OPINION
PER CURIAM.
The Department of Labor’s Benefits Review Board affirmed an award of survivor’s benefits to Dorothy Fultz under the Black Lung Benefits Act, 30 U.S.C.A. §§ 901-945 (1986 & Supp. 2002) (the Act), based on the administrative law judge’s finding that Mrs. Fultz successfully invoked the irrebuttable presumption under 30 U.S.C.A. § 921(c)(3) and 20 C.F.R. § 718.304 (2002) that the death of her husband, a coal miner, was due to pneumoconiosis. Recognizing that there was autopsy evidence that showed lesions of 2 centimeters and autopsy evidence that showed evidence of 1.2 centimeter lesions, the ALJ made an equivalency determination, finding that “regardless of whether [the lesions] exceeded 2 centimeters ... or were 1.2 centimeters ..., [they] would be expected on x-ray to yield one or more large opacities (i.e., greater than 1 centimeter in diamater)” and that “it is undisputed that [Fultz] had at least 1.2 centimeter lesions of coal workers pneumoconiosis on autopsy and I find that these autopsy findings satisfy the statutory and regulatory definition.” (J.A. at 215.) Because the record in this case lacks any evidence establishing that the size of a lesion on autopsy is equivalent to the size of a lesion on x-ray that would support this equivalency determination, we remand this case for such testimony and any other further proceedings consistent with this opinion.
I.
Clarence Fultz worked for at least thirty years as a coal miner, ending in 1982. He died in 1999, and according to his death certificate, the cause of his death was respiratory failure due to extensive squamous cell carcinoma with coal worker’s pneumoconiosis listed as an underlying condition. Following his death, Dorothy Fultz, his widow, filed an application for survivor’s benefits under the Act. The Department of Labor determined that Mrs. Fultz was eligible for benefits, and the claim was referred to the Office of Administrative Law Judges. Clinchfield Coal agreed that it was the “responsible operator” and therefore would be liable for the payment of benefits if any were to be awarded to Mrs. Fultz. See 20 C.F.R. §§ 725.490, 725.492 (2002). Clinchfield Coal has also agreed that Mr. Fultz had pneumo-coniosis and that he had 30 years of coal mine employment. On the issue of whether the miner died due to pneumoconiosis, the administrative law judge (ALJ) found that Mrs. Fultz successfully invoked the irrebuttable presumption of 20 C.F.R. § 718.304 that the miner’s death was due to pneumoconiosis. Although the ALJ considered x-ray evidence, CT scans, autopsy evidence and medical reports, in awarding benefits, the ALJ concluded that only the autopsy evi[868]*868dence supported the invocation of the presumption.
Reviewing the autopsy evidence, the ALJ considered an autopsy report prepared by Dr. Brooks. Upon gross examination, Dr. Brooks found “multiple tracheobronchial lymph nodes showing anthracotic changes and fibrosis” in the trachea, “severe” anthracosis in the lungs, shown by “multiple areas of black macular discoloration,” and “multiple areas of fibrosis and firm nodules in both lungs.” (J.A. at 32.) In the autopsy report, Dr. Brooks listed, but did not discuss, twenty-two slide cassettes of tissue taken during the autopsy. Dr. Brooks concluded that “[t]he immediate cause of this patient’s death is respiratory failure due to complicated coal worker’s pneumoconiosis, COPD, metastatic squamous cell carcinoma of the lungs, and multifocal post obstructive acute pneumonia.” (J.A. at 33.) In her deposition in the administrative proceeding, Dr. Brooks testified that “virtually every slide has no viable lung tissue left. It’s mostly fibrotic.” (J.A. at 110.) Asked whether she had found “lesions ... resulting from coal-dust exposure on his lung in excess of two centimeters,” Dr. Brooks replied that she had, and that the lesions meeting that description were “[t]oo numerous to count.” (J.A. at 119.)
The ALJ also considered the opinions of Dr. Kleinerman and Dr. Caffrey, who reviewed Mr. Fultz’s medical records and tissue slides from the autopsy. In his report, Dr. Kleinerman found “a moderate profusion of lesions of simple CWP,” “[l]esions of simple nodular silicosis,” and “[mjacronodular lesions of silicosis,” in addition to lesions of squamous cell carcinoma. (J.A. at 44.) Dr. Kleinerman concluded that “Mr. Fultz had a moderate extent of simple CWP and simple nodular silicosis,” but that his death was the result of “extensive squamous cell carcinoma involving his lungs.” (J.A. at 45.) The ALJ noted that Dr. Kleinerman “did not provide an estimate of the size of the lesions attributable either to coal worker’s pneumoconiosis or to silicosis.” (J.A. at 214.)
In his report, Dr. Caffrey gave a diagnosis based on the autopsy slides of “simple coal worker’s pneumoconiosis and macro-nodular coal worker’s pneumoconiosis, extensive,” as well as squamous cell carcinoma, emphysema, bronchopneumonia, and pleuritis. (J.A. at 85.) Dr. Caffrey concluded that “the patient’s immediate cause of death was due to extensive keratinizing, squamous cell carcinoma” with “terminal!], acute bronchopneumonia.” (J.A. at 87.) Dr. Caffrey also concluded that Mr. Fultz “showed a moderately severe case of simple coal worker’s pneumoconiosis and nodular coal worker’s pneumoconiosis.” (J.A. at 87.) He reported that “[t]he size of the macronodular lesions that were present on the [autopsy] slides that [he] reviewed were up to 1.2 cms.” (J.A. at 87.)
Based on these reports, the ALJ found “that the lesions found on autopsy, regardless of whether they exceeded 2 centimeters as Dr. Brooks found or were 1.2 centimeters as Dr. Caffrey found, would be expected on x-ray to yield one or more large opacities (i.e., greater than 1 centimeter in diameter).” (J.A. at 215.) The ALJ held that considering all of the evidence together, the pathological evidence, including the well-reasoned opinions of Dr. Brooks and Dr. Caffrey, outweighed the other evidence. (J.A. at 215.) Accordingly, the ALJ held that Mrs. Fultz was entitled to the irrebuttable presumption of death due to pneumoconiosis under 20 C.F.R. § 718.304 and awarded benefits to Mrs. Fultz.
[869]*869The Benefits Review Board affirmed the ALJ’s award of benefits, and Clinchfield Coal filed this petition for review.
II.
We review Mrs. Fultz’s claim for benefits under the Act to determine whether substantial evidence supports the factual findings of the ALJ and whether the legal conclusions of the Board and the ALJ are rational and consistent with applicable law. Bill Branch Coal Corp. v. Sparks, 213 F.3d 186, 190 (4th Cir.2000). When reviewing a factual finding, we must affirm the ALJ’s decision if it is supported by substantial evidence, Thom v. Itmann Coal Co., 3 F.3d 713, 718 (4th Cir.1993), which is “such relevant evidence as a reasonable mind might accept as adequate to support a conclusion,” Richardson v. Perales,
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OPINION
PER CURIAM.
The Department of Labor’s Benefits Review Board affirmed an award of survivor’s benefits to Dorothy Fultz under the Black Lung Benefits Act, 30 U.S.C.A. §§ 901-945 (1986 & Supp. 2002) (the Act), based on the administrative law judge’s finding that Mrs. Fultz successfully invoked the irrebuttable presumption under 30 U.S.C.A. § 921(c)(3) and 20 C.F.R. § 718.304 (2002) that the death of her husband, a coal miner, was due to pneumoconiosis. Recognizing that there was autopsy evidence that showed lesions of 2 centimeters and autopsy evidence that showed evidence of 1.2 centimeter lesions, the ALJ made an equivalency determination, finding that “regardless of whether [the lesions] exceeded 2 centimeters ... or were 1.2 centimeters ..., [they] would be expected on x-ray to yield one or more large opacities (i.e., greater than 1 centimeter in diamater)” and that “it is undisputed that [Fultz] had at least 1.2 centimeter lesions of coal workers pneumoconiosis on autopsy and I find that these autopsy findings satisfy the statutory and regulatory definition.” (J.A. at 215.) Because the record in this case lacks any evidence establishing that the size of a lesion on autopsy is equivalent to the size of a lesion on x-ray that would support this equivalency determination, we remand this case for such testimony and any other further proceedings consistent with this opinion.
I.
Clarence Fultz worked for at least thirty years as a coal miner, ending in 1982. He died in 1999, and according to his death certificate, the cause of his death was respiratory failure due to extensive squamous cell carcinoma with coal worker’s pneumoconiosis listed as an underlying condition. Following his death, Dorothy Fultz, his widow, filed an application for survivor’s benefits under the Act. The Department of Labor determined that Mrs. Fultz was eligible for benefits, and the claim was referred to the Office of Administrative Law Judges. Clinchfield Coal agreed that it was the “responsible operator” and therefore would be liable for the payment of benefits if any were to be awarded to Mrs. Fultz. See 20 C.F.R. §§ 725.490, 725.492 (2002). Clinchfield Coal has also agreed that Mr. Fultz had pneumo-coniosis and that he had 30 years of coal mine employment. On the issue of whether the miner died due to pneumoconiosis, the administrative law judge (ALJ) found that Mrs. Fultz successfully invoked the irrebuttable presumption of 20 C.F.R. § 718.304 that the miner’s death was due to pneumoconiosis. Although the ALJ considered x-ray evidence, CT scans, autopsy evidence and medical reports, in awarding benefits, the ALJ concluded that only the autopsy evi[868]*868dence supported the invocation of the presumption.
Reviewing the autopsy evidence, the ALJ considered an autopsy report prepared by Dr. Brooks. Upon gross examination, Dr. Brooks found “multiple tracheobronchial lymph nodes showing anthracotic changes and fibrosis” in the trachea, “severe” anthracosis in the lungs, shown by “multiple areas of black macular discoloration,” and “multiple areas of fibrosis and firm nodules in both lungs.” (J.A. at 32.) In the autopsy report, Dr. Brooks listed, but did not discuss, twenty-two slide cassettes of tissue taken during the autopsy. Dr. Brooks concluded that “[t]he immediate cause of this patient’s death is respiratory failure due to complicated coal worker’s pneumoconiosis, COPD, metastatic squamous cell carcinoma of the lungs, and multifocal post obstructive acute pneumonia.” (J.A. at 33.) In her deposition in the administrative proceeding, Dr. Brooks testified that “virtually every slide has no viable lung tissue left. It’s mostly fibrotic.” (J.A. at 110.) Asked whether she had found “lesions ... resulting from coal-dust exposure on his lung in excess of two centimeters,” Dr. Brooks replied that she had, and that the lesions meeting that description were “[t]oo numerous to count.” (J.A. at 119.)
The ALJ also considered the opinions of Dr. Kleinerman and Dr. Caffrey, who reviewed Mr. Fultz’s medical records and tissue slides from the autopsy. In his report, Dr. Kleinerman found “a moderate profusion of lesions of simple CWP,” “[l]esions of simple nodular silicosis,” and “[mjacronodular lesions of silicosis,” in addition to lesions of squamous cell carcinoma. (J.A. at 44.) Dr. Kleinerman concluded that “Mr. Fultz had a moderate extent of simple CWP and simple nodular silicosis,” but that his death was the result of “extensive squamous cell carcinoma involving his lungs.” (J.A. at 45.) The ALJ noted that Dr. Kleinerman “did not provide an estimate of the size of the lesions attributable either to coal worker’s pneumoconiosis or to silicosis.” (J.A. at 214.)
In his report, Dr. Caffrey gave a diagnosis based on the autopsy slides of “simple coal worker’s pneumoconiosis and macro-nodular coal worker’s pneumoconiosis, extensive,” as well as squamous cell carcinoma, emphysema, bronchopneumonia, and pleuritis. (J.A. at 85.) Dr. Caffrey concluded that “the patient’s immediate cause of death was due to extensive keratinizing, squamous cell carcinoma” with “terminal!], acute bronchopneumonia.” (J.A. at 87.) Dr. Caffrey also concluded that Mr. Fultz “showed a moderately severe case of simple coal worker’s pneumoconiosis and nodular coal worker’s pneumoconiosis.” (J.A. at 87.) He reported that “[t]he size of the macronodular lesions that were present on the [autopsy] slides that [he] reviewed were up to 1.2 cms.” (J.A. at 87.)
Based on these reports, the ALJ found “that the lesions found on autopsy, regardless of whether they exceeded 2 centimeters as Dr. Brooks found or were 1.2 centimeters as Dr. Caffrey found, would be expected on x-ray to yield one or more large opacities (i.e., greater than 1 centimeter in diameter).” (J.A. at 215.) The ALJ held that considering all of the evidence together, the pathological evidence, including the well-reasoned opinions of Dr. Brooks and Dr. Caffrey, outweighed the other evidence. (J.A. at 215.) Accordingly, the ALJ held that Mrs. Fultz was entitled to the irrebuttable presumption of death due to pneumoconiosis under 20 C.F.R. § 718.304 and awarded benefits to Mrs. Fultz.
[869]*869The Benefits Review Board affirmed the ALJ’s award of benefits, and Clinchfield Coal filed this petition for review.
II.
We review Mrs. Fultz’s claim for benefits under the Act to determine whether substantial evidence supports the factual findings of the ALJ and whether the legal conclusions of the Board and the ALJ are rational and consistent with applicable law. Bill Branch Coal Corp. v. Sparks, 213 F.3d 186, 190 (4th Cir.2000). When reviewing a factual finding, we must affirm the ALJ’s decision if it is supported by substantial evidence, Thom v. Itmann Coal Co., 3 F.3d 713, 718 (4th Cir.1993), which is “such relevant evidence as a reasonable mind might accept as adequate to support a conclusion,” Richardson v. Perales, 402 U.S. 389, 401, 91 S.Ct. 1420, 28 L.Ed.2d 842 (1971) (citations omitted). Under the Act, an eligible claimant is entitled to survivor’s benefits if the miner’s death was “due to” pneumoconiosis. 20 C.F.R. § 718.205 (2002).
When a miner is “afflicted with complicated pneumoconiosis, [it] is ‘irrebuttably presumed’ ... that his death was due to pneumoconiosis.” Usery v. Turner Elkhorn Mining Co., 428 U.S. 1, 11, 96 S.Ct. 2882, 49 L.Ed.2d 752 (1976). The irrebuttable presumption applies if “(A) an x-ray of the miner’s lungs shows at least one opacity greater than one centimeter in diameter; (B) a biopsy or autopsy reveals ‘massive lesions’ in the lungs; or (C) a diagnosis by other means reveals a result equivalent to (A) or (B).” Eastern Associated Coal Corp. v. Director, Office of Workers’ Compensation Programs, 220 F.3d 250, 255 (4th Cir.2000) (citing 30 U.S.C.A. § 921(c)). We have held that the three methods of invoking the irrebuttable presumption found in clauses (A), (B), and (C) “describe a single, objective condition.” Eastern, 220 F.3d at 255. Therefore, the ALJ must make an equivalency determination “to make certain that regardless of which diagnostic technique is used, the same underlying condition triggers the irrebuttable presumption.”1 Double B Min[870]*870ing, Inc. v. Blankenship, 177 F.3d 240, 244 (4th Cir.1999). Because clause (A) sets out an entirely objective scientific standard, i.e., an opacity on an x-ray greater than one centimeter, we have held that it is the benchmark to which evidence under the other clauses in compared. See Eastern, 220 F.3d at 256; Double B, 177 F.3d at 244. Accordingly, “massive lesions” sufficient to invoke the irrebuttable presumption under clause (B) are those that “when x-rayed ... would show as opacities greater than one centimeter.” Eastern, 220 F.3d at 258.
After reviewing the evidence in this case, the ALJ concluded “that the lesions found on autopsy, regardless of whether they exceeded 2 centimeters as Dr. Brooks found or were 1.2 centimeters as Dr. Caffrey found, would be expected on x-ray to yield one or more large opacities (i.e., greater than 1 centimeter in diameter).” (J.A. at 215.) There was no testimony or medical report or evidence indicating that the lesions discovered on autopsy would be expected on x-ray to yield one or more opacities of greater than one centimeter or that the size of a lesion on autopsy was equivalent or less than the expected size on x-ray. In fact, both Dr. Caffrey and Dr. Brooks declined to offer an opinion on that point. When asked whether he could state to a reasonable degree of medical certainty that the lesions he saw on the autopsy slides were “the medical equivalent of a one centimeter x-ray reading,” Dr. Caffrey stated “I don’t know.”2 (J.A. [871]*871at 213-14.) Similarly, when asked if she could opine as to whether the lesions found on autopsy “were complicated pneumoconiosis [that] would have shown up on a chest x-ray,” Dr. Brooks stated, “I can’t comment on that.” (J.A. at 122.) Thus, when specifically questioned, Dr. Brooks herself was unable to correlate her findings on autopsy with the expected size of the lesions on x-ray.
While there may be lesions so large that it is self-evident that they would have shown as opacities greater than one centimeter on x-ray, we cannot presume that lesions of 1.2 centimeters3 are so large that there need be no further testimony or evidence as to whether they would have shown on x-ray as opacities of greater than one centimeter. Cf. Double B, 177 F.3d at 244 (concluding that evidence of lesions of 1.3 centimeters, standing alone, was insufficient to determine whether miner had complicated pneumoconiosis and remanding for an equivalency determination); see also id. (noting that “ ‘nodules are generally larger on autopsy examination than they appear on a chest radiograph’” (quoting N. LeRoy Lapp, M.D., A Lawyer’s Medical Guide to Black Lung Litigation, 83 W. Va. L. Rev. 721, 736 (1981))). Without more, we cannot conclude that the ALJ’s finding that the lesions would have shown as one or more opacities of greater than one centimeter is supported by substantial evidence.4
III.
Because there was insufficient evidence to support the ALJ’s finding that Mr. Fultz had lesions that would have shown as greater than one centimeter on x-ray, we vacate the Board’s decision upholding the award of benefits to Mrs. Fultz and direct the Board to remand the case to an ALJ for further proceedings consistent [872]*872with this opinion.5
VACATED AND REMANDED.