Marstrand Partners, L.P. v. Israel Biotech Fund I, L.P.

Court of Chancery of Delaware·Decided May 27, 2026·No. C.A. No. 2024-0421-KSJM·Published

Opinion

IN THE COURT OF CHANCERY OF THE STATE OF DELAWARE

MARSTRAND PARTNERS, ) L.P., derivatively on behalf of ) AYALA PHARMACEUTICALS, ) INC., a Delaware corporation, )

)

Plaintiff, )

)

v. ) C.A. No. 2024-0421-KSJM )

ISRAEL BIOTECH FUND I, )

L.P., ISRAEL BIOTECH FUND )

II, L.P., ARKIN BIO )

VENTURES L.P., DAVID )

SIDRANSKY, M.D., PINI )

ORBACH, Phd., YUVAL )

CABILLY, Phd., ROBERT )

SPIEGEL, M.D., MURRAY )

GOLDBERG, RONI APPEL, )

KENNETH BERLIN, VERED )

BISKER-LEIB, and BRIDGET )

MARTEL, M.A., M.D., )

Defendants, )

)

and )

)

AYALA PHARMACEUTICALS, ) INC., a Delaware corporation, )

)

Nominal )

Defendant. )

ORDER GRANTING DEFENDANTS’ MOTIONS TO DISMISS1

1 The facts are drawn from the Verified Amended Complaint (the “Amended Complaint”) and documents it incorporates by reference. C.A. No. 2024-0421-KSJM, Docket (“Dkt.”) 39 (Am. Compl.). The director defendants in this action attached Israel Biotech’s marketing presentation and Ayala’s Form 10-Q filing for the third quarter of 2023 as exhibits to their opening brief. Dkt. 50 (“Director Defs.’ Opening Br.”), Exs. A, C. Each document is quoted or explicitly referenced in the Amended Complaint and thus incorporated by reference. Freedman v. Adams, 2012 WL 1345638, at *5 (Del. Ch. Mar. 30, 2012) (“When a plaintiff expressly refers to and

1. Ayala Pharmaceuticals, Inc. (the “Company”) is a Delaware corporation focused on developing cancer treatments. Israel-based venture capital funds Defendants Israel Biotech Fund I, L.P. and Israel Biotech Fund II, L.P. (together, “Israel Biotech”) invested in Ayala in 2017. In April 2018, Israel Biotech led a Series A financing round. In connection with the financing, Israel Biotech appointed non- party Roni Mamluk as CEO, Defendant and Israel Biotech co-founder David Sidransky as executive chairman, and Defendants Robert Spiegel and Murray Goldberg to Ayala’s board of directors (the “Board”). In May 2020, Ayala went public on the NASDAQ stock exchange.

2. By 2021, Ayala was struggling financially. The Company sustained net losses. Creditors doubted its ability to continue as a going concern. Sidransky was a board member of Advaxis, Inc., another struggling biotechnology company, and introduced the two management teams. Ayala began discussing a merger with Advaxis in July 2022. The parties announced a merger (the “Advaxis Merger”) pursuant to a merger agreement dated October 18, 2022.2 3. But Ayala was still in a precarious financial position. The month after the Advaxis Merger was announced, NASDAQ threatened delisting Ayala because the Company was not in compliance with stockholders’ equity and minimum bid price requirements.

heavily relies upon documents in her complaint, these documents are considered to be incorporated by reference into the complaint; this is true even where the documents are not expressly incorporated into or attached to the complaint.”). 2 Am. Compl. ¶ 88.

4. Ayala began to consider another merger—this time with Biosight, a portfolio company of Israel Biotech and another Israel-based venture capital fund, Defendant Arkin Bio Ventures L.P. (“Arkin”). Ayala and Biosight announced a merger (the “Biosight Merger”) pursuant to an agreement dated July 26, 2023. The parties agreed that the board of the merged company would have nine members: four appointed by Ayala; four appointed by Biosight; and Ayala CEO and Board Chair Kenneth Berlin. Berlin would be CEO and Chair of the merged entity.

5. After the Biosight Merger, Ayala’s Board comprised Sidransky, Israel Biotech co-founder Yuval Cabilly, Spiegel, Goldberg, Arkin executive Pini Orbach, Roni Appel, Vered Bisker-Leib, Bridget Martel, and Berlin (together, “Director Defendants”). When the Biosight Merger closed on October 19, 2023, Israel Biotech and Arkin collectively owned approximately 36% of Ayala’s stock.

6. Germane to this litigation, the Amended Complaint identifies Spiegel and Goldberg as “Venture Advisors” of Israel Biotech.3 In its marketing materials, Israel Biotech describes Venture Advisors as industry experts that it appoints to its portfolio company boards.4 Indeed, Spiegel is the former Chief Medical Officer of pharmaceutical company Schering-Plough, and Goldberg is the former Chief Financial Officer of pharmaceutical company Regeneron.5 Israel Biotech publicly touts Venture Advisors as “chang[ing] the equation” in portfolio companies through

3 Director Defs.’ Opening Br., Ex. A at 6. 4 Am. Compl. ¶ 36. 5 Director Defs.’ Opening Br., Ex. A at 6.

hands-on involvement, including “strategic drug development leadership,” “recruiting additional key personnel[,]” and “financial help[.]”6 7. Further, a 2019 article quotes Sidransky as explaining that Venture Advisors are investors in Israel Biotech and have “skin in the game” with respect to Israel Biotech’s investments.7 And Ayala’s public filings suggest that Spiegel and Goldberg, as Venture Advisors, are limited partners in Israel Biotech Fund I, L.P.

8. The Biosight Merger did not stem Ayala’s financial difficulties. In November 2023, the Board announced that without additional funding, it would need to consider “bankruptcy and liquidation of the Company.”8 The Board simultaneously explored financing options and engaged in strategic discussions with third parties.

9. On November 16, 2023, the Board met and considered several financing options, including (i) a potential PIPE financing with third-party investors who had indicated interest in providing up to $15 million at a 20% discount to market price, (ii) ongoing strategic transaction discussions with several parties, and (iii) a proposal for a convertible note issuance jointly presented by Israel Biotech and Arkin.

10. Pursuant to Israel Biotech and Arkin’s proposed transaction, Israel Biotech, Arkin, and non-party and Ayala stockholder Biotel would lend Ayala up to $4 million through convertible notes to be exercised at a 50% discount to market price. The proposed transaction also contemplated granting warrants to Israel Biotech and

6 Am. Compl. ¶ 36; Dkt. 55 (“Pl.’s Answering Br.”) at 36–38. 7 Am. Compl. ¶ 34. 8 Director Defs.’ Opening Br., Ex. C at 5.

Arkin, giving them the right to purchase up to 15 million additional shares at a discount.

11. The Board approved the transaction proposed by Israel Biotech and Arkin that same day. Further, the Board granted Israel Biotech warrants for 7.5 million additional shares of Company stock at the same discount. The Board also gave Israel Biotech, Arkin, and Biotel the ability to fund up to approximately $5.5 million in additional convertible notes—also to be exercised at the same 50% discount (together with the $4 million convertible note issuance, the “Notes Transaction”).

12. After approving the Notes Transaction, Ayala continued to explore strategic options. On December 6, 2023, an advisory firm proposed an asset sale to another biotechnology company, Immunome, Inc. Ayala and Immunome entered into a non-binding term sheet on December 22. Immunome agreed to acquire Ayala’s assets, and the parties executed an Asset Purchase Agreement on February 5, 2024 (the “Immunome Transaction”). The Immunome Transaction was announced on February 6, 2024.

13. Two days later, Israel Biotech and Arkin exercised their conversion and warrant rights. Israel Biotech, Arkin, and Biotel also loaned an additional $2 million to Ayala and exercised conversion rights related to that transaction, bringing Israel Biotech and Arkin’s total ownership interest to over 80%.

14. The Immunome Transaction closed on March 29, 2024. Upon closing, the Board granted each director a one-time payment: Berlin received $1.6 million;

Sidransky received $160,000; Spiegel, Goldberg, Appel, Bisker-Leib, and Martel each received $70,000; and Cabilly and Orbach each received $50,000.

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Marstrand Partners, L.P. v. Israel Biotech Fund I, L.P., (Del. Ct. App. 2026).

Marstrand Partners, L.P. v. Israel Biotech Fund I, L.P. (Marstrand Partners, L.P. v. Israel Biotech Fund I, L.P.) — published by Counsel Stack Legal Research, free access to 12M+ legal documents.

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