Boone v. Boehringer Ingelheim Pharmaceuticals, Inc.

• Court: Supreme Court of Connecticut
• Decided: May 4, 2020
• Docket: SC20200
• Status: Published

Opinion

*********************************************** The “officially released” date that appears near the be- ginning of each opinion is the date the opinion will be pub- lished in the Connecticut Law Journal or the date it was released as a slip opinion. The operative date for the be- ginning of all time periods for filing postopinion motions and petitions for certification is the “officially released” date appearing in the opinion.

All opinions are subject to modification and technical correction prior to official publication in the Connecticut Reports and Connecticut Appellate Reports. In the event of discrepancies between the advance release version of an opinion and the latest version appearing in the Connecticut Law Journal and subsequently in the Connecticut Reports or Connecticut Appellate Reports, the latest version is to be considered authoritative.

The syllabus and procedural history accompanying the opinion as it appears in the Connecticut Law Journal and bound volumes of official reports are copyrighted by the Secretary of the State, State of Connecticut, and may not be reproduced and distributed without the express written permission of the Commission on Official Legal Publica- tions, Judicial Branch, State of Connecticut. *********************************************** GERALYNN BOONE, EXECUTRIX (ESTATE OF MARY BOONE) v. BOEHRINGER INGELHEIM PHARMACEUTICALS, INC., ET AL. (SC 20200) Robinson, C. J., and Palmer, McDonald, D’Auria, Mullins, Kahn and Vertefeuille, Js.

Syllabus

The plaintiff, the executrix of the estate of the decedent, M, sought to recover damages from the defendants, alleging that a certain brand- name anticoagulant medication they had designed, manufactured or sold wrongfully caused M’s death. The defendants had received approval from the United States Food and Drug Administration to market the medication, and, for some time, M took the medication without signifi- cant side effects. Several years later, M suffered a gastrointestinal bleed and subsequently died. The plaintiff alleged that the defendants negli- gently failed to give adequate warnings, directions, and instructions to guard against the risk of bleeding caused by the medication and to investigate the benefits of establishing a therapeutic range for its admin- istration. The plaintiff also alleged that the medication was defectively designed due to the absence of a reversal agent. The trial court granted the defendants’ motion for summary judgment on the claim relating to the absence of a reversal agent, concluding, inter alia, that it was pre- empted by federal law. Thereafter, the plaintiff filed a request to charge, asking the court to instruct the jury that the defendants had improperly failed to maintain certain materials for the purpose of discovery, specifi- cally, that they had lost or destroyed files of a former employee, L, while litigating prior federal actions relating to the medication, and that the jury could draw an adverse inference from the loss or destruction of such materials. At the conclusion of the trial, the court issued a spoliation instruction. The trial court also granted in part the defendants’ motion in limine, seeking to exclude evidence, testimony, or argument regarding their failure to test reagrading a certain dose of the medication on the ground that a failure to test claim was preempted by federal law. The jury returned a verdict for the defendants, finding that, although the defendants negligently failed to give adequate warnings, directions, and instructions to guard against the risk of bleeding caused by the medica- tion, the plaintiff failed to prove that the defendants’ conduct caused M’s death. The trial court rendered judgment thereon for the defendants, from which the plaintiff appealed. Held: 1. The trial court did not abuse its discretion in excluding evidence and arguments relating to the issue of spoliation, as the doctrine of induced error precluded the plaintiff from making that claim: the plaintiff repre- sented during argument on her request to charge regarding the defen- dants’ failure to maintain L’s files that the requested instruction would obviate the need to introduce evidence relating to spoliation and that the instruction itself, together with evidence introduced at trial relating to L’s involvment in the development of the medication, would ade- quately provide the jury with the information it would need to draw an adverse inference against the defendants; accordingly, the plaintiff hav- ing had the opportunity to introduce evidence relating to L’s involvement in developing the medication, having asked the court to give the requested spoliation instruction, and the court having done so in reliance on the plaintiff’s representations, the plaintiff could not prevail on the ground that opening statements and evidence informing the jury about the defendants’ loss or destruction of L’s files was necessary to put the requested instruction in an appropriate context. 2. The trial court did not abuse its discretion in precluding the plaintiff from introducing, on rebuttal, an excerpt from the deposition of C, the defendants’ senior vice president for clinical development; the court correctly concluded that the proffered excerpt was not proper rebuttal because C was not discussing a situation in which a person’s gastrointes- tinal bleed had resolved prior to his or her death but, rather, was dis- cussing only that a gastrointestinal bleed can indirectly lead to death, and such a broad statement did not contradict the more precise testimony of the defendants’ experts that M’s death was caused by other medical conditions rather than M’s gastrointestinal bleed, which had resolved more than two weeks before M’s death. 3. The trial court properly granted the defendants’ motion for summary judgment on the plaintiff’s claim relating to the defendants’ failure to market a reversal agent for its medication, as the plaintiff’s claim was preempted by federal law: five years after the medication was approved by the Food and Drug Administration, and after M’s death, the defendants obtained approval to market a chemical reversal agent for the medica- tion, and, in order to have cured the design defect alleged by the plaintiff, the defendants would have had to bring the reversal agent to market before M’s gastrointestinal bleed, and, because there was no dispute that the reversal agent was not approved by the Food and Drug Adminis- tration until after the incident that gave rise to the plaintiff’s design defect claim, the defendants could not have satisfied their alleged state law duty to M without marketing an unapproved drug in violation of federal law; moreover, the plaintiff’s assertion that it was technologically feasible to develop the reversal agent before M’s death was insufficient to preclude preemption, as that fact was inapposite to the issue of whether marketing the reversal agent prior to M’s gastrointestinal bleed would have required the Food and Drug Adminitration’s special permis- sion and assistance, and the possibility that that agency would have looked favorably on an earlier application for approval of the reversal agent did not alter the fact that, at the time of M’s death, the defendants were precluded from marketing the reversal agent under federal law. 4. The trial court did not commit reversible error when it issued a curative instruction to the jury after closing arguments that it could not hold the defendants liable for failing to conduct tests regarding a particular dose of the medication that were described in a particular exhibit; contrary to the plaintiff’s claim, the defendants did not open the door to the plaintiff’s use of that exhibit during closing argument, the trial court’s instruction merely precluded the jury from considering a single exhibit to support a particular claim that the court had determined was pre- empted by federal law, and the plaintiff was not unfairly prejudiced, as the trial court’s curative instruction was brief, contained no explicit reprimand, and was conveyed to the jury with reasonably measured language. Argued December 19, 2019—officially released May 4, 2020*

Procedural History

Action to recover damages for personal injuries sus- tained as a result of an allegedly defective product designed, manufactured or sold by the defendants, and for other relief, brought to the Superior Court in the judicial district of Hartford, Complex Litigation Docket, where the court, Moll, J., granted in part the defendants’ motions for summary judgment and rendered judgment thereon; thereafter, the case was tried to the jury; ver- dict and judgment for the defendants, from which the plaintiff appealed. Affirmed. Brenden P. Leydon, with whom were Neal L. Moskow and Kelly A. Koehler, pro hac vice, and, on the brief, Richard I. Nemeroff, pro hac vice, for the appellant (plaintiff). Paul W. Schmidt, pro hac vice, with whom were Patrick M. Fahey, Gregory Halperin and Michael X. Imbroscio, pro hac vice, and, on the brief, Phyllis A. Jones, pro hac vice, for the appellees (defendants). Opinion

KAHN, J. The plaintiff, Geralynn Boone, the executrix of the estate of Mary Boone (decedent), brought the present action against the defendants, Boehringer Ingel- heim Pharmaceuticals, Inc., and Boehringer Ingelheim International, GmbH, alleging, inter alia, that an oral anticoagulant medication, Pradaxa, wrongfully caused the decedent’s death. A jury returned a verdict in favor of the defendants, from which the plaintiff now appeals.1 The plaintiff claims that the trial court improp- erly (1) precluded evidence and arguments related to spoliation, (2) prevented the plaintiff from using an excerpt from a particular deposition on rebuttal, (3) granted the defendants’ motion for summary judgment on a design defect claim relating to the absence of a reversal agent, and (4) issued a curative instruction to the jury after closing arguments. We disagree with each of these claims and, accordingly, affirm the judgment of the trial court. The following facts and procedural history are rele- vant to the present appeal. After experiencing intermit- tent heart palpitations in 2003, the decedent was diag- nosed with nonvalvular atrial fibrillation. That condi- tion may cause the formation of blood clots and, as a result, substantially increased the decedent’s risk of suffering an ischemic stroke. In order to reduce that risk, Jeffrey Fierstein, a cardiologist, prescribed an anti- coagulant named warfarin to the decedent. The use of warfarin requires dietary restrictions, frequent blood testing, and dose titration to keep the concentration of medication present in the bloodstream within an accepted therapeutic range. Like all anticoagulants, warfarin increases the risk of uncontrolled bleeding.2 In October, 2010, the defendants received approval from the United States Food and Drug Administration (FDA) to begin selling dabigatran etexilate, an anticoag- ulant marketed under the brand name Pradaxa. Unlike warfarin, Pradaxa requires no dietary restrictions and was approved for use without blood monitoring or dose titration. In November, 2010, Fierstein met with the decedent and recommended switching from warfarin to Pradaxa. Fierstein testified at trial that the decedent had been tolerating warfarin well and that he had rec- ommended the switch ‘‘out of convenience.’’ The dece- dent agreed and, for some time, took Pradaxa without any significant side effects. On March 5, 2014, the decedent suffered a severe gastrointestinal bleed and was admitted to a hospital. The decedent underwent kidney dialysis to remove Pra- daxa from her blood and was administered multiple blood transfusions. Although the bleeding stopped three days later, the decedent’s kidneys began to fail. On March 25, 2014, the decedent died. The death certificate lists ‘‘[a]cute [k]idney [i]njury,’’ ‘‘chronic kidney [d]is- ease,’’ ‘‘[r]etroperitoneal [f]ibrosis,’’ and ‘‘occult neopla- sia’’ as causes of death.3 The death certificate also lists ‘‘[d]abigatran [i]nduced [c]oagulopathy’’ and ‘‘gastroin- testinal bleed’’ as ‘‘significant’’ conditions contributing to the decedent’s death. (Emphasis omitted.) No autopsy was performed. The plaintiff subsequently commenced the present action, alleging, inter alia, that (1) the defendants negli- gently failed to give adequate warnings, directions, and instructions to guard against the risk of bleeding caused by Pradaxa, (2) the defendants negligently failed to test, study, and investigate the benefits of establishing a therapeutic range for Pradaxa, and (3) Pradaxa was defectively designed due to the absence of a reversal agent. On January 24, 2018, the trial court granted the defendants’ motion for summary judgment on the claim relating to the absence of a reversal agent, concluding, among other things, that it was preempted by federal law.4 The plaintiff filed a pretrial motion asking the trial court to instruct the jury that the defendants had improperly failed to maintain certain relevant materials for the purpose of discovery. Specifically, the plaintiff claimed that the defendants had lost or destroyed files of one of its former employees, Dr. Thorsten Lehr, while litigating previous federal actions relating to Pradaxa. The trial court, applying the test set forth in Beers v. Bayliner Marine Corp., 236 Conn. 769, 777–79, 675 A.2d 829 (1996), concluded that a spoliation instruction was warranted and, over the defendants’ objection, provided such an instruction to the jury at the end of the trial. See footnote 6 of this opinion. The jury returned a verdict, finding that, although the defendants had negligently failed to give adequate warnings, directions, and instructions to guard against the risk of bleeding caused by Pradaxa, the plaintiff had failed to prove that the defendants’ wrongful conduct caused the decedent’s death. The trial court subse- quently rendered judgment in favor of the defendants, from which the plaintiff appealed. Additional facts and procedural history will be set forth as necessary. I The plaintiff first claims that the trial court improp- erly precluded certain evidence and arguments related to the issue of spoliation.5 Specifically, the plaintiff pos- its that the absence of such information deprived the jury of the context necessary to decide whether to draw an adverse inference against the defendants, as permit- ted by the trial court’s spoliation instruction. In response, the defendants argue that the trial court’s limitations in this regard were proper.6 For the reasons that follow, we decline to conclude that the trial court abused its discretion by precluding evidence and argu- ments relating to the issue of spoliation in the pres- ent case. The following additional facts and procedural history are relevant to our consideration of this claim. In 2012, certain federal litigation relating to Pradaxa was cen- tralized in the Southern District of Illinois pursuant to 28 U.S.C. § 1407, and a federal district court judge, David R. Herndon, was appointed to preside. In re Pradaxa (Dabigatran Etexilate) Products Liability Litigation, 883 F. Supp. 2d 1355, 1355–56 (J.P.M.L. 2012). Various discovery disputes in that consolidated federal litigation led to motions seeking sanctions against the defen- dants. See In re Pradaxa (Dabigatran Etexilate) Prod- ucts Liability Litigation, Docket No. 3:12-MD-02385 (DRH), 2013 WL 6486921, *1 (S.D. Ill. December 9, 2013). As a result of those disputes, on September 18, 2013, Judge Herndon issued a mandatory injunction requiring the defendants to conduct ‘‘an immediate search for any yet undisclosed materials . . . .’’ (Internal quota- tion marks omitted.) Id., *3–5. During a subsequent deposition, the plaintiffs in that proceeding discovered that Lehr was a potentially relevant source of additional information and, as a result, requested production of his custodial file. Id., *9. Approximately one month after that deposition, the defendants informed Judge Hern- don that Lehr had not been identified as a custodian and that, as a result, some of his documents and files had been destroyed. Id. In reviewing a subsequent motion for sanctions, Judge Herndon found that Lehr ‘‘was a prominent scien- tist . . . that played a vital role in researching Pra- daxa,’’ that the defendants were familiar with his work, and that the evidence on record in that case would ‘‘lead a reasonable person to infer a motive for the defendant[s] to abstain from placing a litigation hold on [Lehr’s] materials . . . .’’ Id., *12. On the basis of these findings, the court concluded that the defendants had failed to maintain Lehr’s files ‘‘in bad faith.’’7 Id., *18. This conduct, together with certain other discovery violations, led Judge Herndon to impose immediate sanctions on the defendants, including a substantial monetary fine and an order compelling the attendance of various corporate employees at depositions in the United States. Id., *20. In a separate ruling, Judge Hern- don also specifically put the defendants on notice that additional sanctions, including an adverse inference instruction, would be considered at the close of discov- ery and would ‘‘apply to any actions pending before [that] court at [that] time . . . .’’ In re Pradaxa (Dabi- gatran Etexilate) Products Liability Litigation, United States District Court, Docket No. 3:12-MD-02385 (DRH), MDL No. 2385, CMO 50-1 (S.D. Ill. December 18, 2013), available at https://www.ilsd.uscourts.gov/ Documents/mdl2385/cmo50-1.pdf (last visited May 1, 2020). The defendants challenged Judge Herndon’s order by filing a petition for a writ of mandamus in the United States Court of Appeals for the Seventh Circuit. In re Petition of Boehringer Ingelheim Pharmaceuti- cals, Inc., 745 F.3d 216–17 (7th Cir. 2014). In that pro- ceeding, the Seventh Circuit concluded that the order compelling the deposition of corporate employees in the United States was improper. Id., 219–20. In reaching this conclusion, the Seventh Circuit expressly declined to revisit the factual findings underlying the District Court’s finding of bad faith and its imposition of other sanctions. Id., 218. Following Judge Herndon’s decision, the consolidated federal litigation settled. See In re Pradaxa (Dabigatran Etexilate) Products Liability Litigation, United States District Court, Docket No. 3:12-MD-02385 (DRH) (S.D. Ill. May 1, 2015), available at https://www.ilsd.uscourts.gov/documents/mdl2385/ MinuteOrder656.pdf (last visited May 1, 2020). Notwithstanding the resolution of the consolidated federal litigation, several cases related to Pradaxa remained pending in this state. Those cases were placed onto a single, consolidated docket governed by a series of case management orders. See In re Connecticut Pra- daxa Litigation, judicial district of Hartford, Complex Litigation Docket, Docket No. HHD-CV-13-5036974S. The trial court in the present case noted that, under one such order dated July 23, 2015, ‘‘all discovery pro- pounded and completed in the [consolidated federal litigation was] deemed propounded and responded to for purposes of [Connecticut’s consolidated Pradaxa litigation] docket . . . .’’ That order, which the parties agreed to be bound by, required the defendants to pro- vide the plaintiff with all evidence produced during the course of the consolidated federal litigation, and provided that all discovery requests and responses in that proceeding ‘‘shall be deem[ed] served in this court for purposes of the parties’ respective rights and obliga- tions with regard thereto.’’ On January 5, 2018, the plaintiff filed a pretrial request to charge, requesting a spoliation charge relating to, among other things, the defendants’ failure to maintain Lehr’s files.8 Relying principally on Judge Herndon’s finding of bad faith, the plaintiff requested an instruc- tion indicating that the elements of spoliation had been met as a matter of law. The defendants objected, and the trial court heard oral argument on January 29, 2018. During oral argument, the plaintiff argued that the pre- sentation of evidence relating to spoliation would be ‘‘time-consuming’’ and ‘‘extraordinarily difficult’’ to put in context.9 The plaintiff indicated that such an endeavor would be an unnecessary ‘‘sideshow’’ that would waste both time and judicial resources. On sev- eral occasions, the plaintiff represented that she would not seek to introduce such evidence, if the court were to conclude, at the outset of the trial, that she was entitled to the requested instruction.10 The court then asked the plaintiff the following spe- cific question: ‘‘[I]f the court granted the requested charge and you didn’t put on any evidence of Judge Herndon’s order, et cetera, how would the jury be equipped to determine whether to draw an adverse inference? As . . . you know, it’s not mandatory.’’ In response, the plaintiff stated that the instruction itself would inform the jury of her claim that the defendants had ‘‘intentionally . . . or recklessly lost or destroyed’’ documents, including files from Lehr, that were relevant ‘‘to the issues of the benefits of assessing and adjusting Pradaxa dosing based on blood concentrations . . . .’’ The plaintiff asserted that, armed with such an instruc- tion and testimony from various witnesses discussing Lehr, the jury ‘‘would be able to put [the spoliation issue] in context.’’11 On February 18, 2018, in a comprehensive, written decision,12 the trial court granted the plaintiff’s request for a spoliation charge, finding that, in light of the pro- ceedings before Judge Herndon, the plaintiff had satis- fied the elements of spoliation set forth in Beers as a matter of law and was entitled to a jury instruction to that effect.13 In so doing, the court noted: ‘‘The parties agreed to be bound by, and not duplicate, the discovery process that had occurred in the [consolidated federal litigation]. It necessarily follows that an offending party who failed to identify a custodian of potentially relevant evidence and who failed to preserve such evidence in the underlying proceeding should also be bound by any judicial findings by the underlying court relating to such discovery failures. The contention that Judge Herndon’s discovery related findings should be ignored altogether smacks of unfairness under the very unusual circum- stances of the discovery process in [Connecticut’s con- solidated Pradaxa litigation] docket.’’ The court then concluded that the ‘‘relitigation of the spoliation issues relating to . . . Lehr . . . would . . . offend princi- ples of judicial economy, would create a trial within a trial, would risk one or more trial counsel being called as witnesses, and would create possible, if not inevita- ble, confusion with the jury, who would be presented with testimony and other evidence (e.g., court orders, among other things) relating to the [consolidated fed- eral litigation].’’ See footnote 6 of this opinion. The following day, the trial court granted a motion in limine filed by the defendants seeking to exclude ‘‘ ‘evidence, testimony, or argument regarding alleged spoliation issues’ ’’ relating to Lehr.14 The trial court based its decision on the plaintiff’s previous representa- tions that such issues would not need to be presented to the jury if the court granted, as it did, her request for a spoliation charge. On February 23, 2018, the plaintiff filed a motion asking the court to issue the instruction on spoliation at the commencement of trial. In that motion, the plain- tiff also sought permission to ‘‘inform the jury during opening, at trial, and during closing argument of [the defendants’] unlawful destruction of critically impor- tant evidence . . . .’’ On that same day, the defendants objected, and the trial court heard oral argument. The court ruled that references to spoliation during opening statements risked unfair prejudice to the defendants and, accordingly, exercised its discretion to proscribe such references. See Practice Book § 15-6. The trial court also made clear that, although the plaintiff was free to discuss Lehr’s importance to the case generally, information relating to the ‘‘destruction’’ of documents could not be communicated to the jury during the evi- dentiary portion of the trial in the absence of a witness with personal knowledge of that event.15 The trial court noted that the sanction the plaintiff had procured was powerful. The court was particularly concerned about the use by the plaintiff’s counsel of the terms ‘‘sanction’’ or ‘‘bad faith’’ because, ‘‘although [it] found as a matter of law that Judge Herndon’s findings satisfies Beers, he made findings that go beyond Beers and so he made a bad faith finding that is not necessary under Beers.’’ (Internal quotation marks omitted.) Finally, the trial court expressly reserved decision on whether argu- ments relating to spoliation would be permitted in clos- ing, noting that it had not yet determined whether it would give the adverse inference instruction when evi- dence relating to Lehr was admitted during trial, or after closing arguments. Lehr’s involvement in the development of Pradaxa featured prominently at trial. In his opening statement, the plaintiff’s counsel told the jury that the defendants had an interest in suppressing scientific information showing a ‘‘therapeutic range’’ for Pradaxa because fre- quent blood testing would place that product at a com- petitive disadvantage. The plaintiff’s counsel noted, in particular, that the defendants had pressured one of their own scientists, Paul Reilly, to remove such infor- mation from a manuscript relating to dabigatran etexi- late exposure. The plaintiff’s counsel indicated that cer- tain corporate documents had identified Lehr as the ‘‘father’’ of that same manuscript and that Reilly had simply continued Lehr’s work.16 The plaintiff’s counsel then urged the jury to ‘‘pay close attention to the paper and how it developed.’’17 One of the plaintiff’s expert witnesses, a pharmacolo- gist named Laura Plunkett, opined during her testimony that blood monitoring should have been required for Pradaxa because, like warfarin, Pradaxa has a particu- lar therapeutic range that balances the various risks posed by clots and bleeds. She based her opinion, in part, on information contained in Reilly’s exposure response paper. Plunkett then testified that she had reviewed various communications about the exposure response paper and that, in her opinion, important sci- entific information demonstrating a specific therapeutic range had been suppressed by the defendants in order to avoid the need for blood monitoring.18 Finally, Plunkett testified, over the defendants’ objection, that she had looked for the first draft of the exposure response paper and had been unable to find that document.19 Our review of the record indicates that, over the course of the nearly three weeks of trial that followed, there was only one particular instance in which the plaintiff proffered, and the trial court excluded, testi- mony directly relating to the destruction of Lehr’s files. On that occasion, the plaintiff sought to introduce an excerpt from a deposition of Andreas Barner, the defen- dants’ chairman of corporate management, relating gen- erally to his awareness of the defendants’ failure to preserve Lehr’s computer. The plaintiff argued that this excerpt would provide ‘‘bread crumbs’’ to assist the jury in determining whether to draw an adverse inference against the defendants. The trial court, however, pre- cluded admission of that excerpt, concluding that the information fell ‘‘squarely within’’ its previous rulings related to spoliation and the adverse inference instruc-tion. On the final day of the plaintiff’s case-in-chief, the defendants filed a motion seeking reconsideration of the court’s previous decision to charge the jury on the issue of spoliation. In that motion, the defendants argued, inter alia, that the plaintiff’s factual basis for requesting a spoliation charge had been undercut at trial. See footnote 19 of this opinion. The plaintiff objected, arguing that the evidence presented to the jury did not undermine the requested charge. The plaintiff further claimed that, even if evidence of spoliation was lacking, precluding the charge on that ground would be improper in light of the fact that the trial court had excluded evidence of spoliation during trial. The plaintiff noted that the trial court’s ‘‘carefully tailored spoliation charge is an appropriate sanction for [the defendants’] wrongful conduct.’’ The trial court denied the defendants’ motion.20 The defendants subsequently called Reilly as a wit- ness during their case-in-chief. During that testimony, Reilly described the defendants’ efforts to evaluate blood concentration data, stating that the exposure response paper had ‘‘gone through . . . multiple itera- tions’’ and that Lehr had ‘‘initiated . . . dose titration modeling to see whether . . . he could identify a target range of dabigatran and a target dose adjustment.’’ Reilly testified that, despite their best efforts, the defen- dants had not been able to identify a particular thera- peutic range for Pradaxa and, had such a range been established, it would have been communicated to physi- cians. Reilly then indicated that the FDA and the scien- tific community had reached the same consensus. On cross-examination, the plaintiff’s counsel ques- tioned Reilly about a specific e-mail in which Andreas Clemens, the head of the department of medical affairs for dabigatran etexilate, referred to Lehr as the ‘‘father’’ of the exposure response paper. (Internal quotation marks omitted.) That correspondence, which was admitted into evidence as a full exhibit, indicates that Reilly ‘‘took [that paper] over and changed it signifi- cantly.’’ In response, Reilly testified that he was person- ally unaware of any drafts of the exposure response paper prior to his own and that Clemens had been ‘‘sadly misinformed.’’ See also footnotes 15 and 19 of this opinion. Following the close of evidence, the plaintiff again requested permission to inform the jury during closing argument of the defendants’ spoliation and the impact it had on the present case. Without such information, the plaintiff argued, the jury would lack the context necessary to draw the adverse inference invited by the court’s instruction. The plaintiff, however, did not prof- fer the substance of the new or additional information relating to spoliation that she wanted to use in closing argument. Rather, she again referenced Lehr’s general importance to the development of Pradaxa and his involvement with the exposure response paper. The trial court ruled that the issue of spoliation would not be ‘‘fodder for closing argument’’ but expressly noted that the parties were free to ‘‘mention what [had] already come into evidence . . . .’’ The plaintiff’s closing argument, in fact, discussed the evidence relating to Lehr at length. Specifically, the plaintiff’s counsel repeated the argument that the defendants had sought to suppress information relating to a therapeutic range for Pradaxa because blood moni- toring would put their product at a competitive disad- vantage. The plaintiff’s counsel emphasized that the authors of the exposure response paper had explored the concept of blood monitoring, that Clemens’ e-mail implied the existence of an early draft manuscript authored by Lehr, and that such a manuscript had never been discovered.21 Finally, the plaintiff’s counsel asked the jury to pay ‘‘close attention’’ to the trial court’s instructions relating to Lehr and to ‘‘be the judge’’ of whether such facts were important. The trial court ultimately issued the following instruc- tion to the jury relating to spoliation: ‘‘The plaintiff claims that certain evidence was not available to her because [the defendants] destroyed or failed to preserve it, at a time when it had a legal duty to preserve it. Specifically, [the defendants] destroyed or failed to pre- serve the desktop computer, laptop computer, Black- berry phone, and paper files of . . . Lehr, about whom there was some evidence during the trial, who was a scientist and employee of [the defendants and] who did research concerning Pradaxa until he left the company in September, 2012. The plaintiff contends such evi- dence is relevant to her claim concerning the benefits of assessing blood plasma concentrations. I instruct you that . . . Lehr’s desktop computer, laptop computer, Blackberry phone, and paper files were not preserved at a time when [the defendants were] on notice of a legal duty to preserve them and that the failure to retain such files was intentional, in the sense that it was not inadvertent. Our law allows you to draw an adverse inference that the destroyed evidence would have been unfavorable to [the defendants]. You may therefore draw an inference that the evidence that was destroyed or not preserved would be unfavorable to [the defen- dants], but you are not required to do so. Understand that this is not a claim for which you would award damages; rather, it permits an adverse inference to be drawn as you consider all the evidence relating to the plaintiff’s claims. If you choose to draw such an infer- ence, you may not use the inference to supply the place of evidence of material facts or to shift the burden of proof from the plaintiff to [the defendants] on the plaintiff’s claims, but it may turn the scale when the evidence is closely balanced. By giving you this instruc- tion, the court does not mean to place emphasis on this issue versus any other aspect of the evidence that you may consider, and the court takes no view as to whether such an inference should be drawn, as that decision is for you, the jury, to decide.’’22 Following the jury’s verdict in favor of the defen- dants, the plaintiff filed a motion to set aside the verdict, claiming, among other things, that the trial court had ‘‘improperly prevented [her] from informing the jury of [the defendants’] acts of spoliation and the court’s sanction regarding the same.’’ The plaintiff argued that the issue of spoliation was itself relevant and probative to the defendants’ reckless disregard for consumer safety. She renewed her claim that the trial court’s restrictions on opening statements, the admission of evidence, and closing arguments prevented her from providing the jury with the context necessary to decide whether to draw an adverse inference against the defen- dants. The trial court found this claim to be ‘‘wholly without merit’’ because the plaintiff, in seeking an instruction, expressly represented that evidence relat- ing to spoliation would not need to be presented at trial. Relying in part on the induced error doctrine, the trial court denied the motion, concluding that the plaintiff had found ‘‘purported error in the very approach for which she successfully advocated.’’ We begin by noting the standard of review and the general principles of law applicable to the plaintiff’s claim. ‘‘The trial court possesses inherent discretionary powers to control proceedings, exclude evidence, and prevent occurrences that might unnecessarily prejudice the right of any party to a fair trial.’’ (Internal quotation marks omitted.) Downs v. Trias, 306 Conn. 81, 102, 49 A.3d 180 (2012). We review the relevant rulings of the trial court in the present case for an abuse of that discretion. See, e.g., McBurney v. Paquin, 302 Conn. 359, 378, 28 A.3d 272 (2011) (‘‘[t]he trial court’s ruling on evidentiary matters will be overturned only upon a showing of a clear abuse of the court’s discretion’’ (internal quotation marks omitted)); Naughton v. Hager, 29 Conn. App. 181, 188, 614 A.2d 852, (‘‘[t]he trial court is vested with broad discretion over the latitude of the statements of counsel during argument’’), cert. denied, 224 Conn. 920, 618 A.2d 527 (1992).23 In applying that standard, ‘‘[w]e [must] make every reasonable pre- sumption in favor of upholding the trial court’s ruling, and only upset it for a manifest abuse of discretion. . . . [Thus, our] review of such rulings is limited to the questions of whether the trial court correctly applied the law and reasonably could have reached the conclu- sion that it did.’’ (Internal quotation marks omitted.) Filippelli v. Saint Mary’s Hospital, 319 Conn. 113, 119, 124 A.3d 501 (2015). We agree with the trial court’s assessment that the present case implicates the doctrine of induced error. ‘‘[T]he term induced error, or invited error, has been defined as [a]n error that a party cannot complain of on appeal because the party, through conduct, encour- aged or prompted the trial court to make the [allegedly] erroneous ruling. . . . It is well established that a party who induces an error cannot be heard to later complain about that error. . . . This principle bars appellate review of induced nonconstitutional error and induced constitutional error. . . . The invited error doctrine rests [on principles] of fairness, both to the trial court and to the opposing party. . . . [W]hether we call it induced error, encouraged error, waiver, or abandon- ment, the result—that the . . . claim is unreview- able—is the same.’’ (Internal quotation marks omitted.) Independent Party of CT—State Central v. Merrill, 330 Conn. 681, 724, 200 A.3d 1118 (2019); see also State v. Fay, 326 Conn. 742, 765 n.22, 167 A.3d 897 (2017) (‘‘a finding of induced error is supportable when a party’s claim on appeal will result in an inappropriate ambush of the trial court’’). With these standards in mind, we turn to the trial court’s rulings in the present case. Our review of the record leads us to conclude that the doctrine of induced error precludes the plaintiff from claiming that the trial court improperly excluded opening statements and evidence relating to spoliation. In response to the plaintiff’s pretrial request for an adverse inference instruction, the court specifically asked the plaintiff how the jury would be able decide whether to draw such an inference without any evi- dence relating to the underlying conduct. The plaintiff not only represented to the trial court that the requested instruction would obviate the need for such evidence; see footnote 10 of this opinion; but also indicated that the instruction itself, together with evidence generally relating to Lehr’s involvement in the development of Pradaxa, would adequately equip the jury with the infor- mation it would need to draw an adverse inference against the defendants. The trial court afforded the plaintiff broad latitude to introduce evidence and testimony describing the nature of Lehr’s work, his research regarding the possi- ble existence of a therapeutic range, and the scope of his involvement in the exposure response paper. The plaintiff used the testimony proffered by Plunkett and Reilly, in particular, to develop a detailed theory that Lehr had authored an early version of the exposure response paper that the defendants had never pro- duced. The trial court’s instruction clearly stated that the defendants had failed to preserve Lehr’s files despite having a legal duty to do so, and that the jury could choose to infer that the information in those files would have been adverse to the defendants. Having encour- aged the trial court to structure the proceeding in this precise manner, the plaintiff cannot now prevail on the ground that opening statements and evidence informing the jury about the defendants’ destruction of Lehr’s files was, in fact, necessary to put the requested instruction in an appropriate context. Cf. Ferri v. Powell-Ferri, 317 Conn. 223, 236–37, 116 A.3d 297 (2015) (‘‘Our rules of procedure do not allow a [party] to pursue one course of action at trial and later, on appeal, argue that a path he rejected should now be open to him. . . . To rule otherwise would permit trial by ambuscade.’’ (Internal quotation marks omitted.)). Reaching the opposite conclusion would substan- tially undercut the grounds on which the trial court concluded that the plaintiff’s requested instruction was appropriate in the first instance, including improving judicial economy, avoiding a trial within a trial, and preventing confusion of the jurors. The trial court’s decision to exclude the deposition testimony relating to Barner’s knowledge regarding the destruction of Lehr’s computer demonstrates this point. If the plaintiff had been permitted to lay a trail of ‘‘bread crumbs’’ for the jury using that testimony, the defendants would have been entitled to marshal any admissible evidence show- ing that this same trail should not be followed. Present- ing such a dispute to the jury would necessitate the very ‘‘sideshow’’ that the plaintiff had purposefully for- gone in requesting a spoliation instruction before the outset of trial.24 Our conclusion that the trial court did not abuse its discretion by declining to admit evidence that could have initially been presented at a sanctions hearing also resolves, in large measure, the plaintiff’s claims relating to the restrictions that the court imposed on closing arguments. As this court has previously noted, a trial court acts well within its broad discretion when it restricts the scope of an argument ‘‘to prevent comment on facts that are not properly in evidence . . . .’’ (Inter- nal quotation marks omitted.) Jackson v. Water Pollu- tion Control Authority, 278 Conn. 692, 713, 900 A.2d 498 (2006); cf. State v. Weatherspoon, 332 Conn. 531, 551, 212 A.3d 208 (2019) (‘‘[w]hile the privilege of coun- sel in addressing the jury should not be too closely narrowed or unduly hampered, it must never be used as a license to state, or to comment [on], or to suggest an inference from, facts not in evidence’’ (internal quo- tation marks omitted)); State v. Lopez, 280 Conn. 779, 803, 911 A.2d 1099 (2007) (‘‘Counsel may comment [on] facts properly in evidence and [on] reasonable infer- ences to be drawn from them. . . . Counsel may not, however, comment on or suggest an inference from facts not in evidence.’’ (Internal quotation marks omit- ted.)).25 Because the trial court ruled at the outset that evidence relating to the conduct underlying Judge Hern- don’s finding of bad faith would not be admitted or presented to the jury, we agree with the trial court’s assessment that such evidence was not proper ‘‘fodder’’ for arguments by counsel. We note that the plaintiff was not compelled to seek the benefit of the findings made by Judge Herndon, or to request an adverse inference instruction as a matter of law. The plaintiff could have, for example, asked the trial court to independently review the evidence relating to the destruction of Lehr’s files and, as is typically the case, argued that any evidence ultimately admitted at trial supported a corresponding instruction.26 See Pay- lan v. St. Mary’s Hospital Corp., 118 Conn. App. 258, 264, 983 A.2d 56 (2009) (discussing whether plaintiff adduced sufficient evidence at trial to warrant spolia- tion instruction under Beers). The plaintiff could have also chosen to pursue still other sanctions available for discovery misconduct under our rules of practice. See Practice Book § 13-14. The plaintiff, as a matter of strat- egy, chose a different path.27 Accordingly, we decline to conclude that the trial court abused its discretion by precluding evidence and arguments relating to spolia- tion in the present case.28 II The plaintiff next claims that the trial court improp- erly excluded certain portions of a video recorded depo- sition of Christopher Corsico, the defendants’ senior vice president for clinical development, from her case on rebuttal. The defendants respond by arguing, inter alia, that the trial court’s ruling was correct because the proffered testimony did not contradict testimony presented by their expert witnesses. We agree with the defendants. The following additional facts are relevant to our discussion of this claim. During their case-in-chief, the defendants called two expert witnesses, Stanley Schneller, a cardiologist, and Michelle Anderson, a gas- troenterologist, to testify on the issue of causation. Schneller testified that the decedent’s gastrointestinal bleed had resolved three days after she arrived at the hospital and that a ‘‘multiplicity of other coexisting medical problem[s]’’ had caused her death. Specifically, Schneller testified that ‘‘acute kidney injury, chronic kidney disease, retroperitoneal fibrosis, and occult neo- plasia’’ directly caused the decedent’s death, and that those conditions were unrelated to her use of Pradaxa or her gastrointestinal bleed. See footnote 3 of this opinion. Anderson’s testimony supported the same con- clusion. After the defendants rested, the plaintiff sought to introduce, as rebuttal, a brief segment from Corsico’s February, 2014 video recorded deposition. During that deposition, Corsico was asked: ‘‘[D]o you understand that there can be a series or a cascade of events that can ultimately lead to one’s demise that may be precipi- tated by a gastrointestinal bleed?’’ Corsico answered in the affirmative. The defendants’ counsel objected, arguing that the admission of that testimony as rebuttal would be improper because it did not conflict with testimony from either Schneller or Anderson. In response, the plaintiff’s counsel argued that Corsico’s testimony undercut Schneller and Anderson’s conclu- sion that, because the decedent’s gastrointestinal bleed had stopped, it did not cause her death. The trial court ultimately sustained the defendants’ counsel’s objection, aptly noting: ‘‘I just don’t see how . . . Corsico’s testimony . . . rebuts testimony by either . . . Schneller or . . . Anderson because . . . Corsico, in this [question and answer], was not specifi- cally asked about a [gastrointestinal] bleed that had ended; nor were [either] Schneller [or] Anderson asked [whether it is] possible that a [gastrointestinal] bleed can lead to a cascade of events that ultimately led to one’s death.’’ ‘‘It is well settled that the admission of rebuttal evi- dence lies within the sound discretion of the trial court.’’ Gomeau v. Gomeau, 242 Conn. 202, 208, 698 A.2d 818 (1997); see also Practice Book § 15-5 (3). ‘‘The issue on appeal is not whether any one of us, sitting as the trial court, would have permitted the disputed testimony to be introduced. The question is rather whether the trial court . . . abused its discretion in not allowing the rebuttal testimony . . . .’’ (Internal quotation marks omitted.) Id., 209. ‘‘[R]ebuttal evidence is that which refutes the evidence [already] presented . . . rather than that which merely bolsters one’s case.’’ (Internal quotation marks omitted.) State v. Wood, 208 Conn. 125, 139, 545 A.2d 1026, cert. denied, 488 U.S. 895, 109 S. Ct. 235, 102 L. Ed. 2d 225 (1988). ‘‘There is no require- ment that a rebuttal witness must respond to every alternate theory offered by the defendant . . . a gen- eral contradiction of the testimony given by the defen- dant is considered permissible rebuttal testimony.’’29 State v. Gray, 221 Conn. 713, 728, 607 A.2d 391, cert. denied, 506 U.S. 872, 113 S. Ct. 207, 121 L. Ed. 2d 148 (1992); see also 1 K. Broun, McCormick on Evidence (7th Ed. 2013) § 4, p. 16 (‘‘the plaintiff . . . is confined to testimony refuting the defense evidence, unless the trial judge in her discretion permits him to depart from the regular scope of rebuttal’’). We agree with the trial court’s conclusion that the proffered question and answer from Corsico’s deposi- tion was not proper rebuttal because Corsico was not discussing a situation in which a person’s gastrointesti- nal bleed had resolved prior to his or her death. The isolated colloquy from Corsico’s deposition establishes only a single, generic proposition: that a gastrointestinal bleed can lead indirectly to death. Such a broad state- ment does not generally contradict Schneller’s and Anderson’s more precise testimony that, in this particu- lar case, the decedent’s death was caused by other medical conditions and not the gastrointestinal bleed, which had resolved more than two weeks before her death.30 In essence, the experts were asked different hypothetical questions, the answers to which were not necessarily contradictory.31 As a result, we conclude that the trial court did not abuse its discretion by exclud- ing Corsico’s testimony from the plaintiff’s case on rebuttal. III The plaintiff’s third claim is that the trial court improperly granted the defendants’ motion for sum- mary judgment on a design defect claim related to the defendants’ failure to develop and market a reversal agent for Pradaxa, pursuant to the impossibility pre- emption doctrine. In response, the defendants assert that the trial court’s preemption analysis was correct because marketing a reversal agent would have required independent approval by the FDA. We agree with the defendants. The following additional facts and procedural history are relevant to our consideration of this claim. The FDA approved Pradaxa in 2010. Five years later, after the decedent’s death, the defendants obtained approval from the FDA to sell idarucizumab, a chemical reversal agent for Pradaxa marketed under the brand name Prax- bind. Because Praxbind was not available at the time of the decedent’s gastrointestinal bleed, kidney dialysis was required to remove dabigatran etexilate, the active ingredient in Pradaxa, from her bloodstream. As a result, the decedent’s gastrointestinal bleed took three days to stop. In the present case, the plaintiff sought to advance a claim that the defendants could have brought Prax- bind to market earlier and that, because they did not do so, the decedent’s gastrointestinal bleed was prolonged. The plaintiff claimed, in particular, that the defendants had defectively designed Pradaxa by failing to seek concurrent approval for a reversal agent. The defen- dants subsequently filed a motion for summary judg- ment, arguing that, because the FDA had not approved Praxbind before the decedent’s death, the plaintiff was foreclosed from pursuing a design defect claim predi- cated on its absence. Specifically, the defendants argued that the reasoning set forth in Mutual Pharma- ceutical Co. v. Bartlett, 570 U.S. 472, 133 S. Ct. 2466, 186 L. Ed. 2d 607 (2013), and PLIVA, Inc. v. Mensing, 564 U.S. 604, 131 S. Ct. 2567, 180 L. Ed. 2d 580 (2011), clearly established that such claims are preempted by federal law. The trial court reached the same conclusion and, accordingly, granted the defendants’ motion for summary judgment on that claim.32 ‘‘The standard of review on summary judgment is well established. Summary judgment shall be rendered forthwith if the pleadings, affidavits and other proof submitted show that there is no genuine issue as to any material fact and that the moving party is entitled to judgment as a matter of law. . . . The scope of our appellate review depends upon the proper characteriza- tion of the rulings made by the trial court. . . . When . . . the trial court draws conclusions of law, our review is plenary and we must decide whether its con- clusions are legally and logically correct and find sup- port in the facts that appear in the record.’’ (Internal quotation marks omitted.) NetScout Systems, Inc. v. Gartner, Inc., 334 Conn. 396, 408, 223 A.3d 37 (2020); see also Byrne v. Avery Center for Obstetrics & Gyne- cology, P.C., 314 Conn. 433, 447, 102 A.3d 32 (2014) (‘‘[w]hether state causes of action are preempted by federal statutes and regulations is a question of law over which our review is plenary’’). The supremacy clause of the United States constitu- tion provides that federal law ‘‘shall be the supreme Law of the Land; and the Judges in every State shall be bound thereby, any Thing in the Constitution or Laws of any State to the Contrary notwithstanding.’’ U.S. Const., art. VI, cl. 2. The dictates of that provision require state law to yield to the extent that it conflicts with federal law. See, e.g., Freightliner Corp. v. Myrick, 514 U.S. 280, 287, 115 S. Ct. 1483, 131 L. Ed. 2d 385 (1995). Such a conflict is implicit where, for example, it is ‘‘impossible for a private party to comply with both state and federal requirements . . . .’’ (Internal quotation marks omitted.) Id. There is, however, ‘‘a strong presumption against federal preemption of state and local legislation.’’ (Internal quotation marks omit- ted.) Murphy v. Darien, 332 Conn. 244, 249, 210 A.3d 56 (2019), cert. denied sub nom. Metro North Commuter Railroad Co. v. Murphy, U.S. , 140 S. Ct. 847, 205 L. Ed. 3d 468 (2020). We begin our analysis of whether such a conflict exists in the present case with a brief review of three decisions from the United States Supreme Court exam- ining the question of impossibility preemption in the pharmaceutical context. The plaintiff in Wyeth v. Levine, 555 U.S. 555, 558, 129 S. Ct. 1187, 173 L. Ed. 2d 51 (2009), brought an action in a state court alleging, among other things, that she would have benefited from certain additional warnings in the label for a particular brand-name drug. After extensively reviewing federal law relating to drug labeling, the United States Supreme Court concluded that the plaintiff’s state law claim was not preempted because a particular federal regulation, in fact, would have permitted the defendant to unilater- ally add such additional warnings to the drug’s label, while remaining in compliance with federal law. Id., 568–72, citing 21 C.F.R. § 314.70 (c) (6) (iii) (2008).33 The plaintiffs in PLIVA, Inc. v. Mensing, supra, 564 U.S. 608–609, also alleged the absence of adequate warning labels. The defendants in that action argued on appeal that, as manufacturers of generic drugs, they could not make unilateral changes to the labels of generic drugs. Id., 610. The United States Supreme Court agreed, concluding that the plaintiffs’ claim was preempted because FDA regulations required manufac- turers of generic drugs to simply mirror the labeling of their brand-name counterparts.34 Id., 614, 624. In reach- ing that conclusion, the court specifically rejected the plaintiffs’ argument that proving impossibility would require the defendants to affirmatively demonstrate that the FDA would have rejected stronger warnings if they had been proposed. Id., 620. The relevant inquiry, the court held, was whether the defendants ‘‘could inde- pendently do under federal law what state law requires . . . .’’ (Emphasis added.) Id.35 The United States Supreme Court extended this rea- soning to a state design defect claim two years later in Mutual Pharmaceutical Co. v. Bartlett, supra, 570 U.S. 472. The plaintiff in that case took a generic drug, sulin- dac, and suffered a severe adverse reaction that was not mentioned in the drug’s warning label. Id., 477–78.36 The plaintiff subsequently brought an action, alleging that sulindac was ‘‘ ‘unreasonably dangerous’ ’’ under state law and obtained a verdict in her favor. Id., 479, 486. On appeal, the United States Supreme Court noted that, to satisfy the obligation imposed by state tort law, the defendant would have had to either (1) alter sulin- dac’s composition or (2) strengthen the warning label. Id., 483–84. The court found that the defendant was legally foreclosed from redesigning sulindac as a generic manufacturer and that, in any event, such alter- ations were physically impossible in light of sulindac’s simplistic composition. Id. The court, citing its decision in Mensing, also concluded that the defendant, as a generic manufacturer, was prohibited by federal law from strengthening the warnings in sulindac’s label. Id., 486. As a result, the court concluded that the plaintiff’s state tort claim was preempted. Id., 486–87. Our review of these decisions compels us to conclude in the present case that the trial court properly granted the defendants’ motion for summary judgment as to the plaintiff’s design defect claim. In order to cure the design defect alleged by the plaintiff, the defendants would have had to bring Praxbind to market before the decedent’s gastrointestinal bleed in 2014. Because there is no dispute that Praxbind was not approved by the FDA until 2015, the defendants could not have satisfied their alleged state law duty to the decedent without marketing an unapproved drug in violation of federal law. In light of that conflict, the trial court correctly concluded that the plaintiff’s design defect claim based on the absence of a reversal agent for Pradaxa was preempted. See PLIVA, Inc. v. Mensing, supra, 564 U.S. 623–24 (‘‘when a party cannot satisfy its state duties without the [f]ederal [g]overnment’s special permission and assistance, which is dependent on the exercise of judgment by a federal agency, that party cannot inde- pendently satisfy those state duties for [preemption] purposes’’). The plaintiff claims that the test for preemption set forth in Mensing and Bartlett is inapplicable to present case because those cases do not involve brand-name drugs. We disagree. Although the different levels of control afforded to brand-name and generic manufac- turers by federal labeling regulations informed the court’s analysis in those cases, the nature of the under- lying test remained consistent: whether the defendant ‘‘could independently do under federal law what state law requires . . . .’’ (Emphasis added.) Id., 620. Because the claim relating to the development and mar- keting of Praxbind in the present case does not relate to labeling, the plaintiff’s attempt to rely on the distinc- tions between generic and brand-name manufacturers discussed in Mensing and Bartlett is unavailing. See Yates v. Ortho-McNeil-Janssen Pharmaceuticals, Inc., 808 F.3d 281, 296–97 (6th Cir. 2015) (‘‘contrary to [the plaintiff’s] contention that the impossibility preemption in Mensing and Bartlett is limited to generic drugs, we view Levine, Mensing, and Bartlett as together stating the same test for impossibility preemption’’). The plaintiff’s remaining arguments against preemp- tion do not warrant a different result. First, the plain- tiff’s assertion that it was technologically feasible to develop Praxbind before the decedent’s death is insuffi- cient to preclude preemption. Although such practical considerations may sometimes limit the options avail- able to a manufacturer; see Mutual Pharmaceutical Co. v. Bartlett, supra, 570 U.S. 484; that fact is inapposite to the question of whether marketing Praxbind in 2014 would have required the FDA’s ‘‘special permission and assistance . . . .’’37 PLIVA, Inc. v. Mensing, supra, 564 U.S. 623–64. For similar reasons, we are also unper- suaded that the FDA’s subsequent approval of Praxbind in 2015 is dispositive. The possibility that the FDA would have looked favorably on an earlier application does nothing to alter the fact that, at the time of the dece- dent’s death, the defendants were prevented from uni- laterally marketing Praxbind under federal law. See footnote 35 of this opinion. Indeed, the United States Supreme Court found that the plaintiff’s failure to warn claim in Bartlett was preempted notwithstanding the fact that, shortly after her injuries, the FDA agreed with her assessment that sulindac’s label should include a stronger warning. See footnote 36 of this opinion. For the foregoing reasons, we agree with the trial court’s assessment that the plaintiff’s design defect claim relating to Praxbind was preempted by federal law.38 As a result, we conclude that trial court properly granted the defendants’ motion for summary judgment on that claim. IV The plaintiff’s final claim is that the trial court com- mitted reversible error by issuing a curative instruction to the jury after closing arguments. Specifically, the plaintiff claims that the trial court abused its discretion by instructing the jury that it could not hold the defen- dants liable for failing to conduct tests described in a particular exhibit. In response, the defendants contend that the trial court’s instruction was merited because the plaintiff improperly used that exhibit to advance a preempted failure to test claim in closing argument. We review this claim for an abuse of discretion. See, e.g., State v. Northrop, 213 Conn. 405, 422 n.13, 568 A.2d 439 (1990). Applying that standard to the arguments and record before us, we find no reversible error. The following additional facts and procedural history are relevant to our analysis of this claim. Before the commencement of trial, the court granted in part a motion in limine filed by the defendants seeking to ‘‘exclude evidence, testimony, or argument regarding [a] 110 [milligram] dose’’ of Pradaxa. In that ruling, the trial court acknowledged that such evidence might be relevant to the plaintiff’s claim that the defendants had failed to adequately warn physicians about the risk of bleeding associated with the 150 milligram dose pre- scribed to the decedent and, accordingly, deferred rul- ing on the admissibility of the evidence for that purpose until trial. The court also concluded, however, that such evidence could not be used to prove that the defendants negligently failed ‘‘to test, study, investigate, or pursue the various action items identified by the FDA in order to secure approval of the 110 [milligram] dose in the United States’’ because such a failure to test claim would be preempted by federal law.39 During trial, the court consistently applied this dichotomy when ruling on objections relating to evidence discussing a 110 milli- gram dose. The defendants’ counsel gave the following closing argument on the plaintiff’s failure to test claim:40 ‘‘The failure to test, you’ve literally not been given the nature of a test that should be done. Instead what you’ve been told is we did do a lot of study of this issue, we went as far we could, we went further than others did, and we came to the view that we couldn’t go farther, a view that the FDA echoed. A failure to test, no.’’ Notwith- standing the trial court’s previous ruling, the plaintiff’s counsel responded by drawing the jury’s attention to a document, admitted into evidence as exhibit 23, dis- cussing in particular detail a ‘‘potential path forward’’ for the 110 milligram dose previously proposed by the FDA. The trial court concluded that the plaintiff’s coun- sel’s argument had improperly suggested to the jury that the defendants could be held liable for failing to pursue a 110 milligram dose and, as a result, gave the following curative instruction: ‘‘[M]embers of the jury, sometimes in closing arguments things are said by one or more lawyers that needs correction by the court. It’s not uncommon for that to happen. . . . [I]t was sug- gested that you look at exhibit 23 during your delibera- tions. I am instructing you that you may not hold [the defendants] liable for a failure to conduct the testing outlined in exhibit 23.’’ The plaintiff’s principal argument is that her use of exhibit 23 was proper because the defendants had ‘‘opened the door’’ to it during their own closing argu- ment. We disagree. This defendants’ closing argument only broadly discussed the plaintiff’s failure to test claim. See footnote 40 of this opinion. The ‘‘potential path forward’’ described in exhibit 23, by contrast, dis- cusses the prospect of FDA approval for a 110 milligram dose. As a result, the defendants did not open the door to the plaintiff’s use of that exhibit in closing. The plaintiff also argues that the trial court instructed the jury to ‘‘disregard’’ a full exhibit and that doing so infringed on her right to use that evidence in support of her claims. The trial court’s instruction, however, only precluded the jury from considering a single exhibit to support a particular claim that it had deter- mined was preempted under federal law. Such a restric- tion was not improper. Finally, the plaintiff claims that she was unfairly prejudiced because the trial court had singled out her argument before the jury as doing ‘‘something wrong . . . .’’ Again, we disagree. The trial court’s instruction was brief, contained no explicit rep- rimand, and was conveyed using reasonably measured language. In fact, the court described such instructions as ‘‘not uncommon . . . .’’ Under these circumstances, we decline to conclude that the trial court abused its discretion by issuing the challenged curative instruction to the jury. The judgment is affirmed. In this opinion the other justices concurred. * May 4, 2020, the date that this decision was released as a slip opinion, is the operative date for all substantive and procedural purposes. 1 The plaintiff appealed from the judgment of the trial court to the Appellate Court, and we transferred the appeal to this court pursuant to Practice Book § 65-1 and General Statutes § 51-199 (c). 2 Stanley Schneller, a cardiologist, testified at trial that ‘‘below [the accepted therapeutic] range [patients] don’t get any benefit, it’s as if they’re not taking the drug, and above that range [patients] get no further benefit in terms of stroke prevention.’’ Thus, Schneller testified, the ‘‘targeted range is designed to give [patients] stroke protection without undue bleeding risk.’’ Fierstein testified that the decedent was inside of the accepted therapeutic range ‘‘at least 75 percent of the time’’ she was taking warfarin. 3 According to testimony offered at trial, retroperitoneal fibrosis is a medi- cal condition that can cause kidney damage by obstructing the flow of urine. This condition was not related to the decedent’s use of Pradaxa. The phrase ‘‘occult neoplasia’’ denoted an undiagnosed cancer. 4 The judgment file incorrectly notes that the defendants’ various motions for summary judgment were denied in their entirety. This appears to have been a scrivener’s error. 5 The plaintiff also makes the conclusory assertion that the trial court’s rulings with respect to spoliation ‘‘would seem to violate basic notions of fundamental fairness, due process, and the right to counsel.’’ The plaintiff’s brief, however, contains no analysis applying those constitutional principles to the facts of the present case. As a result, we deem those claims, insofar as they were raised, to have been abandoned. Connecticut Light & Power Co. v. Gilmore, 289 Conn. 88, 124, 956 A.2d 1145 (2008) (‘‘We repeatedly have stated that [w]e are not required to review issues that have been improperly presented to this court through an inadequate brief. . . . Analy- sis, rather than mere abstract assertion, is required in order to avoid abandon- ing an issue by failure to brief the issue properly.’’ [Internal quotation marks omitted.]). 6 The defendants argue that the trial court’s decision to give a spoliation an instruction was, itself, improper. Because the defendants prevailed at trial, we decline to address that claim of error in the present appeal. See Practice Book § 61-1; see also Seymour v. Seymour, 262 Conn. 107, 110, 809 A.2d 1114 (2002) (‘‘[o]rdinarily, a party that prevails in the trial court is not aggrieved’’). We note, however, that other trial courts overseeing Pradaxa trials in this state have adopted divergent approaches to this issue. See Bedsole v. Boehringer Ingelheim Pharmaceuticals, Inc., Superior Court, judicial district of Hartford, Docket No. CV-XX-XXXXXXX-S (September 14, 2018) (68 Conn. L. Rptr. 206) (declining to provide adverse inference instruc- tion); Gallam v. Boehringer Ingelheim Pharmaceuticals, Inc., Superior Court, judicial district of Hartford, Docket No. CV-XX-XXXXXXX-S (April 13, 2018) (following trial court’s approach in present case, but also giving spolia- tion instruction during presentation of evidence); see also In re Petition of Boehringer Ingelheim Pharmaceuticals, Inc., 745 F.3d 216, 220 (7th Cir. 2014) (noting wide range of sanctions available to district court). 7 Prior to 2015, there was a split in federal courts regarding the factual findings necessary to support an imposition of sanctions, such as an adverse inference instruction, for the spoliation of electronically stored information; some courts imposed sanctions on a finding a gross negligence, while others required intentional destruction. Compare Residential Funding Corp. v. DeGeorge Financial Corp., 306 F.3d 99, 99–101 (2d Cir. 2002) (gross negli- gence standard), and Bracey v. Grondin, 712 F.3d 1012, 1020 (7th Cir. 2013) (bad faith standard). The Federal Rules of Civil Procedure were ultimately amended in 2015 to require a finding of bad faith. See Fed. R. Civ. P. 37 (e) (2) (permitting imposition of sanctions ‘‘only upon finding that the party acted with the intent to deprive another party of the information’s use in the litigation’’). 8 The plaintiff also requested instructions relating to the destruction of certain text messages and corporate e-mails. Those aspects of the plaintiff’s request to charge are not at issue in the present appeal. 9 The plaintiff noted, in particular, that such evidence would likely require calling one of the defendants’ attorneys, Eric Hudson, as a witness. 10 During oral argument, the plaintiff implied that the introduction of such evidence could be avoided at least three times. On one occasion, the plaintiff stated that, ‘‘if the court doesn’t grant this motion, then [she] intend[s] to put on evidence that there was a prior proceeding in which [the defendants] were obligated to preserve this information and they failed to do so.’’ On another occasion, the court asked the plaintiff the following question: ‘‘So your position is that if the court were to grant the request for a spoliation charge, you would not intend to put on any evidence of Judge Herndon’s order?’’ The plaintiff responded by stating: ‘‘That’s correct.’’ Finally, the plaintiff concluded her argument on as follows: ‘‘We believe that the motion should be granted for the reasons we’ve articulated, but if the court denies it, we’d ask that it be denied with direction that we be permitted to put on the evidence as we’ve discussed here today.’’ 11 During a supplemental oral argument before the trial court, the plaintiff repeated her belief that the jury could be provided with an adequate context through evidence regarding Lehr’s involvement in the research underlying Pradaxa and, specifically, the concept of a therapeutic range. 12 The trial court’s written decision summarized the proceedings related to spoliation sanctions before Judge Herndon, including the relevant factual findings and conclusions. 13 As noted subsequently in this opinion, the ultimate question of whether to draw an adverse inference was reserved for the jury. See, e.g., Paylan v. St. Mary’s Hospital Corp., 118 Conn. App. 258, 264, 983 A.2d 56 (2009); see also Connecticut Civil Jury Instructions (2012) § 2.3-4, available at https:// jud.ct.gov/JI/Civil/Civil.pdf (last visited May 1, 2020). 14 The plaintiff’s written objection to the defendant’s motion in limine reiterated her position that she would seek to introduce evidence relating to spoliation only in the event the trial court declined to give the requested instruction. The plaintiff argued, specifically, that ‘‘in the event that the spoliation issues addressed by Judge Herndon’s orders are to be relitigated in this case, then [the] plaintiff believes that the court should admit as full exhibits [the various court orders] reflecting Judge Herndon’s identification of the discovery orders, [the] bad faith conduct in breaching same, and the consequences of that conduct.’’ 15 Although conceding that the scheduled witnesses lacked such personal knowledge, the plaintiff did indicate to the trial court that a particular corporate e-mail had identified Lehr as the ‘‘father’’ of a manuscript relating to dabigatran etexilate exposure, and that expert witnesses who had reviewed the materials produced by the defendants could testify that they had been unable to locate any version of that manuscript authored by Lehr. As discussed subsequently in this opinion, testimony to this effect was, in fact, ultimately presented to the jury. 16 The published version of that paper, which was admitted into evidence as a full exhibit, lists both Reilly and Lehr as authors, and indicates that both Reilly and Lehr ‘‘contributed equally.’’ 17 The plaintiff’s opening statement was accompanied by various slides that were shown to the jury. One such slide read as follows: ‘‘We do not have the first version of the Pradaxa paper.’’ 18 In one e-mail, Reilly writes that, ‘‘I am aware that the conclusions that appear to emerge from this paper are not the ones currently wished for by marketing (that dose adjustment will optimize therapy) . . . .’’ In a separate string of e-mails discussing specific upper and lower blood concentration measurements, Reilly notes that he has ‘‘been facing heavy resistance inter- nally on this paper about the concept of a therapeutic range, at least stating it outright.’’ In certain other communications discussing the need for blood monitoring with Pradaxa in specific populations, Andreas Clemens, the head of the department of medical affairs for dabigatran etexilate, wrote as follows: ‘‘This needs [to be] a TelCon and we should NOT interact via e-mail on this.’’ All of this correspondence was admitted into evidence and placed before the jury for consideration. 19 The defendants sought to undercut this testimony on recross-examina- tion by introducing a version of the exposure response paper that Reilly had characterized in an e-mail as the ‘‘first draft.’’ Plunkett later testified that she had specifically attempted to locate an earlier version of that paper from Lehr in light of an e-mail that identified Lehr as the ‘‘father’’ of the manu- script. 20 During oral argument on the defendants’ motion for reconsideration, the plaintiff stated as follows: ‘‘[W]e wanted the record to be clear that [the] plaintiff has understood the court’s instruction regarding the spoliation charge was that the plaintiff would not be offering evidence during the course of its case as to issues of spoliation or suppression of documents. . . . [T]o the extent that the court entertains the motion to [reconsider], we [do] not want to waive the right to put on such evidence by resting . . . .’’ 21 In response, the defendants posited during their closing argument that Reilly’s testimony, together with various documents and correspondence, had disproved the existence of such a draft. 22 The plaintiff does not claim in the present appeal that the content of the trial court’s ultimate instruction deviated in any material respect from her request. 23 The plaintiff argues that, in light of the trial court’s decision to instruct the jury on spoliation, its decision to ‘‘preclude counsel from commenting [on that issue] in any manner’’ should be reviewed de novo. We disagree for two reasons. First, as set forth previously in this opinion, the plaintiff was permitted to introduce evidence regarding Lehr’s research and his involvement with the exposure response paper. Second, to the extent that the plaintiff assails the scope of the remedy ultimately fashioned, we note that the imposition of sanctions for discovery misconduct is also vested in the sound discretion of the trial court. See, e.g., Ridgaway v. Mount Vernon Fire Ins. Co., 328 Conn. 60, 70, 176 A.3d 1167 (2018); Duncan v. Mill Manage- ment Co. of Greenwich, Inc., 308 Conn. 1, 28, 60 A.3d 222 (2013). 24 The trial court’s exclusion of Barner’s deposition testimony, like its pretrial ruling on the defendants’ motion in limine, placed the plaintiff on notice that the trial court intended to hold her to the representations she had made in requesting an adverse inference instruction. If the plaintiff believed that the instruction she had requested could not properly be consid- ered in the absence of Barner’s testimony, she could have withdrawn her request for the charge and sought to introduce evidence to prove the ele- ments of spoliation under Beers. The plaintiff did not do so. See also footnote 26 of this opinion. 25 We note that this well established legal principle also undercuts the plaintiff’s claim that the trial court’s restriction on closing arguments was unforeseeable. 26 The plaintiff also did not seek to revert to such a procedure after the trial court granted the defendants’ motion in limine and denied her motion for permission to ‘‘inform’’ the jury of the issues relating to spoliation. Both of those rulings, which were issued before the commencement of trial, clearly indicated that the court intended to severely restrict, if not entirely preclude, evidence and arguments relating to the defendants’ destruction of Lehr’s files. 27 The plaintiff raises two ancillary arguments warranting brief attention. First, the plaintiff argues that the trial court’s decision to instruct the jury that an adverse inference was permissible as a matter of law merely relieved her of the burden of proving spoliation. That ruling, the plaintiff argues, should have done nothing to prevent her from informing the jury of the defendants’ unlawful destruction of evidence. This argument ignores the fact that presenting such evidence to the jury would necessitate the very same ‘‘trial within a trial’’ that the court’s decision to give an adverse infer- ence instruction was, itself, expressly designed to avoid. Second, the plaintiff argues that the restrictions imposed by the trial court run contrary to a ‘‘strong public policy . . . of seeking to deter spoliation by product liability defendants.’’ We find this argument unpersuasive because the trial court, in fact, granted the plaintiff’s requested form of relief for spoliation in the present case. 28 This conclusion is a relatively narrow one. This case does not require this court to determine whether a spoliation instruction was required, or whether the instruction ultimately provided to the jury was proper. See footnote 6 of this opinion. Simply put, we only conclude that, in light of the representations made to the trial court in seeking an instruction in the present case, the plaintiff cannot prevail on her claim that the trial court improperly precluded evidence and arguments related to spoliation. 29 The plaintiff argues that the trial court’s ruling was based on the errone- ous legal conclusion that rebuttal evidence must directly contradict testi- mony presented by the defendants. Our independent review of the record has, however, located no support for the contention that such a standard was applied in the present case. 30 The plaintiff does not argue that she was prohibited from calling addi- tional expert witnesses to rebut the testimony from Schneller and Anderson on either the decedent’s unrelated medical conditions or the results of the decedent’s gastrointestinal bleed. 31 The plaintiff asserts that Corsico’s recognition that a gastrointestinal bleed can lead to a fatal cascade was relevant and, indeed, crucial to proving her case. Specifically, the plaintiff argues that such testimony (1) would have helped to bolster her own evidence on causation, (2) would have precluded the defendants from making certain arguments in closing, and (3) was clearly important in light of the jury’s ultimate verdict. None of these arguments, however, relate to whether the trial court erred by declining to admit Corsico’s testimony as rebuttal. See, e.g., DiMaio v. Panico, 115 Conn. 295, 298, 161 A. 238 (1932) (‘‘The rule upon this subject is a familiar one. When, by the pleadings, the burden of proving any matter in issue is thrown upon the plaintiff, he must, in the first instance, introduce all the evidence upon which he relies to establish his claim. He cannot, as said by Lord Ellenborough, go into half his case, and reserve the remainder.’’ (Inter- nal quotation marks omitted.)). Finally, the plaintiff argues that the trial court should have admitted Corsico’s testimony because presentation of that evidence would not have taken much time. Although the trial court may well have been entitled to weigh that fact in reaching its decision; see Gomeau v. Gomeau, supra, 242 Conn. 211; we decline to find an abuse of discretion on that basis alone. 32 The trial court also concluded that the defendants were also entitled to summary judgment on this claim because Praxbind was a ‘‘different product as a matter of law and not a design element of Pradaxa.’’ Because we conclude that the trial court properly granted the defendants’ motion for summary judgment on federal preemption grounds, we need not consider this aspect of the trial court’s ruling. 33 The court noted that the FDA retained authority to retrospectively reject such unilateral changes to the warnings but declined to find impossibility preemption on that ground in the absence of ‘‘clear evidence’’ that the FDA would have done so. Wyeth v. Levine, supra, 555 U.S. 571. The plaintiff in the present case asserts that a recent United States Supreme Court case explaining that particular standard, Merck Sharp & Dohme Corp. v. Albrecht, U.S. , 139 S. Ct. 1668, 203 L. Ed. 2d 822 (2019), stands for the broad proposition that impossibility preemption ‘‘only applies when a defendant can affirmatively show that it attempted to get the FDA to allow the safer alternative proposed by the plaintiff and the FDA affirmatively and officially rejected it.’’ (Footnote omitted.) We disagree. The clear evidence standard in Wyeth applies only when a defendant seeks to prove that compliance with a state law obligation remains impossible notwithstanding its ability to act unilaterally under federal law. See Gibbons v. Bristol-Myers Squibb Co., 919 F.3d 699, 708 (2d Cir. 2019) (describing ‘‘clear evidence’’ standard). The brand-name drug manufacturers in Albrecht and Wyeth, for example, could have satisfied their state law obligation to provide a label with an adequate warning by unilaterally making label amendments. See 21 C.F.R. § 314.70 (c) (6) (iii). No similar federal law would have permitted the defen- dants in the present case to market Praxbind unilaterally and, as a result, Albrecht is inapposite. 34 The court reasoned as follows: ‘‘To be sure, whether a private party can act sufficiently independently under federal law to do what state law requires may sometimes be difficult to determine. But this is not such a case. Before the [defendants] could satisfy state law, the FDA—a federal agency—had to undertake special effort permitting them to do so. To decide these cases, it is enough to hold that when a party cannot satisfy its state duties without the Federal Government’s special permission and assis- tance, which is dependent on the exercise of judgment by a federal agency, that party cannot independently satisfy those state duties for pre-emption purposes.’’ (Emphasis added.) PLIVA, Inc. v. Mensing, supra, 564 U.S. 623–24. 35 Accepting the plaintiffs’ argument, the court concluded, ‘‘would render conflict pre-emption largely meaningless because it would make most con- flicts between state and federal law illusory. We can often imagine that a third party or the Federal Government might do something that makes it lawful for a private party to accomplish under federal law what state law requires of it. . . . If these conjectures suffice to prevent federal and state law from conflicting for Supremacy Clause purposes, it is unclear when, outside of express pre-emption, the Supremacy Clause would have any force.’’ (Emphasis in original.) PLIVA, Inc. v. Mensing, supra, 564 U.S. 620; cf. footnote 33 of this opinion. 36 As a result of a comprehensive review commenced in 2005, the year after the plaintiff in Bartlett was prescribed sulindac, the FDA recommended the inclusion of such a warning in sulindac’s label. See Mutual Pharmaceuti- cal Co. v. Bartlett, supra, 570 U.S. 478–79. 37 We likewise reject the plaintiff’s arguments relating to evidentiary admis- sibility and general foreseeability because they do not inform this analysis. 38 We note that courts in other jurisdictions considering related cases have reached the same conclusion. See Ridings v. Maurice, Docket No. 15-00020- CV-W (JTM), 2019 WL 4888910, *6 (W. D. Mo. August 12, 2019) (holding that plaintiffs’ design defect claims were preempted ‘‘insofar as they are premised on the failure of Boehringer to develop, seek and obtain approval for and/ or market a reversal agent for Pradaxa sooner that it did’’ and noting that issue of feasibility was ‘‘immaterial’’); Chambers v. Boehringer Ingelheim Pharmaceuticals, Inc., Docket No. 4:15-CV-00068 (CDL), 2018 WL 849081, *13 (M. D. Ga. January 2, 2018) (‘‘Regardless of when Boehringer started the process, Praxbind approval still required the FDA’s ‘special permission and assistance.’ Boehringer could not unilaterally offer Praxbind to physi- cians. Therefore, initiating the process that may have led to Praxbind’s approval does not enable Boehringer to comply with both federal and state law. Further, Boehringer was not required to cease production of Pradaxa until Praxbind was approved to comply with federal and state law. . . . Therefore, [the] [p]laintiff’s design defect claim is also preempted. [Citation omitted; emphasis in original.]); but see In re Xarelto (Rivaroxaban) Prod- ucts Liability Litigation, Docket No. 2592 (EEF), 2017 WL 1395312, *3 (E.D. La. April 13, 2017). 39 The plaintiff contends, in a conclusory fashion, that the trial court’s legal conclusion on preemption was incorrect and that, as a result, the trial court improperly excluded evidence regarding certain correspondence between the defendants and the FDA discussing a 110 milligram dose of Pradaxa. Specifically, the plaintiff argues that, because the information con- tained within those documents shows that the defendants could have contin- ued to pursue FDA approval of that lower dose, the trial court incorrectly concluded that the plaintiff’s related, failure to test claim was preempted. For the reasons discussed previously in this opinion, this argument lacks merit. See footnote 35 of this opinion. To the extent that the plaintiff’s brief implies evidentiary error on different grounds, we find those claims to have been inadequately briefed. See, e.g., Connecticut Light & Power Co. v. Gilmore, 289 Conn. 88, 124, 956 A.2d 1145 (2008). 40 The trial court aptly summarized the failure to test claims ultimately presented to the jury in its instructions as follows: ‘‘The plaintiff claims that [the defendants] failed to adequately test, study, and investigate Pradaxa’s safety issues, specifically, that [the defendants]: (1) failed to study, test, and investigate plasma concentrations so as to maximize stroke prevention and minimize risk of bleeding relating to Pradaxa and, (2) failed to study, test, and investigate Pradaxa’s relationship to gastrointestinal issues and gastroin- testinal bleeding.’’