OPINION
ERWIN, Justice.
Appellant, Polee Armstrong, appeals from a conviction by jury verdict of manslaughter in connection with the death of his wife, Corrine Armstrong. The central issue at trial concerned the cause of her death. On appeal appellant complains of deficiency in proof on that issue, contends that the trial court erred in admitting photographs of the deceased, and alleges prejudice from certain comments made by the district attorney to the jury during closing argument and to the trial judge prior to sentencing.
[443]*443SUFFICIENCY OF THE EVIDENCE
We begin with appellant’s primary assertion on appeal, that the state failed to prove, by evidence sufficient to support a conviction, a criminal cause of death. This contention was raised at trial by appellant’s motion for a judgment of acquittal.1 In assessing such a motion the test to be employed is the one enunciated in Bush v. State, 397 P.2d 616, 618 (Alaska 1964), where we said:
On a motion for a judgment of acquittal the judge must take the view of the evidence and the inferences therefrom most favorable to the state. If he determines that fair minded men in the exercise of reasonable judgment could differ on the question of whether guilt has been established beyond a reasonable doubt, then he must submit the case to the jury.
(Footnotes omitted.) 2
Having noted the proper standard, we turn to a consideration of the evidence relevant to cause of death.
Corrine Armstrong died during the early evening of Christmas day, 1969, in the house trailer residence of the Armstrongs. Officer Moerlins, who investigated the death, testified that numerous bruises and lacerations were visible about Corrine’s head and that it appeared to him to have been a violent death. He further testified that furniture in the trailer bedroom was overturned and that there was blood on the closet door mirror. The extent of the deceased’s injuries was also illustrated by a series of photographs.3 Appellant was subsequently charged and tried on the theory that he had unlawfully struck his wife about the head and that these blows were a proximate cause of her death.
Appellant does not contend on appeal that insufficient evidence was produced at trial to permit the jury to conclude that the multiple head injuries suffered by Corrine prior to her death had been inflicted by appellant;4 however, appellant does challenge as insufficient to support a guilty verdict the evidence which tended to show that those injuries contributed to Corrine’s demise. In particular, appellant relies on the inability of the state’s expert medical witness to testify with medical certainty that blows to Corrine’s head had such a contributory effect.
[444]*444To establish cause of death, the state called Dr. Ronald Rogers, a pathologist who performed an autopsy on Mrs. Armstrong. Dr. Rogers testified that the primary cause of death was asphyxiation resulting from the blockage of Corrine’s wind passage by a dense and viscus mucous clot located at the vocal cords in the larynx. He further testified that such a mucous clot ordinarily would have been expectorated automatically by an innate coughing reflex; however, in the case of the deceased, deep unconsciousness inhibited that innate reflex, and asphyxiation resulted. Two possible causes of the reflex-inhibiting unconsciousness were revealed by the autopsy: excessive alcohol consumption and blows to the head. Dr. Rogers testified that in his opinion both factors contributed to the depth of unconsciousness and thus to Corrine’s death.5 On cross-examination the doctor conceded that he could not isolate which factor was the cause of death and that a reflex-inhibiting state of unconsciousness could have resulted solely from the extremely high blood-alcohol level. He further testified, however, that in the absence of any one of the factors in this case, the victim might have survived.6 Appellant argues that this [445]*445concession necessitated a judgment of acquittal. We disagree.
The fact that the victim died from the combined effects of a pre-existing disease or condition and a blow or wound maliciously inflicted by the defendant does not relieve the defendant of liability.7 When a person inflicts a blow or wound upon another
[i]t is well settled that the consequences of an act which is the efficient cause of the death of another are not excused, nor is the criminal responsibility for causing death lessened, by the pre-exist-ing physical condition of the person killed, at the time the act was done, or by his low vitality, which rendered him unable to withstand the shock of the wound inflicted, and without which pre-existing condition the blow would not have been fatal, if a causal connection between the blow and the fact of death is made to appear. Accordingly, the fact that the victim died from the combined effects of the wound maliciously inflicted by the defendant and a disease not connected with the wound does not relieve the defendant of liability.8
Expert testimony is not necessarily essential to support a conviction of homicide. Thus, where it is apparent that ordinary laymen could perceive, from such factors as the nature of the wound or the circumstances surrounding an attack, that a defendant’s acts caused the death, medical testimony as to cause of death is not essential.9 A contrary result is reached, however, where from the nature of the agency alleged to have caused the death, the causal connection is not within the [446]*446average layman’s perception. In such circumstances, expert testimony is essential to support a conviction.10
In the present case, the causal connection sought to be established was beyond the understanding of the average layman.11 Expert testimony therefore was necessary for the state to establish its case; in the absence of such testimony, any deliberation by the jury as to cause of death would have been baseless conjecture.
In this case expert testimony served to reveal the physiological relationships relevant to Corrine’s death; once these were explained, the jury was competent to make an independent determination of cause of death on the basis of all the relevant evidence before it.
Our study of the record of the trial below convinces us that sufficient evidence was produced to present a jury question on the issue of cause of death. Expert testimony presented by both parties established asphyxiation as the primary cause of death. Dr. Rogers indicated a causal connection between the beating and asphyxiation, namely as a factor which, along with extreme intoxication, contributed to the depth of the reflex-inhibiting unconsciousness. Even the defense expert witness, Dr. Michael Beirne, admitted that the head injuries were a “minor” contribution to Corrine’s death, being sufficient to “cause a certain additional grogginess . . . . ” Additionally, the jury had before it the testimony of Officer Moerlins who detailed the condition of the trailer and the deceased as he found them. The extent of the beating suffered by Corrine was also illustrated by photographs.
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OPINION
ERWIN, Justice.
Appellant, Polee Armstrong, appeals from a conviction by jury verdict of manslaughter in connection with the death of his wife, Corrine Armstrong. The central issue at trial concerned the cause of her death. On appeal appellant complains of deficiency in proof on that issue, contends that the trial court erred in admitting photographs of the deceased, and alleges prejudice from certain comments made by the district attorney to the jury during closing argument and to the trial judge prior to sentencing.
[443]*443SUFFICIENCY OF THE EVIDENCE
We begin with appellant’s primary assertion on appeal, that the state failed to prove, by evidence sufficient to support a conviction, a criminal cause of death. This contention was raised at trial by appellant’s motion for a judgment of acquittal.1 In assessing such a motion the test to be employed is the one enunciated in Bush v. State, 397 P.2d 616, 618 (Alaska 1964), where we said:
On a motion for a judgment of acquittal the judge must take the view of the evidence and the inferences therefrom most favorable to the state. If he determines that fair minded men in the exercise of reasonable judgment could differ on the question of whether guilt has been established beyond a reasonable doubt, then he must submit the case to the jury.
(Footnotes omitted.) 2
Having noted the proper standard, we turn to a consideration of the evidence relevant to cause of death.
Corrine Armstrong died during the early evening of Christmas day, 1969, in the house trailer residence of the Armstrongs. Officer Moerlins, who investigated the death, testified that numerous bruises and lacerations were visible about Corrine’s head and that it appeared to him to have been a violent death. He further testified that furniture in the trailer bedroom was overturned and that there was blood on the closet door mirror. The extent of the deceased’s injuries was also illustrated by a series of photographs.3 Appellant was subsequently charged and tried on the theory that he had unlawfully struck his wife about the head and that these blows were a proximate cause of her death.
Appellant does not contend on appeal that insufficient evidence was produced at trial to permit the jury to conclude that the multiple head injuries suffered by Corrine prior to her death had been inflicted by appellant;4 however, appellant does challenge as insufficient to support a guilty verdict the evidence which tended to show that those injuries contributed to Corrine’s demise. In particular, appellant relies on the inability of the state’s expert medical witness to testify with medical certainty that blows to Corrine’s head had such a contributory effect.
[444]*444To establish cause of death, the state called Dr. Ronald Rogers, a pathologist who performed an autopsy on Mrs. Armstrong. Dr. Rogers testified that the primary cause of death was asphyxiation resulting from the blockage of Corrine’s wind passage by a dense and viscus mucous clot located at the vocal cords in the larynx. He further testified that such a mucous clot ordinarily would have been expectorated automatically by an innate coughing reflex; however, in the case of the deceased, deep unconsciousness inhibited that innate reflex, and asphyxiation resulted. Two possible causes of the reflex-inhibiting unconsciousness were revealed by the autopsy: excessive alcohol consumption and blows to the head. Dr. Rogers testified that in his opinion both factors contributed to the depth of unconsciousness and thus to Corrine’s death.5 On cross-examination the doctor conceded that he could not isolate which factor was the cause of death and that a reflex-inhibiting state of unconsciousness could have resulted solely from the extremely high blood-alcohol level. He further testified, however, that in the absence of any one of the factors in this case, the victim might have survived.6 Appellant argues that this [445]*445concession necessitated a judgment of acquittal. We disagree.
The fact that the victim died from the combined effects of a pre-existing disease or condition and a blow or wound maliciously inflicted by the defendant does not relieve the defendant of liability.7 When a person inflicts a blow or wound upon another
[i]t is well settled that the consequences of an act which is the efficient cause of the death of another are not excused, nor is the criminal responsibility for causing death lessened, by the pre-exist-ing physical condition of the person killed, at the time the act was done, or by his low vitality, which rendered him unable to withstand the shock of the wound inflicted, and without which pre-existing condition the blow would not have been fatal, if a causal connection between the blow and the fact of death is made to appear. Accordingly, the fact that the victim died from the combined effects of the wound maliciously inflicted by the defendant and a disease not connected with the wound does not relieve the defendant of liability.8
Expert testimony is not necessarily essential to support a conviction of homicide. Thus, where it is apparent that ordinary laymen could perceive, from such factors as the nature of the wound or the circumstances surrounding an attack, that a defendant’s acts caused the death, medical testimony as to cause of death is not essential.9 A contrary result is reached, however, where from the nature of the agency alleged to have caused the death, the causal connection is not within the [446]*446average layman’s perception. In such circumstances, expert testimony is essential to support a conviction.10
In the present case, the causal connection sought to be established was beyond the understanding of the average layman.11 Expert testimony therefore was necessary for the state to establish its case; in the absence of such testimony, any deliberation by the jury as to cause of death would have been baseless conjecture.
In this case expert testimony served to reveal the physiological relationships relevant to Corrine’s death; once these were explained, the jury was competent to make an independent determination of cause of death on the basis of all the relevant evidence before it.
Our study of the record of the trial below convinces us that sufficient evidence was produced to present a jury question on the issue of cause of death. Expert testimony presented by both parties established asphyxiation as the primary cause of death. Dr. Rogers indicated a causal connection between the beating and asphyxiation, namely as a factor which, along with extreme intoxication, contributed to the depth of the reflex-inhibiting unconsciousness. Even the defense expert witness, Dr. Michael Beirne, admitted that the head injuries were a “minor” contribution to Corrine’s death, being sufficient to “cause a certain additional grogginess . . . . ” Additionally, the jury had before it the testimony of Officer Moerlins who detailed the condition of the trailer and the deceased as he found them. The extent of the beating suffered by Corrine was also illustrated by photographs. Viewed most favorably to the state, this evidence was sufficient to permit the jury to conclude, with the strength of conviction required for a guilty verdict, that the acts of appellant contributed to Corrine’s demise.12
CORPUS DELICTI
In a closely related claim of error, appellant asserts that the state failed to establish the corpus delicti of manslaughter13 [447]*447by evidence other than the purported admission and inconsistent exculpatory statements made by appellant.14
It is a settled principle of American jurisprudence that a criminal conviction must rest on firmer ground than the uncorroborated confession or admission of an accused.15 To avoid convicting a person solely out of his own admissions, the law requires, for a case to be submissible to the trier of fact, additional independent evidence. Thus, in a homicide case, there must be independent evidence of (1) the fact of death which (2) was caused by criminal agency of another16 before the question of guilt of this defendant could be submitted to the jury. Appellant argues that there must also be independent proof of the third element — that he commmitted the crime, without reference to his admissions, but we find no legal authority 17 to support this position and decline to adopt such a rule in Alaska.
There is a wide diversity among jurisdictions as to the extent of corroborative evidence necessary, particular formulas ranging from evidence tending to establish the corpus delicti to proof of the corpus delicti beyond a reasonable doubt.18 We feel that the proper and most workable rule is the one laid down for the federal courts in Opper v. United States, 348 U.S. 84, 75 S.Ct. 158, 99 L.Ed. 101 (1954), where the court held that corroborative evidence need not be sufficient, independent of the statements, to establish the corpus delicti. Rather, the prosecution must introduce “substantial independent evidence which would tend to establish the trustworthiness of the statement.” Id. at 93, 75 S.Ct. at 164, 99 L.Ed. at 109. The court stated:
Thus, the independent evidence serves a dual function. It tends to make the admission reliable, thus corroborating it while also establishing independently the other necessary elements of the offense. (Citation omitted)19
Id. Of course, the independent evidence taken together with evidence of extra-judicial statements by the accused must be sufficient to establish, beyond! a reasonable doubt, all elements of the corpus delicti.
We have previously reviewed the substantial independent evidence which tended to establish a homicide and, thereby, corroborate the evidence of an extra-judicial admission of guilt by defendant. The trial court did not commit error in admitting evidence of extra-judicial statements by appellant.
Appellant additionally argues that the trial court erred in admitting the evidence of extra-judicial admissions prior to independent proof of a criminal cause of death.20 Although it is desirable for [448]*448there to be an orderly presentation of proof,21 it is well established that the order of proof is within the sound discretion of the trial court.22 An abuse of that discretion would appear where, because of probable confusion of issues by the trier of fact, an accused is denied a fair trial. Our examination of the trial record does not reveal any such probability of confusion.
PHOTOGRAPHS
In Stevens v. State, 443 P.2d 600, 603 (Alaska 1968), cert. denied 393 U.S. 1039, 89 S.Ct. 662, 21 L.Ed.2d 586 (1969), we held that:
a photograph is admissible in evidence in the discretion of the trial judge, as an aid to the court or jury, after it has been shown to be a faithful representation of whatever it purports to depict, provided it is relevant, and provided its eviden-tiary value is not outweighed by any prejudice it might create. (Footnote omitted.) 23
Appellant contends that four color photographs of the deceased, admitted at trial over defense objections, inaccurately represented the condition of Corrine Armstrong at the time of her death, were irrelevant, and were unduly prejudicial.
Officer Moerlins testified that the photographs, apparently taken during or soon after the autopsy performed by Dr. Rogers, “fairly accurately]” reflected the condition of the deceased as she appeared soon after her death. However, appellant argues that the trial court was nevertheless obligated to rule the proffered evidence inadmissible because Officer Moerlins conceded that the photographs were tinged with a slight purple hue and depicted several small incisions apparently made during the autopsy by Dr. Rogers.24 We do not agree. The minor discrepancies noted by Officer Moerlins were pointed out to the jury and cautionary instructions were given.25
Nor can we agree that the photographs were irrelevant or unduly prejudicial. The photographs illustrated the testimony of Officer Moerlins and Dr. Rogers concerning the bruises and lacerations suffered by the deceased as well as Dr. Rogers’ testimony regarding the proba[449]*449ble cause of the injuries and their contributory effect to Corrine Armstrong’s death. They were therefore relevant.26 Nor is there anything unusually gruesome or repulsive about the photographs which would have made them more harmful than illuminating. The trial judge did not abuse his discretion in admitting the photographs.27
CLOSING ARGUMENT
Appellant chose not to testify below. However, as previously noted, the prosecution introduced evidence of several inconsistent extra-judicial statements allegedly made by appellant concerning his wife’s death. In closing argument the prosecution commented on those statements as follows :
But the truth of the matter is he told so many stories about this that you know here, don’t you, you know right now that you cannot believe his accounting of what happened. And the judge is going to tell you that if you find that somebody says something that is not true that you may distrust his testimony in others. A willful falsehood should always be considered seriously by the jury.
Objection to these comments is raised for the first time on appeal, appellant arguing that the prosecution’s remarks misrepresented a mandatory instruction given by the court and amounted to an improper comment on the failure of appellant to testify.
Pursuant to Criminal Rule 30(b)(1), the court instructed the jury that “[a] witness wilfully false in one part of his testimony may be distrusted in other parts.” The state concedes that this instruction only concerned statements made by witnesses during the trial and that the reference to it in closing argument was therefore improper. However, the state argues that this impropriety does not amount to reversible plain error. We agree. The misleading reference did not effect substantial rights of appellant28 and could have been corrected by an appropriate objection.29
A more serious contention is that by calling the jury’s attention to the hearsay statements attributed to appellant, the jury was made aware of appellant’s decision not to take the stand. Appellant’s argument derives from reasoning that only he could have explained or contradicted the inconsistent hearsay statements, that the jury would realize this, and that the prosecution was thus commenting on appellant’s failure to testify.
An accused’s privilege against self-incrimination is violated where comment is made at trial concerning his failure to testify on his own behalf.30 In McCracken v. State, 431 P.2d 513 (Alaska [450]*4501967), we adopted the following test of whether prosecutorial remarks amount to such a prohibited comment:
[T]he test is whether the language used was manifestly intended or was of such character that the jury would naturally and necessarily take it to be a comment on the failure of the accused to testify. (Footnote omitted.) 31
Applying this test, we conclude that the challenged statements were neither calculated to be, nor of necessity interpreted by the jury as, a comment on appellant’s failure to testify. Closing argument was made against the tacitly known background that appellant had not taken the stand; but this circumstance could not prohibit the state from commenting on evidence which appellant might have cast doubt on had he testified. The prosecution did not directly refer to appellant’s silence at trial, nor did it note that the evidence of hearsay statements attributed to appellant was uncon-tradicted.32 Rather, the state’s attorney merely reviewed the hearsay statements and indicated their inconsistency and lack of trustworthiness. In doing so he committed no error.
SENTENCING COMMENTS
Appellant does not directly contend that the sentence imposed of ten years imprisonment with five years suspended was excessive. Rather, he asserts that an improper comment by the prosecutor resulted in a denial of a fair sentence proceeding.
In an apparent reference to a notation in the presentence report that two previous wives of appellant had died from “unknown causes,” the prosecutor stated during the sentencing hearing:
We do know that unfortunately this man had a — an experience of having two other wives die prior to this wife for no apparent reason that — at least that he could explain to the probation officer.
Following an objection to these remarks by defense counsel, Mr. Robert Spinde, the probation-parole officer who authored the report, stated:
I did indicate in my report that Mr. Armstrong’s wives number 2 and number 3 I think, did die from unknown causes, I didn’t mean to imply anything sinister in this. I simply meant that I didn’t know what the causes of death were and that I meant to indicate that he had been widowed twice, I didn’t mean to imply anything sinister in that at all.
The court then indicated it was “not gonna consider it as part of any sentence
Despite the court’s statement of nonreliance, appellant asserts that a “wild and vague conjecture” was introduced into the proceeding, necessitating resentencing. Appellant argues that error must be found since it is impossible to determine on appeal whether the judge was in fact influenced by the prosecutor’s statement.
In Egelak v. State, 438 P.2d 712 (Alaska 1968), the prosecutor had similarly referred during the sentencing hearing to alleged prior unpunished offenses. We stated:
While the district attorney’s participation in the sentencing procedures would hardly qualify as model advocacy, we think that our trial judges possess the requisite degree of perceptiveness to recognize and discount any attempt at overreaching, exaggeration, or unfair tactics on the part of counsel. Judges are expected to be at home in frequent extremes of adversary presentation and not to be unduly susceptible to strident pleas for the imposition of harsh sanctions. To a large extent we must rely upon the intelligence, experience, integrity, and discretion of our trial judges in sentencing matters.33
[451]*451In this case the trial judge expressly disclaimed any reliance in imposing sentence on the prosecutor’s improper comments. We cannot conclude that the sentencing proceeding was infected with prejudice.
The judgment of conviction and the sentence imposed are affirmed.