Brewer v. Impact Biomedicines CA4/1

CourtCalifornia Court of Appeal
DecidedJuly 21, 2025
DocketD082594
StatusUnpublished

This text of Brewer v. Impact Biomedicines CA4/1 (Brewer v. Impact Biomedicines CA4/1) is published on Counsel Stack Legal Research, covering California Court of Appeal primary law. Counsel Stack provides free access to over 12 million legal documents including statutes, case law, regulations, and constitutions.

Bluebook
Brewer v. Impact Biomedicines CA4/1, (Cal. Ct. App. 2025).

Opinion

Filed 7/21/25 Brewer v. Impact Biomedicines CA4/1

NOT TO BE PUBLISHED IN OFFICIAL REPORTS

California Rules of Court, rule 8.1115(a), prohibits courts and parties from citing or relying on opinions not certified for publication or ordered published, except as specified by rule 8.1115(b). This opinion has not been certified for publication or ordered published for purposes of rule 8.1115.

COURT OF APPEAL, FOURTH APPELLATE DISTRICT

DIVISION ONE

STATE OF CALIFORNIA

JAMES BREWER, D082594

Plaintiff and Appellant,

v. (Super. Ct. No. 37-2019- 00067876-CU-CO-CTL) IMPACT BIOMEDICINES et al.,

Defendants and Appellants.

APPEAL and cross-appeal from a judgment of the Superior Court of San Diego County, Richard S. Whitney, Judge. Affirmed in part, reversed in part. One, Peter R. Afrasiabi; Ellis George Cipollone O’Brien Annaguey, Ellis George, Christopher W. Arledge and Courtney L. Mitchell for Plaintiff and Appellant. Latham & Watkins, Melissa Arbus Sherry, Colleen C. Smith, John T. Ryan, Andrew R. Gray and Christine C. Smith for Defendants and Appellants.

1 Dr. James Brewer, M.D., Ph.D. (Brewer), an expert in neurology, sued defendants Impact Biomedicines (Impact) and John Hood, Ph.D. (Hood) (together Defendants) for using his preliminary consulting work in submissions to the federal Food and Drug Administration (FDA) without his knowledge or consent. After a trial, the jury returned a special verdict in favor of Brewer on his causes of action for fraudulent concealment and quantum meruit. The jury awarded Brewer $1 million in compensatory damages against Defendants and $4 million in punitive damages against Hood on the fraudulent concealment cause of action and $20,000 in damages against Defendants on the quantum meruit cause of action. After the trial court entered a judgment on the jury’s verdict, Defendants filed motions for judgment notwithstanding the verdict (JNOV) and new trial, arguing, among other things, that there was insufficient evidence to support the jury’s findings of liability and the amounts of damages it awarded. The trial court denied the motion for new trial and granted in part the JNOV motion, reducing the award of compensatory damages for fraudulent concealment to $100,000 and the award of punitive damages to $100,000. The court then entered a revised judgment reflecting those reduced amounts of damages. Brewer filed an appeal challenging that judgment and Defendants filed a cross-appeal. On appeal, Brewer contends that the trial court erred: (1) by granting in part Defendants’ JNOV motion and reducing the jury’s awards of compensatory and punitive damages; (2) by instructing the jury on quantum meruit damages; and (3) by excluding certain evidence he offered in support of his quantum meruit cause of action. He also protectively argues that the trial court properly exercised its discretion in denying Defendants’ motion for new trial.

2 In their cross-appeal, Defendants contend that: (1) the trial court erred by not granting in full their JNOV motion because there is insufficient evidence to support the jury’s finding of liability on Brewer’s fraudulent concealment cause of action; (2) the trial court erred by not alternatively granting their motion for new trial based on insufficiency of the evidence to support the jury’s finding of liability and excessive damages; (3) if the jury’s award of $1 million in compensatory damages on Brewer’s fraudulent concealment cause of action is upheld, we should reduce its award of punitive damages against Hood to $1 million; and (4) if we reverse the judgment and direct that a new trial be held, we should conclude the trial court erred by admitting evidence on equity valuation in the original trial. We conclude that substantial evidence supports the jury’s findings on liability and damages, and the jury’s award of punitive damages was not constitutionally excessive under the due process clause of the Fourteenth Amendment. The trial court erred by granting partial JNOV to reduce the amount of the compensatory and punitive damages. We find no legal basis to disturb the trial court’s order denying a new trial on liability and damages. We also hold that the court erred in instructing on quantum meruit damages, but the error was not prejudicial. Accordingly, we reverse the revised judgment and the order granting partial JNOV and reinstate the original judgment on the jury’s verdict. FACTUAL AND PROCEDURAL BACKGROUND TargeGen developed fedratinib, a drug to treat bone marrow cancer. Hood was TargeGen’s director of research. Catriona Jamieson, M.D., a UCSD doctor, was one of three persons who discovered a mutation involving the JAK2 protein that causes bone marrow cancer. Jamieson was one of TargeGen’s scientific advisors, was the senior principal investigator on its

3 multi-center phase I clinical trial, and had patients who took the drug during its clinical trials. After fedratinib successfully completed a phase I trial, TargeGen was sold to Sanofi, a large pharmaceutical company. Hood left TargeGen and started Wintherix, a new company. In 2013, the FDA placed a clinical hold on Sanofi’s clinical trials of fedratinib, citing concerns, among others, that the drug may have caused Wernicke’s encephalopathy (WE) in eight patients. WE is caused by a thiamine deficiency and, if not timely treated, can result in severe neurological damage or even death. In 2016, after Hood left Wintherix, he paid $250,000 to Sanofi and certain original TargeGen shareholders for an exclusive three-month option to purchase their rights to fedratinib for $5 million. During that three-month option period, Hood, Jamieson, and Raghu Saripalli formed Impact and found a large investor to support its purchase of Sanofi’s rights to fedratinib and bring it to market. Hood was Impact’s largest shareholder and its chief executive officer. Jamieson was a holder of about 5 percent of Impact’s shares of stock and also its chief medical officer. Although Jamieson did not contribute any money or intellectual property to Impact to receive her shares of its stock, she contributed her medical and scientific knowledge, especially regarding myeloproliferative disorders caused by a mutation of the JAK2 gene. In late May or early June 2017, Jamieson asked Brewer to look into the WE issue, which was one of the reasons for the FDA’s hold on the clinical trials of fedratinib. Brewer was the chair of UCSD’s department of neurology and a well-known expert in neurology and neuroradiology. Jamieson explained to Brewer that Impact needed his expertise on WE regarding its problems with the FDA. Brewer agreed to provide his brief feedback and

4 sent a June 9 email to Hood. The email apparently attached “a brief summary of [his] impressions” on the case files of eight patients who had suffered possible WE symptoms during the clinical trials. On June 13, Hood sent Brewer an email thanking him for agreeing to “put together a brief report” for them and offering to compensate him for his time. On June 19, after Brewer provided Hood and Jamieson with his neurology assessments of the patients’ case files, Hood sent Brewer an email thanking him for his brief report. Brewer replied: “I didn’t want to tie it [i.e., compensation for his work] with my provision of the summaries (to avoid the appearance of bias toward a particular outcome), but for future consulting, if it is needed, let me know if there is an ‘option’ for non-employee stock options. I am optimistic that your company can do well, so let me know if you need my assistance when the time comes.” Hood answered: “Definitely Jim. There will be a scientific advisory role that will come up for which that will be appropriate.” On June 20, Brewer replied: “Excellent. Thanks, John.

Free access — add to your briefcase to read the full text and ask questions with AI

Related

BMW of North America, Inc. v. Gore
517 U.S. 559 (Supreme Court, 1996)
State Farm Mutual Automobile Insurance v. Campbell
538 U.S. 408 (Supreme Court, 2003)
In Re Marriage of Mix
536 P.2d 479 (California Supreme Court, 1975)
Stevens v. Parke, Davis & Co.
507 P.2d 653 (California Supreme Court, 1973)
Buttram v. Owens-Corning Fiberglas Corp.
941 P.2d 71 (California Supreme Court, 1997)
Warner Construction Corp. v. City of Los Angeles
466 P.2d 996 (California Supreme Court, 1970)
Wilson v. Sunshine Meat & Liquor Co.
669 P.2d 9 (California Supreme Court, 1983)
Mercer v. Perez
436 P.2d 315 (California Supreme Court, 1968)
Hauter v. Zogarts
534 P.2d 377 (California Supreme Court, 1975)
PLCM Group, Inc. v. Drexler
997 P.2d 511 (California Supreme Court, 2000)
Slater v. Blackwood
543 P.2d 593 (California Supreme Court, 1975)
Neal v. Farmers Insurance Exchange
582 P.2d 980 (California Supreme Court, 1978)
Adams v. Murakami
813 P.2d 1348 (California Supreme Court, 1991)
Ferrier v. Commercial Steel Corp.
298 P.2d 555 (California Court of Appeal, 1956)
Palmer v. Gregg
422 P.2d 985 (California Supreme Court, 1967)
Stout v. Turney
586 P.2d 1228 (California Supreme Court, 1978)
Watson v. Wood Dimension, Inc.
209 Cal. App. 3d 1359 (California Court of Appeal, 1989)
DuBarry International, Inc. v. Southwest Forest Industries, Inc.
231 Cal. App. 3d 552 (California Court of Appeal, 1991)
Teitel v. First Los Angeles Bank
231 Cal. App. 3d 1593 (California Court of Appeal, 1991)

Cite This Page — Counsel Stack

Bluebook (online)
Brewer v. Impact Biomedicines CA4/1, Counsel Stack Legal Research, https://law.counselstack.com/opinion/brewer-v-impact-biomedicines-ca41-calctapp-2025.