Magee v. Wyeth Laboratories, Inc.

214 Cal. App. 2d 340, 29 Cal. Rptr. 322, 1963 Cal. App. LEXIS 2613
CourtCalifornia Court of Appeal
DecidedMarch 22, 1963
DocketCiv. 26565
StatusPublished
Cited by48 cases

This text of 214 Cal. App. 2d 340 (Magee v. Wyeth Laboratories, Inc.) is published on Counsel Stack Legal Research, covering California Court of Appeal primary law. Counsel Stack provides free access to over 12 million legal documents including statutes, case law, regulations, and constitutions.

Bluebook
Magee v. Wyeth Laboratories, Inc., 214 Cal. App. 2d 340, 29 Cal. Rptr. 322, 1963 Cal. App. LEXIS 2613 (Cal. Ct. App. 1963).

Opinion

ASHBURN, J.

Plaintiffs, the widow and children of Tarance S. Magee, deceased, appeal from an adverse judgment in an action for damages for wrongful death caused by administration of Sparine, a Promazine drug, with resulting Agranulocytosis and death.

Originally, Las Encinas Sanitarium, Wyeth Laboratories, Inc., and seven physicians and nine nurses were named as defendants but a settlement was reached before trial between plaintiffs and all defendants other than Wyeth Laboratories, Inc., whereby plaintiffs received the sum of $23,500 in exchange for a covenant not to sue further and the action was dismissed as to all of said defendants other than Wyeth. The cause proceeded to trial against Wyeth and a jury unanimously rendered a verdict in its favor.

Appellants assign as grounds for reversal the following: (1) Refusal to instruct the jury on breach of warranty, (2) erroneous admission into evidence of the final paragraph of a report of the Council on Drugs of the American Medical Association, (3) exclusion of report of Committee on Judiciary of United States Senate, (4) receiving over objection certain testimony of Dr. Keith Ditman, (5) misconduct of defense counsel in advising the jury that a settlement for $23,500 had been made with some defendants.

There is no substantial conflict in the evidence, which is presented through an engrossed settled statement. Mr. Ma-gee, a practicing attorney, who was suffering from an emotional depression, entered Las Encinas Sanitarium on October 7, 1958. Between that date and November 17, 1958, when *345 he died, he was administered the drug Sparine which was manufactured and sold by defendant Wyeth. On or about November 13, 1958, Mr. Magee contracted Agranulocytosis, a blood disorder wherein certain white corpuscles called granulocytes are greatly reduced or completely eliminated. The statement says: “The absence of these granulocytes deprive the human body of its mechanism in fighting infection and, thereafter, deceased became infected over most of his body which resulted in his death. ’ ’

I.

Dr. Dennis S. Shillam, who performed an autopsy and was the only doctor called by plaintiffs, said that Mr. Magee died of Agranulocytosis caused by the drug Sparine; also, “that presumably the Agranulocytosis was the result of drug sensitivity but he had some doubts in his mind.” In the hospital records of the sanitarium he had recorded a diagnosis, reading in part, “due to drug sensitivity?” The statement says: “Plaintiffs’ counsel offered no medical testimony that in any way criticized Sparine or the literature that accompanied the drug, or promazine drugs in general.”

Sparine is a prescription drug, to be used only pursuant to prescription of a physician. There is nothing in the record to suggest that decedent purchased the drug himself or that it was administered in any manner other than injection by or under direction of the attending physician. Pamphlets and other literature on Sparine, such as a direction circular (exhibit 5) and a booklet entitled “Current Clinical Reports on Sparine from the Literature” (exhibit 10) were furnished to the medical profession, for that is the group for whose use Sparine primarily is intended, and those documents were furnished to the Las Encinas group.

Dr. Herbert A. Duncan, one of the original defendants, called as a witness for plaintiffs, is a psychiatrist who has been employed by Las Encinas since 1946. He testified that Sparine and other Promazine drugs are widely used by psychiatrists in treatment of nervous diseases; that he and other doctors at Las Encinas used it extensively before and after the Magee illness. “He testified that he read the direction sheet and literature left by Wyeth Laboratories, Inc. representatives prior to Mr. Magee’s death, and knew, prior to Mr. Magee’s death, that rare individuals might be sensitive to Sparine and other promazine drugs; that death might result in such rare individuals. Dr. Duncan, in no way, criticized Sparine or the literature that accompanied it and testified that *346 he is still using the drug; that, in his opinion, it is a safe drug. Other than Mr. Magee’s case, there were no other adverse reactions associated with the drug at the Las Encinas Sanitarium.

' Dr. Keith Ditman, a well-qualified psychiatrist, a Diplómate of the American Board of Neurology and Psychiatry, “testified that he has used Sparine and promazine drugs since they were put on the market in 1956 and that he has used these drugs in hundreds of eases; that the Council on Drugs of tne American Medical Association, on occasion, solicit his opinion as to particular drugs. He testified that in his opinion, Sparine is a safe and adequate drug; that, in fact, Sparine is safer than most similar drugs in that it has fewer side effects, and in other particulars.” Also, “he testified that promazine drugs had been a greater revolution to medicine than antibiotics; that thousands and thousands of mental patients have been restored to normal life through the use of Sparine and similar promazine drugs. He testified that medical knowledge is such at the present time that it is impossible to manufacture drugs that rare individuals will not be sensitive to; that all drugs have side effects with rare individuals, including aspirin and penicillin; that approximately 200 people a year die from sensitivity to penicillin; that Sparine is a far safer drug than penicillin. He testified that Agranulocytosis is a very serious complication and if a patient develops the condition he must have immediate attention or he will not survive.”

Returning now to the testimony of Dr. Duncan. He had read the direction circular (exhibit 5) and other literature which was furnished periodically by Wyeth and “knew, prior to Mr. Magee’s death, that rare individuals might be sensitive to Sparine and other promazine drugs; that death might result in such rare individuals.” Also was familiar with the following portion of the document: “Agranulocytosis has occurred in 18 instances from some 3% million patients who have received the drug. Patients should be observed frequently and asked to report immediately any sudden appearance of any signs of infection, if white blood cell counts and differential smears give an indication of severe cellular depression the drug should be discontinued and antibiotic and other suitable therapy should be initiated.” He also testified, “that Tarenee Magee entered the Sanitarium on October 7, 1958 and received Sparine in heavy doses from about this time until November 14 or November 15. He developed a temperature and sore throat on November 14 or 15, 1958; *347 that this condition became progressively worse. No white cell blood count was ever done until November 15th or 16th. That the white cell count was reported critically low; that no specialist was called on the case until November 17, 1958, when Dr. Edward R. Evans, a specialist in internal medicine, was called in and determined that Tarence Magee was acutely ill with Agranulocytosis; that this diagnosis was not made until November 17, 1958. There was no testimony that Mr. Magee had been instructed to report any of the signs of Agranulocytosis, as suggested by the Direction Circular. The matters set forth in the above paragraph also appeared in the hospital records of the Las Encinas Sanitarium.”

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Bluebook (online)
214 Cal. App. 2d 340, 29 Cal. Rptr. 322, 1963 Cal. App. LEXIS 2613, Counsel Stack Legal Research, https://law.counselstack.com/opinion/magee-v-wyeth-laboratories-inc-calctapp-1963.