Wisconsin Alumni Research Foun v. Xenon Pharmaceutical

CourtCourt of Appeals for the Seventh Circuit
DecidedJanuary 5, 2010
Docket08-1351
StatusPublished

This text of Wisconsin Alumni Research Foun v. Xenon Pharmaceutical (Wisconsin Alumni Research Foun v. Xenon Pharmaceutical) is published on Counsel Stack Legal Research, covering Court of Appeals for the Seventh Circuit primary law. Counsel Stack provides free access to over 12 million legal documents including statutes, case law, regulations, and constitutions.

Bluebook
Wisconsin Alumni Research Foun v. Xenon Pharmaceutical, (7th Cir. 2010).

Opinion

In the

United States Court of Appeals For the Seventh Circuit

Nos. 08-1351 & 06-3901

W ISCONSIN A LUMNI R ESEARCH FOUNDATION, Plaintiff-Appellee/ Cross-Appellant, v.

X ENON P HARMACEUTICALS, INC.,

Defendant-Appellant/ Cross-Appellee.

Appeals from the United States District Court for the Western District of Wisconsin. No. 05 C 242—Barbara B. Crabb, Chief Judge.

A RGUED D ECEMBER 8, 2008—D ECIDED JANAURY 5, 2010

Before E ASTERBROOK, Chief Judge, and B AUER and S YKES, Circuit Judges. S YKES, Circuit Judge. This case arises out of a complex set of contractual relationships between the Wisconsin Alumni Research Foundation, the patent-management entity for the University of Wisconsin; certain research 2 Nos. 08-1351 & 06-3901

scientists at the University; and Xenon Pharmaceuticals, a Canadian drug company. The Foundation and Xenon jointly own the patent rights to an enzyme that can lower cholesterol levels in the human body. The enzyme’s cholesterol-reducing benefits were discovered and con- firmed by scientists at the University whose research was sponsored in part by Xenon. In 2001, pursuant to an option agreement between the Foundation and Xenon, the Foundation gave Xenon an exclusive license to com- mercialize this discovery and market any resulting prod- ucts in exchange for a share of the profits. The Foundation brought this suit against Xenon alleging violations of its contract rights and seeking damages and declaratory relief. First, the Foundation alleged that Xenon sublicensed its interest in the patented enzyme to a third party but refused to pay the Founda- tion a percentage of the sublicense fees as required under the 2001 license agreement. Second, the Foundation alleged that Xenon wrongly asserted ownership over a set of therapeutic compounds developed from the jointly patented enzyme; the Foundation claimed that it owned rights to these compounds pursuant to its network of written agreements with Xenon and the University re- searcher who confirmed the therapeutic benefits of the compounds. Xenon counterclaimed against the Founda- tion, and on cross-motions for summary judgment, the district court ruled in the Foundation’s favor on the breach-of-contract claim and in Xenon’s favor on the dispute over ownership of the compounds. A jury awarded $1 million in damages for the breach of contract; the Foundation accepted $300,000 after Xenon successfully moved for remittitur. Both parties appealed. Nos. 08-1351 & 06-3901 3

We affirm in part and reverse in part and remand for entry of judgment consistent with this opinion. The district court properly granted summary judgment for the Foundation on the breach-of-contract claim. Xenon breached its license agreement with the Foundation by granting a sublicense in the jointly patented enzyme to a third party without paying the Foundation its share of the sublicense fees. A subsidiary issue is whether Xenon’s breach triggered the Foundation’s right to termi- nate the agreement. We conclude that the district court should not have voided the Foundation’s attempt to do so; the Foundation was entitled to and properly termi- nated the agreement. We also conclude the district court erroneously entered judgment for Xenon on the issue of the Foundation’s claim to an ownership interest in the compounds. Under the web of contracts at issue here, the Foundation was entitled to a declaration of its owner- ship interest in the compounds.

I. Background Researchers at the University of Wisconsin became interested in an enzyme called Stearoyl CoA Desaturase (“SCD”) because of its potential to help treat diabetes, obesity, and other diseases by lowering cholesterol. In 1999 the researchers discovered that suppressing SCD levels in the human body lowered cholesterol levels. Pursuant to University policy, the researchers dis- closed their research results to the Foundation and in January 2000 signed a Memorandum Agreement assigning all their rights in the discovery to the Founda- 4 Nos. 08-1351 & 06-3901

tion. The next month, the Foundation filed a provisional patent application for the discovery. Meanwhile, Xenon, a Canadian pharmaceutical company that was collaborating with the University on research into a separate enzyme, learned of the Univer- sity’s discoveries and expressed interest in jointly pursuing SCD research. The University and Xenon entered into a series of research agreements (referred to as Research Agreements 1, 2, and 3) in which Xenon agreed to jointly sponsor various SCD research projects with the University. Each research agreement identified the scope of the research, the principal researcher, the expected cost, and the period of performance.1 These agreements also referred to a separate Sponsor Option Agreement between the Foundation and Xenon that governed ownership of any discoveries arising from the joint research program. The Sponsor Option Agreement cross-referenced the contracts between the Foundation and the individual University researchers requiring the researchers to assign to the Foundation any property rights in the discoveries emanating from the research and gave Xenon an exclusive option to license any resulting

1 The joint research program ran into problems in November 2002 when Xenon and the University became embroiled in a funding dispute. The University claimed that Xenon had fallen behind on payments for the sponsored research, and as a result the University had to turn to federal funds to fill the gap. Xenon denied that it owed the University any additional money. A year later, Xenon and the University settled this dispute and signed a Settlement and Release Agreement. Nos. 08-1351 & 06-3901 5

technology.2 Attached to the Sponsor Option Agreement were the individual contracts between the Foundation and the University researchers. At the same time that Xenon signed its first research agreement with the University, Xenon also entered into a series of short-term consulting agreements with individ- ual researchers at the University who worked on SCD projects. In exchange for consulting fees, these scientists undertook specific research projects for Xenon and agreed to assign any discoveries arising from these consulting projects to Xenon. In February 2001 Xenon and the Foundation filed a joint patent application deriving from the provisional patent application the Foundation had filed in 2000. The application covered, among other things, the SCD enzyme itself and a method (called an assay) of using the enzyme to identify compounds that lower SCD levels. A patent issued for the assay, but the patent application covering the remaining claims is still pending. Also in February 2001, Xenon exercised its option under the Sponsor Option Agreement to an exclusive license for any discoveries arising from the Xenon-sponsored SCD research at the University. As a result Xenon and the Foundation entered into an Exclusive License Agree- ment giving Xenon an exclusive right to make, use, and sell patented products under the joint patent application within the field of human healthcare. In exchange for

2 The Sponsor Option Agreement was executed in February 2000 but backdated to September 1999. 6 Nos. 08-1351 & 06-3901

these exclusive rights, Xenon agreed to pay the Founda- tion a percentage of any product sales, royalties, or sublicense fees it received. After receiving the exclusive license, Xenon worked with Discovery Partners, Inc., to help identify compounds that inhibit the SCD enzyme. Using the jointly patented assay, Discovery Partners screened thousands of com- pounds and identified a set of 20 (referred to as the PPA compounds) with the potential to suppress SCD levels. Xenon shipped the PPA compounds to Mark Gray-Keller, a University researcher with whom it had a consulting agreement, for confirmatory testing.

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