Green, J.
The Commonwealth appeals from an interlocutory order of the Superior Court, suppressing evidence seized pursuant to a search warrant.1 The motion judge suppressed the evidence based on his conclusion that the affidavit submitted in [837]*837support of the application for the warrant did not furnish probable cause to believe that evidence of illegal activity would be found at the location specified in the application. We reverse.
Background. On January 16, 2006, a clerk magistrate of the District Court issued a search warrant in response to an application filed by Detective Scott C. Richards of the Peabody police department. In an affidavit accompanying the application, Detective Richards described the following particular circumstances giving rise to the request. On the evening of January 16, 2006, Sergeant Cook of the Peabody police department, while in uniform and driving a marked police cruiser, stopped an automobile driven by the defendant with an expired license plate.2 Sergeant Cook approached the vehicle, asked the driver (the defendant) for his license and registration, and informed him that he was going to have the vehicle towed for having an expired registration. While speaking to the defendant, Sergeant Cook observed two large plastic tote containers sitting on the back seat of the vehicle. Cook observed, in plain view, vials and vial tops inside the top container. Cook asked the defendant what he had in the containers, and the defendant replied that “he was a chemist and that he runs a business and a lab out of his house selling performance products.” The defendant further informed Cook that he had needles and drugs in the containers and that he had prescriptions for them. Cook informed the defendant that he did not want to tow the vehicle with chemicals and drugs inside, and asked the defendant to remove the plastic containers from the vehicle so that he, the defendant, could take them home with him. When the defendant removed the containers from the vehicle, Sergeant Cook observed “additional empty vials, covers for the vials, strainers, a bottle of D-Bol, a bottle Benzyl-Benzoate [Ac], Poly-sorbate 80, and other bottles of chemicals.” Detective Richards’s affidavit continued, “[w]ith Sergeant Cook’s training and experience as a police officer the items observed appeared consistent with steroids.” One of the containers also contained a piece of mail addressed to 12 America Drive, in Peabody.3
While Sergeant Cook was engaged with the defendant, another [838]*838police officer (Zawacki) was conducting an inventory search of the front seat area of the vehicle. In a silver container inside a black pouch on the front console, Officer Zawacki found five eighty-milligram Oxycontin pills. Officer Zawacki also found a bag containing several hypodermic needles under the front driver’s seat. The defendant was placed under arrest for possession of a class B controlled substance (Oxycontin), and his car was impounded and towed.
On the basis of the foregoing information, Detective Richards’s affidavit stated that “there is probable cause to believe that Oxycontin, steroids, various chemicals used in the production and manufacturing of steroids and other performance enhancing drugs as well as associated paraphernalia, equipment and implements can be found in or around the residence located #12 America Drive, Peabody, MA.”
Discussion. Under the Fourth Amendment to the United States Constitution and art. 14 of the Massachusetts Declaration of Rights, a search warrant may issue only on a showing of probable cause. See Commonwealth v. Valerio, 449 Mass. 562, 566 (2007). In evaluating whether a warrant application establishes probable cause, our inquiry “always begins and ends with the ‘four comers of the affidavit.’ ” Commonwealth v. O’Day, 440 Mass. 296, 297 (2003), quoting from Commonwealth v. Villella, 39 Mass. App. Ct. 426, 428 (1995). See Commonwealth v. Cefalo, 381 Mass. 319, 328-330 (1980). “To establish probable cause to search, the facts contained in an affidavit, and reasonable inferences that may be drawn from them, must be sufficient for the magistrate to conclude ‘that the items sought are related to the criminal activity under investigation, and that they reasonably may be expected to be located in the place to be searched at the time the search warrant issues.’ ” Commonwealth v. Walker, 438 Mass. 246, 249 (2002), quoting from Commonwealth v. Donahue, 430 Mass. 710, 712 (2000).
“In dealing with probable cause ... we deal with probabilities. These are not technical; they are the factual and practical considerations of everyday life on which reasonable and pmdent [839]*839men, not legal technicians, act.” Commonwealth v. Hason, 387 Mass. 169, 174 (1982), quoting from Brinegar v. United States, 338 U.S. 160, 175 (1949). See generally Grasso & McEvoy, Suppression Matters Under Massachusetts Law § 8-1 (2009-2010 ed.). Accordingly, search warrant affidavits are to be interpreted in a realistic and commonsense manner, and should be “read as a whole, not parsed, severed, and subjected to hypercritical analysis.” Commonwealth v. Donahue, supra, quoting from Commonwealth v. Blake, 413 Mass. 823, 827 (1992). See Commonwealth v. Stewart, 358 Mass. 747, 751 (1971). A showing of probable cause in support of a search warrant does not require definitive proof of criminal activity. See Commonwealth v. Spano, 414 Mass. 178, 184-185 (1993). Instead, “[t]he basic question for the magistrate, when evaluating an affidavit supporting an application for the issuance of a search warrant, is whether there is a substantial basis on which to conclude that the articles or activity described are probably present or occurring at the place to be searched” (emphasis added). Id. at 184. A reviewing court gives considerable deference to the magistrate’s determination of probable cause, see Commonwealth v. Upton, 394 Mass. 363, 377 (1985), and even “the resolution of doubtful or marginal cases . . . should be largely determined by the preference to be accorded to warrants.” Commonwealth v. Germain, 396 Mass. 413, 418 (1985), quoting from United States v. Ventresca, 380 U.S. 102, 109 (1965).
We agree with the Commonwealth that Detective Richards’s affidavit was sufficient to establish probable cause to search the defendant’s residence at 12 America Drive. The defendant contends that the affidavit was deficient because it did not advise that any of the steroids found in the tote container are illegal, and because the question whether any of them are illegal is not a matter of common knowledge.4 See Commonwealth v. Taglieri, 378 Mass. 196, 198-199, cert. denied, 444 U.S. 937 (1979) (affiant must explain inferences that do not follow from com[840]*840mon sense; “issuance of a warrant . . . should not turn on who the magistrate is or how much special knowledge he may have”); Commonwealth v. Byfield, 413 Mass. 426, 429-430 (1992).5 The argument is beside the point, however. Under G. L. c. 112, § 30, amended by St. 1974, c.
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Green, J.
The Commonwealth appeals from an interlocutory order of the Superior Court, suppressing evidence seized pursuant to a search warrant.1 The motion judge suppressed the evidence based on his conclusion that the affidavit submitted in [837]*837support of the application for the warrant did not furnish probable cause to believe that evidence of illegal activity would be found at the location specified in the application. We reverse.
Background. On January 16, 2006, a clerk magistrate of the District Court issued a search warrant in response to an application filed by Detective Scott C. Richards of the Peabody police department. In an affidavit accompanying the application, Detective Richards described the following particular circumstances giving rise to the request. On the evening of January 16, 2006, Sergeant Cook of the Peabody police department, while in uniform and driving a marked police cruiser, stopped an automobile driven by the defendant with an expired license plate.2 Sergeant Cook approached the vehicle, asked the driver (the defendant) for his license and registration, and informed him that he was going to have the vehicle towed for having an expired registration. While speaking to the defendant, Sergeant Cook observed two large plastic tote containers sitting on the back seat of the vehicle. Cook observed, in plain view, vials and vial tops inside the top container. Cook asked the defendant what he had in the containers, and the defendant replied that “he was a chemist and that he runs a business and a lab out of his house selling performance products.” The defendant further informed Cook that he had needles and drugs in the containers and that he had prescriptions for them. Cook informed the defendant that he did not want to tow the vehicle with chemicals and drugs inside, and asked the defendant to remove the plastic containers from the vehicle so that he, the defendant, could take them home with him. When the defendant removed the containers from the vehicle, Sergeant Cook observed “additional empty vials, covers for the vials, strainers, a bottle of D-Bol, a bottle Benzyl-Benzoate [Ac], Poly-sorbate 80, and other bottles of chemicals.” Detective Richards’s affidavit continued, “[w]ith Sergeant Cook’s training and experience as a police officer the items observed appeared consistent with steroids.” One of the containers also contained a piece of mail addressed to 12 America Drive, in Peabody.3
While Sergeant Cook was engaged with the defendant, another [838]*838police officer (Zawacki) was conducting an inventory search of the front seat area of the vehicle. In a silver container inside a black pouch on the front console, Officer Zawacki found five eighty-milligram Oxycontin pills. Officer Zawacki also found a bag containing several hypodermic needles under the front driver’s seat. The defendant was placed under arrest for possession of a class B controlled substance (Oxycontin), and his car was impounded and towed.
On the basis of the foregoing information, Detective Richards’s affidavit stated that “there is probable cause to believe that Oxycontin, steroids, various chemicals used in the production and manufacturing of steroids and other performance enhancing drugs as well as associated paraphernalia, equipment and implements can be found in or around the residence located #12 America Drive, Peabody, MA.”
Discussion. Under the Fourth Amendment to the United States Constitution and art. 14 of the Massachusetts Declaration of Rights, a search warrant may issue only on a showing of probable cause. See Commonwealth v. Valerio, 449 Mass. 562, 566 (2007). In evaluating whether a warrant application establishes probable cause, our inquiry “always begins and ends with the ‘four comers of the affidavit.’ ” Commonwealth v. O’Day, 440 Mass. 296, 297 (2003), quoting from Commonwealth v. Villella, 39 Mass. App. Ct. 426, 428 (1995). See Commonwealth v. Cefalo, 381 Mass. 319, 328-330 (1980). “To establish probable cause to search, the facts contained in an affidavit, and reasonable inferences that may be drawn from them, must be sufficient for the magistrate to conclude ‘that the items sought are related to the criminal activity under investigation, and that they reasonably may be expected to be located in the place to be searched at the time the search warrant issues.’ ” Commonwealth v. Walker, 438 Mass. 246, 249 (2002), quoting from Commonwealth v. Donahue, 430 Mass. 710, 712 (2000).
“In dealing with probable cause ... we deal with probabilities. These are not technical; they are the factual and practical considerations of everyday life on which reasonable and pmdent [839]*839men, not legal technicians, act.” Commonwealth v. Hason, 387 Mass. 169, 174 (1982), quoting from Brinegar v. United States, 338 U.S. 160, 175 (1949). See generally Grasso & McEvoy, Suppression Matters Under Massachusetts Law § 8-1 (2009-2010 ed.). Accordingly, search warrant affidavits are to be interpreted in a realistic and commonsense manner, and should be “read as a whole, not parsed, severed, and subjected to hypercritical analysis.” Commonwealth v. Donahue, supra, quoting from Commonwealth v. Blake, 413 Mass. 823, 827 (1992). See Commonwealth v. Stewart, 358 Mass. 747, 751 (1971). A showing of probable cause in support of a search warrant does not require definitive proof of criminal activity. See Commonwealth v. Spano, 414 Mass. 178, 184-185 (1993). Instead, “[t]he basic question for the magistrate, when evaluating an affidavit supporting an application for the issuance of a search warrant, is whether there is a substantial basis on which to conclude that the articles or activity described are probably present or occurring at the place to be searched” (emphasis added). Id. at 184. A reviewing court gives considerable deference to the magistrate’s determination of probable cause, see Commonwealth v. Upton, 394 Mass. 363, 377 (1985), and even “the resolution of doubtful or marginal cases . . . should be largely determined by the preference to be accorded to warrants.” Commonwealth v. Germain, 396 Mass. 413, 418 (1985), quoting from United States v. Ventresca, 380 U.S. 102, 109 (1965).
We agree with the Commonwealth that Detective Richards’s affidavit was sufficient to establish probable cause to search the defendant’s residence at 12 America Drive. The defendant contends that the affidavit was deficient because it did not advise that any of the steroids found in the tote container are illegal, and because the question whether any of them are illegal is not a matter of common knowledge.4 See Commonwealth v. Taglieri, 378 Mass. 196, 198-199, cert. denied, 444 U.S. 937 (1979) (affiant must explain inferences that do not follow from com[840]*840mon sense; “issuance of a warrant . . . should not turn on who the magistrate is or how much special knowledge he may have”); Commonwealth v. Byfield, 413 Mass. 426, 429-430 (1992).5 The argument is beside the point, however. Under G. L. c. 112, § 30, amended by St. 1974, c. 326, § 1, it is illegal for any person other than a pharmacist (or certain others described therein) to “dispense any controlled substance or any substance intended for hypodermic use” (emphasis added). The defendant’s admission that he ran a business out of his home manufacturing and selling “performance products,” combined with (i) his statement that the tote containers had “needles and drugs” in them, (ii) the presence of empty vials and vial covers in the containers along with other filled vials,6 and (iii) the presence of hypodermic needles under the driver’s seat, suggested a probability that the defendant was engaged in the illegal activity of dispensing substances intended for hypodermic use.7
We also reject the defendant’s contention that the information [841]*841contained in the affidavit furnished an inadequate nexus between the defendant and the residence located at 12 America Drive in Peabody. First, as we have observed, one of the tote containers held, alongside the vials, an envelope addressed to that location. Moreover, the arresting officer had examined the defendant’s license, and Detective Richards described the same location as the defendant’s residence on the warrant application form itself (which Detective Richards signed under the pains and penalties of perjury). See Commonwealth v. McRae, 31 Mass. App. Ct. 559, 561-563 (1991). The sworn information before the magistrate included information sufficient to identify 12 America Drive, Peabody, as the defendant’s address.
Order allowing motion to suppress reversed.