1 2 3 4 UNITED STATES DISTRICT COURT 5 NORTHERN DISTRICT OF CALIFORNIA 6 SAN JOSE DIVISION 7 8 BRIANA LEAKAS, et al., Case No. 22-cv-01422-VKD
9 Plaintiffs, ORDER GRANTING IN PART AND 10 v. DENYING IN PART DEFENDANTS’ MOTION TO EXCLUDE TESTIMONY 11 MONTEREY BAY MILITARY OF DAVID ROSS, M.D. HOUSING, LLC, et al., 12 Re: Dkt. No. 53 Defendants.
13 14 I. BACKGROUND 15 Plaintiffs Briana Leakas and her minor son, D.L. (along with Theodore Leakas, Ms. 16 Leakas’s spouse and D.L.’s guardian ad litem), filed this action in the Monterey County Superior 17 Court for personal injuries they claim they sustained as a result of toxic mold contamination in the 18 home they leased from defendants1 while living on the U.S. Army Garrison Presidio of Monterey 19 from about June 2019 through May 2020. Defendants removed the matter to this Court on the 20 ground that the underlying events occurred on a federal enclave. See Dkt. No. 4; see also Cnty. of 21 San Mateo v. Chevron Corp., 32 F.4th 733, 749 (9th Cir. 2022) (“[B]ecause conduct on a federal 22 enclave is generally subject to federal law, a claim based on injuries stemming from such conduct 23 arises under federal law, and a court has jurisdiction over such a claim under [28 U.S.C.] 24
25 1 Plaintiffs voluntarily dismissed two defendants (Clark Enterprises USA, LLC and Pinnacle Monterey, LLC) and later dropped defendant Clark Pinnacle Monterey Bay, LLC from their 26 operative complaint. See Dkt. Nos. 11, 12, 34. The two remaining defendants are Monterey Bay Military Housing, LLC and Michaels Management Services, LLC. Plaintiffs and all remaining 27 defendants have expressly consented that all proceedings in this matter may be heard and finally 1 § 1331.”); Albers v. Yarbrough World Sols., LLC, No. 5:19-cv-05896-EJD, 2020 WL 2218964, at 2 *7 (N.D. Cal. May 7, 2020) (“The California Legislature ceded the Monterey Presidio to the 3 United States Government in 1897. It is not contested by the Parties and the case law supports 4 that, when California ceded the Presidio to the United States, exclusive jurisdiction over that area 5 was conferred upon the United States.”) (citations omitted). 6 After the Court granted defendants’ motion to dismiss the complaint with leave to amend, 7 (see Dkt. No. 32), plaintiffs filed an amended complaint (the operative pleading), which asserts ten 8 state and common law claims for relief: negligence (claim 1); nuisance (claim 2); negligent 9 misrepresentation (claim 3); negligent infliction of emotional distress (claim 4); breach of implied 10 warranty of habitability (claim 5); breach of implied covenant of quiet use and enjoyment (claim 11 6); gross negligence (claim 7);2 premises liability (claim 8); constructive (wrongful) eviction 12 (claim 9); and fraud—concealment (claim 10). Dkt. No. 34. 13 Defendants move to exclude the testimony of one of plaintiffs’ retained medical experts, 14 David Ross, M.D., a board-certified neuropsychiatrist. Dkt. No. 53. Based on his June 28, 2023 15 examination of Ms. Leakas and a review of her medical records and other documents, Dr. Ross 16 concluded that due to biotoxin (i.e., mold) exposure at the home plaintiffs leased in Monterey, Ms. 17 Leakas developed an acquired brain injury caused by CIRS (i.e., Chronic Inflammatory Response 18 Syndrome), a mold-related illness. Dkt. No. 57-1 ¶¶ 3, 7; see also Dkt. No. 57-2, Ex. 1. 19 Defendants contend that Dr. Ross is not qualified to opine on medical causation and other issues 20 beyond his expertise in neuropsychiatry. Dkt. No. 53. They further contend that Dr. Ross’s 21 opinion that Ms. Leakas has an acquired brain injury caused by CIRS is not based on reliable 22 medical testing and data. Id. Plaintiffs oppose the motion. Dkt. No. 57. Following the motion 23 hearing, and with the Court’s leave, plaintiffs supplemented their opposition by submitting copies 24 of the studies or papers they say support their contentions. See Dkt. Nos. 68, 69. Upon 25 consideration of the moving and responding papers, as well as the oral arguments presented, the 26 2 Pursuant to the Court’s order on defendants’ motion to dismiss, plaintiffs were permitted to 27 pursue a claim for gross negligence, but only in the alternative to their separate claim for 1 Court grants in part and denies in part defendants’ motion to exclude Dr. Ross’s testimony. 2 II. LEGAL STANDARD 3 Rule 702 of the Federal Rules of Evidence provides that a witness “who is qualified as an 4 expert by knowledge, skill, experience, training, or education may testify in the form of an opinion 5 or otherwise,” if the proponent of the testimony “demonstrates that it is more likely than not” that:
6 (a) the expert’s scientific, technical, or other specialized knowledge will help the trier of fact to understand the evidence or to determine a fact in issue; 7 (b) the testimony is based on sufficient facts or data; 8 (c) the testimony is the product of reliable principles and methods; and 9 (d) the expert’s opinion reflects a reliable application of the principles and 10 methods to the facts of the case. 11 Fed. R. Evid. 702. Rule 702 recently was amended, effective December 1, 2023, “to clarify and 12 emphasize that expert testimony may not be admitted unless the proponent demonstrates to the 13 court that it is more likely than not that the proffered testimony meets the admissibility 14 requirements set forth in the rule.” Fed. R. Evid. 702 advisory committee’s note to 2023 15 amendment. 16 Rule 703 further identifies the permissible bases of an expert’s opinion testimony, 17 including “facts or data in the case that the expert has been made aware of or personally 18 observed.” Fed. R. Evid. 703. Additionally, “[i]f experts in the particular field would reasonably 19 rely on those kinds of facts or data in forming an opinion on the subject, [the facts or data] need 20 not be admissible for the opinion to be admitted.” Id. “But if the facts or data would otherwise be 21 inadmissible, the proponent of the opinion may disclose them to the jury only if their probative 22 value in helping the jury evaluate the opinion substantially outweighs their prejudicial effect.” Id. 23 Expert testimony is admissible under Rule 702 if it is both relevant and reliable. See 24 Daubert v. Merrell Dow Pharms., Inc., 509 U.S. 579, 597 (1993). The determination of whether 25 expert testimony is admissible is a matter within the Court’s discretion, see Kumho Tire Co., Ltd. 26 v. Carmichael, 526 U.S. 137, 142 (1999); Gen’l Elec. Co. v. Joiner, 522 U.S. 136, 141-43 (1997), 27 and “entails a preliminary assessment of whether the reasoning or methodology underlying the 1 applied to the facts in issue,” Daubert, 509 U.S. at 592-93. This “basic gatekeeping obligation” 2 applies to all expert testimony, not just scientific testimony. Kumho, 526 U.S. at 147. 3 Additionally, the Court’s inquiry is a flexible one, and “whether Daubert’s specific factors are, or 4 are not, reasonable measures of reliability in a particular case is a matter that the law grants the 5 trial judge broad latitude to determine.” Id. at 153.
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1 2 3 4 UNITED STATES DISTRICT COURT 5 NORTHERN DISTRICT OF CALIFORNIA 6 SAN JOSE DIVISION 7 8 BRIANA LEAKAS, et al., Case No. 22-cv-01422-VKD
9 Plaintiffs, ORDER GRANTING IN PART AND 10 v. DENYING IN PART DEFENDANTS’ MOTION TO EXCLUDE TESTIMONY 11 MONTEREY BAY MILITARY OF DAVID ROSS, M.D. HOUSING, LLC, et al., 12 Re: Dkt. No. 53 Defendants.
13 14 I. BACKGROUND 15 Plaintiffs Briana Leakas and her minor son, D.L. (along with Theodore Leakas, Ms. 16 Leakas’s spouse and D.L.’s guardian ad litem), filed this action in the Monterey County Superior 17 Court for personal injuries they claim they sustained as a result of toxic mold contamination in the 18 home they leased from defendants1 while living on the U.S. Army Garrison Presidio of Monterey 19 from about June 2019 through May 2020. Defendants removed the matter to this Court on the 20 ground that the underlying events occurred on a federal enclave. See Dkt. No. 4; see also Cnty. of 21 San Mateo v. Chevron Corp., 32 F.4th 733, 749 (9th Cir. 2022) (“[B]ecause conduct on a federal 22 enclave is generally subject to federal law, a claim based on injuries stemming from such conduct 23 arises under federal law, and a court has jurisdiction over such a claim under [28 U.S.C.] 24
25 1 Plaintiffs voluntarily dismissed two defendants (Clark Enterprises USA, LLC and Pinnacle Monterey, LLC) and later dropped defendant Clark Pinnacle Monterey Bay, LLC from their 26 operative complaint. See Dkt. Nos. 11, 12, 34. The two remaining defendants are Monterey Bay Military Housing, LLC and Michaels Management Services, LLC. Plaintiffs and all remaining 27 defendants have expressly consented that all proceedings in this matter may be heard and finally 1 § 1331.”); Albers v. Yarbrough World Sols., LLC, No. 5:19-cv-05896-EJD, 2020 WL 2218964, at 2 *7 (N.D. Cal. May 7, 2020) (“The California Legislature ceded the Monterey Presidio to the 3 United States Government in 1897. It is not contested by the Parties and the case law supports 4 that, when California ceded the Presidio to the United States, exclusive jurisdiction over that area 5 was conferred upon the United States.”) (citations omitted). 6 After the Court granted defendants’ motion to dismiss the complaint with leave to amend, 7 (see Dkt. No. 32), plaintiffs filed an amended complaint (the operative pleading), which asserts ten 8 state and common law claims for relief: negligence (claim 1); nuisance (claim 2); negligent 9 misrepresentation (claim 3); negligent infliction of emotional distress (claim 4); breach of implied 10 warranty of habitability (claim 5); breach of implied covenant of quiet use and enjoyment (claim 11 6); gross negligence (claim 7);2 premises liability (claim 8); constructive (wrongful) eviction 12 (claim 9); and fraud—concealment (claim 10). Dkt. No. 34. 13 Defendants move to exclude the testimony of one of plaintiffs’ retained medical experts, 14 David Ross, M.D., a board-certified neuropsychiatrist. Dkt. No. 53. Based on his June 28, 2023 15 examination of Ms. Leakas and a review of her medical records and other documents, Dr. Ross 16 concluded that due to biotoxin (i.e., mold) exposure at the home plaintiffs leased in Monterey, Ms. 17 Leakas developed an acquired brain injury caused by CIRS (i.e., Chronic Inflammatory Response 18 Syndrome), a mold-related illness. Dkt. No. 57-1 ¶¶ 3, 7; see also Dkt. No. 57-2, Ex. 1. 19 Defendants contend that Dr. Ross is not qualified to opine on medical causation and other issues 20 beyond his expertise in neuropsychiatry. Dkt. No. 53. They further contend that Dr. Ross’s 21 opinion that Ms. Leakas has an acquired brain injury caused by CIRS is not based on reliable 22 medical testing and data. Id. Plaintiffs oppose the motion. Dkt. No. 57. Following the motion 23 hearing, and with the Court’s leave, plaintiffs supplemented their opposition by submitting copies 24 of the studies or papers they say support their contentions. See Dkt. Nos. 68, 69. Upon 25 consideration of the moving and responding papers, as well as the oral arguments presented, the 26 2 Pursuant to the Court’s order on defendants’ motion to dismiss, plaintiffs were permitted to 27 pursue a claim for gross negligence, but only in the alternative to their separate claim for 1 Court grants in part and denies in part defendants’ motion to exclude Dr. Ross’s testimony. 2 II. LEGAL STANDARD 3 Rule 702 of the Federal Rules of Evidence provides that a witness “who is qualified as an 4 expert by knowledge, skill, experience, training, or education may testify in the form of an opinion 5 or otherwise,” if the proponent of the testimony “demonstrates that it is more likely than not” that:
6 (a) the expert’s scientific, technical, or other specialized knowledge will help the trier of fact to understand the evidence or to determine a fact in issue; 7 (b) the testimony is based on sufficient facts or data; 8 (c) the testimony is the product of reliable principles and methods; and 9 (d) the expert’s opinion reflects a reliable application of the principles and 10 methods to the facts of the case. 11 Fed. R. Evid. 702. Rule 702 recently was amended, effective December 1, 2023, “to clarify and 12 emphasize that expert testimony may not be admitted unless the proponent demonstrates to the 13 court that it is more likely than not that the proffered testimony meets the admissibility 14 requirements set forth in the rule.” Fed. R. Evid. 702 advisory committee’s note to 2023 15 amendment. 16 Rule 703 further identifies the permissible bases of an expert’s opinion testimony, 17 including “facts or data in the case that the expert has been made aware of or personally 18 observed.” Fed. R. Evid. 703. Additionally, “[i]f experts in the particular field would reasonably 19 rely on those kinds of facts or data in forming an opinion on the subject, [the facts or data] need 20 not be admissible for the opinion to be admitted.” Id. “But if the facts or data would otherwise be 21 inadmissible, the proponent of the opinion may disclose them to the jury only if their probative 22 value in helping the jury evaluate the opinion substantially outweighs their prejudicial effect.” Id. 23 Expert testimony is admissible under Rule 702 if it is both relevant and reliable. See 24 Daubert v. Merrell Dow Pharms., Inc., 509 U.S. 579, 597 (1993). The determination of whether 25 expert testimony is admissible is a matter within the Court’s discretion, see Kumho Tire Co., Ltd. 26 v. Carmichael, 526 U.S. 137, 142 (1999); Gen’l Elec. Co. v. Joiner, 522 U.S. 136, 141-43 (1997), 27 and “entails a preliminary assessment of whether the reasoning or methodology underlying the 1 applied to the facts in issue,” Daubert, 509 U.S. at 592-93. This “basic gatekeeping obligation” 2 applies to all expert testimony, not just scientific testimony. Kumho, 526 U.S. at 147. 3 Additionally, the Court’s inquiry is a flexible one, and “whether Daubert’s specific factors are, or 4 are not, reasonable measures of reliability in a particular case is a matter that the law grants the 5 trial judge broad latitude to determine.” Id. at 153. The proponent of expert testimony has the 6 burden of proving admissibility. Lust v. Merrell Dow Pharm., Inc., 89 F.3d 594, 598 (9th Cir. 7 1996); see also Fed. R. Evid. 702 advisory committee’s note to 2000 amendment. 8 III. DISCUSSION 9 A. Dr. Ross’s Qualifications 10 An expert may be qualified as such “by knowledge, skill, experience, training, or 11 education.” Fed. R. Evid. 702. Rule 702 “contemplates a broad conception of expert 12 qualifications,” and the rule “is broadly phrased and intended to embrace more than a narrow 13 definition of qualified expert.” Thomas v. Newton Int’l Enters., 42 F.3d 1266, 1269 (9th Cir. 14 1994). “The determination whether an expert witness has sufficient qualifications to testify is a 15 matter within the district court’s discretion.” United States v. Little, 753 F.2d 1420, 1455 (9th Cir. 16 1984). 17 Dr. Ross is board-certified in general psychiatry (since 1994), neuropsychiatry (since 18 2010), and brain injury medicine (since 2014). He says that he specializes in the treatment and 19 research of patients with traumatic and other types of brain injury and describes his “[m]ajor 20 career interests” as “[t]raumatic brain injury, MRI brain volume measurement, acquired brain 21 injury, mold-related illness, and other neuropsychiatric disorders.” Dkt. No. 57-2, Ex. 2 at 3-4. In 22 deposition, he testified that his treatment of patients with mold-related brain injury focuses on 23 neuropsychiatric issues, and not on other medical issues. See Dkt. No. 53-1, Ex. B (Ross Dep. at 24 23:9-20). 25 In his report, Dr. Ross states that Ms. Leakas has an acquired brain injury that resulted in 26 various impairments, including a number of non-neuropsychiatric conditions. See Dkt. No. 57-2, 27 Ex. 1 at 35-37. Defendants argue that to the extent Dr. Ross is permitted to testify at all, his 1 not be permitted to offer opinions regarding impairments in Ms. Leakas’s allergic/immunologic 2 system, dermatological system, sexual and reproductive system, musculoskeletal system, 3 gastrointestinal system, and others. See Dkt. No. 53 at 3. Plaintiffs argue that as a 4 neuropsychiatrist, Dr. Ross is qualified to testify about “various systems’ interconnectivity in the 5 human body.” See Dkt. No. 57 at 6. 6 Dr. Ross’s opinion goes beyond testifying about the interconnectivity of systems in the 7 human body. The import of his proposed testimony is that plaintiffs’ alleged exposure to mold at 8 the subject property led to a number of neuropsychiatric and other medical issues. Dr. Ross is 9 qualified to opine that, based on his evaluation, Ms. Leakas has brain abnormalities. Dr. Ross is 10 also qualified to testify about whether and to what extent Ms. Leakas’s brain abnormalities may be 11 consistent with neuropsychiatric symptoms or conditions he has observed in his treatment of 12 patients with mold-related brain injuries. However, plaintiffs have not met their burden to show 13 that Dr. Ross is qualified to opine on other medical issues beyond neuropsychiatric symptoms or 14 conditions. 15 Additionally, Dr. Ross is not qualified to testify regarding Ms. Leakas’s long-term care or 16 life-care planning needs. See Dkt. No. 57-2, Ex. 1 at 39-40. Defendants contend that he does not 17 have knowledge, training, or experience to offer expert testimony on such matters. See Dkt. No. 18 61 at 9-10. Plaintiffs presented no evidence or argument in response, and have failed to 19 demonstrate that Dr. Ross’s proposed testimony regarding Ms. Leakas’s long-term care or life- 20 care planning needs meets the admissibility requirements of Rule 702. 21 B. Dr. Ross’s Diagnosis of Mold-Related Acquired Brain Injury 22 Defendants’ challenge to Dr. Ross’s proposed testimony rests principally on their 23 contention that he cannot reliably testify, based on his evaluation conducted several years after she 24 moved out of the subject property, that Ms. Leakas has an acquired brain injury that was caused by 25 CIRS due to mold exposure. At the motion hearing, defendants clarified that they do not contest 26 that a May 2023 MRI of Ms. Leakas’s brain shows that she has brain abnormalities. Nor do they 27 contend that Dr. Ross lacks qualifications to evaluate that MRI or to assess that she has brain 1 that Ms. Leakas has an acquired brain injury that was caused by mold-related CIRS is unreliable 2 because (1) CIRS is not a diagnosis that is generally accepted within the medical community; and 3 (2) Dr. Ross’s diagnostic methodology is not the product of reliable principles or methods, or a 4 reliable application of any such principles and methods to the particular facts of this case. 5 1. CIRS Diagnosis 6 Preliminarily, the Court agrees with defendants that Dr. Ross may not testify or suggest 7 that Ms. Leakas’s CIRS diagnosis is his own. See Dkt. No. 53 at 3-4. It is undisputed that Dr. 8 Ross is not an ear-nose-throat doctor, a toxicologist, or an industrial hygienist. See Dkt. No. 53-1, 9 Ex. B (Ross Dep. at 64:20-24, 65:19-66:2). Dr. Ross’s report makes clear that he is relying on a 10 CIRS diagnosis reportedly made by Ms. Leakas’s treating providers. See Dkt. No. 57-2, Ex. 1 at 11 4, 24-25; see also Dkt. No. 53-1, Ex. B (Ross Dep. at 67:22-69:13). Additionally, Dr. Ross’s 12 report indicates that he also relied on “[d]iagnostic criteria for CIRS” of another of plaintiffs’ 13 retained experts, Andrew Heyman, M.D. See Dkt. No. 57-2, Ex. 1 at 24-25. As discussed in a 14 separate order on defendants’ motion to exclude Dr. Heyman’s testimony, the Court has 15 determined that Dr. Heyman’s opinion is not sufficiently reliable to meet the admissibility 16 requirements of Rule 702. 17 In any event, defendants argue that CIRS is not a generally accepted diagnosis in the 18 medical community. They cite to two papers, including one by the American College of 19 Occupational and Environmental Medicine and one by the American Academy of Allergy, 20 Asthma, and Immunology, which discuss that mold exposure has been found to impact human 21 health through three mechanisms—namely, allergy and other hypersensitivity reactions, infection, 22 and toxicity. See Dkt. No. 54-1, Ex. B (Hardin, et al., “Adverse Human Health Effects Associated 23 with Molds in the Indoor Environment,” Journal of Occupational and Environmental Medicine, 24 Vol. 45, No. 5, May 2003); id., Ex. C (Bush, et al. “The medical effects of mold Exposure,” 25 Journal of Allergy and Clinical Immunology, Vol. 11 7, No. 2, 2006). 26 Plaintiffs contend that “CIRS” is merely a “jargon” term that is used by members of the 27 “‘mold’ medical community” to describe a “functionally equivalent” condition known as “SIRS” 1 scientific community[.]” See Dkt. No. 57 at 9; see also Dkt. No. 59-1 ¶ 14.3 Plaintiffs therefore 2 propose that Dr. Ross’s “testimony related to CIRS may be accurately evaluated in scope and 3 legitimacy through the lens of SIRS.” Dkt. No. 57 at 9. While the article plaintiffs cite says that 4 CIRS is “modeled after” SIRS, it does not support their contention that “CIRS” and “SIRS” are 5 merely different labels for the same diagnosis. See Dkt. No. 57 at 9 n.3 (citing Shoemaker, et al, 6 “Review of Diagnostic process for chronic inflammatory response syndrome (CIRS): a consensus 7 statement report of the consensus committee of surviving mold,” Internal Medicine Review, 4(5)). 8 The parties also dispute the significance (or lack thereof) of the existence of an International 9 Classification of Diseases code for CIRS, and the Government Accountability Office’s case 10 definition of a biotoxin-based illness, and how that may bear on the general acceptability of CIRS 11 as a diagnosis. See Dkt. No. 53 at 5; Dkt. No. 57 at 10. 12 A court may admit somewhat questionable testimony if it falls within “the range where 13 experts might reasonably differ, and where the jury must decide among the conflicting views of 14 different experts, even though the evidence is ‘shaky.’” Kumho, 526 U.S. at 153 (citing Daubert, 15 509 U.S. at 596). On the record presented, plaintiffs have not demonstrated that Dr. Ross’s CIRS 16 diagnosis falls within that range. But even assuming that the validity of CIRS as a generally 17 accepted diagnosis is a matter more appropriately left to cross-examination and presentation of 18 evidence at trial, the fundamental issue raised by defendants’ Daubert motion is that Dr. Ross’s 19 opinions that Ms. Leakas’s brain injury was caused by CIRS due to an alleged exposure to mold 20 do not meet Rule 702 admissibility requirements. For the reasons discussed below, the Court 21 agrees. 22 2. Dr. Ross’s Differential Diagnosis 23 Defendants argue that in forming his conclusion that Ms. Leakas has an acquired brain 24 injury caused by mold-related CIRS, Dr. Ross did not employ a reliable scientific or medical 25 approach. For example, they point out that other courts, including the court in another toxic mold 26
27 3 Although plaintiffs do not expressly say so, they appear to be quoting from Dr. Heyman’s 1 action pending in the Southern District of California (“Phipps”),4 have observed that “[t]he most 2 widely-used method of demonstrating causation in toxic tort cases is to present scientifically- 3 accepted information about the dose-response curve for the toxin which confirms that the toxin 4 can cause the health effects experienced by the plaintiff at the dosage plaintiff was exposed to,” 5 Young v. Burton, 567 F. Supp. 2d 121, 128 (D.D.C. 2008), and that Dr. Ross did not use a dose- 6 response approach in attributing Ms. Leakas’s brain injury to CIRS. See Dkt. No. 53-1, Ex. K at 7 8-9. 8 There may be multiple ways by which an expert may demonstrate causation. Plaintiffs 9 assert that, using “objective methodologies in advance brain imaging techniques,” and based on 10 his experience, examination of Ms. Leakas, and a review of records and literature, Dr. Ross 11 conducted a differential diagnosis and ruled in CIRS as the cause of Ms. Leakas’s acquired brain 12 injury, while ruling out other potential causes of her symptoms. See Dkt. No. 57 at 16. 13 “Differential diagnosis, or differential etiology, is a standard scientific technique of 14 identifying the cause of a medical problem by eliminating the likely causes until the most probable 15 one is isolated.” Clausen v. M/V New Carissa, 339 F.3d 1049, 1057 (9th Cir. 2003) (citation 16 omitted). While it is true that an expert properly may rely on his extensive clinical experience in 17 making a differential diagnosis, the proper performance of a differential diagnosis involves “first 18 assum[ing] the pertinence of all potential causes, then rul[ing] out the ones as to which there is no 19 plausible evidence of causation, and then determin[ing] the most likely cause among those that 20 cannot be excluded.” Wendell v. GlaxoSmithKline LLC, 858 F.3d 1227, 1234, 1237 (9th Cir. 21 2017). Thus, “[t]he first step in the diagnostic process is to compile a comprehensive list of 22 hypotheses that might explain the set of salient clinical findings under consideration.” Clausen, 23 339 F.3d at 1057. “After the expert rules in all of the potential hypotheses that might explain a 24 patient’s symptoms, he or she must then engage in a process of elimination, eliminating 25 hypotheses on the basis of a continuing examination of the evidence so as to reach a conclusion as 26 to the most likely cause of the findings in that particular case.” Id. at 1058. “The expert must 27 1 provide reasons for rejecting alternative hypotheses ‘using scientific methods and procedures’ and 2 the elimination of those hypotheses must be founded on more than ‘subjective beliefs or 3 unsupported speculation.’” Id. at 1058 (quoting Claar v. Burlington N. R.R. Co., 29 F.3d 499, 502 4 (9th Cir. 1994)). Properly conducted differential diagnoses are generally admissible under 5 Daubert. Id. at 1057. However, a district court may exclude proposed expert evidence if the 6 expert fails to explain why an alternative cause was ruled out. Id. at 1058. 7 Defendants maintain that Dr. Ross did not conduct a proper differential diagnosis based on 8 reliable data, and instead offers opinions that are based on speculative reasoning and assumptions 9 that are not supported by the facts in this case. While some of the matters raised by defendants 10 may go to the weight, rather than the admissibility, of Dr. Ross’s proposed testimony, on the 11 whole Dr. Ross’s differential diagnosis is circular. Although Dr. Ross says that his opinion is that 12 Ms. Leakas has an acquired brain injury caused by mold-related CIRS, as noted above the 13 referenced CIRS diagnosis is not his own. Rather, Dr. Ross’s report indicates that he assumes that 14 Ms. Leakas has CIRS due to mold exposure based on others’ diagnosis, and then says that all of 15 the tests and analyses he performed are consistent with that diagnosis. While Dr. Ross will be 16 permitted to testify to a limited extent as discussed below, his opinions and proposed testimony 17 are inadmissible as a differential diagnosis that Ms. Leakas’s brain abnormalities were caused by 18 CIRS. 19 Dr. Ross’s report indicates that he examined Ms. Leakas, reviewed her medical and other 20 records, reviewed literature, and conducted his own tests and analysis of her brain. He states that 21 “[o]bjective evidence of acquired brain injury caused by mold-related illness” includes “[b]rain 22 volume abnormalities” obtained using NeuroQuant® and NeuroGage® analyses of a May 2023 23 MRI of Ms. Leakas’s brain. Dkt. No. 57-2, Ex. 1 at 27; see also id. at 4. As described by Dr. 24 Ross in deposition, NeuroQuant® and NeuroGage® are proprietary software programs he created 25 that are used to measure and analyze a patient’s brain volume. Dr. Ross further testified that 26 NeuroQuant® is FDA-cleared to measure MRI brain volume in human subjects and “can be 27 objective evidence of brain injury,” but is “not approved to diagnose any disease” or to “predict 1 28:13)). He testified that NeuroGage® is a program that runs data obtained from NeuroQuant® 2 and is used primarily “to look for objective signs of brain injury or disease.” See id. (Ross Dep. at 3 28:14-25). According to Dr. Ross, NeuroGage® does not have FDA clearance, but can “predict 4 whether a subject’s brain MRI is more consistent with the pattern seen with chronic, mild, or 5 moderate traumatic brain injury, or the pattern most commonly seen with normal controls.” See 6 id. (Ross Dep. at 28:14-16, 29:7-16). 7 With respect to Ms. Leakas, Dr. Ross noted that her May 2023 MRI “showed that she had 8 multiple volume abnormalities that was [sic] consistent with the pattern known to occur in 9 acquired brain injury caused by CIRS.” Dkt. No. 57-2, Ex. 1 at 4, 27. According to Dr. Ross, Ms. 10 Leakas has “markedly abnormal asymmetry of the cerebral white matter” that “correlated with her 11 extensive neuropsychiatric symptoms,” and that “[s]everal of her brain volume abnormalities 12 correlated with her clinical symptoms.” Id. at 5, 27. In particular, Dr. Ross stated that Ms. 13 Leakas’s brain volume appeared, in places, to be smaller than or equal to that of women over 14 twice her age. See id. at 5, 27 (“The volume of her right middle frontal cortex was less than that of 15 an average 100-year-old woman, and the volume of her left middle temporal cortex was equal to 16 that of an average normal 89-year-old woman.”). Dr. Ross stated that “[t]hese findings are 17 consistent with chronic effects of CIRS and indicated the extent of [Ms. Leakas]’s brain volume 18 abnormalities,” but he did not specify what neuropsychiatric or clinical symptoms reportedly 19 correlated with Ms. Leakas’s brain volume abnormalities. See id. at 5, 27. 20 Defendants contend that NeuroGage® has not been sufficiently tested or used in the 21 medical community to ensure the reliability of Dr. Ross’s opinion that Ms. Leakas’s brain 22 abnormalities were caused by mold-related CIRS. Plaintiffs argue that NeuroGage® cannot be 23 considered in isolation from NeuroQuant®, because the two programs generally are used in 24 tandem, as Dr. Ross apparently did in analyzing Ms. Leakas’s brain volume. They also present 25 articles, which they say are peer-reviewed, discussing the use of NeuroQuant® in studies of 26 structural brain changes in patients with inflammatory illnesses acquired after exposure to water- 27 damaged buildings, as well as one article by Dr. Ross himself (and others), asserting that 1 Dkt. No. 69, Exs. 1, 2, 5. Plaintiffs also generally cite to one of those litigation matters that they 2 say also concerns alleged toxic mold contamination on military property,5 but they have not 3 directed the Court to any particular document or decision from that case corroborating Dr. Ross’s 4 assertion or the particular circumstances surrounding the evidentiary value of NeuroQuant® and 5 NeuroGage® in that case. Plaintiffs contend that this evidence demonstrates that any dispute 6 regarding Dr. Ross’s NeuroQuant® and NeuroGage® analyses, at most, goes to the weight of his 7 testimony, rather than its admissibility. 8 Dr. Ross may testify about his testing and analysis of Ms. Leakas’s brain, including his use 9 of NeuroQuant® and NeuroGage®, and what that testing and analysis shows with respect to Ms. 10 Leakas’s neuropsychiatric symptoms and conditions. As discussed above, Dr. Ross may also 11 testify about whether and to what Ms. Leakas’s neuropsychiatric symptoms and conditions may be 12 consistent with neuropsychiatric symptoms or conditions he has observed in his treatment of 13 patients with mold-related brain injuries. To the extent defendants contend that Dr. Ross’s 14 NeuroQuant® and NeuroGage® analysis of a single May 2023 MRI was inconsistent with his 15 general practice or procedure, they may probe that issue on cross-examination. However, the 16 record indisputably demonstrates that NeuroQuant® and NeuroGage® are not diagnostic tools for 17 CIRS, or mold exposure, or mold-related illness, and are not FDA-cleared for such purposes. 18 Accordingly, Dr. Ross is not permitted to testify or offer opinions that his NeuroQuant® and 19 NeuroGage® analysis indicates that Ms. Leakas’s brain abnormalities were caused by CIRS due 20 to mold exposure. 21 At the motion hearing, plaintiffs stated that Dr. Ross’s assertion that Ms. Leakas’s brain 22 abnormalities are “consistent with the pattern known to occur in acquired brain injury caused by 23 CIRS” has support in scientific/medical literature—namely, a 2014 article by Ritchie C. 24 Shoemaker (and others) and a 2016 article by S.W. McMahon (and others). Dr. Ross does cite to 25 those articles in his report, although he appears to cite them for the proposition that mold-related 26 illness is “associated with abnormal enlargement of multiple brain regions,” whereas he seemed to 27 1 observe abnormally small regions in Ms. Leakas’s brain. Dkt. No. 57-2, Ex. 1 at 26; see also Dkt. 2 || No. 69, Exs. 1, 2. Whether or not that may be an inconsistency in Dr. Ross’s explanation for his 3 findings is a matter for cross-examination at trial. Plaintiffs have not, in any event, met their 4 || burden to show that Dr. Ross’s differential diagnosis is sufficiently reliable to permit his proposed 5 || testimony that Ms. Leakas’s acquired brain injury was caused by CIRS. 6 Plaintiffs misplace their reliance on Brancati v. Cachuma Village, LLC, 96 Cal. App. 5th 7 499 (2023), which is readily distinguishable from the present action in at least two significant 8 || respects. Unlike the present matter, test data regarding the property at issue in Brancati revealed 9 “high levels” of mold. Brancati, 96 Cal. App. 5th at 436. Additionally, the expert in question was 10 a board-certified allergist and immunologist who opined about the adverse impacts of mold on the 11 plaintiffs respiratory tract—a recognized health impact of exposure to mold. Id. at 430. While 12 || plaintiffs have submitted articles that appear generally to espouse the view that human exposure to 13 mold may cause an inflammatory response, leading to neurologic and neuropsychiatric symptoms 14 (see Dkt. No. 69), for the reasons discussed above, the Court finds that they have not met their 3 15 burden to establish that Dr. Ross has, more likely than not, reliably linked the cause of Ms. a 16 || Leakas’s brain abnormalities to plaintiffs’ alleged exposure to mold from years ago. 2 17 || IV. CONCLUSION Z 18 Based on the foregoing, defendants’ motion to exclude the testimony of Dr. Ross is 19 granted in part and denied in part. Dr. Ross will not be permitted to opine or testify that Ms. 20 || Leakas has an acquired brain injury that was caused by CIRS due to mold exposure. He also will 21 not be permitted to testify about Ms. Leakas’s long-term care or life-care planning needs. Dr. 22 || Ross will otherwise be permitted to testify to a limited extent, consistent with the rulings above. 23 IT IS SO ORDERED. 24 Dated: February 8, 2024
Virginia K. DeMarchi 26 United States Magistrate Judge 27 28