issued Jan. 27, 2015); U.S. Patent No. 9,169,490, at [73] 14 (issued Oct. 27, 2015); U.S. Patent No. 10,017,744, at [73] (issued Jul. 10, 2018); U.S. 15 Patent No. 10,457,917, at [73] (issued Oct. 29, 2019). Plaintiffs allege that Fate is the 16 exclusive licensee of the asserted patents. (Doc. No. 162, Supp. FAC ¶¶ 16, 19.) 17 The ’369 Patent is entitled “Compositions for reprogramming somatic cells” and 18

19 1 Induced pluripotent stem cells (“iPSCs”) “are pluripotent stem cells generated from 20 somatic cells by reprogramming.” (Doc. 162, Supp. FAC ¶ 31; see Doc. No. 184, Answer to Supp. FAC ¶ 31; see also Doc. No. 151-14, Plath Decl. ¶ 59; Doc. No. 152, Snyder Decl. 21 ¶ 43.) “Four specific genes—cMYC, OCT3/4, SOX2 and KLF4—encoding transcription 22 factors play a role in converting or reprogramming somatic cells into pluripotent stem cells.” (Doc. 162, Supp. FAC ¶ 32; see Doc. No. 184, Answer to Supp. FAC ¶ 32; Doc. 23 No. 199, Answer to Supp. FAC ¶ 32; see also Doc. No. 184, Counterclaims ¶ 43 (“iPSCs 24 are generated in culture from somatic cells through the introduction of reprogramming factors that transform a somatic cell into a pluripotent state.”); Doc. No. 152, Snyder Decl. 25 ¶¶ 41, 43.) 26 2 The asserted claims in this action are: claims 1-6, 8 and 9 of the ’369 Patent; claims 27 1-7 of the ’856 Patent; claims 1-6 and 8 of the ’797 Patent; claims 1-10 and 12-17 of the ’536 Patent; claims 1-6 and 8-10 of the ’490 Patent; claims 1-18 of the ’917 Patent; and 28 1 was issued on December 6, 2011. ’369 Patent at [45], [54]. The ’856 Patent is entitled 2 “Methods for reprogramming somatic cells” and was issued on January 13, 2015. ’856 3 Patent at [45], [54]. The ’797 Patent is entitled “Compositions for identifying 4 reprogramming factors” and was issued on February 10, 2015. ’797 Patent at [45], [54]. 5 The ’536 Patent is entitled “Methods for making somatic cells more susceptible to 6 reprogramming” and was issued on January 27, 2015. ’536 Patent at [45], [54]. The ’490 7 Patent is entitled “Methods for reprogramming somatic cells” and was issued on October 8 27, 2015. ’490 Patent at [45], [54]. The ’744 Patent is entitled “Methods for 9 reprogramming somatic cells” and was issued on Jul. 10, 2018. ’744 Patent at [45], [54]. 10 The ’917 Patent is entitled “Methods for reprogramming somatic cells” and was issued on 11 October 29, 2019. ’917 Patent at [45], [54]. 12 The asserted patents are all related and all share a common specification.3 (See Doc. 13 No. 149 at 5 & n.2; Doc. No. 151 at 2 & n.2 (the parties agreeing that the asserted patents 14 all share the same specification); see also Doc. No. 162, Supp. FAC ¶ 132.) The shared 15 specification states that the disclosed invention is directed to “methods for reprogramming 16 somatic cells to a less differentiated state.” ’369 Patent col. 2 ll. 24-25; see also id. at [57] 17 (“The invention provides methods for reprogramming somatic cells to generate multipotent 18 or pluripotent cells.”). 19 The asserted composition patents are the ’369 Patent, the ’797 Patent, and the ’490 20 Patent. Independent claim 1 of the ’369 Patent claims: 21 A composition comprising an isolated primary somatic cell that comprises an exogenously introduced nucleic acid encoding an Oct4 protein operably 22 linked to at least one regulatory sequence. 23 ’369 Patent col. 20 ll. 40-43. 24 Independent claim 1 of the ’797 Patent claims: 25 A composition comprising an isolated primary somatic cell that comprises an 26 exogenously introduced nucleic acid encoding Oct 4, wherein the

27 3 The Court will cite to the ’369 Patent’s specification as the “shared specification” of 28 1 exogenously introduced nucleic acid increases Oct4 expression in the cell. 2 ’797 Patent col. 20 ll. 40-43. 3 Independent claim 1 of the ’490 Patent claims: 4 A somatic cell comprising an exogenous nucleic acid encoding Oct4 and an amount of Oct4 expression comparable to the amount of Oct4 expression in 5 an embryonic stem cell. 6 ’490 Patent col. 20 ll. 39-41. 7 The asserted method patents are the ’856 Patent, the ’536 Patent, the ’744 Patent, 8 and the ’917 Patent. Independent claim 1 of the ’856 Patent claims: 9 A method of making a somatic cell more susceptible to reprogramming to a 10 pluripotent state comprising introducing at least one exogenous nucleic acid encoding Oct 4 operably linked to at least one regulatory sequence into the 11 cell, thereby increasing expression of Oct4 protein in the somatic cell, wherein 12 increased expression of Oct4 protein makes the cell more susceptible to reprogramming to a pluripotent state. 13 ’856 Patent col. 20 ll. 38-44. 14 Independent claim 1 of the ’536 Patent claims: 15 A method of making a primary somatic cell more susceptible to 16 reprogramming to a less differentiated state, comprising: introducing an 17 exogenous nucleic acid encoding an Oct 4 protein operably linked to at least one regulatory sequence into the somatic cell, wherein expression of the 18 exogenously introduced nucleic acid results in making the somatic cell more 19 susceptible to reprogramming to a less differentiated state. 20 ’536 Patent col. 20 ll. 37-44.

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Fate Therapeutics, Inc. v. Shoreline Biosciences, Inc., (S.D. Cal. 2023).

Fate Therapeutics, Inc. v. Shoreline Biosciences, Inc. (Fate Therapeutics, Inc. v. Shoreline Biosciences, Inc.) — published by Counsel Stack Legal Research, free access to 12M+ legal documents.

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