AbbVie Inc. v. Adcentrx Therapeutics Inc.

District Court, S.D. California·Decided February 6, 2025·No. 3:23-cv-02290·Unknown

Opinion

ABBVIE INC., a Delaware corporation, Case No.: 23-CV-2290 TWR (DEB)

Plaintiff, ORDER (1) DENYING MOTION v. TO COMPEL ARBITRATION, (2) DENYING AS MOOT MOTIONS TO STAY, AND a Delaware corporation; DONG JUN (3) DENYING MOTIONS TO (Danny) LEE, an individual; and DOES DISMISS 1–10,

Defendants. (ECF Nos. 32, 33)

Presently before the Court are the Motion to Stay Pending Arbitration of Claims Against Dr. Lee, or Alternative Motion to Dismiss (“Adcentrx Mot.,” ECF No. 32) filed by Defendant Adcentrx Therapeutics Inc. (“Adcentrx”) and Motion to Compel Arbitration and Stay Proceedings or, in the Alternative, to Dismiss the First Amended Complaint (“Lee Mot.,” ECF No. 33) (together, the “Mots.”) filed by Defendant Dong Jun (Danny) Lee, as well as the Opposition (“Opp’n,” ECF No. 35) filed by Plaintiff AbbVie, Inc. (“AbbVie”) and Defendants’ joint Reply (“Reply,” ECF No. 36). The Court held a hearing on December 19, 2024. (See generally ECF No. 37; see also ECF No. 38 (“Tr.”).) Upon consideration of the Parties’ arguments, Plaintiff’s First Amended Complaint (“FAC,” ECF No. 29), the record, and the applicable law, the Court DENIES Dr. Lee’s Motion to compel AbbVie to arbitration, DENIES AS MOOT Dr. Lee’s and Adcentrx’s Motions to stay pending arbitration of AbbVie’s claims against Dr. Lee, and DENIES Dr. Lee’s and Adcentrx’s Motions to dismiss. I. Factual Background1 A. AbbVie “AbbVie is a global biopharmaceutical company headquartered in North Chicago, Illinois.” (FAC ¶ 28.) “AbbVie was formed as an independent company in 2013, following its separation from Abbott Laboratories.” (Id.) “In 2015, AbbVie began the MTi (microtubule inhibitor) [antibody drug conjugate (“ADC”)] program [(the “MTi ADC program”)], which focused on developing new ADCs that incorporated microtubule inhibitors (“MTi”) as anti-cancer payloads/linker-drugs.” (Id. ¶ 31.) “Unlike conventional chemotherapy, ADCs are targeted medicines that selectively deliver anti-cancer payloads directly to cancer cells.” (Id. ¶ 30.) “ADCs comprise (i) a monoclonal antibody that binds to a specific target (antigen) on the surface of a cancer cell, plus (ii) an anti-cancer payload which is attached (conjugated) to the antibody through (iii) a chemical linker.” (Id.) “The combination of the anti-cancer payload and the linker is typically referred to as a ‘linker-drug.’” (Id. ¶ 2.) “AbbVie’s MTi ADC program aimed to improve upon clinical stage and FDA- approved MTi ADC products such as ADCETRIS®.” (Id. ¶ 31.) “These clinical stage and FDA-approved products were predominantly based on the monomethyl auristatin E

1 For purposes of Defendants’ motions to dismiss, the Court “must accept as true all material allegations in the complaint, as well as any reasonable inferences to be drawn from them,” and construe AbbVie’s First Amended Complaint “in the light most favorable to the plaintiff.” See Broam v. Bogan, 320 F.3d 1023, 1028 (9th Cir. 2003). In resolving Dr. Lee’s motion to compel arbitration, however, “district courts rely on the summary judgment standard of Rule 56 of the Federal Rules of Civil Procedure.” See Hansen v. LMB Mortg. Servs., Inc., 1 F.4th 667, 670 (9th Cir. 2021). Accordingly, “the Court will consider the substance of evidence that would be admissible at trial.” See S.S. ex rel. Stern v. Peloton Interactive, Inc., 566 F. Supp. 3d 1019, 1044 (S.D. Cal. 2021) (citing Dinkins v. Schinzel, 362 F. (“MMAE”) platform developed by Seattle Genetics (“SeaGen”).” (Id.) “AbbVie’s MTi ADC program sought to develop novel payload designs and novel linker-drug designs not based on the MMAE platform, to create highly effective, novel MTi ADCs.” (Id.) In May 2015, AbbVie acquired Pharmacyclics, Inc., thereby becoming Pharmacyclics LLC (“PCYC”), a wholly owned subsidiary of AbbVie. (See ECF No. 32- 1 (“Lee Decl.”) ¶ 5; ECF No. 32-2 (“Ex. 1”).) B. Dr. Lee’s Employment with AbbVie “AbbVie hired Lee as an ADC Chemist/Senior Scientist in February of 2015.” (FAC ¶ 32). “As a condition of his employment with AbbVie, on February 2, 2015, Lee and AbbVie executed an Employment Agreement.” (Id. ¶ 146; see also generally ECF No. 29- 5 (“Ex. E”).) This Employment Agreement included certain Inventions Assignment Provisions providing that AbbVie owned all of Dr. Lee’s inventions during his employment with AbbVie, (see FAC ¶¶ 149–51, 153, 204, 205; Ex. E ¶¶ 3–5), and Confidentiality Provisions prohibiting Dr. Lee from disclosing or using AbbVie’s confidential information for any purposes outside his employment with AbbVie. (See FAC ¶¶ 149, 152, 154, 215, 216; Ex. E ¶¶ 2, 3, 8.) “Beginning in or around the fall of 2015, Lee worked on a team of chemists who designed and synthesized payloads that were part of AbbVie’s MTi ADC program.” (FAC ¶ 32.) “Thereafter, Lee quickly established himself as one of the key scientists in AbbVie’s MTi ADC program, where Lee dedicated the bulk of his time from late 2015 until he left for PCYC in January 2019.” (Id.) Dr. “Lee’s role in AbbVie’s MTi ADC program was primarily to design, synthesize, and evaluate AbbVie proprietary payload and linker-drug designs.” (Id. ¶ 33.) Dr. “Lee tracked the payloads he designed and synthesized by using his initials: DJL (for Dong Jun Lee),” i.e., Dr. “Lee designated the first payload he designed and synthesized while employed at AbbVie as DJL-1, the second as DJL-2, and so on.” (See id. (emphasis in original).) / / / Of particular significance to the instant action are payload designs DLJ-43 (also referred to as ABBV-1), which Dr. Lee synthesized on November 8, 2016, and DLJ-51, which Dr. Lee synthesized no later than January 4, 2017. (See id. 4948, 49.) The structural formulas of DJL-43/ABBV-1 and DLJ-51/ABBV-2 are depicted below: ne ~ ABBV - 1 - 4 OL Peps ry □□ se ABBV-2 hy A vt a Oo. Oo oO oO id. 9 45.) “ABBV-1 has (4) an ortho-oriented anilino moiety at the C-terminus [green box], and (11) a tertiary amine-based hydrophilic moiety at the N-terminus [blue box].” (/d. 46.) “ABBV-2 has a (i) meta-oriented anilino moiety at the C-terminus [orange box], /and (ii) a tertiary amine-based hydrophilic moiety at the N-terminus [blue box].” (/d.) “These compounds and their designs—including the orientation of the structural components at the C- and N-terminus—are among the AbbVie payload trade secret information.” (/d. 47.) “Documents created by Lee describing his work on DJL-43 and DJL-51 characterize these MTi-ADC payloads as ‘novel.’” (Ud. 4 50.) C. Dr. Lee’s Employment with Pharmacyclics LLC “In the second half of 2018, [Dr. Lee] became interested in potentially moving to California.” (Lee Decl. § 8.) Dr. Lee therefore explored the option of transferring from AbbVie, in Chicago, to PCYC, in Sunnyvale, (see id. J 9), and “communicated [his] desire to relocate [to California] via an internal transfer to [his] mentor Dr. Anthony Haight and to [his] manager Dr. Dennie Welch at AbbVie.” (See id. § 11.) “On or around September 25, 2018, Dr. Jeff Zablocki, the recently appointed head of medicinal chemistry at PCYC, visited the AbbVie Lake County facility . . . for an

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AbbVie Inc. v. Adcentrx Therapeutics Inc., (S.D. Cal. 2025).

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