The Research Institute at Nationwide Children’s Hospital v. Illumina, Inc.

District Court, D. Delaware·Decided September 18, 2026·No. 1:25-cv-00683·Unknown

Opinion

IN THE UNITED STATES DISTRICT COURT FOR THE DISTRICT OF DELAWARE

THE RESEARCH INSTITUTE AT ) NATIONWIDE CHILDREN’S HOSPITAL, ) ) Plaintiff, ) ) v. ) C.A. No. 25-683-JLH-EGT ) ILLUMINA, INC., ) ) Defendant. )

REPORT AND RECOMMENDATION

Presently before the Court is the motion of The Research Institute at Nationwide Children’s Hospital (“Plaintiff” or “NCH”) to dismiss Illumina, Inc.’s (“Defendant” or “Illumina”) equitable estoppel, implied license and patent misuse counterclaims and to strike certain related affirmative defenses. (D.I. 23). For the reasons set forth below, the Court recommends that Plaintiff’s motion be GRANTED-IN-PART and DENIED-IN-PART. I. BACKGROUND NCH is the assignee of U.S. Patent No. 9,552,458 (“the ’458 Patent”), which is generally directed to systems and methods for determining and analyzing an individual’s genomic sequence. (D.I. 1 ¶¶ 8, 13-15). The ’458 Patent purports to improve on prior systems by splitting genetic sequence data into subsets, thus allowing for parallel processing that can reduce computation times and improve reproducibility. (Id. ¶¶ 30, 35). Illumina develops and markets genetic sequencing systems. In 2018, Illumina acquired Edico Genome, Inc., the creator of a suite of genetic sequence analysis tools called DRAGEN Bio- IT (“DRAGEN”). (D.I. 1 ¶ 41; see also D.I. 32, Ex. A at 1). Later that year, Illumina was contacted by GenomeNext LLC (“GenomeNext”) – an exclusive licensee of the ’458 Patent – to discuss Illumina potentially acquiring GenomeNext and its rights to the ’458 Patent. (D.I. 21 at 13 ¶ 9 & 30 ¶ 30). Nothing seemingly came of this discussion. (See id. at 16-18 ¶¶ 13-14). Then, in September 2019, NCH gave a similar presentation to Illumina on the benefits of the ’458 Patent. (Id. at 18-20 ¶¶ 14-15). This time, Illumina declined a license to the ’458 Patent. (Id. at 22 ¶ 17).

In November 2023 – nearly four years after Illumina declined NCH’s initial offer – NCH again reached out to Illumina, suggesting that Illumina “may wish to have its patent counsel examine” the ’458 Patent in view of the DRAGEN system. (D.I. 21 at 22-23 ¶ 18). Illumina responded to NCH in February 2024, stating that it did not believe the ’458 Patent was infringed or valid but invited NCH to further explain why Illumina’s positions were wrong. (See D.I. 21 at 23-25 ¶¶ 19-20; see also D.I. 21, Ex. I). In May 2025, NCH finally responded to Illumina’s assertions of invalidity and non-infringement, calling Illumina’s claims “conclusory” and “without factual support.” (D.I. 21 at 25 ¶ 21). NCH filed this case four days later, accusing Illumina of infringing the ’458 Patent. (See D.I. 1). On August 11, 2025, Illumina responded to NCH’s complaint by asserting several

declaratory judgment counterclaims and affirmative defenses. (See D.I. 11). On September 23, 2025 and in response to a motion to dismiss filed by NCH (D.I. 15), Illumina amended its answer and counterclaims (D.I. 21). On October 7, 2025, NCH filed the present motion, which seeks to dismiss Illumina’s counterclaims of equitable estoppel, implied license and patent misuse, as well as to strike the related affirmative defenses and the defense of waiver. (See D.I. 23 & 24). The motion is fully briefed. (D.I. 32 & 35). II. LEGAL STANDARDS A. Motion to Dismiss for Failure to State a Claim In ruling on a motion to dismiss pursuant to Federal Rule of Civil Procedure 12(b)(6), the Court must accept all well-pleaded factual allegations in the complaint as true and view them in the light most favorable to the plaintiff. See Mayer v. Belichick, 605 F.3d 223, 229 (3d Cir. 2010); see also Phillips v. Cnty. of Allegheny, 515 F.3d 224, 232-33 (3d Cir. 2008). “[A] court need not ‘accept as true allegations that contradict matters properly subject to judicial notice or by exhibit,’ such as the claims and the patent specification.” Secured Mail Sols. LLC v. Universal Wilde, Inc.,

873 F.3d 905, 913 (Fed. Cir. 2017) (quoting Anderson v. Kimberly-Clark Corp., 570 F. App’x 927, 931 (Fed. Cir. 2014)). Dismissal under Rule 12(b)(6) is only appropriate if a complaint does not contain “sufficient factual matter, accepted as true, to ‘state a claim to relief that is plausible on its face.’” Ashcroft v. Iqbal, 556 U.S. 662, 678 (2009) (quoting Bell Atl. Corp. v. Twombly, 550 U.S. 544, 570 (2007)); see also Fowler v. UPMC Shadyside, 578 F.3d 203, 210 (3d Cir. 2009). B. Motion to Strike Under Federal Rule of Civil Procedure 12(f), a party may move to strike from a pleading an insufficient defense or other matter that is “redundant, immaterial, impertinent, or scandalous.” FED. R. CIV. P. 12(f). Motions to strike are generally disfavored and a court should not strike a defense unless the “insufficiency of the defense is clearly apparent.” Cipollone v. Liggett Grp., 789 F.2d 181, 188 (3d Cir. 1986) (cleaned up); see also Proctor & Gamble Co. v. Nabisco Brands,

Inc., 697 F. Supp. 1360, 1362 (D. Del. 1988) (court should construe all facts in favor of non- movant and allow defense to proceed if “sufficient under law”). That being said, a court need not “accept affirmative defenses that are mere bare bones conclusory allegations” and “may strike such inadequately pleaded defenses.” IOENGINE, LLC v. PayPal Holdings, Inc., C.A. No. 18-452- WCB, 2019 WL 2121395, at *2 (D. Del. May 15, 2019) (Bryson, J., sitting by designation). III. DISCUSSION Based on the ’458 Patent discussions with GenomeNext and NCH, Illumina asserts counterclaims and related affirmative defenses based on equitable estoppel, implied license and patent misuse. (D.I. 21 at 12-43 ¶¶ 6-60). Illumina also asserts a waiver defense based on the licensing discussions. (Id. at 47-69 ¶¶ 19-60). NCH seeks dismissal of these counterclaims and to strike the four affirmative defenses. The Court addresses the counterclaims and affirmative defenses in turn. A. Equitable Estoppel Counterclaim Equitable estoppel is “an absolute bar” to recovery for patent infringement. John Bean

Techs. Corp. v. Morris & Assocs., 887 F.3d 1322, 1327 (Fed. Cir. 2018). To prevail on a theory of equitable estoppel, a party must show that: “(1) the patentee engage[d] in misleading conduct that leads the accused infringer to reasonably infer that the patentee does not intend to assert its patent against the accused infringer; (2) the accused infringer relies on that conduct; and (3) as a result of that reliance, the accused infringer would be materially prejudiced if the patentee is allowed to proceed with its infringement action.” Id. NCH argues that Illumina fails to adequately plead the elements of misleading conduct and material prejudice. (D.I. 24 at 7-13). In particular, NCH insists that it did not threaten to sue Illumina and thus the ensuing silence cannot be misleading and, further, that Illumina’s alleged prejudice is not legally cognizable. (Id.). As to the first element, although “attempts to negotiate licenses . . . followed by a period

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The Research Institute at Nationwide Children’s Hospital v. Illumina, Inc., (D. Del. 2026).

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