Alzamend Neuro, Inc. v. Biorasi, LLC

CourtDistrict Court, S.D. Florida
DecidedJanuary 30, 2026
Docket1:25-cv-20481
StatusUnknown

This text of Alzamend Neuro, Inc. v. Biorasi, LLC (Alzamend Neuro, Inc. v. Biorasi, LLC) is published on Counsel Stack Legal Research, covering District Court, S.D. Florida primary law. Counsel Stack provides free access to over 12 million legal documents including statutes, case law, regulations, and constitutions.

Bluebook
Alzamend Neuro, Inc. v. Biorasi, LLC, (S.D. Fla. 2026).

Opinion

UNITED STATES DISTRICT COURT SOUTHERN DISTRICT OF FLORIDA

Case No. 25-cv-20481-BLOOM/Elfenbein

ALZAMEND NEURO, INC.,

Plaintiff,

v.

BIORASI, LLC,

Defendant. _________________________/

ORDER ON MOTION TO DISMISS

THIS CAUSE is before the Court upon Defendant’s Motion to Dismiss Amended Complaint (“Motion”), ECF No. [49]. The Plaintiff filed a Response in Opposition (“Response”), ECF No. [60] and the Defendant filed a Reply in Support (“Reply”), ECF No. [62]. The Court has carefully reviewed the Motion, the record in this case, the applicable law, and is otherwise fully advised. For the reasons discussed below, the Motion is granted in part and denied in part. I. BACKGROUND Alzamend Neuro, Inc (“Alzamend”) is a clinical-stage biopharmaceutical company focused on developing treatments for Alzheimer’s disease and other neurodegenerative diseases. ECF No. [40] ¶ 1. To advance the development of a new treatment called ALZN002, Plaintiff sought to conduct a phase I/IIA clinical trial to evaluate its safety, tolerability, and preliminary efficacy. ECF No. [40] ¶ 4-5. In February 2023, Alzamend retained Biorasi, LLC. (“Biorasi”) to conduct a first-in- human, randomized, double-blind, placebo controlled, parallel-group, Phase I/II clinical trial for ALZN002. ECF No. [40] ¶ 6. Alzamend and Biorasi executed a Master Services Agreement for Clinical Research Organization Services (“MSA”), under which Biorasi agreed to oversee aspects of the clinical trial. ECF. No [40] ¶ 17. The MSA incorporated other writings into the contractual terms, including an executed Work Order (“Work Order”). The Work Order contained a list of services to be performed by Biorasi. ECF No. [40] ¶ 18. Before executing the MSA, Alzamend and Biorasi executed a Letter of Intent (“LOI”), effective January 2, 2023, pursuant to which

Alzamend paid Biorasi $437,466.00 for set-up services. After signing the LOI, Biorasi provided assurances that it understood Alzamend’s needs and expectations for clinical sites and represented it could secure sites with committed leukapheresis centers and experience for the clinical trial. ECF No [40] ¶ 26. Alzamend chose Biorasi to act as the Clinical Research Organization based upon that representation. ECF No. [40] ¶ 27. Alzamend and Biorasi finalized a protocol for the ALZN002 trials. (“ALZN002-01 Protocol”). ECF No. [40] ¶ 30. Biorasi was responsible for supervising the flow of materials and information during the study, given that Alzamend was to be “blinded’ and incapable of performing such supervision. ECF No. [40] ¶ 32. In the trial “blinded personnel could not know whether a subject was assigned to the treatment group or the placebo group, while the unblinded personnel were

aware of a subject’s status. ECF No. [40] ¶ 33. Ultimately, the testing sites proposed by the Biorasi did not have the necessary leukapheresis capabilities, and Alzamend was forced to create a leukapheresis center for use in the study, causing at least a six-month delay in the clinical trial. ECF No. [40] ¶ 35. Three facilities participated in the clinical trial providing different services: the IMIC Clinical Research Center (“IMIC’) which was located by the Plaintiff, The University of Miami, and the First Excellent Research Group. ECF No. [40] ¶ 37. “The MSA required that the Defendant perform services ‘in compliance with this agreement, the applicable approved protocol, [and] applicable professional standards. . . using a degree of skill, diligence and expertise consistent with industry standards”. ECF No. [40] ¶ 40. Moreover, the MSA required Biorasi to “ensure its employees and Subcontractors performing services [had] the level of skill necessary for BIORASI to meet its obligations under [the MSA]”, train all employees on “BIORASI’s Standard Operating Procedures and All Applicable Laws”, and Biorasi

agreed to “provide prompt written notice to [Alzamend] of any circumstances. . .[that] could adversely affect” the ALZN002 Trial. ECF No. [40] ¶ 41. Under the Work Order’s Task Ownership Matrix (“Task Matrix”), Biorasi expressly undertook the responsibility of creating and implementing communications-monitoring and data- management plans for the trial, including developing a Communication Plan, Monitoring Plan, Data Management Plan, and Medical Monitoring Plan consistent with professional and industry standards. ECF No. [40] ¶ 42. Under Section 1.4 of the Task Matrix, Biorasi was responsible for “[d]evelop[ing] material for training” including investigational product and supplies management. Protocol deviation handling, and queries. ECF No. [40] ¶ 43. The Project Documents required Defendant to “maintain strict segregation between blinded and unblinded personnel and

communications, train and supervise site personnel regarding trial protocols, resolve protocol queries, escalate protocol deviations and safety concerns to Alzamend within 24 hours, monitor clinical operations for protocol and regulatory compliance, and take corrective action for any protocol breaches”. ECF No. [40] ¶ 45. On January 18, 2024, an unblinded study coordinator at IMIC preparing a Cryoport shipment became confused about how to handle Subject 1005’s shipment following sham leukapheresis. The IMIC coordinator did not know that the blinding protocol required her to ship an empty Cryoport for the placebo subject to maintain the blind. Shipment of the empty Cryoport concealed the identity of the subject receiving the placebo because blinded personnel at Biorasi ordered the shipments and blinded personnel at Alzamend received record of the shipments. ECF No. [40] ¶ 61. The IMIC study coordinator sought to resolve her confusion in accordance with protocol by calling her associate contact at Biorasi. ECF No. [40] ¶ 64. The Biorasi associate instructed the IMIC study coordinator to resolve her own query by sending an email requesting guidance to a

larger group. ECF No. [40] ¶ 66. Upon direction of the Biorasi, the IMIC study coordinator sent an email to distribution lists for both the blinded and unblinded study personnel. The communication breached the study’s double-blind design. ECF No. [40] ¶ 68. The Biorasi associate subsequently contacted the Vice President of Project Management at Biorasi to report his conversation with the IMIC study coordinator. ECF No. [40] ¶ 70. The Biorasi VP then initiated a series of communications with First Excellence Research Group and claimed that blood samples for both sentinel subjects 1003 and 1005 had been missing for some time and later contending the active treatment for Subject 1003 might be defective or misidentified. ECF No. [40] ¶ 74; 79. An independent auditor later confirmed that neither sample had been misplaced. ECF No. [40] ¶ 76. Trial protocol would have suggested that the treatment earmarked for Subject

1003 was safe as the investigational product required 10-12 weeks to manufacture. As such, Subject 1005 who received sham leukapheresis in January 2024 could not have contributed to the product assigned to Subject 1003. ECF No. [40] ¶ 77. Following the incident, Alzamend presented Biorasi with a protocol waiver, which would have allowed the study to continue. ECF No. [40] ¶ 81. The Biorasi VP asserted that administering the treatment to Subject 1003 could jeopardize the Principal Investigator’s medical license. ECF No. [40] ¶ 82. On January 24, 2025, the Principal Investigator and First Excellence Research Clinic withdrew from the study. ECF No. [40] ¶ 83. Alzamend was in a blinded position and unaware this was happening. ECF. No. [40] ¶ 84. The Biorasi VP did not report her concerns about potentially unaccounted-for blood samples to Alzamend. ECF No. [40] ¶ 86. With the sole clinical site and its lead investigator gone, the ALZN002 Trial could no longer proceed. ECF. No. [40] ¶ 85. On January 30, 2024, Alzamend held a conference call with Biorasi, the Principal

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