Novocol Chemical Mfg. Co. v. Powers & Anderson Dental Co.

37 F. Supp. 594, 49 U.S.P.Q. (BNA) 322, 1941 U.S. Dist. LEXIS 3524
CourtDistrict Court, W.D. North Carolina
DecidedMarch 10, 1941
DocketNo. 28
StatusPublished

This text of 37 F. Supp. 594 (Novocol Chemical Mfg. Co. v. Powers & Anderson Dental Co.) is published on Counsel Stack Legal Research, covering District Court, W.D. North Carolina primary law. Counsel Stack provides free access to over 12 million legal documents including statutes, case law, regulations, and constitutions.

Bluebook
Novocol Chemical Mfg. Co. v. Powers & Anderson Dental Co., 37 F. Supp. 594, 49 U.S.P.Q. (BNA) 322, 1941 U.S. Dist. LEXIS 3524 (W.D.N.C. 1941).

Opinion

WEBB, District Judge.

The complainant seeks an injunction against the respondent, asking that the respondent be restrained from packaging the well known cartridge in a vacuumized bakelite cup. The respondent alleges that it has a right to use the bakelite vacuumized cup for shipping cartridges, and alleges that the Goldberg patent is void. As the respondent alleges, the Goldberg patent produces “nothing unknown and produces no new result by putting the old dental cartridges invented by Cook into an old tin can”.

[595]*595For many years before the Goldberg patent, it was generally known that air would discolor and finally destroy adrenalin, called in this suit epinephrin.

As an example of this public knowledge, the Journal of the American Pharmaceutical Association in 1914 published an article by C. P. Beckwith entitled “The Pharmacy of Adrenalin”. In this article the author, among other things, says: “Under the combined action of air and moisture, adrenalin is decomposed rapidly. It is well, therefore, to store the product away from strong light and heat in absolutely dry, closed bottles or tubes sealed airtight. So protected and hermetically sealed, it is probable that adrenalin would prove absolutely permanent. The oxygen of the air is destructive of adrenalin. Given good storage, the precaution most essential to the preservation of the commercial solution of adrenalin chloride is to minimize contact with air. The oxidation that occurs upon undue exposure is evidenced by change of color. The solution becomes pink, then red, then brown, and a brown precipitate settles out.”

Again, Dr. L. S. Fosdick, Professor of Chemistry at Northwestern University, as a witness before the Court, stated, in answer to this question: “Did you understand at that time (1933) that air caused the discoloration of the liquid (adrenalin) ?” “It was generally known, yes.”

He further said that the epinephrin (adrenalin) became discolored on the first day, if permitted to stand in air, and in a vacuum it remained from January to June 5 without any discoloration.

The Court asked Dr. Fosdick: “How long have you known that air would discolor this anesthetic (adrenalin) ?” And the Doctor answered: “I don’t know exactly, but I have studied chemistry for at least — that is, I knew it at least when I was an undergraduate in college — 15 years at least.”

Dr. Fosdick further swore that he was called in by the Minimax Company as a consultant in 1935, probably in August or September. “I developed the solution for them, and suggested that they put them up in vacuum package, due to the fact that air would cause oxidation of the bisulphite; or they could substitute the vacuum by any other inert gas or material.”

Again, he was asked: “You say you suggested in 1935 that they put this in vacuum?” To which the Doctor replied: “Or in an oxygen-free container. You can fill the can with an inert material, for instance. I told them they would have to exclude air from the package in order to preserve the alkalinity. I suggested that they could package them in vacuum or inert gas.”

By the Court: “Did you know this solution would turn yellow?” Ans. “I had been teaching it to my students for years. The plaintiff’s solution has the same constituents, but not perhaps the same proportions. I think they are identical.”

The Court: “You mean by that, if there were no bisulphite in this solution, the oxidation would take place much more quickly?” Ans. “In about 10 seconds. When you put this mixture (that is, this anesthetic solution) in a vacuum, you stop the oxidation of the bisulphite because the bisulphite is the first thing to oxidize in any of these solutions.”

The Doctor further stated that it was impossible to put enough bisulphite in the solution to prevent discoloration of the adrenalin.

“Q. As I understand you, the vacuum package now prevents the oxidation of the bisulphite, but the bisulphite protects the adrenalin? A. That is right.”

The Doctor further stated that he taught organic chemistry to dental students, that he gave them a fairly comprehensive review of the subject of anesthetics in general, and that he told them to make up their own solution, because the cartridge would oxidize, because the air leaks into the cartridge and causes an oxidation of the sulphite and adrenalin.

“I was teaching that in 1927, and the man there (at Northwestern University) before me was teaching it too.”

Samuel D. Goldberg, the original patentee, stated that he knew all along when he wás making his experiments that air would cause the solution to discolor; that he made his experiments to determine if air was getting into the solution.

“Q What were you doing these experiments for? Dr. Goldberg: It was not known conclusively at that time what was causing the discoloration.”

Dr. Goldberg stated further: “The next thing after I satisfied myself that the exclusion of the air from the bottle had prevented discoloration, I went to the American Can Company.”

“The Court: You knew all along that the air would discolor the solution? A. [596]*596Yes, but I did not know that air was getting into the cartridge until these experiments convinced me. That was about October, 1934, and I got the cans from the Continental Can Company abput April, 1935, but the vacuum-sealed tin cans were put on the market about October 1, 1935, and the patent was granted August 18, 1936, although I made application for it on May 10, 1935.”

Dr. Nevin, the president of the complainant company, stated in substance that he had always known that air would discolor adrenalin, that it first produces a pink coloration, then brown, then a chocolate color.

Another witness for the complainant, Dr. Harold E. Story, of Charlotte, an exodontist and oral surgeon, stated when asked the following:

“Q. How long have you understood that the cause of the discoloration is by oxygenation? A. Since 1923 or 1924. Before that time dentists usually made up their own solution and used tablets.”

Dr. Wilkie testified:

“Q. What caused the discoloration of these cartridges? A. I believe it is the epinephrin; an oxidation process takes place there.
“Q. How long have you known that? A. Almost since I have been using it, or shortly after I graduated from college, in 1923 or 1924.”

Thus it will be seen that it was long known that air, in contact with the well known solution in the cartridge, would discolor and finally make useless the solution.

The Cartridge.

The cartridge mentioned all through the testimony in this suit is a small glass tube about the size of a lead pencil, about 3 inches long, filled with the solution known as adrenalin and procaine, the tube being closed at each end with a rubber plunger or stopper. The rubber plunger or stopper serves two purposes — (1) to keep the solution in the tube, and (2) to keep the air out of the solution. The rubber plunger must not fit so tightly as to prevent its being moved inside the tube. . The glass tube so described is called by the trade a cartridge. These cartridges are made by probably a hundred different manufacturers of dental anesthetics in the United States.

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Bluebook (online)
37 F. Supp. 594, 49 U.S.P.Q. (BNA) 322, 1941 U.S. Dist. LEXIS 3524, Counsel Stack Legal Research, https://law.counselstack.com/opinion/novocol-chemical-mfg-co-v-powers-anderson-dental-co-ncwd-1941.