Roche Molecular Systems, Inc. v. Foresight Diagnostics Inc.

District Court, N.D. California·Decided July 16, 2025·No. 5:24-cv-03972·Unknown

Opinion

ROCHE MOLECULAR SYSTEMS, INC., Case No. 24-cv-03972-EKL et al., Plaintiffs, ORDER GRANTING IN PART AND DENYING IN PART DEFENDANT v. FORESIGHT DIAGNOSTICS, INC.’S FORESIGHT DIAGNOSTICS INC., et al., Re: Dkt. No. 103 Defendants.

This action arises out of the Defendants’ alleged misappropriation of Plaintiffs’ trade secrets. Defendant Foresight Diagnostics, Inc. moves to dismiss the first amended complaint. Mot. to Dismiss, ECF No. 103 (“Mot.”). The Court carefully reviewed the parties’ briefs and heard argument on April 30, 2025. For the reasons discussed below, the motion is GRANTED without prejudice as to Count 3 (Delaware Uniform Trade Secrets Act, 6 Del. Code § 2001 et seq. (“DUTSA”)), Count 8 (California Unfair Competition Law, Bus. And Prof. Code § 17200 et seq. (“UCL”)), and Count 9 (Unfair Competition under Delaware Common Law), and DENIED as to Count 1 (Defend Trade Secrets Act, 18 U.S.C. § 1836 et seq. (“DTSA”)), Count 2 (California Uniform Trade Secrets Act, Cal. Civ. Code § 3426 et seq. (“CUTSA”), and Count 10 (Declaratory Judgment of Ownership).1 1 After hearing, the parties agreed that Plaintiffs may amend the complaint to convert their DUTSA claim in Count 3 into CUTSA claims, so that Plaintiffs’ state law trade secret claims against Defendants Foresight Diagnostics, Inc., Arash Alizadeh, and Maximilian Diehn will proceed under the CUTSA in Count 2. Plaintiffs have also agreed to withdraw Count 8, under the UCL, and Count 9, for common law unfair competition under Delaware law, reserving the right to seek leave to amend if discovery reveals additional facts establishing unfair competition. See Status Report at 7, ECF No. 162. Thus, the Court dismisses Counts 3, 8, and 9 without prejudice, I. FACTUAL BACKGROUND2 This case involves claims by Roche Molecular Systems, Inc. and Roche Sequencing Solutions, Inc. (collectively, “Roche”) against three former consultants, and the company they founded, for misappropriation of Roche’s trade secrets. The three former consultants are Stanford University (“Stanford”) oncologists Maximilian Diehn (“Dr. Diehn”), Arash A. Alizadeh (“Dr. Alizadeh”), and David Kurtz (“Dr. Kurtz”) (together, the “Doctors”). The Doctors founded Foresight Diagnostics Inc. (“Foresight”) in 2020, while working for Roche. Together, the Doctors allegedly misappropriated Roche’s trade secrets relating to methods for detecting and monitoring certain types of cancer, and developed a competing technology with Stanford, which Stanford licensed to Foresight for commercial development. Below, the Court summarizes the relevant allegations. A. Development of CAPP-Seq and Founding of CappMed Drs. Diehn and Alizadeh developed CAPP-Seq, a novel DNA sequencing method for tracking circulating tumor DNA in the bloodstream.3 First Am. Compl. ¶ 39, ECF No. 87 (“FAC”); id. Ex. 3, ECF No. 101-2. In March 2013, Stanford filed U.S. Provisional Patent Application 61/798,925 (“’925 Application”), which covered CAPP-Seq, and named Drs. Diehn and Alizadeh as inventors.4 Decl. of Alan Heinrich (“Heinrich Decl.”) Ex. A, ECF No. 104-1. In October 2013, Drs. Diehn and Alizadeh founded Capp Medical, Inc. (“CappMed”) to commercialize the CAPP-Seq technology. FAC ¶ 39. In April 2014, Stanford granted CappMed an exclusive license to the ’925 Application (“Stanford Agreement”). Id. ¶ 40. Under the Stanford Agreement, Stanford and Drs. Diehn and Alizadeh received equity in CappMed. Id. 2 This Order assumes familiarity with the facts of the case, and discusses the facts to the extent they are relevant to this motion and the related motions filed by Stanford, Maximilian Diehn, Arash A. Alizadeh, and David Kurtz. 3 CAPP-Seq stands for “cancer personalized profiling by deep sequencing[.]” FAC ¶ 10. 4 The Court GRANTS Foresight’s unopposed request for judicial notice of patent applications 61/798,925, PCT/US/2014/025020, and 62/931,688, and Patent No. 11,085,084. Heinrich Decl. Exs. A-D, ECF Nos. 104-1, 104-2, 104-3, 104-4. The Court may take judicial notice of patents as public records. Vineyard Investigations v. E. & J. Gallo Winery, 510 F. Supp. 3d 926, 942 n.4 ¶ 41. B. Roche’s Acquisition of CappMed and Execution of Non-Competition and Non- Disclosure Agreements With the Doctors In 2015, Roche acquired CappMed, including “all of CappMed’s assets and intellectual property, including all patent rights, trade secrets, and know-how relating to the CAPP-Seq technology[.]” FAC ¶ 47. “Roche’s goal was to incorporate CappMed’s technology into commercially viable products for non-invasive cancer detection and monitoring of certain cancers in patients.” Id. ¶ 50. In connection with the acquisition, Stanford and CappMed executed a Fourth Amendment to the Stanford Agreement whereby Stanford “‘consent[ed] to any deemed assignment by CappMed of the [Stanford] Agreement in connection with’ the Acquisition.” Id. ¶ 48; id. Ex. 4, ECF No. 159-3. Following the acquisition, Roche hired Drs. Diehn and Alizadeh to further develop the CAPP-Seq technology. FAC ¶ 4. Drs. Diehn and Alizadeh entered into two-year non-competition agreements (“Non-Competition Agreements”) and consulting services agreements (“Consulting Agreements”) with Roche. Id. ¶ 52; id. Ex. 1, ECF No. 159-1 (“Consulting Agreements”), Ex. 5, ECF No. 159-4 (“Non-Competition Agreements”). Under the Non-Competition Agreements, Drs. Diehn and Alizadeh agreed not to compete with Roche or CappMed by conducting research other than “Permitted Clinical Research” as defined therein. Id. ¶ 53. Under the Consulting Agreements, Roche acknowledged that Drs. Diehn and Alizadeh were Stanford employees subject to “certain obligations to Stanford regarding ownership of intellectual property,” and required Drs. Diehn and Alizadeh to provide notice of any conflicting obligations with Stanford. Id. ¶ 54. Drs. Diehn and Alizadeh also agreed to assign inventions conceived or developed during the contract period to Roche, id. ¶ 55, and agreed not to disclose confidential information, i.e., “technical information known to Drs. Diehn and Alizadeh through performance of consulting services with Roche,” id. ¶ 57. The Agreements were later extended through June 10, 2021. Id. ¶¶ 58-60. Roche also hired Dr. Kurtz to further develop the CAPP-Seq technology. Dr. Kurtz worked for Roche as a contractor from September 2017 to July 2020. FAC ¶ 4. Roche and Dr. Kurtz entered into a Proprietary Information and Invention Agreement (“Kurtz Agreement”). Id. Ex. 2, ECF No. 159-2. The Kurtz Agreement prohibited Dr. Kurtz from obtaining outside employment in Roche’s defined “Area of Interest” without Roche’s approval and required disclosure of inventions, discoveries, improvements, products, or devices in Roche’s Area of Interest during Dr. Kurtz’s employment. Id. ¶¶ 65-69; id. Ex. 2. C. Roche’s Improvements to CAPP-Seq and Development of Trade Secrets Roche alleges that it “extensively developed and made numerous improvements to” CAPP- Seq and iDES, CAPP-Seq’s associated “integrated digital error suppression” workflow. FAC ¶¶ 44, 74. Roche identifies nineteen trade secrets based on Roche’s acquisition and improvement of the CAPP-Seq/iDES technology: adapters; barcodes; biotinylated oligos (“probes” or “selectors”); blocking oligos; workflow; single-sample capture; algorithm for selector library generation; data polishing algorithm; adaptive variant caller algorithm; algorithm for filtering germline variants; SNV caller algorithm; indel (insertion-deletion) caller algorithm; fusion caller algorithm; CNV caller algorithm; cell of origin (COO) caller algorithm; Selector Library Files (BED Files); “blacklisted” genes; “whitelisted” genes; and detection of phased variants. Id. ¶¶ 86- 227. D. Defendants’ Development of PhasED-Seq and Launch of Foresight Roche al

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Roche Molecular Systems, Inc. v. Foresight Diagnostics Inc., (N.D. Cal. 2025).

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