Larson v. Crowther

1 F.2d 761, 55 App. D.C. 58, 1924 U.S. App. LEXIS 1889
CourtCourt of Appeals for the D.C. Circuit
DecidedOctober 6, 1924
DocketNos. 1656, 1657
StatusPublished
Cited by5 cases

This text of 1 F.2d 761 (Larson v. Crowther) is published on Counsel Stack Legal Research, covering Court of Appeals for the D.C. Circuit primary law. Counsel Stack provides free access to over 12 million legal documents including statutes, case law, regulations, and constitutions.

Bluebook
Larson v. Crowther, 1 F.2d 761, 55 App. D.C. 58, 1924 U.S. App. LEXIS 1889 (D.C. Cir. 1924).

Opinion

SMITH, Acting Associate Justice.

Win-ford P. Larson, in March, 1918, applied to the Patent Office for a patent on a process and apparatus for the destruction of bacteria and the production of material for the making of vaccines. The applications were declared by the Patent Office on tho 25th of June, 1918, to be in interference with applications to patent similar inventions filed by David Crowther in January and February, 1918. Upon the preliminary statement and evidence submitted by the parties to the interferences, the Examiner of Interferences rendered a decision on June 10, 1919, awarding priority of invention for the apparatus to David Crowther, the senior party*

On appeal that decision was reversed on the 23d of December, 1919, by Examiners in Chief Fairfax Bayard, Frank C. Skinner, and E. E. Marino, who held that Larson was entitled to patent both process and apparatus.

Crowther appealed to the Commissioner of Patents, and asked that the matter bo remanded to tho Examiner of Interferences, with instructions to reopen the case for the introduction of further evidence and for tho determination of tho rights of the parties to both process and apparatus.

After consolidating the process and apparatus interferences, and after a trial of the issues involved, the Examiner of Interferences on the 14th of May, 1921, again awarded priority of invention for process and apparatus to the senior party, David Crowther. That decision was affirmed by Examiners in Chief E. E. Marine, S. E. Pouts, and Sidney P. Smith on the 17th of October, 1922, and their decision was affirmed on appeal by the Commissioner of Patents. From the decisions of the Commissioner of Patents, Larson appealed to this court.

The Facts as Contended for by Larson.

In 1913, 1914, and 1915, Dr. Thomas Bradford Hartzell, professor of mouth infections in tho school of medicine and professor of oral surgery in the school of dentistry in the University of Minnesota, engaged in research work for the purpose of determining whether kidney, heart, and human joint inflammations wrere caused by pathogenic bacteria of the mouth and teeth. Dr. Hartzell endeavored to extract for his experiments the “juices” of living bacteria by means of heat, but found that that means produced a chemical change in the “juices” which rendered them unfit for his purposes, and that suitable material for his investigations must be derived from tho bacteria by some other method. Not being well versed in bacteriology, be sought in 1916 tho assistance of Dr. Winford B. Larson, who was an eminent bacteriologist. At that time Dr. Larson was professor of bacteriology and immunology in the University of Minnesota, and was then engaged in a series of experiments for the purpose of determining the efficiency of vaccines injected into ani[762]*762mals and human beings for protective and for therapeutic purposes.

The valuable element of vaccines is the protoplasm which is contained in the cells of pathogenic bacteria, and which as the important component of vaccines excites the production of anti-bodies to battle with the particular form of disease carried by the protoplasm when introduced into the animal system. Dr. Larson’s experiments proved that, when dead bacteria of vaccines were injected into the blood of an animal or human being, the phagocytes, or white blood corpuscles, immediately surrounded and devoured the bodies of the bacteria before the release of the protoplasm from the bacterial cells, thus minimizing or destroying the usefulness of the vaccines for the development of the active immunizing agencies known as anti-bodies. In other words, the white corpuscles did away with the bacteria so quickly that the protoplasm had no opportunity to act, and therefore failed to provoke the creation of the anti-bodies which conferred immunity.

Dr. Hartzell and Dr. Larson were therefore equally interested in securing the unmodified protoplasm of living bacteria, the one for the purpose of establishing that certain bacteria caused certain diseases, and the other for the purpose of producing a medium which would give immunity against the same or other diseases. Dr. Larson knew that bacteriologists had tried to make vaccines more effective by shaking the bacteria with glass beads, which treatment it was thought would break the cells and release the protoplasm. He was aware that that method of securing the protoplasm of live bacteria had been only moderately successful, inasmuch as it failed in large measure to break up the protoplasmic cells.

Dr. Larson thought that the bacteria could be more effectively disrupted .by first freezing them and then grinding them in a ball grinder, which was purchased out of University funds in October, 1916. The freezing and grinding process did not succeed, and Dr. Hartzell requested the University to assign David Crowther to the duty of making equipment required' by Dr. Larson and himself. At the x*equest of Drs. Larson and Hartzell, Crowther made a small metal cylinder provided with a plate having a groove around its outer edge. Bacteria mixed with infusorial earth were placed in the cylinder and subjected to hydraulic pressure in a Buchner press. Dr. Larson was of the opinion that the pressure would reduce the bacteria from a corpuscular to a eollodial or jelly-like form, which would escape immediate consumption by the phagocytes. The pressure of the Buchner press was not sufficient, however, to crush the bacteria, and the desired result was not achieved.

Crowther then bored a hole in a piece of common steel, and, after closing one end of the hole with a steel wedge, he ground a steel piston to fit the hole. Bacteria mixed with infusorial earth were placed in a lead cartridge, which was inverted and put into the steel cylinder. The. lead cartridge so placed and resting on a lead disk which effected a perfect closure was then subjected by a powerful press to a pressure of 50,-000 pounds per square inch. That pressure forced the cylinder to give way, but did not kill the bacteria.

Prof. Hoyt, of the School of Mines, was then called into consultation, and he suggested that the cylinder be made of nickel chrome steel and he agreed, after the steel bar had been bored, to temper the metal so that it would resist a pressure of 225,000 pounds per square inch. The nickel chrome st.eel was bought on February 13, 1917, and at the request of Dr. Larson, Crowther bored it and fitted it with a piston in'accordance with instructions from Dx\ Larson. The device was then sent to Professor Hoyt to be tempered, and was returned to Dr. Larson on or about the 15th of February, 1917, fitted with a plunger or piston, and ready for use.

In the nickel chrome steel tube bacteria were 'subjected to a pressure of 100,000 pounds for 14 hours, with the result that the bacteria were killed and disrupted, but whether that effect was caused by the pres-. sure or its sudden release remained to be determined. Dr. Larson thought that possibly the air in the bacteria had been greatly compressed, and that the release of the pressure brought about a sudden expansion of the air, which broke, up the cells of the bacteria and accomplished their death. To put that theory to the test Dr. Larson decided to expose the bacteria to the pressure of carbon dioxide gas, which he knew was absorbed more readily than air by liquids. Mr. Crowther then made, according to Dr. Larson’s instructions, a container with a suitable coupling which could be attached to a carbon dioxide tanlc in Dr. Larson’s department, and in that container living bacteria suspended in distilled water were subjected to the pressure of carbon dioxide gas.

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Bluebook (online)
1 F.2d 761, 55 App. D.C. 58, 1924 U.S. App. LEXIS 1889, Counsel Stack Legal Research, https://law.counselstack.com/opinion/larson-v-crowther-cadc-1924.