The State of North Carolina v. Chas. Pfizer & Co., Inc.

537 F.2d 67, 189 U.S.P.Q. (BNA) 262
CourtCourt of Appeals for the Fourth Circuit
DecidedJanuary 12, 1976
Docket74-2154
StatusPublished
Cited by23 cases

This text of 537 F.2d 67 (The State of North Carolina v. Chas. Pfizer & Co., Inc.) is published on Counsel Stack Legal Research, covering Court of Appeals for the Fourth Circuit primary law. Counsel Stack provides free access to over 12 million legal documents including statutes, case law, regulations, and constitutions.

Bluebook
The State of North Carolina v. Chas. Pfizer & Co., Inc., 537 F.2d 67, 189 U.S.P.Q. (BNA) 262 (4th Cir. 1976).

Opinion

FIELD, Circuit Judge:

Alleging violations of sections 1 and 2 of the Sherman Act, the State of North Carolina instituted this action for damages on behalf of itself, its governmental subdivisions and all citizen consumers who had purchased broad-spectrum antibiotics manufactured and sold by the defendants in North Carolina during the period 1952 to 1966. The defendants are Chas. Pfizer & Co., Inc. (Pfizer), American Cyanamid Company (Cyanamid), Bristol-Myers (Bristol), Olin-Mathieson Chemical Corporation (Squibb), and The Upjohn Company (Upjohn).

The thrust of the plaintiff’s case is that Pfizer, aided by Cyanamid, obtained the Conover patent 1 on the antibiotic, tetracycline, by conduct which amounted to a fraud on the Patent Office and thereafter, in combination with the other defendants, exploited it for the purposes of restraining and monopolizing trade and commerce in the broad-spectrum antibiotic market and particularly the tetracycline market. 1a The case was tried to the court without a jury, and after an extended trial the district judge filed an opinion containing his findings of fact and conclusions of law. 2 The court concluded that the plaintiff had failed to establish that the defendants had violated the Sherman Act, or that Pfizer was guilty of fraudulent procurement or misuse of the Conover patent. Accordingly, judgment was entered in favor of the defendants and North Carolina has appealed.

North Carolina’s appeal presents two issues: (1) Whether the district court erred as a matter of law when it denied the plaintiff’s motion for partial summary judgment on the basis of collateral estoppel that Pfizer and Cyanamid had caused the Conover patent to be issued by defrauding the United States Patent Office; and (2) whether the district court’s findings of fact were clearly erroneous.

The Conover patent has been involved, either directly or indirectly, in extensive litigation commencing with a proceeding before the Federal Trade Commission (Commission) in 1958, and the background of the present controversy has been chronicled in a number of decisions. 3 The relevant facts developed in the district court are as follows. Prior to 1952 three effective and patented broad-spectrum antibiot *70 ics were produced and marketed. They were Aureomycin which was.produced by Cyanamid and was covered by the Duggar patent, U.S. Patent No. 2,482,055 and the Niedercorn patent, U.S. Patent No. 2,609,-329; Terramycin which was produced by Pfizer and was covered by the Sobin patent, U.S. Patent No. 2,516,080; and Chloromycetin which was patented and produced by Parke-Davis. Parke-Davis is not a party to the present litigation. None of these three manufacturers granted licenses or cross-licenses for these particular drugs. Each of the antibiotics are prescription drugs and their sales are largely dependent upon the physician’s opinion of their effectiveness. Since they have a high degree of interchangeability, each manufacturer priced his drugs at a level competitive with the other two producers, thereby creating a stable and parallel price structure, and price reductions by one manufacturer were met by the others during these years.

Prior to 1952, neither the molecular structure of Terramycin nor that of Aureomycin was known, and Dr. Conover, a Pfizer scientist, was a member of a research team which was seeking to determine the structure of Pfizer’s Terramycin. In the spring of 1952 the Pfizer team succeeded in ascertaining the structures of both Terramycin and Aureomycin. Shortly thereafter, Dr. Conover discovered that another antibiotic, tetracycline, could be produced by the application of a deschlorination process to Aureomycin. Pfizer filed the Conover application for a product and process patent on tetracycline in October of 1952, and in March of 1953 Cyanamid filed its BootheMorton. application for a similar patent. In addition to these two applications, in September of 1953 Heyden Chemical Corporation filed its Minieri application 4 for a patent on tetracycline and the fermentation process for producing it, and in October, 1953, Bristol filed a similar application under the name of Heinemann.

The competing claims of Pfizer and Cyan-amid resulted in the declaration of an interference by Herbert J. Lidoff, the Patent Examiner, in December of 1953. While Pfizer believed that it possessed priority of invention, it was aware that its sole method of tetracycline production depended upon the application of the deschlorination process to Cyanamid’s patented Aureomycin thereby making it wholly dependent upon Cyanamid for its supply of bulk Aureomycin. In an attempt to resolve the question, representatives of the two companies worked out an agreement providing (1) that the parties would exchange proof of priority and that the prevailing party would grant a nonexclusive license to the other in consideration of a fixed royalty; (2) that Cyanamid would grant Pfizer a nonexclusive license to produce Aureomycin for use in tetracycline production; and (3) that Cyanamid would sell to Pfizer an initial quantity of bulk tetracycline so that Pfizer might immediately enter the tetracycline market. After an exchange of proofs relative to the discovery Cyanamid conceded priority to Pfizer and, upon this concession, the Patent Office terminated the interference.

In the meantime, Bristol continued the prosecution of its Heinemann application, and in March of 1954 the Examiner declared a second interference between the Heinemann, Conover and Cyanamid’s Minieri applications. The interference proceeding continued until October 14, 1954, on which date the Examiner dissolved the interference, primarily on the ground that tetracycline was unpatentable over the pri- or art as disclosed in Cyanamid’s Duggar and Niedercorn patents because tetracycline, as well as Aureomycin, appeared to be co-produced in fermentation processes disclosed by those two prior patents. There *71 after, in November of 1954 the Examiner issued rejections on all of the claims in the Conover, Minieri and Heinemann applications. Following this dissolution of the second interference Pfizer continued the ex parte prosecution of the Conover application and endeavored to convince Examiner Lidoff that he was in error. Subsequently, Lidoff requested Pfizer to run tests on “Example 28” which was one of the forty-four samples of media contained in the Niedercorn patent. Pfizer conducted the tests to determine whether tetracycline could be recovered from “Example 28” using the recovery procedures described in the BogertWalsh, 5 Minieri and Heinemann applications. Based upon these tests Pfizer submitted affidavits to the Examiner, reporting that efforts to recover products clearly identifiable as tetracycline from the “Example 28” fermentation broths were unsuccessful. Following the submission of further information by Pfizer, Examiner Li-doff withdrew his previous rejection and allowed the Conover application. The patent on tetracycline and the deschlorination process was issued to Pfizer on January 11, 1955.

I

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Bluebook (online)
537 F.2d 67, 189 U.S.P.Q. (BNA) 262, Counsel Stack Legal Research, https://law.counselstack.com/opinion/the-state-of-north-carolina-v-chas-pfizer-co-inc-ca4-1976.