Xoma Royalty Corporation (f/k/a Xoma Corporation) v. Janssen Biotech, Inc. (f/k/a Centocor, Inc.)

CourtDistrict Court, E.D. Pennsylvania
DecidedDecember 30, 2025
Docket2:25-cv-04484
StatusUnknown

This text of Xoma Royalty Corporation (f/k/a Xoma Corporation) v. Janssen Biotech, Inc. (f/k/a Centocor, Inc.) (Xoma Royalty Corporation (f/k/a Xoma Corporation) v. Janssen Biotech, Inc. (f/k/a Centocor, Inc.)) is published on Counsel Stack Legal Research, covering District Court, E.D. Pennsylvania primary law. Counsel Stack provides free access to over 12 million legal documents including statutes, case law, regulations, and constitutions.

Bluebook
Xoma Royalty Corporation (f/k/a Xoma Corporation) v. Janssen Biotech, Inc. (f/k/a Centocor, Inc.), (E.D. Pa. 2025).

Opinion

IN THE UNITED STATES DISTRICT COURT FOR THE EASTERN DISTRICT OF PENNSYLVANIA XOMA ROYALTY CORPORATION CIVIL ACTION (f/k/a Xoma Corporation), NO. 25-4484 Plaintiff, v. JANSSEN BIOTECH, INC. (f/k/a Centocor, Inc.), Defendant.

OPINION Slomsky, J. December 30, 2025

TABLE OF CONTENTS

I. INTRODUCTION............................................................................................................. 1 II. BACKGROUND ............................................................................................................... 1 A. Factual Background ............................................................................................................ 1 1. Xoma and MorphoSys—the early days .......................................................................... 1 2. MorphoSys grows its business ........................................................................................ 4 3. MorphoSys partners with Janssen ................................................................................... 5 4. Discovery of Guselkumab using BCE Technology ........................................................ 7 5. Guseklkumab is approved as Tremfya® ......................................................................... 8 B. Procedural Background ....................................................................................................... 8 III. STANDARD OF REVIEW............................................................................................... 9 A. The appropriate standard of review is under Federal Rule of Civil Procedure 12(b)(6) ...... 9 IV. ANALYSIS ....................................................................................................................... 12 A. Defendant’s Motion to Dismiss the Breach of Contract Claim Will Be Denied. ............. 12 1. The Meaning of “Disposition” and “Transferred Materials” is ambiguous .................. 14 2. The Centocor Agreement is ambiguous on whether ..................................................... 17 it permits commercialization. ....................................................................................... 17 3. The Limitation of Liability Clause is ambiguous. ........................................................ 22

4. Plaintiff has plausibly alleged a Breach of Contract Claim .......................................... 25 B. Plaintiff has plausibly alleged, in the alternative, an Unjust Enrichment Claim. ............. 26 C. Plaintiff has Standing to assert Claims against Defendant. .............................................. 27

V. CONCLUSION ............................................................................................................... 28 I. INTRODUCTION At its core, this case is a story about two different interpretations of a contract. And, like many good stories, this one is rife with compelling characters and a long history that goes back more than two decades. Plaintiff Xoma Royalty Corporation (“Plaintiff”) is an antibody research and

development company. Defendant Janssen Biotech, Inc. (“Defendant”) is a biopharmaceutical company that develops and markets pharmaceuticals. At issue here is whether Defendant is in breach of a contract and owes royalties to Plaintiff in connection with the development of, and sales generated by, the pharmaceutical, Tremfya®. Before the Court is Defendant’s Motion to Dismiss the Complaint filed against it for (1) Lack of Standing, (2) Lack of Subject Matter Jurisdiction under Federal Rule of Civil Procedure 12(b)(1), and (3) Failure to State a Claim under Federal Rule of Civil Procedure 12(b)(6). For reasons discussed below, Defendant’s Motion to Dismiss the Complaint will be denied. II. BACKGROUND

A. Factual Background The following factual recitation is taken from Plaintiff’s Complaint, as well-pleaded allegations within the Complaint are taken as true at the Motion to Dismiss stage of litigation. Fowler v. UPMC Shadyside, 578 F.3d 203, 210–11 (3d Cir. 2009). 1. Xoma and MorphoSys—the early days Plaintiff Xoma is one of the oldest antibody research and development companies in the world. (Doc. No. 1, ¶ 11.) After its founding in 1981, Plaintiff’s business focused primarily on the identification and development of novel therapeutic antibodies1 and antibody fragments. (Id.)

1 Antibodies are proteins, produced by the immune system, that attach to antigens (foreign Plaintiff developed and now owns the patent rights to what is known as Bacterial Cell Expression Technology (“BCE Technology”). (Doc. No. 1, ¶ 13.) BCE Technology allows scientists to produce antibodies and antibody fragments within certain kinds of bacterial cells. (Id.) In essence, BCE Technology uses certain viral vectors2 to introduce DNA required to

produce antibodies in bacterial cells. (Id.) BCE Technology is vital to the operation of an antibody discovery system known as a phage display library.3 Since the mid-1990’s, Plaintiff established a program by which it licensed its BCE Technology to third parties as a discovery and production platform for proteins, particularly antibodies and antibody fragments. (Doc. No. 1, ¶ 14.) As part of this licensing program, in the early 2000’s, Plaintiff initiated discussions with another company, MorphoSys,4 about a possible license permitting MorphoSys to use Plaintiff’s BCE Technology patents. (Doc. No. 1, ¶ 15.)

substances) and remove them from the body. Antibodies, CLEVELAND CLINIC (May 6, 2022) https://my.clevelandclinic.org/health/body/22971-antibodies. Another word for antibody is immunoglobulin. Id.

2 Viral vectors are tools used to deliver genetic material to cells. Viral Vector, BRITANNICA (Nov. 17, 2025) https://www.britannica.com/science/viral-vector. The most common applications of viral vectors are in research and development of vaccines and gene therapy. Id. Often, cells targeted by viral vectors are manipulated to express genes that could have therapeutic effects. Id.

3 Phage display technology allows for human antibody proteins to be engineered and expressed on the surface of bacteriophage virion particles. Monoclonal Antibody, BRITANNICA (Dec. 2, 2025), https://www.britannica.com/science/monoclonal- antibody#ref1278452. One asset Plaintiff licenses to third parties is use of its phage display library. XOMA, https://xoma.com/opportunities/assets-available-for-license/ (last visited Dec. 5, 2025).

4 MorphoSys was a German-based global biopharmaceutical company that was acquired by Novartis in 2024. See Novartis to strengthen oncology pipeline with agreement to acquire MorphoSys AG for EUR 68 per share or an aggregate of EUR 2.7bn in cash, NOVARTIS (Feb. 5, 2024) https://www.novartis.com/news/media-releases/novartis-strengthen-oncology- pipeline-agreement-acquire-morphosys-ag-eur-68-share-or-aggregate-eur-27bn-cash. At that time, MorphoSys focused on discovering antibodies for development as biopharmaceutical products. (Id.) MorphoSys sought the license from Plaintiff to compete with other phage display companies and attract third parties with whom MorphoSys could collaborate to ultimately discover new antibodies. (Id.) Before seeking the license from Plaintiff,

MorphoSys was mostly a service-based company, meaning it offered access to its own antibody libraries and/or provided antibody discovery services to larger companies. (Id.) MorphoSys’s core patented technology is what is called a Human Combinatorial Antibody Library (“HuCAL”). (Id.

Free access — add to your briefcase to read the full text and ask questions with AI

Related

Bell Atlantic Corp. v. Twombly
550 U.S. 544 (Supreme Court, 2007)
Ashcroft v. Iqbal
556 U.S. 662 (Supreme Court, 2009)
Santiago v. Warminster Township
629 F.3d 121 (Third Circuit, 2010)
Transcore v. Electronic Transaction Consultants Corp.
563 F.3d 1271 (Federal Circuit, 2009)
Karen Malleus v. John George
641 F.3d 560 (Third Circuit, 2011)
Mellon Bank, N.A. v. Aetna Business Credit, Inc.
619 F.2d 1001 (Third Circuit, 1980)
Phillips v. County of Allegheny
515 F.3d 224 (Third Circuit, 2008)
Fowler v. UPMC SHADYSIDE
578 F.3d 203 (Third Circuit, 2009)
Krizovensky v. Krizovensky
624 A.2d 638 (Superior Court of Pennsylvania, 1993)
Wulf v. Bank of America, N.A.
798 F. Supp. 2d 586 (E.D. Pennsylvania, 2011)
United States v. International Brotherhood of Teamsters
961 F. Supp. 665 (S.D. New York, 1997)
Omicron Systems, Inc. v. Weiner
860 A.2d 554 (Superior Court of Pennsylvania, 2004)
Dale Kaymark v. Bank of America NA
783 F.3d 168 (Third Circuit, 2015)
Hullett v. Towers, Perrin, Forster & Crosby, Inc.
38 F.3d 107 (Third Circuit, 1994)
Hartig Drug Co Inc v. Senju Pharmaceutical Co Ltd
836 F.3d 261 (Third Circuit, 2016)
Michelle Tatis v. Allied Interstate LLC
882 F.3d 422 (Third Circuit, 2018)
Alejandro Lupian v. Joseph Cory Holdings LLC
905 F.3d 127 (Third Circuit, 2018)
SM Kids, LLC v. Google LLC
963 F.3d 206 (Second Circuit, 2020)

Cite This Page — Counsel Stack

Bluebook (online)
Xoma Royalty Corporation (f/k/a Xoma Corporation) v. Janssen Biotech, Inc. (f/k/a Centocor, Inc.), Counsel Stack Legal Research, https://law.counselstack.com/opinion/xoma-royalty-corporation-fka-xoma-corporation-v-janssen-biotech-inc-paed-2025.